Teachware
Metrohm AG
CH-9100 Herisau
teachware@metrohm.com
This documentation is protected by copyright. All rights reserved.
Although all the information given in this documentation has been
checked with great care, errors cannot be entirely excluded. Should you
notice any mistakes please send us your comments using the address
given above.
Documentation in additional languages can be found on
http://documents.metrohm.com.
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Table of contents
1Introduction 1
1.1Welcome to tiamo ................................................................ 1
9.10No help available ............................................................ 1683
tiamo 2.4
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XIII
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1 Introduction
1.1 Welcome to tiamo
Introduction
1 Introduction
tiamo = titration and more
tiamo is a control and database software for titrators, dosing devices and
sample changers and makes complete laboratory automation possible. It is
for that reason that the name tiamo stands for "titration and more" tiamo can do more than just titrate.
tiamo is the successor software to TiNet and Workcell. Metrohm thus provides a uniform software product for laboratory automation. Companies
with international operations can use the same software platform at all
sites around the globe for the processing of their samples and exchange
data and methods without loss.
Overview of the main program features
■Easy-to-operate and easily configurable user interface
■Simple integration of devices and accessories
■Convenient method editor
■Database-based program with client/server functionality
■Wide range of import and export functions
■FDA compatibility in accordance with 21 CFR Part 11
■Comprehensive online help
tiamo 2.4
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1
1.2 Operation
■Program versions
■What is new in tiamo 2.4?
1.2 Operation
Introduction
The modern user interface makes it simple for users to find their way
around tiamo. All commands and control elements are located where you
would expect. The bar on the left edge of the screen gives you access to
the five basic elements of tiamo:
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Workplace
DatabaseMethodConfigura-
Manual
tion
Depending on the access permissions, these buttons are either visible or
invisible. The menu bar is in the upper part of the screen. It is also possible
for the individual commands to be hidden, depending on the access permissions.
In the center of the screen, you can find the information windows with
the settings, sample entry masks, live curves or results. This view can be
set individually for each user with the aid of the new Layout Manager. As
a result, users see only those windows or buttons they actually need for
their work. This reduces the introductory period for routine users to a minimum. Incorrect operation as a result of overcrowded screens is also a
thing of the past.
The method and calculation templates successfully introduced with
the Titrando system are also available in tiamo. A wide range of tried-andtested methods allow any user to create new methods quickly and simply
and to use them immediately.
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2
tiamo 2.4
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1.3 Device integration
Introduction
tiamo brings together the world of Titrino devices and the new genera-
tion of the Titrando System under the same roof. Compatibility with
existing Metrohm devices is not a matter of course in the software sector.
The entire product range of the Titrino family, which was already integrated in TiNet, can be used with tiamo, and this after more than 10 years on
the market! In addition, sample changers which to some extent are no
longer included in the sales program, are integrated in tiamo. That is how
Metrohm secures your investments!
It goes without saying that all of the models of the new Titrando generation, as well as the new sample processors, are compatible with tiamo.
Thus, the advantages of USB communications, such as plug-and-play or
recognition of intelligent dosing systems, can be used with tiamo to their
fullest extent. Even a mixed operation made up of older RS-232-operated
devices and newer USB devices is possible without any problem.
The new graphic method editor gets more out of your titration system.
With the aid of the numerous templates, methods can be created quickly
and easily. For most routine and automated tasks, there are tried-andtested methods available. Just a few clicks and they are adapted and ready
to use.
One new feature is that actions running in parallel at the same time
can now be programmed and linked. Together with the new Titrando system and the Robotic Sample Processors, a sample can be prepared while
the previous one is being titrated. This saves time and increases the sample throughput. The crowning feature is the simultaneous processing of
several samples. This means that one Titrando can carry out two titrations
at the same time. As a result, sample throughput is doubled!
tiamo is flexible and accommodates itself to analysis procedures, and not
the other way around.
