Metrohm tiamo 2.2 User Manual

Name: Metrohm tiamo 2.2
Brand: Metrohm
SKU: 1624776
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tiamo 2.2

Manual

8.101.8033EN

Metrohm AG CH-9101 Herisau Switzerland

Phone +41 71 353 85 85 Fax +41 71 353 89 01 info@metrohm.com www.metrohm.com

tiamo 2.2

Manual

8.101.8033EN

02.2010 doe/ek/pkl

Teachware Metrohm AG CH-9101 Herisau

teachware@metrohm.com

Although all the information given in this documentation has been checked with great care, errors cannot be entirely excluded. Should you notice any mistakes please send us your comments using the address given above.

Table of contents

1 Introduction		1
1.1	Welcome to tiamo ................................................................	1
1.2	Operation ..............................................................................	2
1.3	Connecting devices ...............................................................	3
1.4	Method editor ......................................................................	4
1.5	Database ...............................................................................	4
1.6	Communication .....................................................................	5
1.7	Conformity ...........................................................................	6
1.8	Versions ................................................................................	7
1.9	Online help ...........................................................................	8
1.10	What is new in tiamo 2.2? ...................................................	9
1.10.1	New features ...........................................................................	9
1.10.2	Improvements .......................................................................	10
1.10.3 Fixed bugs and problems .......................................................		11

2 General program functions		13
2.1	Program parts .....................................................................	13
2.1.1	Program parts ........................................................................	13
2.1.2	Workplace - Desktop .............................................................	14
2.1.3	Database - Desktop ...............................................................	14
2.1.4	Method - Desktop ..............................................................	15
2.1.5	Configuration - Desktop ........................................................	15
2.1.6	Manual control - Desktop ......................................................	16
2.2	Login/password protection ................................................	16
2.2.1	General information on Login/Password protection ...............	16
2.2.2	Login .....................................................................................	17
2.2.3	Log out manually ..................................................................	18
2.2.4	Log out automatically ............................................................	18
2.2.5	Changing password ...............................................................	18
2.3	Electronic signatures ..........................................................	19
2.3.1	Rules for electronic signatures ...............................................	19
2.3.2	Procedure for electronic signatures ........................................	20
2.3.3	Signature Level 1 ...................................................................	21
2.3.4	Signature Level 2 ...................................................................	22
2.3.5	Delete Signature Level 2 ........................................................	24
2.4	Formula editor ....................................................................	25
2.4.1	Input field ..............................................................................	25
2.4.2	Calculation algorithms ...........................................................	26
2.4.3	Variables ...............................................................................	28

tiamo 2.2

III

Table of contents
2.4.4	Operators/functions ...............................................................	49
2.4.5	Molar mass calculator ............................................................	83
2.5	Editing .................................................................................	83
2.5.1	Select date ............................................................................	83
2.5.2	Text editor .............................................................................	84
2.5.3	Hyperlink ...............................................................................	85
2.6	E-mail ...................................................................................	86
2.6.1	Send E-mail ...........................................................................	86
3 Workplace		87
3.1	Workplace - General .........................................................	87
3.1.1	Workplace - Definition ...........................................................	87
3.1.2	Workplace - Desktop .............................................................	87
3.1.3	Workplace - Menu bar ...........................................................	87
3.1.4	Workplace - Toolbar ..............................................................	89
3.1.5	Workplace - Subwindows ......................................................	90
3.1.6	Workplace - Functions ...........................................................	91
3.1.7	Views ....................................................................................	92
3.2	Workplaces .........................................................................	95
3.2.1	Create new workplace ...........................................................	95
3.2.2	Edit workplace .......................................................................	95
3.2.3	Displaying workplaces ...........................................................	96
3.2.4	Close workplace ....................................................................	97
3.3	Sample tables ......................................................................	97
3.3.1	Editing the sample table ........................................................	97
3.3.2	Sample table - Properties .....................................................	107
3.3.3	Sample table manager .........................................................	116
3.4	Sample assignment table .................................................	118
3.4.1	Sample assignment table ..................................................	118
3.4.2	Sample assignment .............................................................	119
3.4.3	Enter assignment ID .............................................................	120
3.5	Text templates ..................................................................	120
3.5.1	List of text templates ...........................................................	120
3.5.2	Edit text template ................................................................	121
3.6	Subwindow Run ...............................................................	121
3.6.1	Run - General ......................................................................	121
3.6.2	Run test ...............................................................................	122
3.6.3	Single determination ............................................................	123
3.6.4	Determination series ............................................................	138
3.7	Subwindow Method .........................................................	169
3.7.1	Method window - General ..................................................	169
3.7.2	Method window - Zoom .....................................................	169
3.7.3	Method window - Live modifications ...................................	170
3.7.4	Method window - Cancel command ....................................	171
3.8	Subwindow Live display ..................................................	171
3.8.1	Live display - General ...........................................................	171

