Metrohm 845 User Manual

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845 Eluent Synthesizer

Handbuch

8.845.8001EN

Metrohm AG CH-9100 Herisau Switzerland Phone +41 71 353 85 85 Fax +41 71 353 89 01 info@metrohm.com www.metrohm.com

845 Eluent Synthesizer

8.845.8001EN

Handbuch

08.2008 zst

Teachware Metrohm AG CH-9100 Herisau teachware@metrohm.com

Although all the information given in this documentation has been checked with great care, errors cannot be entirely excluded. Should you notice any mistakes please send us your comments using the address given above.

Documentation in additional languages can be found on

http://documents.metrohm.com.

Contents

Table of contents

1 Introduction.................................................... 1

1.1 Instrument description ............................................................. 1

1.2 Parts and controls .................................................................... 1

1.2.1 Front of 2.845.0010 .......................................................................2

1.2.2 Front of 2.845.0020 .......................................................................3

1.2.3 Rear view .......................................................................................4

1.3 Information on the Instructions for Use .................................. 6

1.3.1 Organization ..................................................................................6

1.3.2 Notation and pictograms ..............................................................7

1.4 Safety information..................................................................... 8

1.4.1 Electrical safety..............................................................................8

1.4.2 General precautionary rules .......................................................... 8

2 Installation ..................................................... 9

2.1 Setting up the instrument ......................................................... 9

2.1.1 Packaging...................................................................................... 9

2.1.2 Check.............................................................................................9

2.1.3 Location ......................................................................................... 9

2.2 Mains connection...................................................................... 9

2.3 Connection to PC.................................................................... 10

2.4 Dosino(s)/Stirrer connections................................................ 11

2.5 Tubing connections ................................................................ 11

2.5.1 Instrument with tubing connections ............................................12

2.5.2 Connecting the drainage tubing .................................................13

2.5.3 Connections to bottle adapter ....................................................13

2.5.4 Connecting the components.......................................................13

2.6 pH Controller........................................................................... 14

2.6.1 Tubing connection for pH Controller........................................... 14

2.6.2 pH Controller cable connection ..................................................15

3 «Mix Control» software................................. 16

3.1 Introduction to the software ................................................... 16

3.1.1 The principle of «Mix Control» .....................................................16

3.1.2 Procedure after the first start of «Mix Control» ............................16

3.2 Main Window........................................................................... 16

3.2.1 Menus..........................................................................................16

3.2.2 Description of the symbols .........................................................19

3.3 Method..................................................................................... 20

3.3.1 General information about methods ...........................................20

3.3.2 Parameters ..................................................................................20

3.3.3 pH Adjustment.............................................................................21

3.3.4 Creating a method.......................................................................23

3.4 Configuration .......................................................................... 23

3.4.1 Depot ........................................................................................... 23

3.4.2 Components................................................................................25

3.4.3 System Settings........................................................................... 26

3.4.4 Report Configuration ...................................................................27

3.4.5 User Administration ..................................................................... 29

3.4.6 Rinse............................................................................................33

3.5 Extras....................................................................................... 36

3.5.1 Sign methods ..............................................................................36

845 Eluent Synthesizer / Instructions for Use 8.845.8001EM

Contents

3.5.2 Audit trail...................................................................................... 37

3.5.3 Window "Report List" ................................................................... 39

3.5.4 GLP Manager .............................................................................. 41

3.5.5 Firmware Update......................................................................... 43

3.5.6 Login Service............................................................................... 44

4 Maintenance - Troubleshooting...................45

4.1 Care .........................................................................................45

4.1.1 Decommissioning .......................................................................45

4.2 Dosing units ............................................................................ 45

4.2.1 Deinstallation............................................................................... 45

4.2.2 Cleaning ...................................................................................... 46

4.2.3 Installation ...................................................................................47

4.3 Troubleshooting...................................................................... 49

5 Annex ............................................................50

5.1 Technical data......................................................................... 50

5.1.1 Interfaces..................................................................................... 50

5.1.2 Mains connection........................................................................ 50

5.1.3 Safety specifications ...................................................................50

5.1.4 Electromagnetic compatibility (EMC) .........................................50

5.1.5 Ambient temperature ..................................................................51

5.1.6 Dosing drive ................................................................................ 51

5.1.7 Dosing Unit.................................................................................. 51

5.1.8 Reference conditions .................................................................. 51

5.1.9 Dimensions ................................................................................. 51

5.2 Standard equipment ............................................................... 52

5.2.1 Standard equipment for 2.845.0010........................................... 52

5.2.2 Standard equipment for 2.845.0020........................................... 54

5.2.3 Accessories for pH adjustment (optional) .................................. 57

5.2.4 Optional accessories ..................................................................61

5.2.5 Producers of concentrates and standards ................................. 62

5.2.6 Systems for producing ultra pure water ..................................... 62

5.3 Warranty .................................................................................. 63

5.3.1 Warranty ......................................................................................63

5.3.2 Declaration of Conformity ...........................................................64

5.3.3 Quality Management Principles .................................................. 65

5.3.4 Index............................................................................................ 66

List of figures

Figure 1: Front of 2.845.0010 ....................................................................... 2

Figure 2: Front of 2.845.0020 ....................................................................... 3

Figure 3: Rear view of 845 Eluent Synthesizer ............................................. 4

Figure 4: Tubing connections..................................................................... 12

Figure 5: Dosing unit attachment ............................................................... 46

Figure 6: Connections with one Dosino ..................................................... 47

Figure 7: Connections with two Dosinos.................................................... 48

845 Eluent Synthesizer / Instructions for Use 8.845.8001EN

1.1 Instrument description

1 Introduction

The 845 Eluent Synthesizer and its associated «Mix Control» software can be used for the fully automatic preparation of solutions and mixtures such as eluents, mobile phases, buffer solutions or standards with the required concentration and component ratios.

The 845 Eluent Synthesizer is based on the Dosino technology which allows high-precision dosing to be carried out. Both aqueous (acidic or basic) and organic mixtures can be prepared. The system (with an optional extension) can also be used to adjust the pH.

1.1 Instrument description

Two versions of the instrument are available :

• 2.845.0010 845 Eluent Synthesizer with one Dosino

• 2.845.0020 845 Eluent Synthesizer with two Dosinos

The 2.845.0010 Eluent Synthesizer with one Dosino can be used to mix together three components (of which one is the main component). The 2.845.0020 Eluent Synthesizer with two Dosinos can be used to mix together five components (of which one is the main component).

Both versions contain a built-in magnetic stirrer The software «Mix Control» is supplied with the instrument.

The 2.702.0120 Eluent Synthesizer Package for the automatic pH adjustment is offered as an option. In addition to a 702 Titrino this also contains an Aquatrode, a 10 mL exchange unit and a Remote Box (see

Section

The 845 Eluent Synthesizer is connected to a PC via a USB and operated with the «Mix Control» PC software provided. The operation of the software is described in the online help and in Section structions for Use.

5.2.3).

1.2 Parts and controls

3 of these In-

In this Section you will find the numbers and designations of the parts and controls of the 845 Eluent Synthesizer. The numbering applies throughout the Instructions for Use, i.e. bold numbers in the text (e.g.

) refer to the parts and controls illustrated here.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

1 Introduction

1.2.1 Front of 2.845.0010

Figure 1: Front of 2.845.0010

LED "Power"

Lights up green when the instrument is switched on.

Place for eluent bottle

To place the eluent bottle while preparing the mixture. There is a built-in magnetic stirrer beneath it.

Holder for bottle adapter

21.

Dosino 1 outlet

Outlet for the components from Dosino

Connections for components

Connections for components 1 - 3.

Recesses for magnetic labels

For identifying components 1 - 3.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

1.2 Parts and controls

1.2.2 Front of 2.845.0020

Figure 2: Front of 2.845.0020

1 LED "Power"

Lights up green when the instrument is switched on.

2 Place for eluent bottle

The eluent bottle is placed here for preparing the mixture. There is a builtin magnetic stirrer beneath it.

3 Holder for bottle adapter

Holder for bottle adapter

21.

4 Dosino 1 outlet

Outlet for the components from Dosino

5 Connections for components

Connections for components 1 - 5.

6 Recesses for magnetic labels

For identifying components 1 - 5.

Dosino 2 outlet

Outlet for components from Dosino 2.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

1 Introduction

1.2.3 Rear view

Figure 3: Rear view of 845 Eluent Synthesizer

Lead-throughs for Dosino cables

Lead-through for stirrer cable

Connection "Stirrer / MSB3"

For connecting a stirrer (cable marked with "Stirrer").

USB-connections USB1 and USB2

USB-ports (type A) for connecting devices with a USB cable.

Controller connection

For connecting to a PC.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

1.2 Parts and controls

Connection "MSB1 / Dosino 1"

For connecting Dosino 1 (cable marked with "Dosino 1").

Connection "MSB2 / Dosino 2"

For connecting Dosino 2 (cable marked with "Dosino 2") (only for version 2.845.0020).

Connection "Remote Box / MSB4"

For connecting the Remote-Box for pH adjustment with Titrino(s) (see Section

2.6.2).

Mains connection socket

Mains connection (see Section

Device type and serial number

Connection for drainage tubing

For draining off any liquid that has escaped inside the instrument (see Sec-

2.5.2).

tion

Rear panel

2.2).