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Overview of functions
■Graphical method editor (see Chapter 5.6.1.2, page 438)
■Method manager (see Chapter 5.3.1, page 417)
■Separate management of access permissions for each method group
(see Chapter 5.4.2.3, page 429)
■Templates for method development and calculations (see Chapter
5.2.1, page 404)
■Plausibility check for methods (see Chapter 5.2.5, page 413)
■Comments can be added to the methods (see Chapter 5.2.4.2.9, page
412)
■Parallel runs (see Chapter 5.6.10.3.1, page 1285)
■Loop functions (see Chapter 5.6.10.4.1, page 1287)
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4
tiamo 2.4
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1.5 Database
Introduction
tiamo is based on an object-oriented database, that has proven itself
in practice. All program settings, the user administration, methods and
templates are stored in the configuration database and the determination data is stored in the determination databases defined by the user.
These databases can be installed locally on the computer reserved for
measurements and make up a simple measurement system. tiamo is
however scalable and grows with operational requirements. As soon as
data security and central data management make it necessary, tiamo is
installed as a Client/Server configuration. The tiamo database is then
installed on a server. All measurement and office computers work as clients. All results are stored centrally in this network and can be accessed
and processed by all Client PCs. All clients also access the same pool of
methods.
The new database has all the major tools necessary for management of,
searching for and grouping of results. Quick filters allow the user to search
through thousands of determinations within seconds and to display the
result clearly. Chart plots give a fast overview of the sequence of results
based on time.
1 Introduction
All options for reprocessing are available to the user.
Overview of functions
■Object-oriented Client/Server database (see Chapter 6.2.3.1, page
1322).
■Layout manager for the database view (see Chapter 3.1.7, page 99).
■Quick filter (see Chapter 4.5.2.4.3, page 306).
■Efficient search functions (see Chapter 4.5.2.3, page 303).
■Access permissions control for every database (see Chapter 4.3.5.3,
page 208).
■Automatic database backup (see Chapter 4.3.5.4, page 209).
■Control charts (see Chapter 4.5.2.17, page 345).
■Reprocess determinations (see Chapter 4.5.2.6, page 316).
tiamo 2.4
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5
1.6 Communication
1.6 Communication
Introduction
The decisive factor for the acceptance of PC-controlled analysis systems is
being able to integrate it easily and economically in existing laboratory
information systems, central databases and long-term archiving systems.
tiamo is communicative. LIMS systems can easily import work lists into
the tiamo sample table and control them remotely, without extra modules. Data generated in tiamo can be exported in XML format. Connection to LIMS systems on the market is thus not difficult. Export to longterm archiving systems such as NuGenesis SDMS or Scientific Software
Cyberlab is also supported.
The Report generator provides a simple and flexible solution for creating analysis reports. The report generator allows you to freely define the
report templates. It is therefore possible at any time to display one or
more determinations in a choice of PDF layouts or as a printout.
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A special feature is that tiamo messages, error messages or results from
the method run can be sent to the user by e-mail.
Overview of functions
■Import of sample data (see Chapter 3.3.1.6, page 111).
■Various export formats , e.g. XML, CSV, SLK (see Chapter 4.4.4.2.1,
page 260).
■Automatic data export, e.g. to NuGenesis SDMS, Scientific Software
CyberLAB, etc. (see Chapter 5.6.8.5.1, page 1258).
■Report designer (see Chapter 4.4.1.4.1.1, page 216).
■E-mail functions for status messages, error messages or results (see
Chapter 2.6, page 93).
■Import of external measured values (see Chapter 5.6.3.11.2, page
934).
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6
tiamo 2.4
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1.7 Conformity
Introduction
tiamo also sets new standards with respect to the fulfilling of GMP, GLP
and FDA requirements. The latest quality standards and validation pro-
cedures were implemented in developing and programming the software.
tiamo has been designed to fulfill the FDA directive 21 CFR Part 11
and the customer-specific interpretations. This is evidenced by a Certificate
of Conformity. A centralized user administration defines the access permissions for program functions, methods and results, whereby any number of users with freely definable access profiles are possible. The system
administrator can conveniently access the user administration from any
tiamo client. Access to the software is password-protected and there is a
choice of tiamo or Windows login.