tiamo 2.2

		Table of contents
3.8.2	Live display - Tracks .............................................................	171
3.8.3	Live display - Application note .............................................	173
3.8.4	Live display - Messages ........................................................	173
3.8.5	Live display - Properties ........................................................	173
3.9	Subwindow Report .........................................................	180
3.9.1	Report - General .................................................................	180
3.9.2	Latest report .......................................................................	181
3.9.3	Selected report ...................................................................	181
3.9.4	Report overview .................................................................	181
3.9.5	Properties report overview ...................................................	182
4 Database		183
4.1	Database - General ...........................................................	183
4.1.1	Database - Definition ...........................................................	183
4.1.2	Database - Desktop .............................................................	183
4.1.3	Database - Menu bar ...........................................................	184
4.1.4	Database - Toolbar ............................................................	188
4.1.5	Database - Subwindows ....................................................	190
4.1.6	Database - Functions ...........................................................	190
4.1.7	Views ..................................................................................	191
4.2	Database display ..............................................................	194
4.2.1	Open database ...................................................................	194
4.2.2	Select database ...................................................................	195
4.2.3	Display single database .......................................................	196
4.2.4	Display databases next to one another .................................	196
4.2.5	Display databases one below the other ................................	196
4.2.6	Close database ...................................................................	197
4.3	Manage databases ...........................................................	197
4.3.1	Manage databases .............................................................	197
4.3.2	Create new database ...........................................................	198
4.3.3	Rename database ................................................................	199
4.3.4	Delete database ...................................................................	199
4.3.5	Database properties .............................................................	199
4.3.6	Backup database manually ...................................................	203
4.3.7	Restore database ...............................................................	204
4.4	Templates ..........................................................................	205
4.4.1	Report templates .................................................................	205
4.4.2	Templates for control chart ..................................................	240
4.4.3	Curve overlay templates .......................................................	244
4.4.4	Export templates .................................................................	250
4.5	Determination overview ..................................................	283
4.5.1	Determination overview - General ........................................	283
4.5.2	Determination overview - Functions .....................................	289
4.6	Subwindow Information ..................................................	333
4.6.1	Information - Overview .....................................................	333
4.6.2	Information - Determination ...........................................	334
4.6.3	Information - Method .....................................................	337

tiamo 2.2

Table of contents
4.6.4	Information - Sample ...........................................................	339
4.6.5	Information - Configuration .........................................	340
4.6.6	Information - Messages .....................................................	346
4.6.7	Information - Determination comment	.............................. 347
4.7	Subwindow Results ..........................................................	347
4.7.1	Results - General ..................................................................	347
4.7.2	Results - Results overview ....................................................	348
4.7.3	Results - Raw data ...............................................................	349
4.7.4	Results - Calculation # .........................................................	358
4.7.5	Results - Properties ..............................................................	360
4.8	Subwindow curves ...........................................................	361
4.8.1	Curves - General ..................................................................	361
4.8.2	Curves - Measuring point list ................................................	362
4.8.3	Curves - Monitoring report ..................................................	362
4.8.4	Properties ............................................................................	364
5 Method		379
5.1	Method - General .............................................................	379
5.1.1	Method - Definition .........................................................	379
5.1.2	Method - Desktop ............................................................	380
5.1.3	Method - Menu bar .............................................................	380
5.1.4	Method - Toolbar ...............................................................	382
5.1.5	Method - Functions .............................................................	384
5.2	Method editor ...................................................................	385
5.2.1	Creating new method ..........................................................	385
5.2.2	Opening method .................................................................	385
5.2.3	Select method ...................................................................	387
5.2.4	Edit method ........................................................................	389
5.2.5	Checking method ................................................................	394
5.2.6	Saving method ....................................................................	394
5.2.7	Modification comment on method ......................................	396
5.2.8	Print method report .............................................................	397
5.2.9	Closing method ...................................................................	397
5.3	Managing methods ..........................................................	398
5.3.1	Managing methods .............................................................	398
5.3.2	Renaming method ..............................................................	400
5.3.3	Copying method ..................................................................	400
5.3.4	Moving method ..................................................................	400
5.3.5	Deleting method .................................................................	401
5.3.6	Sending method to ..............................................................	401
5.3.7	Exporting a method .............................................................	402
5.3.8	Importing method ..............................................................	402
5.3.9	Renaming imported method ................................................	402
5.3.10	Signing methods .................................................................	403
5.3.11	Showing method history ......................................................	408
5.4	Method groups .................................................................	409
5.4.1	Manage method groups ....................................................	409

tiamo 2.2

		Table of contents
5.4.2	Edit method groups .............................................................	410
5.5	Tracks ................................................................................	411
5.5.1	Tracks - General ...................................................................	411
5.5.2	Track types ..........................................................................	412
5.5.3	Edit tracks ...........................................................................	417
5.6	Commands ........................................................................	418
5.6.1	Commands - General ...........................................................	418
5.6.2	Track commands .................................................................	422
5.6.3	Titration commands .............................................................	437
5.6.4	Measuring commands .........................................................	881
5.6.5	Calibration commands .......................................................	1016
5.6.6	Dosing commands .............................................................	1060
5.6.7	Automation commands .....................................................	1115
5.6.8	Result commands ..............................................................	1140
5.6.9	Communications commands ..............................................	1158
5.6.10	Miscellaneous commands ..................................................	1179
6 Configuration		1195
6.1	Configuration - General .................................................	1195
6.1.1	Configuration - Definition ..................................................	1195
6.1.2	Configuration - Desktop ....................................................	1195
6.1.3	Configuration - Menu bar ..................................................	1196
6.1.4	Configuration - Toolbar ....................................................	1198
6.1.5	Configuration - Subwindows ........................................	1198
6.1.6	Configuration - Functions ..................................................	1199
6.1.7	Views ................................................................................	1200
6.2	Administration ................................................................	1203
6.2.1	User administration ...........................................................	1203
6.2.2	Security settings ................................................................	1212
6.2.3	Program administration .....................................................	1222
6.3	Configuration data .........................................................	1226
6.3.1	Export/Import ....................................................................	1226
6.3.2	Backup/Restore ..................................................................	1231
6.3.3	Templates ..........................................................................	1234
6.3.4	Options .............................................................................	1241
6.4	Audit Trail .......................................................................	1244
6.4.1	Audit Trail - General ..........................................................	1244
6.4.2	Audit Trail table .................................................................	1248
6.5	Subwindow Devices ......................................................	1259
6.5.1	Configuration - Devices .....................................................	1259
6.5.2	Device table .......................................................................	1260
6.5.3	Device properties ...............................................................	1264
6.6	Subwindow Titrants/Solutions ......................................	1265
6.6.1	Titrants/Solutions - General ................................................	1265
6.6.2	Solution table ....................................................................	1266
6.6.3	Solution properties ............................................................	1269