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

1 Introduction

1.3 Information on the Instructions for Use

Please read through these Instructions for Use carefully before you put the 845 Eluent Synthesizer into operation. The Instructions for Use contain information and warnings to which the user must pay attention in order to assure safe operation of the instrument.

1.3.1 Organization

These Instructions for Use 8.845.1003 for the 845 Eluent Synthesizer provide a comprehensive overview of installation, operation, maintenance, fault rectification and technical specifications of this instrument. The Instructions for Use are organized as follows:

Sect.

1 Introduction

General description of instrument, parts and controls and safety notes.

Sect.

2 Installation

Installation of the instrument, mains connection, connection to PC, connection of Dosino(s)/stirrer, pH controller.

3 «Mix Control» software

Sect.

Explanation of how to use the «Mix Control» software.

Sect.

4 Maintenance - Troubleshooting

Care, cleaning the dosing units, troubleshooting.

Sect.

5 Annex

Technical data, standard equipment, options, warranty, conformity declarations, index.

To find the required information on the instruments, use either the Ta-

ble of contents or the Index at the back.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

1.3 Information on the Instructions for Use

1.3.2 Notation and pictograms

The following notations and pictograms (symbols) are used in these Instructions for Use:

12 Part or control

Hazard

This symbol draws attention to a possible danger to life or of injury if the associated directions are not followed correctly.

Warning This symbol draws attention to possible damage to instruments or instrument parts if the associated directions are not followed correctly.

Caution This symbol marks important information. First read the associated directions before you continue.

Comment This symbol marks additional information and tips.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

1 Introduction

1.4 Safety information

This instrument must only be operated in accordance with the information provided in these Instructions for Use.

1.4.1 Electrical safety

While electrical safety in the handling of the 845 Eluent Synthesizer is assured in the context of the specifications EN / IEC 61010-1, the following points should be noted:

• Electronic parts

Only qualified Metrohm technicians should carry out service work on electronic components.

• Protection against electrostatic charges

Electronic components are sensitive to electrostatic charges and can be destroyed by a discharge.

1.4.2 General precautionary rules

• Handling of solvents

Check all lines of the IC system periodically for possible leaks. Follow the relevant instructions regarding the handling of flammable and/or toxic solvents and their disposal.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

2.1 Setting up the instrument

2 Installation

2.1 Setting up the instrument

2.1.1 Packaging

The 845 Eluent Synthesizer is supplied together with the separately packed accessories in special packagings containing shock-absorbing foam linings designed to provide excellent protection. Please store all these special packagings as only they assure transport of the instrument free from damage.

2.1.2 Check

After receipt, immediately check whether the shipment is complete and has arrived without damage (compare with delivery note and list of accessories in Section structions in Section

5.2). In the case of transport damage, see in-

5.3.1 "Warranty".

2.1.3 Location

This instrument was developed for internal laboratory use; it should not be used in explosion-endangered locations.

Place the instrument on a suitable vibration-free laboratory bench, protected as much as possible from corrosive atmospheres and contact with chemicals. Choose a location where the temperature is usually between +5°C and +45°C. The instrument should be protected against excessive variations in temperature and direct sunlight.

2.2 Mains connection

Mains cable

The instrument is supplied with one of three mains cables

• 6.2122.020 with plug SEV 12 (Switzerland, …)

• 6.2122.040 with plug CEE(7), VII (Germany, …)

• 6.2122.070 with plug NEMA 5-15 (USA, …)

which are three-cored and fitted with a plug with a grounding pin. If a different plug has to be fitted, the yellow/green lead (IEC standard) must be connected to protective ground (protection class 1).

Any break in the grounding inside or outside the instrument can make it a hazard!

Mains connection

Plug the mains cable into mains connection plug Synthesizer.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

16 of the 845 Eluent

2 Installation

2.3 Connection to PC

The 845 Eluent Synthesizer is controlled by the «Mix Control» PC software (see Section

System requirements

• Processor: Pentium III

• Main memory: 256 MB RAM

• Free memory space: 100 MB for program files

• CD-ROM drive

• Connection: one free USB slot (type A)

Microsoft Windows must be used as the operating system.

Installation

To connect the instrument and install the software proceed as follows:

3).

2000 or WindowsTM XP or WindowsTM Vista

1 Installing the «Mix Control» program

• Insert installation CD in CD disk drive.

• If autostart has not

<Start> and Run. Search for the Setup.exe file on the in-

stallation CD and click on

• Click on "

Mix Control" and follow the instructions of the

been activated for the CD drive: select

<OK>.

setup program.

2 Connection 845 - PC

• Connect the 845 Eluent Synthesizer (socket "Controller" 12) to a USB connection (type A) of your computer with the

6.2151.000 Cable (see the instruction manual for your computer).

• A system test will automatically be carried out on the 845 Eluent Synthesizer.

• The LED "Power"

1 lights up when the system test has been

completed and the instrument is ready for use.

The plug for connection of the 845 Eluent Synthesizer is fitted with a "pull-out protection device" which prevents the cable from being pulled out accidentally. When you wish to insert or remove the plug you must first pull back the outer plug sleeves (marked with arrows).

You can extend the connection with a commercially available USB extension cable (type A/m – type A/f). The length of the connection should not exceed 5 m. If you require a longer connection then you must use a USB signal amplifier. Up to five USB signal amplifiers can be connected in series; this allows a maximum extension of 25 m.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

2.4 Dosino(s)/Stirrer connections

3 Start the «Mix Control» program

• Double click on the icon of the «Mix Control» software.

• The device is recognized automatically.

2.4 Dosino(s)/Stirrer connections

Dosino(s) and stirrer are part of the instrument. The instrument is supplied with them already connected up; these connections should not be altered.

Correct connection:

Cable markings Connection markings

Dosino 1

Dosino 2

Stirrer

2.5 Tubing connections

The drainage tubing (Section 2.5.2) and the component inlets and outlets (Sections

2.5.3/2.5.4) must be connected.

MSB1

Dosino 1

MSB2

Dosino 2

Stirrer MSB3

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

2 Installation

2.5.1 Instrument with tubing connections

Figure 4: Tubing connections

4 Dosino 1 outlet

Outlet for components from Dosino 1.

5 Connections for components

Connections for components 1 - 5.

7 Dosino 2 outlet

Outlet for components from Dosino 2 (only for version 2.845.0020).

FEP tubing connection

6.1838.000 Tubing connections for

6 Recesses for magnetic labels

For identifying components 1 - 5.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

connecting "Dosino 1 outlet" ino 2" outlet

7 to the bottle adapter 21.

4 / "Dos-

2.5 Tubing connections

Bottle adapter

6.1602.180 Bottle adapter as connection piece between eluent bottle and tubing connection

Eluent bottle

6.1608.070 Clear glass bottle for the mixed eluent.

20.

2.5.2 Connecting the drainage tubing

Connect 6.1816.020 Silicone tubing to connection 18 on the rear panel of the 845 Eluent Synthesizer and place the other end in a waste bottle.

2.5.3 Connections to bottle adapter

The tubing should not dip into the produced mixture. Make sure that the FEP- Tubing Connection 6.1838.000 into the bottle.

2.845.0010:

Connect 6.1838.000 FEP Tubing connection Bottle adapter and to Dosino outlet the Eluent bottle 6.1608.070.

Pressure screw

6.2744.170 Pressure screw for connecting component capillary component connection

PTFE capillary

6.1803.130 Capillary for connecting the components.

does not loom too deep

20 to the 6.1602.180 21

4. Then, attach the Bottle adapter to

24 to

2.845.0020:

Connect two 6.1838.000 FEP Tubing connections 21 Bottle adapter and to Dosino outlets 4 and 7. Then, attach the Bottle adapter to the Eluent bottle 6.1608.070.

2.5.4 Connecting the components

The main component (e.g. water) must be connected to the component connection with the number 1 (see Section component is used (at the end of the mixing process) to make the volume up to the total volume given in the method (see Section

3.3).

Proceed as follows to connect the various components:

1 Connect capillary to 845

Connect 6.1803.130 PTFE capillary 24 with 6.2744.170 Pressure screw 23 to component connection 5.

20 to the 6.1602.180

3.4.2). The main

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

2 Installation

2 Connect capillary to the components

Components from a bottle:

• Insert 6.1803.130 PTFE tubing ment into the component bottle (e.g. the combination

6.1602.160 bottle attachment GL 45 and 6.1608.030 bottle; see Optional accessories section 5.2.4).

Components from an MPak (from Chata Biosystems, see section

5.2.5):

• Push the 6.1808.200 MPak coupling onto 6.1803.130 PTFE tubing 24 by loosening the screw cap from the coupling and pushing the smaller opening over the tubing. Then screw the coupling into the cap:

24 through the bottle attach-

• Click the 6.1808.200 MPak coupling onto the lower outlet of the MPak.

2.6 pH Controller

The pH of the prepared mixture can, if necessary, be adjusted automatically by using the (optional) extension kit. If the pH is to be adjusted from one side then one pH Controller is required, adjustment from both sides (without changing the titrant solution) requires two pH Controllers.

We recommend the use of 702 Titrinos as pH Controllers (for supply package see Section package for required accessories see Section

2.6.1 Tubing connection for pH Controller

If the pH is to be adjusted automatically after the mixing process then adaptations are required to the tubing connections to the 845 Eluent Synthesizer.

