Metrohm tiamo 1.0 User Manual

CH-9101 Herisau/Switzerland
E-Mail [e-mail]
Internet www.metrohm.com

tiamo User Manual

Program version 1.0

8.101.0003 12.2004/dö

Teachware
Metrohm AG
Oberdorfstrasse 68
CH-9101 Herisau

[e-mail]

This tutorial is protected by copyright. All rights reserved.

Although this tutorial has been prepared with the greatest care, errors cannot be completely excluded.
Should you notice any please contact the above address.

Table of contents

Chapter 1 Introduction .................................. 1

1.1 Welcome to tiamo ................................................................1

1.2 User interface ......................................................................2

1.3 Integration of devices..........................................................2

1.4 Method editor .......................................................................3

1.5 Database ..............................................................................3

1.6 Communication ....................................................................4

1.7 Compliance ..........................................................................4

1.8 Versions................................................................................5

1.9 Online Help...........................................................................6

Chapter 2 General program functions .......... 7

2.1 Program parts ......................................................................7

2.2 Login/Password protection..................................................8

2.2.1 General .......................................................................................8

2.2.2 Login ...........................................................................................9

2.2.3 Manual logout............................................................................. 9

2.2.4 Automatic logout........................................................................9

2.2.5 Change password.......................................................................9

2.3 Electronic signatures.........................................................11

2.3.1 Rules .........................................................................................11

2.3.2 Procedure ................................................................................. 11

2.3.3 Signature Level 1 .....................................................................12

2.3.4 Signature Level 2 .....................................................................13

2.3.5 Delete Level 2 signatures ........................................................14

2.4 Formula editor....................................................................15

2.4.1 Overview ................................................................................... 15

2.4.2 Input field .................................................................................16

2.4.3 Variables...................................................................................17

Overview ................................................................................................... 17

Method variables ...................................................................................... 17

Table of contents iii

Command variables.................................................................................. 18

Result variables ........................................................................................ 23

Determination variables ........................................................................... 23

System variables ...................................................................................... 24

Common variables.................................................................................... 25

2.4.4 Operators/Functions ................................................................ 26

Operators - Arithmetic.............................................................................. 27

Addition .............................................................................................. 27

Subtraction......................................................................................... 28

Multiplication ...................................................................................... 29

Division............................................................................................... 30

Potentiation ........................................................................................ 31

Operators - Logic...................................................................................... 32

AND .................................................................................................... 32

OR ...................................................................................................... 33

Operators - Compare................................................................................ 34

Equal .................................................................................................. 34

Larger than ......................................................................................... 35

Larger than or equal to....................................................................... 36

Smaller than ....................................................................................... 37

Smaller than or equal to..................................................................... 38

Unequal .............................................................................................. 39

Functions - Arithmetic .............................................................................. 40

Exponential function........................................................................... 40

Natural logarithm................................................................................ 40

Common logarithm ............................................................................ 40

Square root ........................................................................................ 41

Absolute value.................................................................................... 41

Fraction .............................................................................................. 42

Integer ................................................................................................ 42

Round integer..................................................................................... 42

Sign .................................................................................................... 43

Functions - Date/Time .............................................................................. 44

Time() ................................................................................................. 44

Time(Date).......................................................................................... 44

Time(Date + Time) .......................................................................45

Functions - Type conversion.................................................................... 46

NumberToText ................................................................................... 46

NumberToTime .................................................................................. 46

TextToNumber.................................................................................... 46

TextToTime......................................................................................... 47

TimeToNumber .................................................................................. 48

TimeToText......................................................................................... 48

Functions - Text ........................................................................................ 50

TextPosition........................................................................................ 50

SubText .............................................................................................. 50

Trim .................................................................................................... 51

Miscellaneous functions .......................................................................... 52

Case ................................................................................................... 52

Error.................................................................................................... 53

ASCII table ................................................................................................ 54

2.5 Edit..................................................................................... 55

2.5.1 Text editor ................................................................................ 55

2.5.2 Select date ............................................................................... 56

iv Table of contents

2.6 Manual control ...................................................................57

2.6.1 General ..................................................................................... 57

2.6.2 Select device ............................................................................57

2.6.3 Functions .................................................................................. 58

2.6.4 Graphic display ........................................................................58

2.6.5 Dosing .......................................................................................58

General...................................................................................................... 59

Prepare...................................................................................................... 60

Fill .............................................................................................................. 61

Empty ........................................................................................................ 62

Add fixed volume...................................................................................... 63

Dosing ....................................................................................................... 65

2.6.6 Stirring ......................................................................................66

Switch on/off ............................................................................................. 67

Continuous operation............................................................................... 68

2.6.7 Remote functions ..................................................................... 69

2.6.8 Sample changer functions....................................................... 70

General...................................................................................................... 71

Move .......................................................................................................... 72

Assign position ......................................................................................... 74

Pump ......................................................................................................... 76

Heating/Gas .............................................................................................. 77

Chapter 3 Workplace ................................... 79

3.1 General ...............................................................................79

3.1.1 General ..................................................................................... 79

3.1.2 Desktop..................................................................................... 79

3.1.3 Menu bar...................................................................................79

Menu File................................................................................................... 80

Menu View................................................................................................. 80

Menu Tools ............................................................................................... 80

Menu Help ................................................................................................. 81

3.1.4 Toolbar......................................................................................81

3.1.5 Subwindows .............................................................................82

3.1.6 Functions .................................................................................. 82

3.1.7 Workplace views ......................................................................83

Change layout........................................................................................... 84

Save view .................................................................................................. 85

Load view .................................................................................................. 86

Rename view............................................................................................. 86

Delete view................................................................................................ 86

3.2 Workplaces.........................................................................87

3.2.1 Create new workplace.............................................................87

3.2.2 Edit workplace .........................................................................87

Table of contents v

Show workplace ...................................................................... 88

3.2.3

Select workplace in workplace symbol................................................... 88

Show single workplace ............................................................................ 88

Show workplaces beside each other ...................................................... 88

Show workplaces one below the other ................................................... 88