tiamo 2.2

VII

Table of contents
6.7	Subwindow Sensors .......................................................	1288
6.7.1	Sensors - General ...............................................................	1288
6.7.2	Sensor table ......................................................................	1289
6.7.3	Sensor properties ...............................................................	1293
6.8	Subwindow Common variables ...................................	1312
6.8.1	Configuration - Common variables ...................................	1312
6.8.2	Table of common variables ................................................	1312
6.8.3	Common variables properties ............................................	1315
6.9	Subwindow Global variables .........................................	1321
6.9.1	Configuration - Global variables .........................................	1321
6.9.2	Table of global variables ....................................................	1321
6.9.3	Properties Global variables .................................................	1324
6.10	Subwindow Sample solutions (TC conductivity) .........	1330
6.10.1	Sample solutions (TC conductivity) - General ......................	1330
6.10.2	Sample solutions (TC conductivity) table .............................	1330
6.10.3	Sample solutions (TC conductivity) properties .....................	1333
6.11	Subwindow Rack data ...................................................	1337
6.11.1	Configuration - Rack data ...............................................	1337
6.11.2	Rack table .........................................................................	1337
6.11.3	Rack properties ..................................................................	1339
7 Devices		1346
7.1	Titrando ..........................................................................	1346
7.1.1	Titrando - Overview ...........................................................	1346
7.1.2	Properties - General ...........................................................	1346
7.1.3	Properties - Measuring inputs ............................................	1347
7.1.4	Properties - MSB # .............................................................	1348
7.1.5	Properties - GLP ................................................................	1350
7.1.6	Load new program version ...............................................	1351
7.2	Titrino ..............................................................................	1352
7.2.1	Titrino - Overview ..............................................................	1352
7.2.2	Properties - General ...........................................................	1353
7.2.3	Properties - Int. Dosing device D0 ......................................	1354
7.2.4	Properties - Ext. Dosing device D# ......................................	1355
7.2.5	Properties - RS-232 ............................................................	1356
7.2.6	Properties - GLP ................................................................	1357
7.3	756/831 Coulometer ......................................................	1359
7.3.1	756/831 Coulometer - Overview ........................................	1359
7.3.2	Properties - General ...........................................................	1359
7.3.3	Properties - RS-232 ............................................................	1360
7.3.4	Properties - GLP ................................................................	1361
7.4	712 Conductometer .......................................................	1363
7.4.1	712 Conductometer - Overview .........................................	1363
7.4.2	Properties - General ...........................................................	1363
7.4.3	Properties - RS-232 ............................................................	1364
7.4.4	Properties - GLP ................................................................	1365

VIII

tiamo 2.2

		Table of contents
7.5	856 Conductivity Module ..............................................	1367
7.5.1	856 Conductivity Module - Device .....................................	1367
7.5.2	Properties - General ...........................................................	1367
7.5.3	Properties - Measuring inputs ............................................	1368
7.5.4	Properties - MSB # .............................................................	1369
7.5.5	Properties - GLP ................................................................	1370
7.6	867 pH Module ...............................................................	1372
7.6.1	867 pH Module - Overview ................................................	1372
7.6.2	Properties - General ...........................................................	1373
7.6.3	Properties - Measuring inputs ............................................	1374
7.6.4	Properties - MSB # .............................................................	1375
7.6.5	Properties - GLP ................................................................	1376
7.7	846 Dosing Interface .....................................................	1378
7.7.1	846 Dosing Interface - Overview ........................................	1378
7.7.2	Properties - General ...........................................................	1378
7.7.3	Properties - MSB # .............................................................	1379
7.7.4	Properties - GLP ................................................................	1380
7.8	730 Sample Changer ......................................................	1382
7.8.1	730 Sample Changer - Overview ........................................	1382
7.8.2	Properties - General ...........................................................	1383
7.8.3	Properties - Tower .............................................................	1384
7.8.4	Properties - Rack ................................................................	1385
7.8.5	Properties - Dosing device ..................................................	1385
7.8.6	Properties - RS-232 ............................................................	1386
7.8.7	Properties - GLP ................................................................	1386
7.9	774 Oven Sample Processor ..........................................	1388
7.9.1	774 Oven Sample Processor - Overview .............................	1388
7.9.2	Properties - General ...........................................................	1389
7.9.3	Properties - Tower .............................................................	1390
7.9.4	Properties - Rack ................................................................	1390
7.9.5	Properties - Dosing device ..................................................	1391
7.9.6	Properties - Oven ...............................................................	1392
7.9.7	Properties - Gas .................................................................	1393
7.9.8	Properties - RS-232 ............................................................	1393
7.9.9	Properties - GLP ................................................................	1394
7.10	778/789 Sample Processor ............................................	1396
7.10.1	778/789 Sample Processor - Overview ...............................	1396
7.10.2	Properties - General ...........................................................	1396
7.10.3	Properties - Tower # ..........................................................	1397
7.10.4	Properties - Rack ................................................................	1399
7.10.5	Properties - MSB # .............................................................	1400
7.10.6	Properties - RS-232 ............................................................	1401
7.10.7	Properties - GLP ................................................................	1402
7.11 814/815 USB Sample Processor ....................................		1404
7.11.1	814/815 USB Sample Processor - Overview ........................	1404
7.11.2	Properties - General ...........................................................	1404
7.11.3	Properties - Tower # ..........................................................	1405