5.2.3). Other Titrinos can also be used (supply

5.2.3).

1 Replace bottle adapter 21

6.1602.180 Bottle adapter 21 must be replaced by 6.1602.190 Eluent bottle head.

• Screw off the 6.1838.000 FEP tubing connection(s)

6.1602.180 Bottle adapter 21.

• Screw the 6.1838.000 FEP tubing connection(s) thread(s) of 6.1602.190 Eluent bottle head.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

20 from

20 to M6

2.6 pH Controller

2 Install tubing connection to pH Controller

6.1838.010 FEP tubing connection should be used to make the tubing connection to the pH Controller.

• Insert the black O-ring belonging to the 6.1838.010 FEP tubing connection into an M6 thread of 6.1602.190 Eluent bottle head.

• Then push the tip of the 6.1838.010 FEP tubing connection through the O-Ring and M6 thread.

• Attach the 6.2726.090 Antidiffusion micro-valve to the tip of the 6.1838.010 FEP tubing connection.

• Connect the other end of the 6.1838.010 FEP tubing connection to the pH Controller (see Instructions for Use – Exchange Unit).

3 Screw on bottle adapter

• Now screw 6.1602.190 Eluent bottle head onto eluent bottle

22.

806

4 Insert the Aquatrode in the Eluent bottle head

• Insert 6.0257.020 Aquatrode into the large opening of the

6.1602.190 Eluent bottle head. Watch out, that the Aquatrode looms deep enough into the mixture when the pH is measured.

2.6.2 pH Controller cable connection

The methods at the pH Controller are started via a remote signal from the 845 Eluent Synthesizer (see Section ler to the 845 Eluent Synthesizer as follows:

1 Connect Remote Box

• Connect the 6.2148.010 Remote Box to connection "Remote Box / MSB4"

2 Connect pH Controller

• Connect 6.2141.210 Cable to the remote output of

6.2148.010 Remote Box.

• Connect the end of the 6.2141.210 Cable marked A remote input of the pH Controller.

• Connect the end of the 6.2141.210 Cable marked B remote input of the second pH Controller.

The Metrohm 702 Titrino can be used with the SET method to set the pH to a defined value (see the Instructions for Use of the corresponding Titrino).

3.3.3). Connect the pH Control-

15.

to the

The method for the pH-adjustment and the corresponding parameters have to be defined on the pH-Controller. The pH-adjustment is started by a remote signal sent from the 845 Eluent Synthesizer to the pHController. For the installation and operation of the pH Controllers please refer to the corresponding Instructions for Use.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

3 «Mix Control» software

The 845 Eluent Synthesizer is controlled with the «Mix Control» PC software provided. This section explains the ideas behind the software and how to use it. For further information please consult the online help of the software.

3.1 Introduction to the software

3.1.1 The principle of «Mix Control»

What and how much is to be mixed in which ratio is defined via Depot (see section Components (see section specified. The Method is the recipe for preparing the mixture.

3.1.2 Procedure after the first start of «Mix Control»

3.4.1) and Method (see section 3.3). In the Depot the

3.4.2) connected to the instrument are

1. Define the Users (see section 3.4.5).

2. Draw up and save the configuration for the Depot (see section

3.4.1).

3. Draw up and save a Method (see section

After carrying out these steps you can already start mixing processes

(with

In the next step you should define the settings for Directories, Re- ports, Rinsing and GLP.

3.2 Main Window

3.2.1 Menus

Menu File

New... Method /

For creating and configuring a new Method. The parameters of the Method are set to the default values.

3.3).

New... Depot

For creating and configuring a new Depot. The DEPOT window opens.

Save Method /

For saving the current Method under a new name.

Save Method as...

For saving the current Method under a new name.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

3.2 Main Window

Open... Method /

For opening a saved Method (see section 3.3).

Open... Depot

For opening a saved Depot.

Print... /

For printing the current Method. The sections selected in the

REPORT CONFIGURATION window (without the

Produced Composition section) get printed. No preview

is shown.

Print Preview...

Opens the print preview for the current Method (without the Produced Composition section). A printout can be made directly from the preview.

Printer Configuration...

Opens the PRINTER window. In the PRINTER window the printer settings can be adapted.

A Report of a previous mixing process can be printed out via the

Logout... /

Logs out the User. The LOGIN window opens so that a (active) User can log in.

Quit...

Closes the software.

Menu Configuration

Depot...

Opens the DEPOT window (see section 3.4.1).

System...

Opens the SYSTEM SETTINGS window (see section

3.4.3).

Report...

REPORT LIST window.

Opens the REPORT CONFIGURATION window (see sec-

3.4.4).

tion

User Admin...

Opens the USER ADMINISTRATION window (see section

3.4.5).

Rinsing...

Opens the RINSE window (see section 3.4.6).

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

3 «Mix Control» software

Menu Extras

Sign Method...

Opens the SIGNATURE window (see section 3.5.1).

Audit trail...

Opens the AUDIT TRAIL window (see section 3.5.2).

Report...

Opens the REPORT LIST window (see section 3.5.3).

GLP Manager

Opens the GLP MANAGER window (see section 3.5.4).

Firmware Update

Opens the FIRMWARE UPDATE window (see section

3.5.5).

Service

Opens the LOGIN SERVICE window (see section 3.5.6).

Menu Help...

Help Topics...

Info

Opens the Online Help.

Opens the ABOUT window.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

3.2 Main Window

3.2.2 Description of the symbols

/ New... Method

For creating and configuring a new Method. The parameters of the Method (see section default values.

/ Open... Method

For opening a saved Method.

/ Save Method

Saves the current Method.

/ Print...

For printing the current Method. The sections selected in the

REPORT CONFIGURATION window (without the

Produced Composition section) get printed. No preview

is shown.

3.3) are set to the

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

3 «Mix Control» software

/ Logout...

Logs out the user. The LOGIN window opens so that an (active) User can log in.

/ Start

Starts the mixing process.

/ Stop

Stops all actions.

/ Rinse

Starts the rinsing process.

To move the symbol strip, click on the dotted bar and move it to the desired position. The position is saved.

3.3 Method

3.3.1 General information about methods

The method is configured and shown on the Main Page.

The method is the recipe for preparing the mixture. The amounts/concentrations and the fined and saved in the method. The the pH-adjustment are also saved with the method.

Number, names and units of the Components are specified in the

Depot.

The calculated volumes of the Components (except for Component 1 see section used to fill up to the

3.3.2 Parameters

Current Method [ ]

Description [ ]

3.4.2) are added in succession. At the end Component 1 is

Total Volume of the mixture to be produced are de-

Total Volume.

Name of the currently loaded method.

Stirrer Speed and the settings for

Notes about the currently loaded method.

Component X [ ]

Components (see section 3.4.2) with names and units

(they correspond to the Components specified in the loaded Depot).

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

3.3 Method

Total Volume mL [ 200...5000 ; 200 ]

Volume (in mL) to be prepared in the course of a mixing process.

Changing the Total Volume does not affect the ratio of the Components mixed. The numerical values of the Components given with the (absolute) unit mL are adapted automatically.

Stirrer Speed [ -15...15 ; 4 ]

Speed of the stirrer.

Switch on / switch off stirrer.

3.3.3 pH Adjustment

General information about pH adjustment

pH adjustment is always carried out after the main component has been added (i.e. at the end of the mixing process).

For automatic pH adjustment 702 Titrinos from Metrohm are intended for use. If the pH needs to be adjusted from both sides (without changing the pH-Controller liquid), two 702 Titrinos are required as pH-Controllers.

In the fields pH-Adjustment and pH-Controller define whether and how the pH is to be adjusted.

If autonomous is selected for pH-Adjustment then none must not be selected for pH-Controller. For autonomous a pH-Controller must be used.

When starting the mixing process (by clicking on the stirrer is always switched on.

Opens the window PH-ADJUSTMENT CONFIGURATION.

)

Window "pH-Adjustment Configuration"

The dialog window

by clicking on the button

In the

PH-ADJUSTMENT CONFIGURATION window the pH adjustment

PH-ADJUSTMENT CONFIGURATION can be opened

in the Main Window.

procedure can be defined.

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3 «Mix Control» software

No [ 1 ; display only ]

Number of the Component (see section 3.4.2).

Component

Name of the Component.

pH-Adjustment

none

No pH adjustment will take place.

with request

pH adjustment will take place. It can be carried out manually or automatically (702 Titrinos from Metrohm are recommended). After pH adjustment the

PLAY

window opens in which the volume added for pH

LIVE DIS-

adjustment should be entered. This added volume is taken into account in the volume calculations of the

mixing process.

The titration volume should be below 10 mL. Titration volumes above 10 mL result in an increased Total Volume.

autonomous

pH adjustment will take place. It will be carried out automatically (702 Titrinos from Metrohm are recommended). A pH-Controller must be selected. The added volume will not be taken into account in the volume calculations of the mixing process.

pH-Controller (see section 2.6)

none

pH adjustment is carried out manually (must not be selected if

ment

pH-Controller A

autonomous has been selected for pH-Adjust-

The pH is adjusted with the instrument that is connected with the cable end marked A (of the two-headed

6.2141.210 Cable).

pH-Controller B

The pH is adjusted with the instrument that is connected with the cable end marked B (of the two-headed

6.2141.210 Cable).

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

3.4 Configuration

Details Of pH-Adjustment

Field for notes about the pH adjustment that can be included in the report (see section

3.4.4), e.g. set pH

value, solution used, etc.