3.2.4 Close workplace ...................................................................... 88

3.3 Sample tables.................................................................... 89

3.3.1 Edit ........................................................................................... 89

Create new sample table.......................................................................... 89

Open sample table.................................................................................... 89

Edit sample table ...................................................................................... 90

Edit sample data ....................................................................................... 91

Import sample data................................................................................... 93

Save sample table .................................................................................... 93

Print sample table (PDF) .......................................................................... 94

3.3.2 Properties................................................................................. 94

Display................................................................................................ 95

Edit ..................................................................................................... 96

Process............................................................................................... 97

Data import......................................................................................... 98

Comment............................................................................................ 99

3.3.3 Manager ................................................................................. 100

Sample table manager ........................................................................... 100

Rename sample table............................................................................. 101

Copy sample table.................................................................................. 101

Delete sample table ................................................................................ 101

Export sample table................................................................................ 101

Import sample table................................................................................ 101

3.4 Tools ................................................................................ 102

3.4.1 Run test .................................................................................. 102

3.4.2 Sample assignment table...................................................... 102

General .................................................................................................... 102

Sample assignment table....................................................................... 103

Sample assignment ................................................................................ 103

Sample assignment request .................................................................. 104

3.4.3 Text templates ....................................................................... 105

3.5 Subwindow Run............................................................... 106

3.5.1 General................................................................................... 106

3.5.2 Single determination ............................................................. 106

Overview.................................................................................................. 106

Operating tools ....................................................................................... 107

Status display ......................................................................................... 107

Determination parameters ..................................................................... 108

Modify remark .................................................................................. 108

Sample data ............................................................................................ 109

Live modifications .................................................................................. 110

Modification comment for sample data................................................. 110

Determination run................................................................................... 111

vi Table of contents

Properties................................................................................................ 114

Display ..............................................................................................114

Process .............................................................................................115

Data import .......................................................................................115

3.5.3 Determination series .............................................................117

Overview ................................................................................................. 117

Operating tools ....................................................................................... 117

Status display ......................................................................................... 118

Determination parameters ..................................................................... 119

Modify remark ...................................................................................120

Modify autostart counter...................................................................120

Sample data ............................................................................................ 120

Determination run................................................................................... 121

Working sample table............................................................................. 124

Load new and empty sample table ..................................................124

Load sample table ............................................................................124

Edit working sample table ................................................................125

Edit sample data ...............................................................................127

Import sample data...........................................................................129

Save sample table.............................................................................129

Run test.............................................................................................130

Print sample table (PDF)...................................................................130

Properties................................................................................................ 131

Display ..............................................................................................131

Edit ....................................................................................................132

Process .............................................................................................134

Data import .......................................................................................135

Comment ..........................................................................................136

3.6 Subwindow Method..........................................................137

3.6.1 General ................................................................................... 137

3.6.2 Zoom for method window ......................................................137

3.6.3 Live modifications ..................................................................137

3.6.4 Quit command ........................................................................ 138

3.7 Subwindow Live display ..................................................139

3.7.1 General ................................................................................... 139

3.7.2 Tracks .....................................................................................139

3.7.3 Application note .....................................................................140

3.7.4 Properties ...............................................................................140

3.8 Subwindow Report ...........................................................143

3.8.1 General ................................................................................... 143

3.8.2 Current report.........................................................................143

3.8.3 Selected report.......................................................................143

3.8.4 Report overview .....................................................................143

Table of contents vii

Chapter 4 Database ................................... 145

4.1 General ............................................................................ 145

4.1.1 General................................................................................... 145

4.1.2 Desktop .................................................................................. 145

4.1.3 Menu bar ................................................................................ 145

Menu File................................................................................................. 146

Menu Edit ................................................................................................ 146

Menu View............................................................................................... 146

Menu Determinations ............................................................................. 147

Menu Tools.............................................................................................. 148

Menu Help ............................................................................................... 148

4.1.4 Toolbar ................................................................................... 148

4.1.5 Subwindows ........................................................................... 150

4.1.6 Functions................................................................................ 150

4.1.7 Database views...................................................................... 151

Change layout......................................................................................... 152

Save view ................................................................................................ 152

Load view ................................................................................................ 153

Rename view........................................................................................... 154

Delete view.............................................................................................. 154

4.2 Open/display database ................................................... 155

4.2.1 Open database....................................................................... 155

4.2.2 Select database in database symbol.................................... 156

4.2.3 Show single database ........................................................... 156

4.2.4 Show databases beside each other...................................... 156

4.2.5 Show databases one below the other .................................. 156

4.2.6 Close database ...................................................................... 157

4.3 Manage databases.......................................................... 158

4.3.1 Database manager ................................................................ 158

4.3.2 Create new database ............................................................ 159

4.3.3 Rename database.................................................................. 159

4.3.4 Delete database..................................................................... 159

4.3.5 Database properties .............................................................. 160

General............................................................................................. 160

Access rights.................................................................................... 161

Backup ............................................................................................. 161

Monitoring ........................................................................................ 162

4.3.6 Manual database backup ...................................................... 163

4.3.7 Restore database................................................................... 163

4.4 Report templates ............................................................ 165

4.4.1 Create new report template.................................................. 165

4.4.2 Open report template ............................................................ 165

viii Table of contents

Edit report templates .............................................................166

4.4.3

General.................................................................................................... 166

Desktop.............................................................................................167

Menu bar...........................................................................................167

Menu File.................................................................................... 168

Menu Edit ................................................................................... 168

Menu View .................................................................................. 168

Menu Insert................................................................................. 169

Menu Tools................................................................................. 169

Menu Help .................................................................................. 169

General toolbar .................................................................................169

Module-specific toolbar ....................................................................170

Module bar........................................................................................170

Functions................................................................................................. 171

Page setup........................................................................................171

Define sections..................................................................................172

Insert pages ......................................................................................173

Insert modules ..................................................................................173

Edit modules .....................................................................................174

Zoom for report templates ................................................................175

Page preview ....................................................................................175