tiamo 2.2

Table of contents
7.11.4	Properties - Rack ................................................................	1407
7.11.5	Properties - MSB # .............................................................	1408
7.11.6	Properties - GLP ................................................................	1409
7.11.7	Configuration Robotic arm ................................................	1411
7.11.8	External position ...............................................................	1412
7.12	855 Robotic Titrosampler ..............................................	1413
7.12.1	855 Robotic Titrosampler - Overview .................................	1413
7.12.2	Properties - General ...........................................................	1413
7.12.3	Properties - Measuring inputs ............................................	1414
7.12.4	Properties - Tower # ..........................................................	1415
7.12.5	Properties - Rack ................................................................	1417
7.12.6	Properties - MSB # .............................................................	1418
7.12.7	Properties - GLP ................................................................	1419
7.13	864 Balance Sample Processor .....................................	1421
7.13.1	864 Balance Sample Processor - Overview .........................	1421
7.13.2	Properties - General ...........................................................	1421
7.13.3	Properties - Tower # ..........................................................	1422
7.13.4	Properties - Rack ................................................................	1424
7.13.5	Properties - MSB # .............................................................	1425
7.13.6	Properties - GLP ................................................................	1426
7.14	874 Oven Sample Processor ..........................................	1428
7.14.1	874 Oven Sample Processor - Overview .............................	1428
7.14.2	Properties - General ...........................................................	1429
7.14.3	Properties - Tower .............................................................	1430
7.14.4	Properties - Rack ................................................................	1430
7.14.5	Properties - MSB # .............................................................	1431
7.14.6	Properties - Oven ...............................................................	1432
7.14.7	Properties - GLP ................................................................	1433
7.15	Avantes Spectrometer ...................................................	1435
7.15.1	Avantes Spectrometer - Overview ......................................	1435
7.15.2	Properties - General ...........................................................	1435
7.15.3	Properties - Settings ...........................................................	1436
7.15.4	Properties - Detector ..........................................................	1437
7.15.5	Properties - Calibration ......................................................	1438
7.15.6	Properties - Dark spectrum ................................................	1438
7.15.7	Properties - Reference spectrum ........................................	1439
7.15.8	Properties - GLP ................................................................	1440
7.16	RS-232 device .................................................................	1442
7.16.1	RS-232 device - Overview ..................................................	1442
7.16.2	Properties - General ...........................................................	1442
7.16.3	Properties - RS-232 ............................................................	1443
7.16.4	Properties - GLP ................................................................	1445
7.16.5	Establish a connection to the RS-232 device ......................	1447
7.17	Balances ..........................................................................	1448
7.17.1	Balance - Overview ............................................................	1448
7.17.2	Properties - General ...........................................................	1448
7.17.3	Properties - RS-232 ............................................................	1449

tiamo 2.2

			Table of contents
	7.17.4	Properties - GLP ................................................................	1450
	7.17.5	Establish a connection to the balance ................................	1452
	7.18	Barcode reader ...............................................................	1453
	7.18.1	Barcode reader - General ...................................................	1453
	7.18.2	Barcode reader - Overview .................................................	1454
	7.18.3	Properties - General ...........................................................	1454
	7.18.4	Properties - Settings ...........................................................	1455
	7.18.5	Properties - GLP ................................................................	1455
	7.18.6	Establish a connection to the barcode reader .....................	1457
8	Manual Control		1458
	8.1	Manual Control - General ..............................................	1458
	8.2	Manual control - Desktop ..............................................	1458
	8.3	Manual Control - Device selection ................................	1459
	8.4	Manual Control - Functions ...........................................	1459
	8.4.1	Dosing ...............................................................................	1459
	8.4.2	Stirring ..............................................................................	1465
	8.4.3	Remote functions ..............................................................	1467
	8.4.4	Sample changer functions ..................................................	1469
	8.4.5	Measure ............................................................................	1478
	8.5	Manual Control - Graphical display ..............................	1482
9	How to proceed?		1483
	9.1	Audit Trail .......................................................................	1483
	9.1.1	Opening Audit Trail .........................................................	1483
	9.1.2	Filtering Audit Trail ...........................................................	1483
	9.1.3	Exporting Audit Trail .........................................................	1484
	9.1.4	Archiving Audit Trail .........................................................	1485
	9.1.5	Deleting Audit Trail ..........................................................	1486
	9.2	Backup ............................................................................	1487
	9.2.1	Backing up database .........................................................	1487
	9.2.2	Restoring database ............................................................	1489
	9.2.3	Backing up configuration data ...........................................	1490
	9.2.4	Restoring configuration data .............................................	1491
	9.2.5	Backing up methods ..........................................................	1492
	9.2.6	Archive Audit Trail ............................................................	1494
	9.3	Determinations ...............................................................	1496
	9.3.1	Starting single determination .............................................	1496
	9.3.2	Starting determination series .............................................	1497
	9.3.3	Search for determinations ..................................................	1499
	9.3.4	Filter determinations ..........................................................	1499
	9.3.5	Signing determination .......................................................	1501
	9.3.6	Export determinations .......................................................	1503
	9.3.7	Importing determinations ..................................................	1504
	9.3.8	Deleting determinations ...................................................	1505
	9.3.9	Make the determination version current ............................	1506