3.3.4 Creating a method

There are 2 ways of creating a method:

• Editing an existing method and saving it under a new name

• Creating a completely new method (by clicking on

File, New... Method)

Procedure for configuring a method:

1. Enter the

Total Volume to be produced.

2. For all Components (except for

3.4.2) enter the desired amount/concentration.

3. Enter the

Stirrer Speed.

4. If you want to adjust the pH: configure the pH-adjustment.

5. Save the method.

3.4 Configuration

3.4.1 Depot

General information about Depot

The dialog window

The Components (see section need to be defined in the Depot. The numbers correspond to the numbers of the Component connections

or via the

Component 1, see section

DEPOT can be opened via Configuration, Depot....

3.4.2) connected to the instrument

5 on the instrument.

Window "Depot"

Define and describe each Component connected to the instrument under the corresponding number. Save the Depot you have drawn up as a

.meco file. The settings in the Depot must always be edited when

alterations are made to the connected Components.

The Methods (see section loaded when they were drawn up. This means that overwriting an existing Depot influences the Methods that are based on this Depot.

In order for the mixing process to supply the desired result, the Com-

ponents specified in the Depot must correspond to the Components physically connected to the instrument. The concentrations/-

amounts defined in the Depot will be used for the volume calculations in the Method.

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3.3) are based on the Depot that was

3 «Mix Control» software

No. [ 1...5 ; display only ]

Number of the Component.

The number under which the components are defined here must be the same as that of the connection (

) which the components are connected to.

Component [ Component name ]

Name of the Component (see section 3.4.2). You can choose it from a selection list or enter it yourself.

Only Components with a defined Component name are displayed in the Method part of the Main Window (see section

3.3). If the Component name is deleted, the Component is not displayed in the Method part of the Main Window anymore (that does not apply for Component 1, which can not be deleted ).

Concentration [ 1...20000 ; 0.0 ] (for unit mmol/L) ; [ 1...800000 ; 0.0 ]

(for unit mg/L)

Numerical value for concentration.

Unit [ mmol/L, mg/L, %, mL ;mmol/L ]

Unit for the given concentration/amount. This Component's unit will also be adopted in the Main Window.

Manufacturer [ Name of manufacturer ]

Name of the manufacturer of the Component. You can choose it from a selection list or enter it yourself.

Date Of Expiry [ Date ; current date ]

Expiry date of the Component. If you click on the field the Date window opens, in which you can select the required date. If the current date is later than one of the defined expiry dates then a message will be shown at the start of a mixing process.

Date Of First Use [ Date ; current date ]

Date of the first use of the Component. If you click on the field the Date window opens, in which you can select the required date.

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3.4 Configuration

Note [ empty ]

Notes field for the Component (e.g. for pH information). Max. 254 characters.

3.4.2 Components

General information about components

Components are defined in the Depot (see section

3.4.1) .

Components as related to the «Mix Control» software are the liquids which are connected to the instrument.

Relationship Dosinos - Components

Dosinos form part of the instrument and are responsible for the accurate delivery of the particular volumes of the Components. They are attached to 50 mL Dosing Units.

Whether your instrument is equipped with one or two Dosinos depends on the particular instrument version. Version 2.845.0010 has one Dosi- no, Version 2.845.0020 two Dosinos.

The Component connected to connection 1 ("Component 1") is the

Main Component (in the case of two Dosinos, it is the Main Component for both Dosinos). After the end of an action (mixing or rinsing) the Dosino is always filled with the Main Component (except after a rinsing process "Empty components" with activated Main Component:

the Dosino is then empty).

Dosino 1 Dosino 2

Main Component Component 1 Component 1

Further Components

Component 2 Component 4

Component 3 Component 5

The number of the component correspond to the number of the component connection

For the work with version 2.845.0020:

If two Components - in addition to the Main Component - are used, it is recommended to connect these two Components to the same Dosino (Connections 2 and 3, or 4 and 5).

Main Component (Component 1)

The following conditions apply for the Main Component:

• In the Depot the

Component 1 must always be defined as it is

used (at the end of each mixing process) to fill to the given in the Method (see section

• The volume calculated in the Method for least 70 mL if one Dosino is used; with two Dosinos it must be at least 140 mL.

3.3).

Component 1 must be at

Total Volume

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3 «Mix Control» software

3.4.3 System Settings

General information about system settings

Check the default folders. If you wish to use different folders then, in order to save the file in the required folder, enter the Depot ( Method ( format for exporting Reports (

.meme), the raw data of the prepared mixture (.meda) and the

.pdf or .xml). You can search through the

.meco), the

workplace by clicking on the

button.

Window "System Settings"

The dialog window

tion, System...

In the

SYSTEM SETTINGS window the directories are defined in which

SYSTEM SETTINGS can be opened via Configura-

the generated files are to be saved. The software also set here.

dialog language is

Depot Directory [ ]

Directory for saving a Depot (see section 3.4.1).

Method Directory [ ]

Directory for saving a Method (see section 3.3).

Raw Data Directory [ ]

Directory for saving the data of a mixing process.

Export Directory [ ]

Directory for the Export of a Report (see section 3.5.3).

Dialog language [ English, German ]

Selects the language for the software interface. Any alteration to the language will only become effective for the Main Window after the software has been restarted.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

3.4 Configuration

3.4.4 Report Configuration

General information about report configuration

In the

REPORT CONFIGURATION window the settings for generating

the reports are defined.

Select everything that is to appear in the report. There are two predefined presentations (

Standard / Full Report). If you want to create your

report differently you can also select the sections individually (

ized

You should also define what is to be done with the data when the mixture has been prepared. You can print out the data automatically or ex- port it as a PDF- or XML-file.

Window "Report Configuration"

The dialog window

figuration, Report...

REPORT CONFIGURATION can be opened via Con-

Custom-

Selection box [ Standard, Full Report, Customized ]

Standard

The sections

duced Composition

Full Report

Identification, Method, Depot and Pro-

are shown in the report.

All sections are shown in the report.

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3 «Mix Control» software

Customized

The activated sections are shown in the report.

Identification

Information about User, report and program version.

Depot

Information about the Depot used (see section 3.4.1).

Method

Information about Method (see section 3.3), method parameters, concentrations/amounts.

Produced Composition

Information about the mixing process.

Hardware

Information about the hardware used.

GLP Data

Logo

Print Report

Preview

Information about GLP tests and service work to be carried out (see section

3.5.4).

The selected logo will be shown at the top right of the report.

Selects the logo graphics (possible file formats: .jpeg or

.gif). Clicking opens the OPEN window, in which the

workplace can be searched. After selection the logo will be shown to the left of the button.

The report is printed out on the defined default-printer (Windows: Start/Settings/Printer) as soon as the mixture has been prepared (if Preview has been activated a

preview

is shown before printing takes place).

A print preview is shown before printing takes place.

Export Report As PDF

The report is exported as soon as the mixture has been prepared as a PDF-file into the directory chosen below.

Export Report As XML

The report is exported as soon as the mixture has been prepared as an XML-file into the directory chosen below.

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3.4 Configuration

After the mixture has been prepared the mixture data is saved automatically as a .meda-file in the Raw data folder. If Export Report As PDF/XML has been activated then it will also be saved in the corresponding file format in the Export Directory selected in the window

SYSTEM SETTINGS.

If you have not activated Print Report or Export Report As PDF/XML the reports can still be printed out or exported as a PDF- or XML-file later via the

REPORT LIST window (see section 3.5.3).

3.4.5 User Administration

Window "User Administration"

The dialog window

guration, User Admin...

In the

USER ADMINISTRATION window the users are defined and

USER ADMINISTRATION can be opened via Confi-

managed.

As long as no user has been defined the software can be opened without Login. We recommend that the users are defined immediately after the software has been opened for the first time.

User

Short name of the user. This short name is always to be entered when the User logs in.

Full Name

First or given name and last or family name of the user.

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3 «Mix Control» software

Active

Only users set to "active" can log in.

Admin.-rights

Only Administrators have the following rights:

• Depot editing (see section

• System Settings editing (see section

• Report Configuration editing (see section

3.4.1)

3.4.3)

3.4.4)

• User administration

• Drawing up and saving methods (see section

3.4.6)

• Signing methods (see section

• Audit trail opening (see section

• GLP Manager opening (see section

• Firmware update (see section

3.5.1)

3.5.2)

3.5.4)

3.5.5)

Inserts a new line in the user table in which a new user can be defined.

Prints a list with the selected (blue highlighted) users.

Opens the

PASSWORD window.

The button Password is only active, if at least one user with Administrator rights is defined and active.

Define user

After the software has been opened for the first time define an Administrator as the first user:

1. Click on

2. Enter the

3. Activate

4. Click on [OK]. The

User and Full name.

Active and Admin.-rights.

5. Enter the previously defined User. Leave the

. A new line will be shown.

Password field

empty.

6. Now edit the password. Click on

PASSWORD

window opens.

. The CHANGE

7. Leave the

word under [OK]. A return is now made to the

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

Old Password field empty. Enter the required pass-

New Password and Confirm Passw..., and click on

3.4 Configuration

8. Enter the previously selected password under Password and click

on [OK].