Comment ..........................................................................................176

Options..............................................................................................177

Save report template.........................................................................177

Modules................................................................................................... 178

Text field............................................................................................178

Data field ...........................................................................................179

Date field ...........................................................................................181

Time field...........................................................................................182

Page number ....................................................................................183

Number of pages ..............................................................................184

Fixed report ................................................................................ 185

Image ................................................................................................185

Line....................................................................................................186

Rectangle ..........................................................................................187

Curve field .........................................................................................187

Curve field - x axis.............................................................................188

Curve field - y1 axis...........................................................................189

Curve field - y2 axis...........................................................................191

Curve field - options..........................................................................192

Calibration curve field .......................................................................194

4.4.4 Manage report templates ...................................................... 194

Manage report templates..................................................................194

Rename report template ...................................................................195

Copy report templates ......................................................................195

Delete report templates ....................................................................195

Export report templates ....................................................................196

Import report template ......................................................................196

4.5 Templates for control chart.............................................197

4.5.1 Manage control chart templates...........................................197

4.5.2 Properties ...............................................................................198

Graphical settings .............................................................................198

Limits .......................................................................................... 199

Statistics ..................................................................................... 199

Comment.................................................................................... 200

Table of contents ix

4.6 Templates for curve overlay ........................................... 201

4.6.1 Manage curve overlay templates.......................................... 201

4.6.2 Properties............................................................................... 201

x Axis ................................................................................................ 202

y-axis ................................................................................................ 203

Options........................................................................................204

Comment ....................................................................................205

4.7 Export templates............................................................. 206

4.7.1 Manage................................................................................... 206

4.7.2 Properties............................................................................... 207

Options........................................................................................208

Select fields.................................................................................209

4.8 Subwindow Determination overview.............................. 210

4.8.1 General................................................................................... 210

Overview.................................................................................................. 210

Determination table ................................................................................ 210

Column display....................................................................................... 211

Filter selection ........................................................................................ 212

Navigation bar......................................................................................... 212

Table navigation ..................................................................................... 213

Data record selection ............................................................................. 213

4.8.2 Functions................................................................................ 214

Functions................................................................................................. 214

Update determination table.............................................................. 214

Determination comment......................................................................... 215

Search determinations ........................................................................... 215

Filter determinations .............................................................................. 217

Last filter ........................................................................................... 217

Quick filter ........................................................................................ 217

Special filter...................................................................................... 218

Edit filter criterion ........................................................................219

Save filter.......................................................................................... 220

All statistics records ....................................................................220

Remove filter .................................................................................... 220

Sign determinations ............................................................................... 221

Rules................................................................................................. 221

Sign determinations at Level 1......................................................... 221

Sign determinations at Level 2......................................................... 222

Show determination signatures ....................................................... 223

Delete signatures 2 for determinations ............................................ 224

Export determinations ............................................................................ 225

Import determinations ............................................................................ 225

Delete determinations ............................................................................ 225

Print determination overview ................................................................. 226

Print determination report...................................................................... 226

Show determination method.................................................................. 228

Show determination history ................................................................... 229

Show calibration curve................................................................230

Control chart ........................................................................................... 231

Overlay curves ........................................................................................ 232

x Table of contents

Reprocess determinations.....................................................234

4.8.3

General.................................................................................................... 234

Reprocessing window............................................................................ 234

Reprocessing rules ................................................................................ 235

Modifications .......................................................................................... 237

Variables ...........................................................................................237

Method ..............................................................................................238

Statistics............................................................................................239

Curve evaluation ...............................................................................241

Edit curve ebvaluation............................................................................ 242

Edit curve evaluation.........................................................................242

Properties..........................................................................................244

x axis........................................................................................... 244

y axis........................................................................................... 245

Options....................................................................................... 246

Result view.............................................................................................. 248

Modification comment for determinations............................................ 249

4.9 Subwindow Information...................................................250

4.9.1 Overview ................................................................................. 250

4.9.2 Determination.........................................................................250

4.9.3 Method .................................................................................... 252

4.9.4 Sample ....................................................................................253

4.9.5 Configuration.......................................................................... 254

4.9.6 Messages................................................................................257

4.9.7 Determination comment ........................................................257

4.10 Subwindow Results..........................................................258

4.10.1 Overview .................................................................................258

4.10.2 Results overview .................................................................... 258

4.10.3 Command name .....................................................................259

4.10.4 Properties ...............................................................................260

4.11 Subwindow Curves...........................................................261

4.11.1 General ...................................................................................261

4.11.2 Properties ...............................................................................262

Overview..................................................................................... 262

x Axis .......................................................................................... 263

y1-axis ........................................................................................ 264

y2 Axis ........................................................................................ 265

Options....................................................................................... 267

Measuring point list................................................................................ 268

Table of contents xi

Chapter 5 Method ....................................... 271

5.1 General ............................................................................ 271

5.1.1 General................................................................................... 271

5.1.2 Desktop .................................................................................. 271

5.1.3 Menu bar ................................................................................ 272

Menu File................................................................................................. 272

Menu Edit ................................................................................................ 273

Menu View............................................................................................... 273

Menu Insert ............................................................................................. 273

Menu Tools.............................................................................................. 273

Menu Help ............................................................................................... 274

5.1.4 Toolbar ................................................................................... 274

5.1.5 Functions................................................................................ 275

5.2 Method editor .................................................................. 276

5.2.1 Create new method ............................................................... 276

5.2.2 Open method.......................................................................... 276

5.2.3 Display method ...................................................................... 278

Selecting the method in the method symbol ........................................ 278

Display single method............................................................................ 278

Display methods beside each other...................................................... 278

Display methods one below the other................................................... 278

Zoom for methods .................................................................................. 279

5.2.4 Edit method ............................................................................ 279

Edit tracks ............................................................................................... 279

Insert new track................................................................................ 279

Select track....................................................................................... 280

Move track........................................................................................ 280

Copy track........................................................................................ 280

Cut track........................................................................................... 280

Insert track........................................................................................ 280

Delete track ...................................................................................... 281

