Bio-Rad HR-S Media User Manual
™
Nuvia
HR-S
Strong Cation
Exchange Media
Instruction Manual
Catalog numbers
156-0511
156-0513
156-0515
156-0517
Please read these instructions before you use Nuvia HR-S
cation exchange media. If you have any questions or
comments regarding these instructions, please contact
your Bio-Rad Laboratories representative.
Table of Contents
Section 1: Introduction ................................................. 1
Section 2 : Technical Description ................................ 2
Section 3 : Preparation ................................................. 3
Section 4 : Column Packing ........................................ 4
Section 5 : Column Packing Evaluation ....................... 6
Section 6 : Operation and Maintenance ..................... 7
Section 7 : Regeneration and Sanitization ................. 9
Section 8 : Cleaning in Place (CIP)
and Sanitization ......................................... 9
Section 9 : Storage ....................................................... 9
Section 10: Regulatory Support ................................. 9
Section 11: Ordering Information .............................. 10
Section 1:
Nuvia™ HR-S cation exchange media is a new highresolution chromatography media designed for
intermediate and final polishing purification steps where
separating closely related product impurities (that is,
charged variants) is a challenge. Its exceptional selectivity
and high recovery meet the biomolecule purification needs
at both laboratory and large bioprocess scale.
Nuvia HR-S media joins the family of Nuvia S and Nuvia Q
ion exchange media and may be used for the separation
of proteins, nucleic acids, viruses, plasmids, and other
macromolecules. The unique properties of Nuvia HR-S
media, with its smaller particle size and fast mass transfer,
allow the media to be effective for the resolution of various
biomolecules.
If you have questions about Nuvia media, contact either
your local Bio-Rad process chromatography sales
representative or the Bio-Rad chromatography Technical
Support department for further assistance at
1-510-741-6563.
Introduction
Nuvia HR-S Instruction Manual 1
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