tiamo 2.2

Table of contents
9.3.10	Reprocessing determinations ...........................................	1507
9.3.11	Printing determination report ............................................	1511
9.3.12	Printing determination overview ......................................	1512
9.4	Databases .......................................................................	1513
9.4.1	Database in general ...........................................................	1513
9.4.2	Open database .................................................................	1514
9.4.3	Close database .................................................................	1514
9.4.4	Create database ................................................................	1515
9.4.5	Backing up database .........................................................	1516
9.4.6	Restoring database ............................................................	1517
9.4.7	Delete database .................................................................	1518
9.5	Configuration data .........................................................	1519
9.5.1	Configuration data in general ............................................	1519
9.5.2	Export configuration data ..................................................	1519
9.5.3	Importing configuration data .............................................	1520
9.5.4	Backing up configuration data ...........................................	1520
9.5.5	Restoring configuration data .............................................	1521
9.6	Methods ..........................................................................	1523
9.6.1	Open method ....................................................................	1523
9.6.2	Closing method ................................................................	1523
9.6.3	Create method .................................................................	1524
9.6.4	Save method .....................................................................	1524
9.6.5	Deleting method ..............................................................	1525
9.6.6	Exporting method ............................................................	1526
9.6.7	Import methods ..............................................................	1526
9.6.8	Sign methods ..................................................................	1527
9.6.9	Making previous method version current .........................	1528
9.6.10	Print method report ..........................................................	1529
9.6.11	Backup methods ...............................................................	1530
9.7	Method groups ...............................................................	1532
9.7.1	Creating method group ....................................................	1532
9.7.2	Deleting method group ....................................................	1532
9.8	Sample tables .................................................................	1533
9.8.1	Create sample table ..........................................................	1533
9.8.2	Edit sample table ..............................................................	1534
9.8.3	Loading working sample table ..........................................	1535
9.8.4	Edit working sample table .................................................	1536
9.9	Reports ............................................................................	1537
9.9.1	Creating report template ..................................................	1537
9.9.2	Edit report template .........................................................	1538
9.9.3	Printing determination report ...........................................	1540
9.9.4	Printing determination overview ......................................	1541
Index		1543

XII

tiamo 2.2

1 Introduction

1.1Welcome to tiamo

Introduction

tiamo = titration and more

tiamo is a control and database software for titrators, dosing devices and sample changers and makes complete laboratory automation possible. It is for that reason that the name tiamo stands for «titration and more» - tiamo can do more than just titrate.

tiamo is the successor software to TiNet and Workcell. Metrohm thus provides a uniform software product for laboratory automation. Companies with international operations can use the same software platform at all sites around the globe for the processing of its samples and exchange data and methods without loss.

Overview of the main program features

Program interface: easy to operate and configure

Simple integration of devices and accessories

Convenient method editor

Database-based program with Client/Server functionality

A wide range of import and export functions

FDA-compatibility in acc. with 21 CFR Part 11

Comprehensive online help

tiamo 2.2

1.2 Operation

Program versions

What is new in tiamo 2.2?

1.2Operation

Introduction

The modern user interface makes it simple for the user to find his/her way around tiamo. All the commands and control elements are where you would expect to find them. The bar on the left edge of the screen gives you access to the five basic elements of tiamo:

Workplace	Database	Method	Configura-	Manual
			tion

Depending on the access rights, these buttons are either visible or invisible. The menu bar is in the upper part of the screen. It is also possible for the individual commands to be masked out, depending on the access rights.

In the centre of the screen are the information windows with the settings, sample entry masks, live curves or results. This view can be set individually for each user with the aid of the new Layout Manager. This means that the users only see the buttons needed for their work. This reduces the introductory period for routine users to a minimum; incorrect operation as a result of overcrowded screens are also a thing of the past.

The method and calculation templates successfully introduced with the Titrando system are also available in tiamo. A wide range of tried and tested methods allow any user to create new methods fast and simply and to use them immediately.

tiamo 2.2

1 Introduction

1.3Connecting devices

Introduction

tiamo brings together the world of Titrino devices and the new generation of the Titrando System under the same roof. Compatibility with existing Metrohm devices is not a matter of course in the software sector. The entire product range of the Titrino family, which was already integrated in TiNet, can be used with tiamo, and this after more than 10 years on the market! In addition, sample processors which to some extent are no longer included in the sales program, are integrated in tiamo. That is how Metrohm secures your investments!

Naturally, all of the models of the new Titrando generation, as well as the new sample processors, are compatible with tiamo. Thus, for example, the advantages of USB communications, such as plug-and-play or recognition of intelligent dosing systems, can be used with tiamo to their fullest extent. Even a mixed operation made up of older RS-232-operated devices and newer ones with USB controls is possible without any problem.