Edit commands ....................................................................................... 281

Insert new command........................................................................ 281

Select commands ............................................................................ 282

Move commands.............................................................................. 282

Copy commands.............................................................................. 282

Cut commands................................................................................. 282

Insert commands ............................................................................. 282

Delete commands ............................................................................ 283

Command properties ....................................................................... 283

Command comment ........................................................................ 283

5.2.5 Check method ........................................................................ 284

5.2.6 Save method .......................................................................... 284

5.2.7 Comment on modification for method .................................. 286

5.2.8 Close method ......................................................................... 286

xii Table of contents

5.3 Manage methods..............................................................287

5.3.1 Manage methods....................................................................287

5.3.2 Rename method .....................................................................288

5.3.3 Copy method...........................................................................289

5.3.4 Move method ..........................................................................289

5.3.5 Delete method ........................................................................ 289

5.3.6 Export method ........................................................................289

5.3.7 Import method........................................................................290

5.3.8 Sign methods..........................................................................290

Rules........................................................................................................ 290

Sign method at level 1............................................................................ 291

Sign method at level 2................................................................ 292

Show method signatures ....................................................................... 293

Delete signatures 2................................................................................. 293

Show method history ................................................................. 294

5.4 Manage method groups ...................................................295

5.4.1 Manage method groups .........................................................295

5.4.2 Method group properties .......................................................295

General.................................................................................................... 296

Access rights .......................................................................................... 296

5.5 Tracks...............................................................................297

5.5.1 General ................................................................................... 297

5.5.2 Track types.............................................................................297

Main track................................................................................................ 297

Normal track ........................................................................................... 298

Series start track .................................................................................... 299

Series end track...................................................................................... 299

Exit track ................................................................................................. 299

Error track ............................................................................................... 300

5.5.3 Edit tracks .............................................................................. 301

5.6 Commands .......................................................................302

5.6.1 General ................................................................................... 302

5.6.2 Edit commands.......................................................................302

5.6.3 Command overview................................................................303

5.6.4 Track commands....................................................................305

START...................................................................................................... 305

General ....................................................................................... 306

Application note ......................................................................... 307

Method variables (table) ............................................................ 308

Method variables (properties).................................................... 309

TRACK ..................................................................................................... 311

SERIES START........................................................................................ 312

SERIES END............................................................................................ 312

EXIT ......................................................................................................... 312

ERROR .................................................................................................... 313

END.......................................................................................................... 313

Table of contents xiii

Titration commands............................................................... 314

5.6.5

DET .......................................................................................................... 314

DET pH............................................................................................. 315

General/Hardware.......................................................................316

Start conditions ...........................................................................318

Titration parameters ....................................................................320

Stop conditions ...........................................................................322

Potentiometric evaluation............................................................323

Additional evaluations.................................................................327

Additional measured values .......................................................329

DET U ............................................................................................... 331

General/Hardware.......................................................................332

Startbedingungen .......................................................................334

Titration parameters ....................................................................336

Stop conditions ...........................................................................336

Potentiometric evaluation............................................................337

Additional evaluations.................................................................339

Additional measured values .......................................................341

DET Ipol............................................................................................ 341

General/Hardware.......................................................................342

Start conditions ...........................................................................344

Titration parameters ....................................................................344

Stop conditions ...........................................................................344

Potentiometric evaluation............................................................344

Additional evaluations.................................................................345

Additional measured values .......................................................347

DET Upol .......................................................................................... 347

General/Hardware.......................................................................348

Start conditions ...........................................................................350

Titration parameters ....................................................................352

Stop conditions ...........................................................................354

Potentiometric evaluation............................................................355

Additional evaluations.................................................................357

Additional measured values .......................................................359

MET.......................................................................................................... 359

MET pH ............................................................................................ 360

General/Hardware.......................................................................360

Start conditions ...........................................................................360

Titration parameters ....................................................................361

Stop conditions ...........................................................................362

Potentiometric evaluation............................................................362

Additional evaluations.................................................................363

Additional measured values .......................................................363

MET U............................................................................................... 363

General/Hardware.......................................................................363

Start conditions ...........................................................................364

Titration parameters ....................................................................364

Stop conditions ...........................................................................364

Potentiometric evaluation............................................................364

Additional evaluations.................................................................364

Additional measured values .......................................................364

MET Ipol ........................................................................................... 364

General/Hardware.......................................................................365

Start conditions ...........................................................................365

Titration parameters ....................................................................365

Stop conditions ...........................................................................365

Potentiometric evaluation............................................................365

xiv Table of contents

Additional evaluations ................................................................ 365

Additional measured values....................................................... 365

MET Upol ..........................................................................................366

General/Hardware ...................................................................... 366

Start conditions .......................................................................... 366

Titration parameters ................................................................... 366

Stop conditions .......................................................................... 367

Potentiometric evaluation........................................................... 367

Additional evaluations ................................................................ 367

Additional measured values....................................................... 367

SET .......................................................................................................... 368

SET pH..............................................................................................369

General/Hardware ...................................................................... 370

Start conditions .......................................................................... 370

Control parameters .................................................................... 372

Titration parameters ................................................................... 374

Conditioning ............................................................................... 375

Additional evaluations ................................................................ 377

Additional measured values....................................................... 378

SET U ................................................................................................378

General/Hardware ...................................................................... 379

Start conditions .......................................................................... 379

Control parameters .................................................................... 379

Titration parameters ................................................................... 381

Stop conditions .......................................................................... 381

Conditioning ............................................................................... 381

Additional evaluations ................................................................ 382

SET Ipol.............................................................................................383

General/Hardware ...................................................................... 384

Start conditions .......................................................................... 384

Control parameters .................................................................... 384

Titration parameters ................................................................... 384

Stop conditions .......................................................................... 384

Conditioning ............................................................................... 384

Additional evaluations ................................................................ 384

Additional measured values....................................................... 384

SET Upol...........................................................................................385

General/Hardware ...................................................................... 385

Start conditions .......................................................................... 386

Control parameters .................................................................... 387