After the definition of the first user there must always be at least one user with Administrator rights who is active.

Now (or later as necessary) define new users (with or without Administrator rights).

1. Open the

USER ADMINISTRATION window.

2. Click on

3. Enter the

User and Full Name.

4. When necessary, activate

5. Click on [OK].

The defined users can set their Passwords after they log in for the first time.

Define if a password is required for login.

1. Click on

PASSWORD window appears.

The

2. Define if a password is required for login.

3. Define password expiry period.

Password

. A new line will be shown.

Active and Admin.-rights.

In the

PASSWORD window, the administrator defines whether a pass-

word is required for login.

Additionally, if a password is required for login, the administrator can set an expiry period for the password.

This setting applies to all users and administrators.

At next login, a password must be created in the

CHANGE PASSWORD window.

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3 «Mix Control» software

Password expires every ... days

Password expires every [365] days.

Selection box

1...[365]...999

Expiry period of the password.

If the password expires, the user/administrator will receive a message reminding him to change the password.

The

at least one User has already been defined), as well as for the definition of the first User (the first defined user must be an Administrator).

Enter the

User and Password and click on [OK].

Change password:

Click on

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

. The CHANGE PASSWORD window opens.

3.4 Configuration

Change Password

The

CHANGE PASSWORD window opens when the but-

ton is clicked on in the

Proceed as follows to change the password:

3.4.6 Rinse

General information about rinse

Window "Rinse"

1. Enter your password under

Old Password.

2. Enter your new password under

Password

3. Click on [OK].

In the

RINSE window the rinsing process is defined (the rinsing pro-

cess is triggered by clicking on the

Decide which

components

mode is to be used - Prepare components or Empty

- and for which Component(s) the rinsing process is to

be carried out.

The dialog window

RINSE can be opened via Configuration, Rinsing....

New Password and Confirm

button in the Main Window).

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3 «Mix Control» software

Mode

Economy

Component X

Prepare components

The

mode "Prepare components" is used in the rinsing

process.

Empty components

The

mode "Empty components" is used in the rinsing

process.

If Economy has been activated then the Dosino contents (is always the Main Component, after an action has been completed) will be ejected into the component container at the start of the rinsing process. If

has not been activated then the Dosino contents will

Econo-

be ejected in the usual way and can be collected in a waste container.

Economy is intended for circumstances in which the Main Component has to be used very sparingly.

The Components (see section 3.4.2) configured in the Depot (see section

3.4.1) are listed. The rinsing process

is always carried out for those Component(s) that have been set as

active.

Rinsing Mode "Empty components""

The rinsing mode " window under the parameter

What effect has a rinsing process with

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

Empty components" can be selected in the RINSE

Mode.

Mode "Empty components"?

3.4 Configuration

Dosino(s) and component tubing (of the activated Components) are emptied.

When should a rinsing process with

Mode "Empty components" be

carried out?

• When the instrument is not to be used for a long time (in

this case: activate all Components).

• When a Component is to be removed (in this case: only activate the particular Component).

How is a rinsing process with

Mode "Empty components" trig-

gered?

1. Configure: in the Rinse window set the parameter to

Empty components. Select the Components whose

tubing is to be emptied.

2. Start: the rinsing process is started in the Main Window

by clicking on the

button.

What happens during a rinsing process with

nents

Before the start of the rinsing process disconnect all

Component connections Component) from the instrument.

(except those of the Main

Mode

Mode "Empty compo-

1. The cylinder(s) of the Dosino(s) is/are completely emptied.

If in the

RINSE window the parameter Economy has

been activated then the Dosino contents will be ejected into the component container of the Main Component.

2. For each of the activated Components (except the Main Component(s)) 10 mL air will be drawn in and the

Dosing unit emptied. That is done in order to empty the tubing connections inside the instrument.

3. The Dosino(s) is/are rinsed with the Main Component.

If you have also activated the Main Component:

4. Disconnect the Main Component from the instrument.

5. From the Main Component 10 mL (per Dosino) will be

drawn in and the Dosing unit emptied. That is done in order to empty the tubing connections inside the instrument.

"Rinsing Mode "Prepare components"

The rinsing mode " window under the parameter

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

Prepare components" can be selected in the RINSE

Mode.

3 «Mix Control» software

What effect has a rinsing process with Mode "Prepare compo-

nents

Air bubbles are removed by rinsing Dosino(s) and component tubing (from the activated Components) (see section

3.4.2).

When should a rinsing process with be carried out?

We recommend that such a rinsing process is carried out at least once per day, as well as each time that a new Component has been added. Removal of air bubbles increases the mixing accuracy.

How is a rinsing process with

Modus "Prepare components" trig-

gered?

1. Configure: in the

Prepare components. Select the Components to be

RINSE window set the parameter Mode

"prepared".

2. Start: the rinsing process is started in the Main Win-

dow by clicking on the

How does a rinsing process with proceed?

1. The cylinder(s) of the Dosino(s) is/are completely emp-

tied.

If in the

RINSE window the parameter Economy is ac-

tivated then the Dosino contents will be ejected into the component container of the Main Component.

Modus "Prepare components"

button.

Modus "Prepare components"

3.5 Extras

3.5.1 Sign methods

The dialog window SIGNATURE can be opened via Extras, Sign

Method...

In the

Enter your

reason for signing the method and click on [OK].

(only when you are logged in as Administrator).

SIGNATURE window the current Method can be signed.

2. From each of the activated Components 10 mL will be

drawn in and ejected in succession.

3. At the end the Dosino(s) will be refilled with the Main

Component.

user name and your password (see section 3.4.5), select a

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

3.5 Extras

User

Enter User name. You can also enter a user name that is different from the currently logged in User. Prerequirement: the user is active and has Administrator rights.

Password

Reason [ Selection of standard reasons ]

Comment [ 255 Characters ]

If you change a method and save it, the signature is deleted.

3.5.2 Audit trail

The term Audit trail is used for the protocol of all user actions that generate, edit or delete data. Each of these actions is saved as a line in the Audit trail table together with the date, time and name of the logged-in user.

Window "Audit trail"

AUDIT TRAIL window can be opened via Extras, Audit trail....

The

Enter the password.

Give the reason for signing the method.

Notes about the signature.

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3 «Mix Control» software

Table headers:

Icon

Date

User

Number of the Audit trail entry.

Information about an action that is neither safety-relevant nor altered any data.

Information about an action that is safety-relevant or with which data has been altered.

Information about a fault or incorrect action.

Date and time of the action.

Short name of logged-in user.

3.5.3 Window "Report List"

The REPORT LIST window can be opened via Extras, Report List....

REPORT LIST window the data of all prepared mixtures is shown.

In the

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3 «Mix Control» software

Date/Time

Method

Depot

Description

User

Date and time at which the mixture was prepared.

Name of the Method used for preparing the mixture (see

section

3.3).

Name of the Depot used for preparing the mixture (see

section

3.4.1).

Text that was entered in the Description field in the Main Page when the mixture was prepared.

Short name of the User logged in when the mixture was prepared.

Prints out the marked, or all (if none have been marked) entries in the

report list.

Prints the marked Reports.

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3.5 Extras

Exports the marked Reports as Pdf-files to the directory defined in the

Export Directory, see section 3.4.3.

SYSTEM SETTINGS window (parameter

Exports marked Reports as XML-files to the directory defined in the

port Directory

SYSTEM SETTINGS window (parameter Ex-

3.5.4 GLP Manager

The dialog window GLP MANAGER can be opened via Extras, GLP

Manager

GLP validations and service work that have been carried out are en-

tered in the

The date of each validation/service work should be entered in the

GLP MANAGER window. In addition, the date for the next validation or

next service should also be entered.

GLP MANAGER window.

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3 «Mix Control» software

Validation:

Method

Information about the Method (see section 3.3) used for

the validation. With

the workplace can be searched

through for Methods.

User

Information about the logged-in User when validation was carried out.

SOP

Possibility of entering an SOP (Standard Operation Procedure) name or number.

Date Of Last Test

Date of last validation.

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3.5 Extras

Test Result [ No Test Accomplished Yet, Test OK, Test not OK ]

Information about the result of the last validation.

Note

Notes about the last validation.

Date Of Next Test

Date for the next validation.

Display Message

If activated: if the current date is later than the date given for

Date Of Next Test then a message will be shown at

the start of a mixing process.

Service:

Date Of Last Service

Information about date of last service.

Service-Status [No Service Accomplished Yet, Service Accomplished]

Shows whether a service has been carried out.

Note

Notes about the last service.

Date Of Next Service

Date for the next service.

Display Message

If activated: if the current date is later than the date given for the shown at the start of a mixing process.

3.5.5 Firmware Update

The FIRMWARE UPDATE window can be opened via Extras, Firmware

Update

Via the copied to the instrument.

FIRMWARE UPDATE window a current Firmware version can be

Date Of Next Service then a message will be

In order to update the instrument Firmware you should first select the file for the

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

Binary-File Path parameter that contains the current Firm-

3 «Mix Control» software

ware. With you can search through the workplace. Then click on

in order to start Firmware updating.

3.5.6 Login Service

The service section of the software can be accessed via the LOGIN

SERVICE

should carry out work in the service section. It is protected by a special service password.

window. Only service technicians from a Metrohm agency

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

4.1 Care

4 Maintenance - Troubleshooting

4.1 Care

The 845 Eluent Synthesizer requires adequate care. If it becomes excessively dirty then this could interfere with its functions and shorten the working life of its robust mechanism and electronics.