Devices that can be used with tiamo

Titrando

808, 809, 835, 836, 841, 842, 851, 852, 855, 857, 888, 890, 901, 902, 904, 905, 906, 907

Titrino

702, 716, 718, 719, 720, 721, 736, 751, 758, 784, 785, 794, 795, 798, 799

Conductometer

712, 856

KF coulometer

756, 831

Sample changer

730, 774, 778, 789, 814, 815, 855, 864, 874

Miscellaneous

846 Dosing Interface, 859 Titrotherm, 867 pH module, Avantes spectrometer, balances, barcode readers, IO controllers, …

tiamo 2.2

1.4 Method editor

1.4Method editor

Introduction

The new graphic method editor gets more out of your titration system. With the aid of the numerous templates, methods can be created fast and easily. For most routine and automated tasks, there are tried and tested methods available. Just a few clicks and they are adapted and ready to use.

One new feature is that actions running parallel in terms of time can now be programmed and linked. Now a sample can be prepared with the new Titrando System and the Robotic Sample Processors while the previous one is being titrated. This saves time and increases sample throughput. The crowning feature is the simultaneous processing of several samples at once. This means that one Titrando can carry out two titrations at the same time. As a result, sample throughput is doubled!

tiamo is flexible and accommodates itself to analysis procedures, and not the other way around.

Overview of functions

Graphic method editor (see Chapter 5.6.1.2, page 419)

Method manager (see Chapter 5.3.1, page 398)

Separate management of access rights for each method group (see Chapter 5.4.2.3, page 410)

Templates for method development and calculation (see Chapter 5.2.1, page 385)

Plausibility check for methods (see Chapter 5.2.5, page 394)

Comments can be added to the methods (see Chapter 5.2.4.2.9, page 393)

Parallel runs (see Chapter 5.6.10.3.1, page 1183)

Loop functions (see Chapter 5.6.10.4.1, page 1185)

1.5Database

Introduction

tiamo is based on an object-oriented database, that has proven itself in practice. In the configuration database, all program settings, user administration, methods and templates are stored and in the determination databases defined by the user, the determination data. These databases can be installed locally on the computer reserved for measurements and make up a simple measurement system. tiamo is however scalable and grows with operational requirements. As soon as data security and central data management make it necessary, tiamo is installed as a Client/Server configuration. The tiamo database is then installed on a server. All measurement and office computers work as clients. All results are stored centrally

tiamo 2.2

1 Introduction

in this network and can be accessed and processed by all Client PCs. All clients also access the same pool of methods.

The new database has all the major tools necessary for management of, searching for and grouping of results. Quick filters allow the user to search through thousands of determinations within seconds and to display the result clearly. Chart plots give a fast overview of the sequence of results based on time.

All options for reprocessing are available to the user.

Overview of functions

Object-oriented Client/Server database (see Chapter 6.2.3.1, page 1222).

Layout manager for the database view (see Chapter 3.1.7, page 92).

Quick filter (see Chapter 4.5.2.4.3, page 293).

Efficient search functions (see Chapter 4.5.2.3, page 289).

Access rights control for every database (see Chapter 4.3.5.3, page 200).

Automatic database backup (see Chapter 4.3.5.4, page 201).

Control cards (see Chapter 4.5.2.17, page 330).

Reprocess determinations (see Chapter 4.5.2.6, page 303).

1.6Communication

Introduction

The decisive factor for the acceptance of PC-controlled analysis systems is being able to integrate it easily and economically in existing laboratory information systems, central databases and long-term archiving systems.

tiamo is communicative. LIMS systems can easily import work lists into the tiamo sample table and control them remotely, without extra modules. Data generated in tiamo can be exported in XML format. Connection to LIMS systems on the market is thus not difficult. Export to long-term archiving systems such as NuGenesis SDMS or Scientific Software Cyberlab is also supported.

The Report generator provides a simple and flexible solution for creating analysis reports. The report generator allows you to freely define the report. It is therefore possible at any time to display one or more determinations in a choice of PDF layouts or as a printout.

A special feature is that tiamo messages, error messages or results from the method run can be sent to the user by E-mail.

Overview of functions

Importing sample data (see Chapter 3.3.1.6, page 104).

tiamo 2.2

1.7 Conformity

Various export formats , e.g. XML, CSV, SLK (see Chapter 4.4.4.2.1, page 251).

Automatic data export, e.g. to NuGenesis SDMS, Scientific Software CyberLAB, etc.(see Chapter 5.6.8.5.1, page 1157)

Report designer (see Chapter 4.4.1.4.1.1, page 208).

E-mail functions for status messages, error messages or results (see Chapter 2.6, page 86).

Importing external measured values (see Chapter 5.6.3.11.2, page 880).

1.7Conformity

Introduction

tiamo also sets new standards with respect to the fulfilling of GMP, GLP and FDA requirements. The latest quality standards and validation procedures were already being applied at the time of software development and programming.tiamo has been designed to fulfill the FDA directive 21 CFR Part 11 and its customer-specific interpretations. This is evidenced by a Certificate of Conformity. A centralized user administration defines the access rights for program functions, methods and results, whereby any number of users with freely definable access profiles are possible. The system administrator can conveniently access the user administration from any tiamo client. Access to the software is password-protected and there is a choice of tiamo or Windows login.

The use of digital signatures makes it possible to sign methods and results. There are two signatures available with differing properties. With the first signature (Level 1, Review) the user confirms that he has programmed the method correctly or carried out the analysis correctly. With the second signature (Level 2, Release) the method or result is released and protected against further modifications. It is thus possible to mirror customized workflows in tiamo.