Titration parameters ................................................................... 389

Stop conditions .......................................................................... 389

Conditioning ............................................................................... 389

Additional evaluations ................................................................ 389

Additional measured values....................................................... 390

KFT .......................................................................................................... 391

KFT Ipol.............................................................................................392

General/Hardware ...................................................................... 393

Start conditions .......................................................................... 395

Control parameters .................................................................... 395

Titration parameters ................................................................... 397

Stop conditions .......................................................................... 397

Conditioning ............................................................................... 398

Additional evaluations ................................................................ 398

Additional measured values....................................................... 398

KFT Upol ...........................................................................................398

General/Hardware ...................................................................... 399

Table of contents xv

Start conditions ...........................................................................399

Control parameters .....................................................................399

Titration parameters ....................................................................399

Stop conditions ...........................................................................399

Conditioning................................................................................399

Additional evaluations.................................................................399

Additional measured values .......................................................399

KFC .......................................................................................................... 400

General/Hardware.......................................................................401

Start conditions ...........................................................................402

Control parameters .....................................................................403

Titration parameters ....................................................................404

Stop conditions ...........................................................................405

Conditioning................................................................................405

Additional evaluations.................................................................406

Additional measured values .......................................................407

Evaluation................................................................................................ 407

pK value and half neutralization potential ........................................ 407

Minimum and maximum evaluation ................................................. 408

Break point evaluation...................................................................... 409

5.6.6 Measuring commands ........................................................... 410

MEAS pH ................................................................................................. 410

General/Hardware.......................................................................411

Measuring parameters................................................................ 412

Evaluations..................................................................................414

Additional measured values .......................................................416

MEAS U ................................................................................................... 416

General/Hardware.......................................................................417

Measuring parameters................................................................ 418

Evaluations..................................................................................420

Additional measured values .......................................................422

MEAS Ipol................................................................................................ 422

General/Hardware.......................................................................423

Measuring parameters................................................................ 424

Evaluations..................................................................................424

Additional measured values .......................................................424

MEAS Upol .............................................................................................. 425

General/Hardware.......................................................................425

Measuring parameters................................................................ 427

Evaluations..................................................................................429

Additional measured values .......................................................430

MEAS T.................................................................................................... 431

General/Hardware.......................................................................431

Measuring parameters................................................................ 432

Evaluations..................................................................................434

Additional measured values .......................................................436

MEAS T/Flow........................................................................................... 436

General/Hardware.......................................................................436

Measuring parameters................................................................ 437

Evaluations..................................................................................438

Additional measured values .......................................................438

MEAS Conc ............................................................................................. 439

General/Hardware.......................................................................439

Measuring parameters................................................................ 440

Additional measured values .......................................................440

xvi Table of contents

MEAS Cond............................................................................................. 441

General/Hardware ...................................................................... 441

Measuring parameters ............................................................... 442

Evaluations ................................................................................. 443

Additional measured values....................................................... 445

5.6.7 Calibration commands...........................................................445

Calibrating with manual solution changing .......................................... 446

Calibrating with automatic solution changing ...................................... 447

CAL LOOP pH ......................................................................................... 448

CAL LOOP pH - properties ........................................................ 449

CAL MEAS pH ......................................................................................... 450

General/Hardware ...................................................................... 450

Measuring parameters ............................................................... 452

CAL LOOP Conc ..................................................................................... 453

CAL LOOP Conc - properties .................................................... 453

CAL MEAS Conc..................................................................................... 454

General/Hardware ...................................................................... 454

Measuring parameters ............................................................... 455

5.6.8 Dosing commands.................................................................. 456

ADD.......................................................................................................... 456

General/Hardware ...................................................................... 457

Parameters ................................................................................. 458

LQH.......................................................................................................... 459

General/Hardware ...................................................................... 459

Parameters ................................................................................. 460

PREP........................................................................................................ 462

PREP - properties....................................................................... 462

EMPTY ..................................................................................................... 463

EMPTY - properties .................................................................... 464

5.6.9 Automation commands..........................................................465

MOVE....................................................................................................... 465

MOVE - properties...................................................................... 466

SWING ..................................................................................................... 468

SWING - properties .................................................................... 468

LIFT.......................................................................................................... 469

LIFT - Properties ......................................................................... 470

PUMP....................................................................................................... 471

PUMP - properties...................................................................... 471

STIR ......................................................................................................... 472

STIR - properties ........................................................................ 473

RACK ....................................................................................................... 474

RACK - properties ...................................................................... 474

HEATER................................................................................................... 475

HEATER - properties .................................................................. 476

FLOW....................................................................................................... 477

FLOW - properties...................................................................... 478

5.6.10 Result commands...................................................................479

CALC ....................................................................................................... 479

CALC - result table ..................................................................... 480

CALC result properties......................................................................482

Result - definition........................................................................ 482

Result - Monitoring ..................................................................... 483

Result - options .......................................................................... 485

Send e-mail ................................................................................ 486

Table of contents xvii

Result templates............................................................................... 486

Manage result templates ............................................................486

Save result template ...................................................................487

Rename result template..............................................................487

DATABASE .............................................................................................. 488

DATABASE - properties ..............................................................488

REPORT................................................................................................... 489

REPORT - Properties ..................................................................489

EXPORT................................................................................................... 490

EXPORT - properties...................................................................490

5.6.11 Communication commands................................................... 491

CTRL........................................................................................................ 491

CTRL - Properties........................................................................491

SCAN ....................................................................................................... 493

SCAN - Properties.......................................................................493

SEND ....................................................................................................... 494

SEND - properties.......................................................................495

SEND - event messages.............................................................495

RECEIVE.................................................................................................. 497

RECEIVE- properties...................................................................497

SEND - event/state......................................................................498

TRANSFER .............................................................................................. 499

TRANSFER - properties ..............................................................499

TRANSFER - transfer commands...............................................501

5.6.12 Miscellaneous commands ..................................................... 503

REQUEST ................................................................................................ 503

REQUEST - properties ................................................................503