Spilt chemicals and solvents must be wiped up immediately. The electrical connections on the rear panel of the instrument should be protected against contamination.

If aggressive media penetrate into the interior of the instrument the mains plug should be pulled out immediately to prevent massive damage to the electronics. If such damage does occur then please contact Metrohm Service.

4.1.1 Decommissioning

Proceed as follows, if the instrument is not to be used for a long time:

1. Connect water to all component connections (

2. Carry out a rinsing process in the "

components should be activated for the rinsing process (see Section

3.4.6).

4.2 Dosing units

Depending on the version, the 845 Eluent Synthesizer has either one (Version 2.845.0010) or two (Version 2.845.0020) 807 Dosing units (each with a 50 mL glass cylinder). These are located inside the instrument, screwed onto a pull-out drawer. Each dosing unit is controlled by an 800 Dosino.

Depending on the solutions used, the dosing units should be cleaned every 6 to 12 months.

4.2.1 Deinstallation

In order to clean a Dosino it must first be removed from the 845 Eluent Synthesizer.

5).

Empty components" mode. All

The procedure for deinstallation of the Dosino is as follows:

1 Empty instrument

• Use the «Mix Control» software to carry out a rinsing process in the "Empty components" mode (make sure that all components have been activated in the RINSE window, see Section 3.4.6).

2 Remove rear panel

• Remove rear panel 19 by using a screwdriver.

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4 Maintenance - Troubleshooting

3 Screw off tubing connections

• Screw off all tubing connections from the dosing unit.

4 Loosen attachment

• Loosen thread adapter 26 while holding the dosing unit/Dosino in your other hand.

• Also remove holder plate

27.

Figure 5: Dosing unit attachment

Distance ring

Thread adapter

Holder plate

For attaching the tubing connections to port 2 and 4

4.2.2 Cleaning

Cleaning the 807 Dosing unit is described in the 8.807.1008 Instructions for Use – 807 Dosing unit, Section 6.

Slip-on nipple

For connecting component 1 to port 4

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4.2 Dosing units

4.2.3 Installation

After cleaning the dosing units should be reinstalled together with the Dosinos.

Diagram showing connections with one Dosino:

(Dosing unit seen from below)

Figure 6: Connections with one Dosino

Component connection strip

Dosing unit (from below)

4 Dosino 1 outlet

Outlet for component to be added (from Dosino 1).

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4 Maintenance - Troubleshooting

Diagram showing connections with two Dosinos:

(Dosing units seen from below)

Figure 7: Connections with two Dosinos

29 Component connection strip

30 Dosing unit from Dosino 1 (from

below)

Dosing unit from Dosino 2 (from

below)

T-piece for component 1

For connecting the main component (see Section

3.4.2)

4 Dosino 1 outlet

Outlet for the component to be added from Dosino 1.

7 Dosino 2 outlet

Outlet for the component to be added from Dosino 2.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

4.3 Troubleshooting

Problem Cause Remedy

Liquids escaping from drainage tubing or from bottom of rear panel.

Components are not aspirated.

LED "Power" (1) does not light up when instrument is connected.

Instrument not recognized at software startup (LED "Power" ( lights up)

• Leaking connections

• Leak in instrument

• Leaking or blocked con-

nections

• Dosing units/Dosinos defect

• Mains cable defect

• Internal power supply

defect

• Instrument not connected to USB

• USB cable defect

1. Stop the current process

2. Remove rear panel check the connections and dosing units (see Section

1. Stop the current process

2. Check the connections outside the instrument

3. Remove rear panel check the connections and Dosinos/Dosing units (see Section

4.2)

• Replace the mains cable

• Contact Metrohm Service

• Connect instrument to USB of

the PC (see Section

• Replace USB cable

19 and

4.2)

19 and

2.3)

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

5 Annex

5.1 Technical data

5.1.1 Interfaces

USB-connections

USB ports 2 USB downstream ports (type A sockets), each 500

mA, for connecting USB devices.

Controller connection

Controller port USB upstream port with additional signals (mini-DIN

socket) for connecting a computer to control the instrument (with 6.2151.000 Cable).

MSB-connections (MSB = Metrohm Serial Bus)

MSB1 Dosino For connecting Dosino 1

MSB2 Dosino For connecting Dosino 2 (if present)

MSB3 Stirrer Connection for built-in stirrer

Stirrer control: switched on/off via «Mix Control» software (manual or in method). Selectable speed (15 steps) and direction of rotation.

MSB4 Remote Box For connecting 6.2148.010 Remote-Box for automatic

pH adjustment (see Section Remote boxes are used to address and control external devices.

5.1.2 Mains connection

Voltage Frequency Power consumption Fuse

100...240 V (± 10%)

50...60 Hz max. 45 W electronic overload protection

5.1.3 Safety specifications

Construction and testing As per EN/IEC/UL 61010-1, CSA 22.2 No. 61010-1 pro-

tection class 1

Safety information These instructions contain safety information that must

be observed by the user in order to guarantee the safe operation of the instrument.

2.6).

5.1.4 Electromagnetic compatibility (EMC)

Emission Standards complied with:

- EN/IEC 61326

- EN 55022 / CISPR 22

Immunity Standards complied with:

- EN/IEC 61326

845 Eluent Synthesizer / Instructions for Use 8.845.1003

5.1 Technical data

- EN/IEC 61000-4-2

- EN/IEC 61000-4-3

- EN/IEC 61000-4-4

- EN/IEC 61000-4-5

- EN/IEC 61000-4-6

- EN/IEC 61000-4-11

- EN/IEC 61000-4-14

5.1.5 Ambient temperature

Nominal working range Automatic inner temperature monitoring Storage Transport

5.1.6 Dosing drive

Resolution Dosing/Filling rates

5.1.7 Dosing Unit

Volumes of cylinders

Chemical resistance of the PETG housing

+5 C...+45 C (at max. 85% relative humidity) > 70°C initial alarm > 75°C alarm –20°C...+60 °C –40°C...+60 °C

10'000 increments per cylinder volume 18 seconds each per cylinder volume

50 mL

Good resistance to: aqueous solutions, dilute acids, alcohols and hydrocarbons

Limited resistance to: conc. organic acids, dilute aqueous alkalis (stress cracks), acetone, isopropanol, tetrahydrofuran, hot water

Not resistant to: concentrated inorganic acids and bases, bromine, chlorinated solvents, phenol, water vapor >100 °C

5.1.8 Reference conditions

Ambient temperature Relative humidity Instrument status

+25 °C (±3 °C) ≤ 60% In operation for at least 30 min

5.1.9 Dimensions

Housing material Polyurethane

Width Height Depth

Weight

2.844.0010

2.844.0020

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

314 mm 378 mm 280mm

6920 g 7639 g

5 Annex

5.2 Standard equipment

Subject to changes! All dimensions are given in mm.

The 845 Eluent Synthesizer is available in the following versions:

• 2.845.0010 845 Eluent Synthesizer with 1 Dosino

• 2.845.0020 845 Eluent Synthesizer with 2 Dosinos

5.2.1 Standard equipment for 2.845.0010

The following parts are supplied under the order number 2.845.0010:

Quantity Order no. Description

1 1.845.0010 Eluent Synthesizer with 1 Dosino

1 6.1546.030 Piston rod

For PTFE piston of Dosing Unit

1 6.1602.180 Bottle Adaptor to 845

Adaptor to the eluent bottle of the Eluent Synthesizer without pH adjustment

1 6.1608.070 Eluent bottle / 2 L / GL 45

Material Clear glass

Height (mm) 262

Volume in mL 2000

3 6.1803.130 Capillary 1/8 in. / 1/16 in. i.d. / 1.5 m

Connecting capillary from the component containers to the Eluent Synthesizer

Material PTFE

Outer diameter in inches

Inner diameter in inches

1/8

1/16

845 Eluent Synthesizer / Instructions for Use 8.845.1003

5.2 Standard equipment

Quantity Order no. Description

1 6.1808.200 Connectors to MPak, set of 3

1 6.1816.020 Silicone tubing 6 mm i.d., 1 m

Drainage tube

Material Silicone rubber

Outer diameter in mm 9

Inner diameter in mm 6

1 6.1838.000 FEP Tubing Connection to 845, 1 x

M6 / 45 cm

Tubing connection from Eluent Synthesizer to eluent bottle adaptor

1 6.1903.060 Teflon Stirring bar 30 mm

Stirring Bar with magnetic core, PTFE coated, length 30 mm. For Eluent Synthesizer.

1 6.2122.0X0 Mains cable

to customer's specifications:

Cable socket

Type IEC 320/C 13 Type SEV 12 (CH…) 6.2122.020 Type IEC 320/C 13 Type CEE (7), VII (D…) 6.2122.040 Type CEE (22), V Type NEMA 5-15 (USA…) 6.2122.070

Cable connector

1 6.2151.000 Cable USB A - mini-DIN 8P

Cable for connecting the Eluent Synthesizer to the PC (USB connection, type A)

1 6.2248.010 Magnetic shield , 15 x 68 mm, 3

pieces

1 6.2739.000 Wrench

For tightening nipples.