All data is organized according to the version and protected against unauthorized access, modification or deleting in the database. The database itself controls access to the data in network operation and provides archiving and restore functions.

The «Audit Trail» protocols all actions by the user and all major system processes.

Conformity relevant properties of tiamo

Conformity is priority in development and validation.

Centralized user administration (see Chapter 6.2.1.1, page 1203).

Detailed access rights (see Chapter 6.2.1.2.2, page 1205).

Password protection under tiamo or Windows (see Chapter 6.2.2.2, page 1213).

tiamo 2.2

1 Introduction

Digital signature on two levels (see Chapter 2.3, page 19).

One signature each for methods and results.

Documentation of all methods and changes in results (see Chapter 4.5.2.14, page 329).

Traceability thanks to detailed Audit Trail (see Chapter 6.4.1.1, page 1244).

1.8Versions

Introduction

tiamo is available in three sales versions, which differ with regard to the scope of functions. An upgrade is possible at any time.

	tiamo 2.2	tiamo 2.2	tiamo 2.2
	light	full	multi

Product	6.6056.221	6.6056.222	6.6056.223
Maximum number	2	unlimited	unlimited
of devices per PC
Compatible with		•	•
FDA 21 CFR Part 11
User administration	•	•	•
Security settings		•	•
Traceability («Audit		•	•
Trail»)
Client/Server sup-			•
port
Number of licenses	1	1	3
Additional licenses			•
as an option
XML data export to		•	•
LIMS
Parallel titrations		•	•
Upgrade possible	•	•

tiamo 2.2

1.9 Online help

1.9Online help

Introduction

Calling up the Help

tiamo has an extensive and detailed online help that can be requested in two ways:

General request With the menu item Help tiamo Help, or the symbol the online help with the topic Welcome to tiamo is opened. From there you can jump via Contents, Index, Search or personal Favorites to the desired topic.

Context-sensitive request With the function key [F1] on the keyboard you can jump directly to the topic which will show information on the active element in tiamo (dialog window, tab).

Symbols and conventions

The following symbols and styles are used in this documentation:

Devoce table	Link to another help topic in which information is
	shown for the marked term.

Method	Dialog text
	Designation for names of parameters, menu items,
	tabs and dialog windows in the software.

100	Designation for parameter values in input fields.

File New	Menu or menu item; Path needed to reach a certain
	point in the program.

[Continue]	Button

	Formula editor
	Formulae can be entered in fields with this symbol, and
	the formula editor opens when you click on the symbol
	(see Chapter 2.4, page 25).

	Instruction step
	Carry out these steps in the sequence shown.

	Warning
	This symbol draws attention to a possible risk of fatal
	injury or risk of injury.

	Warning
	This symbol draws attention to a possible hazard due
	to electrical current.

tiamo 2.2

1 Introduction

Warning

This symbol draws attention to a possible hazard due to heat or hot instrument parts.

Warning

This symbol draws attention to a possible biological hazard.

Caution

This symbol draws attention to a possible risk of damage to instruments or instrument parts.

Note

This symbol marks additional information and tips.

1.10What is new in tiamo 2.2?

Introduction

In this chapter the changes since tiamo 2.1 are described.

1.10.1New features

New instruments

859 Titrotherm

Note

When installing tiamo 2.2 an eventually existing USB driver for the 859 Titrotherm from the Multitrator software will be deleted and replaced by the tiamo driver. Therefore it cannot be titrated with the Multitrator software on this system anymore.

New commands

TET: Command for thermometric titration with the 859 Titrotherm.

RLS DEV: Release device for parallel working on another workplace.

RLS DOS: Release dosing device for parallel working on another workplace.

News in the program part Workplace

Sample data: By typing in the first characters to the field Method the selection of the method is continuously restricted and allows fast selecting of the method required.

tiamo 2.2

1.10 What is new in tiamo 2.2?

Statistical results are being additionally regressed against the Sample size. This results in the new variables .SLO, .ITC, .COR. This can be used e.g. for validation purposes, for titer and blank value determinations (thermal titration).

News in the program part Method

In the formula editor the sample data variables of the next sample line are available.

News in the program part Configuration

Besides client-specific common variables, there are also global variables available which are saved over all clients and can be used in formulas under the designation 'GV.Name'.

New sensor type: Thermoprobe for Titrotherm.

1.10.2Improvements

Program part Workplace

With single determinations in which the option Autorepeat determination is set, the field Autostart is displayed for the determination parameteres in which the number of determination starts already carriedout is shown.

The request windows for the commands WAIT and REQUEST are now automatically resized if the text content needs more space.

Program part Database

The dialog window Open database opens immediately and shows all databases. Additional information (database size, etc.) is displayed one after the other. The access rights are then checked when opening the databases.

The databases are opened even faster if they are sorted by the Determination start.

In the menu File the last five databases opened on this client are listed.

Reading-in barcodes has been improved.

tiamo repairs databases automatically.

Fixed values are being displayed inactive in the Recalculating.

The sequence of the results in the statistics dialog corresponds to the definition in the CALC command (this concerns the results view in the determination database, views in the Recalculating, report result list, report statistics short, report statistics overview).

Program part Method

Command REPORT: The path for PDF and E-mail address can be transferred as variables.

Command WAIT: The E-mail address can be transferred as a variable.