REQUEST - sample data request...............................................505

CALL ........................................................................................................ 506

CALL - properties........................................................................506

CALL - call...................................................................................507

LOOP ....................................................................................................... 507

LOOP - properties.......................................................................509

WAIT ........................................................................................................ 510

WAIT - properties ........................................................................510

SEQUENCE ............................................................................................. 511

SEQUENCE - properties.............................................................511

5.7 Method reports ................................................................ 513

Select method reports ................................................................513

Method sequence report ............................................................513

Method parameters report..........................................................513

Titration and measurement parameters report...........................514

xviii Table of contents

Chapter 6 Configuration ............................ 515

6.1 General .............................................................................515

6.1.1 General ................................................................................... 515

6.1.2 Desktop................................................................................... 515

6.1.3 Menu bar.................................................................................516

Menu File................................................................................................. 516

Menu View............................................................................................... 516

Menu Tools ............................................................................................. 516

Menu Help ............................................................................................... 517

6.1.4 Toolbar....................................................................................517

6.1.5 Subwindows ...........................................................................518

6.1.6 Functions ................................................................................ 518

6.1.7 Configuration views ............................................................... 519

Change layout......................................................................................... 520

Save view ................................................................................................ 521

Load view ................................................................................................ 521

Rename view........................................................................................... 522

Delete view.............................................................................................. 522

6.2 Administration..................................................................523

6.2.1 Security settings ....................................................................523

Login/Password protection...............................................................524

Send e-mail ................................................................................ 526

Audit Trail/Modifications....................................................................527

Signatures.........................................................................................528

Default reasons .................................................................................529

6.2.2 User administration ............................................................... 530

User groups ............................................................................................ 532

User group information.....................................................................532

Access rights.....................................................................................533

Signatures.........................................................................................534

Options..............................................................................................535

Add user group .................................................................................535

Copy user group...............................................................................536

Rename user group ..........................................................................536

Delete user group .............................................................................536

Add user............................................................................................537

Users ....................................................................................................... 537

User information................................................................................537

Add user............................................................................................538

Set start password ............................................................................539

6.2.3 Program administration......................................................... 539

Backup directories ................................................................................. 540

Backup directories ............................................................................540

Create new backup directory............................................................540

Edit backup directory........................................................................541

Computer identifications...................................................................541

Licenses ............................................................................................542

Table of contents xix

6.3 Configuration data .......................................................... 543

6.3.1 Export/Import ......................................................................... 543

Export configuration data....................................................................... 543

Import configuration data....................................................................... 544

6.3.2 Backup/Restore...................................................................... 545

Backup configuration data automatically ............................................. 545

Backup configuration data manually..................................................... 546

Restore configuration data .................................................................... 546

6.3.3 Templates .............................................................................. 548

Custom calibration buffers..........................................................548

Templates for input lines.............................................................549

Templates for output lines ..........................................................550

6.3.4 Options ................................................................................... 551

Overview......................................................................................551

General............................................................................................. 551

Save.............................................................................................552

PDF................................................................................................... 553

6.4 Audit Trail ........................................................................ 554

6.4.1 General................................................................................... 554

General .................................................................................................... 554

Desktop ................................................................................................... 554

Menu bar ................................................................................................. 554

Menu File................................................................................................. 555

Menu View............................................................................................... 555

Menu Filter .............................................................................................. 555

Menu Tools.............................................................................................. 555

Menu Help ............................................................................................... 555

6.4.2 Toolbar ................................................................................... 556

6.4.3 Filter selection ....................................................................... 556

6.4.4 Audit Trail - navigation bar.................................................... 556

6.4.5 Functions................................................................................ 557

6.4.6 Audit Trail table ..................................................................... 557

Column display....................................................................................... 559

Filter Audit Trail ...................................................................................... 559

Last filter ........................................................................................... 559

Quick filter ........................................................................................ 560

Special filter...................................................................................... 560

Edit filter condition ......................................................................561

Save filter.....................................................................................562

Remove filter .................................................................................... 562

Update Audit Trail ................................................................................... 563

Export Audit Trail .................................................................................... 563

Archive Audit Trail .................................................................................. 563

Delete Audit Trail .................................................................................... 564

Print Audit Trail ....................................................................................... 565

Audit Trail monitoring............................................................................. 565

xx Table of contents

6.5 Subwindow Devices .........................................................566

6.5.1 General ................................................................................... 566

6.5.2 Device table............................................................................ 566

Column display....................................................................................... 568

Add new device ...................................................................................... 568

Delete device .......................................................................................... 569

Print devices list ..................................................................................... 569

6.5.3 Device properties ...................................................................570

Overview ................................................................................................. 570

Titrando ................................................................................................... 570

General..............................................................................................571

Load new program version ........................................................ 571

Measuring inputs ..............................................................................572

MSB #...............................................................................................573

GLP ...................................................................................................574

Titrino ...................................................................................................... 575

General..............................................................................................575

Load new program version ........................................................ 576

Int. dosing device D0 ........................................................................576

Ext. dosing device D# ......................................................................577

RS 232...............................................................................................578

GLP ...................................................................................................578

Coulometer ............................................................................................. 579

General..............................................................................................580

Load new program version ........................................................ 580

RS 232...............................................................................................581

GLP ...................................................................................................581

Conductometer ....................................................................................... 582

General..............................................................................................583

Load new program version ........................................................ 583

RS 232...............................................................................................584

GLP ...................................................................................................584

Dosing Interface ..................................................................................... 585

General..............................................................................................586

Load new program version ........................................................ 586

MSB #...............................................................................................587

GLP ...................................................................................................588

814/815 USB Sample Processor............................................................ 589

General..............................................................................................589

Load new program version ........................................................ 590

Tower #.............................................................................................591

Robotic arm configuration.......................................................... 592

External position......................................................................... 593

Rack ..................................................................................................593

MSB #...............................................................................................594

GLP ...................................................................................................595

778/789 Sample Processor .................................................................... 596

General..............................................................................................596

Load new program version ........................................................ 597

Tower #.............................................................................................598