The use of digital signatures makes it possible to sign methods and
results. There are two signatures available with differing properties. With
the first signature (Level 1, Review) the user confirms that he has programmed the method correctly or carried out the analysis correctly. With the
second signature (Level 2, Release) the method or result is released and
protected against further modifications. It is thus possible to mirror customized workflows in tiamo.
1 Introduction
All data is organized according to the version and protected against
unauthorized access, modification or deletion in the database. The database itself controls access to the data in network operation and provides
archiving and restore functions.
The "Audit Trail" protocols all actions by the user and all major system
processes.
Conformity relevant properties of tiamo
■Conformity is priority in development and validation.
■Centralized user administration (see Chapter 6.2.1.1, page 1303).
■Detailed access permissions (see Chapter 6.2.1.2.2, page 1306).
■Password protection under tiamo or Windows (see Chapter 6.2.2.2,
page 1313).
■Digital signature on two levels (see Chapter 2.3, page 24).
■One signature each for methods and results.
■Documentation of all method and result modifications (see Chapter
4.5.2.14, page 343).
■Traceability thanks to detailed Audit Trail (see Chapter 6.4.1.1, page
1352).
tiamo 2.4
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7
1.8 Versions
1.8 Versions
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Introduction
tiamo is available in three sales versions which differ with regard to the
scope of functions. An upgrade is possible at any time.
tiamo 2.4
light
tiamo 2.4
full
tiamo 2.4
multi
Product6.6056.2416.6056.2426.6056.243
Maximum number
2unlimitedunlimited
of Metrohm
instruments per PC
Compatible with
••
FDA 21 CFR Part
11
User administra-
•••
tion
Security settings••
Traceability ("Audit
••
Trail")
Client/server sup-
•
port
Number of licen-
113
ses
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8
Additional licenses
•
as an option
XML data export
••
to LIMS
Parallel titrations••
Upgrade possible••
tiamo 2.4
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1.9 Online help
Introduction
Calling up the help
tiamo has an extensive and detailed online help that can be accessed in
two ways:
■General call With the menu item Help ▶ tiamo help, or the symbol
there you can jump via Contents, Index, Search or personal Favor-ites to the desired topic.
■Context-sensitive call With the function key [F1] on the keyboard
you can jump directly to the topic which will show information on the
active element in tiamo (dialog window, tab).
Symbols and conventions
The following symbols and styles are used in this documentation:
1 Introduction
the online help with the topic Welcome to tiamo is opened. From
Device table
Link to another help topic in which information is
shown for the marked term.
MethodDialog text
Designation for names of parameters, menu items,
tabs and dialog windows in the software.
100Designation for parameter values in input fields.
File ▶ NewMenu or menu item; Path needed to reach a certain
point in the program.
[Next]Button
Formula editor
Formulae can be entered in fields with this symbol,
and the formula editor opens when you click on the
symbol (see Chapter 2.4, page 30).
Instruction step
Carry out these steps in the sequence shown.
Caution
tiamo 2.4
This symbol draws attention to a possible damage of
instruments or instrument parts.
Note
This symbol marks additional information and tips.
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9
1.10 What is new in tiamo 2.4?
1.10 What is new in tiamo 2.4?
This chapter describes the changes that were made from tiamo 2.3 to
tiamo 2.4.
1.10.1 New features
General
■New determination examples for conductometric titrations are
included in the delivery (was already implemented in tiamo 2.3, Patch
1).
■It is now possible to carry out two-channel measurements using two
USB2 Avantes spectrometers that are connected with each other with
a synchronization cable.
Method program part
The flash rate can now be defined for the commands that can be carried
out with the Avantes spectrometer (MEAS Ref, MEAS Spec, MEASOpt, MEAS Opt Conc, CAL MEAS Opt).
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New instrument firmware
The new versions allow the instruments listed below to be operated
directly via the computer's USB3.0 connectors.