Command CALC: The E-mail address can be transferred as a variable.

tiamo 2.2

1 Introduction

Program part Configuration

Global variables, text templates and sample assignment tables can be exported and imported.

When changing the titer, the values Date titer det., Titration method, User are additionally saved in the Audit Trail.

Program part Manual Control

If all stirrers are selected, no Stirring time for continuous operation can be entered.

1.10.3Fixed bugs and problems

General

When tiamo is closed before the login dialog appears, then an exception may occur.

If having canceled after the entry of the licence update (tiamo 1.x to tiamo 2.x) and tiamo is normally started afterwards, an error message occurs.

Program part Workplace

Fast reading-in of barcodes can lead to the fact, that no more barcodes can be read-in.

If a titration command is started via a SEND command in status Cond not ok, then no entry appears in the message list.

Program part Database

The data of a conductivity determination is not displayed with the menu item Determinations Show calibration curve....

The blank value with a concentration calibration is not being recalculated in the Recalculating.

Indexed method variables get lost during the Recalculating.

With fixed reports, in the selection list, the report Used titrants/solutions is missing.

The run test returns an exception when a WEIGH command is present in the method.

Program part Method

DOS: For Titrinos, the stirrer mistakenly occurs on the tab General/ Hardware.

In the method parameters report the field Tolerance is missing for CAL Spec.

Program part Configuration

When newly adding a Titrando, the firmware version is not being checked.

The PREP warning does not appear for the 700 Dosino and 685 Dosimat.

tiamo 2.2

1.10 What is new in tiamo 2.2?

If a rack has the same name as a rack template in the directory .../tiamo/ res/rackdata, an exception may occur.

tiamo 2.2

2 General program functions

2.1Program parts

2.1.1Program parts

General program functions

tiamo™ has five different program parts which can be opened by clicking on the corresponding symbol in the vertical bar on the left. The symbol for the opened program part is shown in color, the symbols for the other program parts in black and white. The menus, symbol bars and content of the main window depend on the program part currently opened.

Workplace program part

Opening/closing workplaces

Starting single determinations and determination series

Sample tables

Database program part

Opening/closing databases

Managing databases

Reprocessing

Creating report templates

Method program part

Opening/closing existing methods

Creating new methods

Managing methods

Configuration program part

Configure devices, solutions, sensors, common variables and rack data

Security settings

User administration

Program administration

Audit Trail

tiamo 2.2

2.1 Program parts

Manual program part

Manual control of devices

Note

Access to the individual program parts can be deactivated in the user administration. In this case, the corresponding symbols are hidden.

2.1.2Workplace - Desktop

Program part: Workplace

Workplace symbol

Clicking on the workplace symbol in the vertical bar on the left opens the program part Workplace while, at the same time, the workplace symbol is shown in color. The upper left corner of the symbol contains a black field displaying the number of workplaces currently opened (see Chapter 3.2.3.1, page 96).

Elements

The desktop of the program part Workplace comprises the following elements:

Workplace-specific menu bar.

Workplace-specific toolbar.

Main window in which up to 5 subwindows can be displayed.

2.1.3Database - Desktop

Program part: Database

Database symbol

Clicking on the database symbol in the vertical bar on the left opens the program part Database while, at the same time the database symbol is

tiamo 2.2

2 General program functions

shown in color. The upper left corner of the symbol contains a black field displaying the number of databases currently opened (see Chapter 4.2.2, page 195).

Elements

The desktop of the program part Database comprises the following elements:

Database-specific menu bar.

Database-specific toolbar.

Main window in which up to 6 subwindows can be displayed.

2.1.4Method - Desktop

Program part: Method

Method Symbol

Clicking on the method symbol in the vertical bar on the left opens the program part Method while, at the same time the method symbol is shown in color. The upper left corner of the symbol contains a black field displaying the number of methods currently opened (see Chapter 5.2.3, page 387).

Elements

The desktop of the program part Method comprises the following elements:

Method-specific menu bar.

Method-specific toolbar.

Main window, in which several methods can be opened but only two methods can be shown at the same time.

2.1.5Configuration - Desktop

Program part: Configuration

Configuration symbol

By clicking on on the configuration symbol in the vertical bar at the left-hand margin the program part Configuration is opened, at the same time the configuration symbol is shown in color.

tiamo 2.2

2.2 Login/password protection

Elements

The desktop of the program part Configuration comprises the following elements:

Configuration-specific menu bar.

Configuration specific toolbar.

Main window in which up to 6 subwindows can be displayed.

2.1.6Manual control - Desktop

Program part: Manual Control

Manual Control symbol

If you click on the Manual symbol in the vertical bar on the left margin, the program part Manual Control will be opened in its own window, while the Manual symbol will be shown in color at the same time.

Elements

The desktop of the program part Manual control comprises the following elements:

Selecting device

Functions/Parameters

Graphic function

2.2Login/password protection

2.2.1General information on Login/Password protection

Program parts: Workplace / Database / Method / Configuration

tiamo can be configured so that all users have to log in with their user name and password and this data is automatically checked. This requires a user administration to be set up and the corresponding security settings to be made. This data is saved in the configuration database. In the case of client/server systems, this is on the server and applies globally for all clients (central user administration).

FDA-conforming settings

If you are to be in conformity with FDA, the settings on the tab Login/ Password protection in the dialog window Security settings have to be activated corresponding to 21 CFR 11 with the button [Set]. The following conditions are therefore complied with:

tiamo 2.2

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