Robotic arm configuration.......................................................... 599

External position......................................................................... 600

Rack ..................................................................................................600

MSB #...............................................................................................601

Table of contents xxi

RS 232.............................................................................................. 602

GLP................................................................................................... 602

730 Sample Changer .............................................................................. 603

General............................................................................................. 604

Load new program version.........................................................604

Towers.........................................................................................605

Rack ................................................................................................. 606

Dosing device................................................................................... 607

RS 232.............................................................................................. 607

GLP................................................................................................... 608

774 Oven Sample Processor ................................................................. 609

General............................................................................................. 609

Load new program version.........................................................610

Towers.............................................................................................. 611

Rack ................................................................................................. 611

Edit rack properties (774)................................................................. 612

Lift positions ..................................................................................... 613

Special beakers................................................................................ 613

Dosing device................................................................................... 614

Oven ................................................................................................. 614

Gas ................................................................................................... 615

RS 232.............................................................................................. 616

GLP................................................................................................... 616

Balance.................................................................................................... 617

General............................................................................................. 617

RS 232.............................................................................................. 618

Test connection...........................................................................619

GLP................................................................................................... 620

Barcode reader ....................................................................................... 621

General............................................................................................. 621

Settings ............................................................................................ 622

Check connection .......................................................................622

GLP................................................................................................... 623

RS232 device .......................................................................................... 624

General............................................................................................. 624

RS 232.............................................................................................. 625

Test connection...........................................................................626

GLP................................................................................................... 627

6.6 Subwindow Titrants/Solutions........................................ 629

6.6.1 General................................................................................... 629

6.6.2 Solution table......................................................................... 629

Column display....................................................................................... 631

Add new solution .................................................................................... 631

Delete solution........................................................................................ 632

Print solution list..................................................................................... 632

6.6.3 Solution properties ................................................................ 632

Solution ............................................................................................ 633

Titer................................................................................................... 634

Titer history....................................................................................... 636

Exchange unit .................................................................................. 637

Dosing unit ....................................................................................... 640

GLP................................................................................................... 643

xxii Table of contents

6.7 Subwindow Sensors.........................................................645

6.7.1 General ................................................................................... 645

6.7.2 Sensor table ...........................................................................645

Column display....................................................................................... 647

Add new sensor...................................................................................... 647

Delete sensor.......................................................................................... 648

Print sensor list....................................................................................... 648

6.7.3 Sensor properties...................................................................649

Edit properties ............................................................................ 649

Sensor...............................................................................................649

Calibration data.................................................................................651

Limits.................................................................................................653

History...............................................................................................654

Sensor history - Limits................................................................ 655

6.8 Subwindow Common Variables.......................................658

6.8.1 General ................................................................................... 658

6.8.2 Table of common variables ...................................................658

Column display....................................................................................... 659

Add new common variable..................................................................... 660

Delete common variable ........................................................................ 660

Print list of common variables ............................................................... 660

6.8.3 Common variables properties ...............................................661

Common variable..............................................................................661

History...............................................................................................663

History - limits ...................................................................................664

6.9 Subwindow Rack data .....................................................665

6.9.1 General ................................................................................... 665

6.9.2 Rack table ..............................................................................665

Add new rack .......................................................................................... 666

Delete rack .............................................................................................. 667

Print rack list........................................................................................... 667

6.9.3 Rack properties......................................................................668

Rack parameters...............................................................................669

Lift positions......................................................................................670

Special beakers ................................................................................671

Special beaker............................................................................ 672

Chapter 7 Index.......................................... 675

Table of contents xxiii

xxiv Table of contents

Chapter 1 Introduction

1.1 Welcome to tiamo

tiamo = titration and more

tiamo is a control and database software for titrators, dosing devices and sample
changers that allows complete laboratory automation, which is why the name

tiamo stands for «titration and more» – tiamo can do far more than just titrate.

tiamo is the successor of the TiNet and Workcell software. With it Metrohm now of-

fers worldwide a uniform software product for laboratory automation. This means
that an internationally operating concern can now use the same software platform
for processing all its samples and exchange data and methods without any loss.

The most important program features

• Easy to use and configurable user interface

• Easy integration of instruments and accessories

• Comfortable method editor

• Database program with client/server fuctionality

• Manifold import and export possibilities

• FDA compatibility according to 21 CFR Part 11

• Extensive online help

Welcome to tiamo 1

1.2 User interface

The modern user interface makes it easy for users to familiarize themselves with
tiamo quickly. All command and control functions are located where users would
expect them. The tiamo bar on the left-hand side of the screen allows access to
the four basic tiamo components:

Whether these buttons are visible or concealed depends on the user’s rights of
access. The menu bar is located in the upper part of the screen. Again, each indi­vidual command can be concealed in accordance with the rights of access of the
user.

In the center of the screen are the information windows, in which settings, sam­ple input templates, real-time curves or results are shown. This display can be ad­justed individually for each user with the aid of the new Layout Manager. This
means that each user can only see the windows or buttons necessary for his or
her work. This shortens the familiarization time for users carrying out routine work
to a minimum; operating errors resulting from a cluttered screen are now a thing
of the past.

The methods and calculation templates successfully introduced with the Ti­trando system are also available with tiamo. Numerous tried and tested methods
allow users to draw up their own individual methods quickly and simply and to use
them immediately.

1.3 Integration of devices

tiamo brings together the world of Titrino devices with the new generation of the
Titrando system. In the software sector such compatibility with existing Metrohm

devices is not just a matter of course. The whole Titrino family, which was previ­ously also controlled by TiNet, can continue to be operated under tiamo, and this
after more than 10 years on the market! In addition, sample changers, some of
which are no longer in our sales program, can also be operated under tiamo.
That's how Metrohm protects your investments!

Of course, all the models of the latest Titrando generation as well as the new
Sample Processors are compatible with tiamo. In this way all the advantages of
USB communication, such as plug and play or recognition of the intelligent dosing
systems, can be utilized to the full with tiamo. Even the mixed operation of older
RS 232-controlled and the new USB-controlled instruments is possible without any
problems.