Instruments
Firmware version
814 USB Sample Processor5.814.0025
815 Robotic USB Sample Processor XL5.815.0026
846 Dosing Interface5.846.0022
851 Titrando5.851.0012
852 Titrando5.852.0012
855 Robotic Titrosampler5.855.0014
856 Conductivity Module5.856.0022
857 Titrando5.857.0022
859 Titrotherm5.846.0022
864 Robotic Balance Sample Processor XL5.815.0026
867 pH Module5.867.0022
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10
874 USB Oven Sample Processor5.874.0012
888 Titrando5.888.0022
tiamo 2.4
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1 Introduction
InstrumentsFirmware version
890 Titrando5.890.0022
901 Titrando5.901.0022
902 Titrando5.902.0022
904 Titrando5.904.0022
905 Titrando5.905.0022
906 Titrando5.906.0022
907 Titrando5.907.0022
Manual program part
■Dosing devices and stirrers can now be controlled in the section of the
089 Photometer.
■In two-channel instrument setups, it is possible to control the flash rate
for the instrument for the measuring channel.
1.10.2 Improvements
General
■Starting with version 2.4, tiamo also runs on Windows 8 operating sys-
tem.
■The installation manual now contains a description of the directories
that can be stored in a network.
■E-mails can now be sent simultaneously to several recipients.
■The Calculation algorithms ▶ Statistics chapter in the online help
has been revised.
Workplace program part
■If an instrument required in the method does not exist, the message
009-032 Device not OK is displayed instead of 009-117 Device
not ok. The new message also contains the corresponding command
name, in addition to the instrument name.
■The determination of the transmission factor (MEAS TMF command)
has been optimized.
Database program part
■If a regular spectrum is measured with the Avantes spectrometer
(MEAS Spec), it is now possible to modify the evaluation areas during
the reprocessing of the determination.
■In the Calibration curve/Calibration data dialog window, the num-
ber of decimal places for Variance has been increased from 1 to 3 for
CAL LOOP pH, CAL LOOP Conc and ELT LOOP.
tiamo 2.4
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11
1.10 What is new in tiamo 2.4?
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Method program part
■New method examples are supplied for the 864 validation. They are
stored in the directory
...\examples\methods\english\Automation\864 Validation methods.
■In the MET Cond command, the lower limit of the threshold value of
the minimum and maximum evaluation has been lowered on the
Additional evaluations tab.
■The off selection for the Control range parameter is described in the
online help in more detail for the commands SET and KFT.
■In the CAL LOOP Conc command, the selection for the Number of
standards parameter has been raised from 5 to 9.
■A recommendation has been added in the Standard addition -
Overview chapter in the online help.
■The description of the principle of titration and the optimization of the
parameters has been improved in the STAT - Overview chapter in the
online help.
■Variance is now also available as the VAR command variable in the
commands CAL LOOP pH, ELT LOOP and CAL LOOP Conc.
■The default value for the stirring rate of the 089 Photometer has been
increased to 5. This modification affects the commands MEAS TMF,
MEAS Opt, MEAS Opt Conc and CAL MEAS Opt.
Configuration program part
■The limitation to two instruments applies only for Metrohm instru-
ments (Titrino, Titrando, etc.). That means that balances and other
generic (i.e. non-Metrohm) instruments can be included without limitation (was already implemented in tiamo 2.3, Patch 1).
■The online help did not describe how signing affects the number of
login attempts, i.e. the relationship between signing and login monitoring.
1.10.3 Fixed bugs and problems
General
■Beginning with tiamo 2.3 (Build 98), communication between software
and devices has been optimized (was already implemented in tiamo
2.3, Patch 1).
■Client ID was output as text in various places (in the header of PDF
reports and the report templates, in the Information subwindow on
the Determination tab in the Database program part, in the Global
Variables subwindow on the Global Variable tab in the Configuration program part). The associated value, however, corresponded tothe computer name. Client ID has now been replaced with Computer name (the error was already eliminated in tiamo 2.3, Patch 1).
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tiamo 2.4
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1 Introduction
Workplace program part
■If a method was programmed in which a check at the time of the start
was required for one or several method variables of the type Number
(e.g. the Sample size) or Date/Time and which contained an ERROR
track, the exception wizard appeared in the Workplace program part
after the 014-152 Field empty message was exited when the determination was started (tiamo crashed) (this error was already eliminated
in tiamo 2.3, Patch 1).