1 6.2744.170 Pressure screw PEEK UNF 1/4-28, 3

pieces

Fixing connecting capillaries from the component containers to the Eluent Synthesizer.

Material PEEK

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

5 Annex

Quantity Order no. Description

1 6.2803.010 Grease (2 g)

Special quality (without silicone). For grease-free ground joint connections.

1 6.6057.000 845 PC Software Mix Control 1.0 CD

Software for the 845 Eluent Synthesizer.

1 8.800.1003 Instructions for Use 800 Dosino (e)

1 8.807.1008 Instructions for Use 807 Dosing Unit (g, e, f, s)

1 8.845.1003 Instructions for Use 845 Eluent Synthesizer (e)

5.2.2 Standard equipment for 2.845.0020

The following parts are supplied under the order number 2.845.0020:

Quantity Order no. Description

1 1.845.0020 Eluent Synthesizer with 2 Dosinos

1 6.1546.030 Piston rod

For PTFE piston of Dosing Unit

1 6.1602.180 Bottle Adaptor to 845

Adaptor to the eluent bottle of the Eluent Synthesizer without pH adjustment

845 Eluent Synthesizer / Instructions for Use 8.845.1003

5.2 Standard equipment

Quantity Order no. Description

1 6.1608.070 Eluent bottle / 2 L / GL 45

Material Clear glass

Height (mm) 262

Volume in mL 2000

5 6.1803.130 Capillary 1/8 in. / 1/16 in. i.d. / 1.5 m

Connecting capillary from the component containers to the Eluent Synthesizer

Material PTFE

Outer diameter in inches

Inner diameter in inches

2 6.1808.200 Connectors to MPak, set of 3

1/8

1/16

1 6.1816.020 Silicone tubing 6 mm i.d., 1 m

Drainage tube

Material Silicone rubber

Outer diameter in mm 9

Inner diameter in mm 6

2 6.1838.000 FEP Tubing Connection to 845, 1 x

M6 / 45 cm

Tubing connection from Eluent Synthesizer to eluent bottle adaptor

1 6.1903.060 Teflon Stirring bar 30 mm

Stirring Bar with magnetic core, PTFE coated, length 30 mm. For Eluent Synthesizer

1 6.2122.0X0 Mains cable

to customer's specifications:

Cable socket

Type IEC 320/C 13 Type SEV 12 (CH…) 6.2122.020 Type IEC 320/C 13 Type CEE (7), VII (D…) 6.2122.040 Type CEE (22), V Type NEMA 5-15 (USA…) 6.2122.070

Cable connector

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

5 Annex

Quantity Order no. Description

1 6.2151.000 Cable USB A - mini-DIN 8P

Cable for connecting the Eluent Synthesizer to the PC (USB connection, type A)

2 6.2248.010 Magnetic shield , 15 x 68 mm, 3

pieces

1 6.2739.000 Wrench

For tightening nipples.

2 6.2744.170 Pressure screw PEEK UNF 1/4-28, 3

pieces

Fixing connecting capillaries from the component containers to the Eluent Synthesizer.

Material PEEK

1 6.2803.010 Grease (2 g)

Special quality (without silicone). For grease-free ground joint connections.

1 6.6057.000 845 PC Software Mix Control 1.0 CD

Software for the 845 Eluent Synthesizer.

1 8.800.1003 Instructions for Use 800 Dosino (e)

1 8.807.1008 Instructions for Use 807 Dosing Unit (g, e, f, s)

1 8.845.1003 Instructions for Use 845 Eluent Synthesizer (e)

845 Eluent Synthesizer / Instructions for Use 8.845.1003

5.2 Standard equipment

5.2.3 Accessories for pH adjustment (optional)

The following accessory packages are offered under their own order numbers as an extension to the 845 Eluent Synthesizer for automatic pH adjustment:

• 2.702.0120 with 702 Titrino

• 6.5329.000 without Titrino

The following parts are supplied under the order number 2.702.0120:

Quantity Order no. Description

1 1.140.0200 Impact printer CUSTOM DP40-S4N

1 1.702.0020 SM Titrino

1 6.0257.020 Aquatrode Plus (30 cm) with Pt 1000

For pH adjustment of eluents at the Eluent Synthesizer.

1 6.1446.000 SGJ stopper / B-14/(15)

Material PP

Height (mm) 30.5

SGJ size B-14/(15)

2 6.1446.040 Thread stopper M6

Material PVDF

Height (mm) 21.5

Outer diameter in mm 4.9

1 6.1602.190 Eluent Bottle Head, 1 x NS 14, 4 x

Eluent bottle head to connect up to 4 tubings with M6 connectors. For eluent bottle of the Eluent synthesizer.

1 6.1838.010 Connecting Tubing to 845, 85 cm

Connection eluent bottle at the eluent Synthesizer - Titrino

Material FEP

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

5 Annex

Quantity Order no. Description

1 6.2125.130 Cable RS232, DB25 f / DB9 m

For connecting RS232 interface - printer

1 6.2132.120 Keypad for 702

1 6.2141.210 Cable Remote Box MSB-2 x Titrino

For the connection of up to two Titrinos to 845

1 6.2148.010 Remote Box MSB

Remote interface for the connection of Titrinos (via 6.2141.210 Cable).

1 6.2307.230 Buffer solutions pH 4/7/9

Mixed buffer solutions pH

4.00/7.00/9.00 (25 °C) in single use sachets, colorless, box of 3 X 10 x 30 mL

1 6.2308.050 KCl Solution 3 mol/L (50 mL)

845 Eluent Synthesizer / Instructions for Use 8.845.1003

5.2 Standard equipment

Quantity Order no. Description

1 6.2323.000 Storage solution

Storage solution for all combined pH glass electrodes with reference electrolyte c(KCl) = 3 mol/L

1 6.2726.090 Antidiffusion valve

For 6.1541.XXX and 6.1543.130,

6.1543.140, 6.1543.150, 6.1543.160,

6.1543.200 antidiffusion buret tips

1 6.2739.010 Wrench

For 6.3011.XXX ... 6.3014.XXX exchange units

1 6.3026.210 Exchange Unit 10 mL

Intelligent dosing unit with 10 mL glass cylinder and light protection. PCTFE/PTFE flat stopcock, FEP tubing connection, antidiffusion buret tip and standard amber glass reagent bottle

Volume in mL 10

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

5 Annex

The following parts are supplied under the order number 6.5329.000 (for pH-adjustment, no Titrino included):

Quantity Order no. Description

1 6.0257.020 Aquatrode Plus (30 cm) with Pt 1000

For pH adjustment of eluents at the Eluent Synthesizer.

1 6.1446.000 SGJ stopper / B-14/(15)

Material PP

Height (mm) 30.5

SGJ size B-14/(15)

2 6.1446.040 Thread stopper M6

Material PVDF

Height (mm) 21.5

Outer diameter in mm 4.9

1 6.1602.190 Eluent Bottle Head, 1 x NS 14, 4 x

Eluent bottle head to connect up to 4 tubings with M6 connectors. For eluent bottle of the Eluent synthesizer.

1 6.1838.010 Connecting Tubing to 845, 85 cm

Connection eluent bottle at the eluent Synthesizer - Titrino

Material FEP

1 6.2141.210 Cable Remote Box MSB-2 x Titrino

For the connection of up to two Titrinos to 845

1 6.2148.010 Remote Box MSB

Remote interface for the connection of Titrinos (via 6.2141.210 Cable).

845 Eluent Synthesizer / Instructions for Use 8.845.1003

5.2 Standard equipment

Quantity Order no. Description

1 6.2726.090 Antidiffusion valve

For 6.1541.XXX and 6.1543.130,

6.1543.140, 6.1543.150, 6.1543.160,

6.1543.200 antidiffusion buret tips

1 6.3026.210 Exchange Unit 10 mL

Intelligent dosing unit with 10 mL glass cylinder and light protection. PCTFE/PTFE flat stopcock, FEP tubing connection, antidiffusion buret tip and standard amber glass reagent bottle

Volume in mL 10

5.2.4 Optional accessories

Order no. Description

6.1602.160 Eluent bottle attachment GL 45

For eluent bottles, with connections for absorber tube and aspiration tubing.

Opening ground joint A-14/15

6.1608.030 Bottle / 1000 mL / GL 45

To Exchange Units.

Material Clear glass

Width (mm) 96

Height (mm) 223

Volume in mL 1000

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

5 Annex

Order no. Description

6.1609.000 Drying tube, large and bent

For Exchange Units and eluent bottle.

Material Glass

Height (mm) 129

Inner diameter in mm 32

SGJ size B-14/15

6.2023.020 SGJ clip

Clip for SGJ 14/16

Material POM

6.2062.000 MPak cabinet

Holder for three MPak eluent bag

5.2.5 Producers of concentrates and standards

This list is not exhaustive.

Producer Internet address

J.T. Baker http://www.jtbaker.com

Chata Biosystems (MPak Reagents) http://www.chatabiosystems.com

Merck http://www.merck.de

Reagecon http://www.reagecon.com

Sigma Aldrich (Fluka, Riedel-de Haën) http://www.sigmaaldrich.com

5.2.6 Systems for producing ultra pure water

Several manufacturers offer systems for producing ultra pure water. This list is not exhaustive.