Devices compatible with tiamo

• Titrando
808, 809, 835, 836, 841

• Titrino
702, 716, 718, 719, 720, 721, 736, 751, 758, 784, 785, 794, 795, 798,
799

• Conductometer
712

2 Introduction

• KF Coulometer
756, 831

• Sample Changer
730, 774, 778, 789, 814, 815

• Miscellaneous
Dosing Interface 846, balances, barcode readers...

1.4 Method editor

The new graphical Method Editor makes more of your titration system. Methods
can be drawn up quickly and simply by using the numerous templates. Methods
that have been proved in practice are available for most routine and automation
tasks. A few clicks are all that is needed to adapt them and make them ready for
use.

It is now possible to program and link activities that take place in parallel. This
means that, together with the new Titrando system and the Robotic Sample Proc­essors, a sample can now be titrated while the next sample is already being pre­pared. This saves time and increases sample throughput. The crowning achieve­ment is the simultaneous processing of several samples – one Titrando can carry
out two titrations at the same time. This doubles sample throughput!

tiamo is flexible and adapts itself to the analytical sequence, not vice versa.

Overview of functions

• Graphical method editor

• Method manager

• Access rights management for each method group

• Templates for method development and calculations

• Method test

• Comments for methods

• Parallel track function

• Loop function

1.5 Database

tiamo is based on an industrially tested, object-oriented database. All settings,
the user administration, methods and results are stored in databases. These da­tabases can be installed locally on the computer used and represent a simple ti­tration system. However, tiamo is also scaleable and grows to meet the operating
requirements. As soon as data security and central data administration come to
the fore, tiamo can be set up in a client-server configuration, with the tiamo da­tabase installed on a server. All measuring and office computers then act as cli­ents. In this titration network all results are stored centrally and can be viewed and
recalculated by all client PCs. In addition, all clients can access the same pool of
methods.

The new database provides all the necessary tools for managing results as well as
for searching for them and grouping them together. Quick Filters allow users to
search through thousands of determinations in a few seconds and present the
search results in a clear manner. Control charts provide a rapid overview of the
chronological sequence of the results.

All the possibilities for recalculation and re-evaluation are available to the us­ers.

Method editor 3

Overview of functions

• Object-oriented Client/Server database

• Quick filter and powerful search functions

• Access rights management for each database

• Automatic database backup function

• Layout manager for database view

• Reprocessing function for variables, methods, statistics, and curve

evaluation

• Control charts

1.6 Communication

Easy and inexpensive integration into existing laboratory information systems,
central databases and long-term archiving systems is crucial for the acceptance
of PC-controlled analytical systems.

tiamo is communicative. LIMS systems can easily import work lists into tiamo’s
own sample table and also control them remotely, without any additional modules.
Data generated in tiamo are now exported in XML format. This enables the simple
incorporation into all LIMS systems currently on the market. Export to long-term
archiving systems such as NuGenesis SDMS or Scientific Software CyberLABlab
is also supported.

With the new Report Designer the analysis reports can now be drawn up simply
and flexibly. The Report Designer allows report templates to be freely defined. In
this way reports of one or more determinations can be produced at any time with
a selectable layout in pdf format or as a paper printout.

A special feature of tiamo is that status messages, error messages or results can
be transmitted from the method sequence to the user by E-Mail.

Overview of functions

• Import of sample data

• Several data export formats,such as XML, CSV, SLK

• Direct export to NuGenesis SDMS, Scientific Software CyberLAB, etc.

• Report designer

• E-mail function for status messages, error messages, or results

• Import of external measured values

1.7 Compliance

tiamo also sets new standards with respect to compliance with GMP, GLP and
FDA requirements. The latest quality standards and validation procedures have

been used during the development and programming of the software. Right from
the very start tiamo has been designed to comply with the demands of FDA
Regulation 21 CFR Part 11 and its customer-specific interpretations. This is
confirmed by a compliance certificate. A central user administration determines
rights of access to program functions, methods and results. Any number of users
with freely definable user profiles are possible. The system administrator has com­fortable access to the user administration from any tiamo client. Access to the
software is password-protected and either the tiamo or Windows login can be se­lected.

4 Introduction

The use of digital signatures allows to sign methods and results. Two signatures
with different features are available. With the Level 1 Signature (Review) the user
confirms the he has correctly programmed the method or correctly performed the
analysis, whatever the case. The Level 2 Signature (Release) is used to release
the method or the result and protect it against further changes. This means that
company-specific workflows can be displayed in tiamo.

All data are managed by version control and protected against unauthorized
access, alteration or deletion in the database. The database itself controls access
to the data in network operation and offers archiving and recovery functions.

The Audit Trail protocols all user actions as well as important system events.

Compliance features of tiamo

• Designed and validated for compliance

• Central user administration

• Detailed access rights management

• tiamo or Windows password protection

• Digital signature with two levels

• Different signatures for methods and results

• Method and results history

• Detailed Audit Trail guarantees traceability

1.8 Versions

tiamo is available in three versions; these differ in the range of functions offered.
An upgrade is possible at any time.

tiamo 1.0 light tiamo 1.0 full tiamo 1.0 multi
Article 6.6056.101 6.6056.102 6.6056.103
Maximum number of instruments per PC 2 unlimited unlimited
Compliant with FDA 21 CFR Part 11
User administration
Security policies
Audit Trail
Client-server support
Number of licenses 1 1 3
Additional licenses (optional)
XML data export to LIMS
Parallel titrations
Upgrade available

z z z

z z

z z

z z
z z

z

z
z z
z z

Versions 5

1.9 Online Help

Help call

tiamo contains an extensive and detailed online help that can be called in two dif­ferent ways:

• General call
With the menu item

opens with the subject Welcome. From there you can jump to desired
subject via

• Context-sensitive call
By pressing the key [F1] on the keypad the online help opens directly
with the subject showing information about the activated element (dia­log window, tab).

Content, Index or Search.

Help, tiamo Help or the icon the online help

6 Introduction