■If a method was written in which the file name did not have the exten-
sion .pdf in the REPORT command in the PDF file field (completely
forgotten or only the period forgotten, e.g. abc or abcpdf), then this
would lead to a crash at the start of a determination (the error was
already eliminated in tiamo 2.3, Patch 1).
■If the digital output of the Avantes spectrometer was used (CTRL com-
mand) while a measuring command using the same device was also
present in the method, then the message 014-122 Device occupied
appeared (the error was already eliminated in tiamo 2.3, Patch 1).
■In the View ▶ Properties menu item, the properties of the respective
live display were always displayed as Properties Live display instead
of Properties Live display # (the error was already eliminated in
tiamo 2.3, Patch 1).
■If it is determined during the start test that the wavelength of the cali-
bration of the colorimetric sensor does not match the wavelength of
the light source of the 089 Photometer in the MEAS Opt Conc command, then the message 014-042 Incorrect wavelength appears.
Instead of the wavelength value of the colorimetric sensor calibration,
the wavelength value of the light source of the 089 Photometer was
specified in the message (the error was already eliminated in tiamo 2.3,
Patch 1).
■In the ELT MEAS command for the electrode test, the drift was not
evaluated at the correct time. This resulted in the sensor rating being
too strict.
■If a measuring command contained in a separate track was called from
a loop, then the command's indexed variables were not available after
the first run.
■If, in a REPORT command, all options were selected in the Report
output section (Printer, PDF file and Send e-mail), then it could
happen that e-mails were not sent during the run.
■If Calibration data monitoring was enabled for a conductivity sen-
sor and the validity for the calibration had expired, then no message
was displayed in the method run of a conductivity measurement,
MEAS Cond, and a titration, MET Cond.
■No message was displayed while the CAL Cond command was being
carried out when the new cell constant was outside the limit values
defined for the conductivity sensor.
tiamo 2.4
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13
1.10 What is new in tiamo 2.4?
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■The DBL command variable, which indicates the total time for process-
ing the command in s, yielded incorrect times for the commands
MEAS Ref, MEAS Spec and CAL Spec.
■If a standard addition was performed with no sample size entry, tiamo
crashed.
■The 016-003 Invalid position message used wrong parameters
(instrument name).
■If, on the Determination series tab in the Run subwindow, a new
line was added to the working sample table, then the method was
entered in the new line also when the Method check box was deactivated in the Copy automatically into next determination section
under [Sample table] ▶ Properties... ▶ Edit.
■When a method consisting of several parallel tracks was run, two dif-
ferent tracks were displayed at the same time in the live displays. When
you selected Quit in the context menu while hovering with the cursor
over one of the two live displays, then both tracks were canceled.
■In the CAL MEAS Opt command, no check was made during start
test as to whether the Wavelength measuring parameter corresponded with the wavelength of the calibration of the colorimetric sensor.
■The MEAS TC Cond command was not executed correctly in determi-
nations for the temperature coefficient measurement of the conductivity. When the start temperature was reached, the actual measurement
was not started, i.e., there was no live display of the curve. Instead, the
text Waiting for data... was still displayed. The error message
013-258 Invalid TC conductivity appeared when the stop time was
reached; the determination was canceled after the confirmation of the
error message.
Database program part
■If a determination was carried out with intelligent electrodes, then the
ADC data (ADC type and serial number) of the analog (non-intelligent)
measuring input to which the iConnect was connected was stored in
the Database, on the Configuration tab in the Information subwindow (this error was already eliminated in tiamo 2.3, Patch 1).
■If a determination was carried out with the 089 Photometer, then the
blank value was not subtracted in the database from the raw data IME
and EME (initial and end measured values, respectively) associated
with the commands MEAS Opt and MEAS Opt Conc (this error was
already eliminated in tiamo 2.3, Patch 1).
■If statistically linked determinations that also contained as results such
things as the slope, the axis intercept and the correlation coefficient for
linear regressions (variables SLO, ITC, COR) were recalculated in such
a way that a determination or a result was switched off, then the recalculated results of slope, axis intercept and correlation were not correct
(this error was already eliminated in tiamo 2.3, Patch 1).
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14
tiamo 2.4
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