Producer Internet address

Millipore http://www.millipore.com

ELGA http://www.elgalabwater.com

Barnsted http://www.barnsteadthermolyne.com/index.cfm

845 Eluent Synthesizer / Instructions for Use 8.845.1003

5.3 Warranty

5.3.1 Warranty

The warranty on our products is limited to defects that are traceable to material, construction or manufacturing error which occur within 12 months from the day of delivery. In this case, the defects will be rectified in our workshops free of charge. Transport costs are to be paid by the customer.

For day and night operation, the warranty is limited to 6 months.

Glass breakage in the case of electrodes or other parts is not covered by the warranty. Checks which are not a result of material or manufacturing faults are also charged during the warranty period. For parts of outside manufacture insofar as these constitute an appreciable part of our instrument, the warranty stipulations of the manufacturer in question apply.

With the regard to the guarantee of accuracy, the technical specifications in the instruction manual are authoritative.

Concerning defects in material, construction or design as well as the absence of guaranteed features, the orderer has no rights or claims except those mentioned above.

If damage of the packaging is evident on receipt of a consignment or if the goods show signs of transport damage after unpacking, the carrier must be informed immediately and a written damage report demanded. lack of an official damage report releases Metrohm from any liability to pay compensation.

If any instruments and parts have to be returned, the original packaging should be used if at all possible. This applies above all to instruments, electrodes, burette cylinders and PTFE pistons. Before embedment in wood shavings or similar material, the parts must be packed in a dustproof package (for instruments, use of a plastic bag is imperative). If open assemblies are enclosed in the scope of delivery that are sensitive to electromagnetic voltages (e.g. data interfaces etc.) these must be returned in the associated original protective packaging (e.g. conductive protective bag). (Exception: assemblies with built-in voltage source belong in a non-conductive protective packaging).

No warranty responsibility whatsoever will be accepted by Metrohm for damage which arises as a result of non-compliance with these instructions.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

5 Annex

5.3.2 Declaration of Conformity

This is to certify the conformity to the standard specifications for electrical appliances and accessories, as well as to the standard specifications for security and to system validation issued by the manufacturing company.

Name of commodity

845 Eluent Synthesizer

Description The 845 Eluent Synthesizer is a device to produce mixtures like eluents, mobile phases

or standards automatically.

This instrument has been built and has undergone final type testing according to the standards:

Electromagnetic compatibility: Emission IEC 61326, EN 55022/CISPR 22

Electromagnetic compatibility: Immunity

IEC 61326, IEC 61000-4-2, IEC 61000-4-3, IEC 61000-4-4, IEC 61000-4-5, IEC 61000-4-6, IEC 61000-4-11, IEC 61000-4-14

CH-9101 Herisau/Switzerland E-Mail info@metrohm.com www.metrohm.com

Safety specifications IEC 61010-1, UL61010-1, CSA 22.2 No. 61010-1

It has also been certified by ElectroSuisse, a member of the International Certification Body (CB/IEC).

The instrument meets the requirements of the CE mark as contained in the EU directives 89/336/EEC and 73/23/EEC and fulfils the following specifications:

EN 61326 Electrical equipment for measurement, control and laboratory use – EMC requirements EN 61010-1 Safety requirements for electrical equipment for measurement, control and laboratory

use

Metrohm Ltd. is holder of the SQS-certificate of the quality system ISO 9001 for quality assurance in design/development, production, installation and servicing.

The system software, stored in Read Only Memories (ROMs) has been validated in connection with standard operating procedures in respect to functionality and performance. The technical specifications are documented in the instruction manual.

Herisau, October 5, 2005

D. Strohm Ch. Buchmann Vice President Vice President Head of R&D Head of Production Responsible for Quality Assurance

845 Eluent Synthesizer / Instructions for Use 8.845.1003

5.3 Warranty

5.3.3 Quality Management Principles

Metrohm Ltd., CH-9101 Herisau, Switzerland

CH-9101 Herisau/Switzerland E-Mail info@metrohm.com Internet www.metrohm.com

Metrohm Ltd. holds the ISO 9001 Certificate, registration number 10872-02, issued by SQS (Swiss Association for Quality and Management Systems). Internal and external audits are carried out periodically to assure that the standards defined by Metrohm’s QM Manual are maintained.

The steps involved in the design, manufacture and servicing of instruments are fully documented and the resulting reports are archived for ten years. The development of software for PCs and instruments is also duly documented and the documents and source codes are archived. Both remain the possession of Metrohm. A non-disclosure agreement may be asked to be provided by those requiring access to them.

The implementation of the ISO 9001 quality system is described in Metrohm’s QM Manual, which comprises detailed instructions on the following fields of activity:

Instrument development

The organization of the instrument design, its planning and the intermediate controls are fully documented and traceable. Laboratory testing accompanies all phases of instrument development.

Software development

Software development occurs in terms of the software life cycle. Tests are performed to detect programming errors and to assess the program’s functionality in a laboratory environment.

Components

All components used in the Metrohm instruments have to satisfy the quality standards that are defined and implemented for our products. Suppliers of components are audited by Metrohm as the need arises.

Manufacture

The measures put into practice in the production of our instruments guarantee a constant quality standard. Production planning and manufacturing procedures, maintenance of production means and testing of components, intermediate and finished products are prescribed.

Customer support and service

Customer support involves all phases of instrument acquisition and use by the customer, i.e. consulting to define the adequate equipment for the analytical problem at hand, delivery of the equipment, user manuals, training, after-sales service and processing of customer complaints. The Metrohm service organization is equipped to support customers in implementing standards such as GLP, GMP, ISO 900X, in performing Operational Qualification and Performance Verification of the system components or in carrying out the System Validation for the quantitative determination of a substance in a given matrix.

845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN

5 Annex

5.3.4 Index

.meco .............................................26

.meda ............................................. 26

.meme ............................................ 26

702 Titrinos.....................................14

Active

User............................................ 30

Admin.-rights

User............................................ 30

Ambient temperature ..................... 50

Annex .............................................49

Audit trail ........................................36

autonomous...................................22

Bottle .............................................. 13

Bottle adapter ................................13

Care................................................44

Caution.............................................7

Change password .........................32

Check ............................................... 9

Cleaning

Dosing unit.................................45

Comment .........................................7

Component .............................. 46, 47

Component 1 ................................. 25

Components ..................................25

Connection................................. 13

Depot .........................................23

Concentration

Components ..............................24

Configuration .................................23

Report ........................................27

Connection................................... 4, 5

to PC ..........................................10

Connection 18

Illustration.....................................5

Connection 845 - PC .....................10

Connections...........................2, 3, 12

Connections with one Dosino ....... 46

Connections with two Dosinos ......47

Controller.................................... 4, 49

Controller connection .................... 49

Creating a method ......................... 23

Customized....................................28

Date Of Expiry

Components ..............................24

Date Of First Use

Components ..............................24

Declaration of Conformity..............63

Decommissioning .......................... 44

Depot .............................................23

Device ..............................................5

Dialog language ............................26

Dimensions ....................................50

Metrohm 845 User Manual

Specifications and Main Features

Frequently Asked Questions

User Manual

1.1 Instrument description

1 Introduction

1.2 Parts and controls

1.2.1 Front of 2.845.0010

1.2.2 Front of 2.845.0020

1.2.3 Rear view

1.3 Information on the Instructions for Use

1.3.1 Organization

1.3.2 Notation and pictograms

1.4 Safety information

1.4.1 Electrical safety

1.4.2 General precautionary rules

2 Installation

2.1 Setting up the instrument

2.1.1 Packaging

2.1.2 Check

2.1.3 Location

2.2 Mains connection

2.3 Connection to PC

2.4 Dosino(s)/Stirrer connections

2.5 Tubing connections

2.5.1 Instrument with tubing connections

2.5.2 Connecting the drainage tubing

2.5.3 Connections to bottle adapter

2.5.4 Connecting the components

2.6 pH Controller

2.6.1 Tubing connection for pH Controller

2.6.2 pH Controller cable connection

3 «Mix Control» software

3.1 Introduction to the software

3.1.1 The principle of «Mix Control»

3.1.2 Procedure after the first start of «Mix Control»

3.2 Main Window

3.2.1 Menus

3.2.2 Description of the symbols

3.3 Method

3.3.1 General information about methods

3.3.2 Parameters

3.3.3 pH Adjustment

3.3.4 Creating a method

3.4 Configuration

3.4.1 Depot

3.4.2 Components

3.4.3 System Settings

3.4.4 Report Configuration

3.4.5 User Administration

3.4.6 Rinse

3.5 Extras

3.5.1 Sign methods

3.5.2 Audit trail

3.5.3 Window "Report List"

3.5.4 GLP Manager

3.5.5 Firmware Update

3.5.6 Login Service

4 Maintenance - Troubleshooting

4.1 Care

4.1.1 Decommissioning

4.2 Dosing units

4.2.1 Deinstallation

4.2.2 Cleaning

4.2.3 Installation

4.3 Troubleshooting

5 Annex

5.1 Technical data

5.1.1 Interfaces

5.1.2 Mains connection

5.1.3 Safety specifications

5.1.4 Electromagnetic compatibility (EMC)

5.1.5 Ambient temperature

5.1.6 Dosing drive

5.1.7 Dosing Unit

5.1.8 Reference conditions

5.1.9 Dimensions

5.2 Standard equipment

5.2.1 Standard equipment for 2.845.0010

5.2.2 Standard equipment for 2.845.0020