Metrohm 711 User Manual

711 Liquino

Manual

8.711.1023

Metrohm AG CH-9101 Herisau Switzerland Phone +41 71 353 85 85 Fax +41 71 353 89 01 info@metrohm.com www.metrohm.com

711 Liquino

Manual

8.711.1023 02.99 dm

Teachware Metrohm AG CH-9101 Herisau teachware@metrohm.com

Although all the information given in this documentation has been checked with great care, errors cannot be entirely excluded. Should you notice any mistakes please send us your comments using the address given above.

Documentation in additional languages can be found on

http://products.metrohm.com under Literature/Technical documenta-

tion.

Table of content

page

1 Overview 1

1.1 Application range __________________________________________1

1.2 Application possibilities ____________________________________1

1.3 Instrument description ______________________________________2

1.3.1 Front view ......................................................................................... 2

1.3.2 Rear view .......................................................................................... 3

2 Installation 4

2.1 Instrument setup __________________________________________4

2.1.1 Mains connection ............................................................................. 4

2.2 Safety information _________________________________________5

2.3 Setup ____________________________________________________7

2.3.1 Connecting the keyboard ................................................................. 7

2.3.2 Connecting the Dosinos ................................................................... 7

2.3.3 Connecting a Pt100 temperature sensor ......................................... 7

2.3.4 Installing the pipetting attachment ................................................... 8

2.4 Memory card ______________________________________________8

2.5 Connections ______________________________________________9

2.5.1 Remote connections ...................................................................... 10

2.5.2 Serial connections .......................................................................... 16

2.5.3 Connecting a printer ....................................................................... 17

2.5.4 Connecting a balance .................................................................... 19

3 Introduction 20

3.1 The Liquino concept ______________________________________20

3.2 Tutorial _________________________________________________21

3.2.1 Basic configuration ......................................................................... 21

3.2.2 Defining dosing units ...................................................................... 22

3.2.3 Dosing and dispensing .................................................................. 24

3.2.4 Changing the dosing unit ............................................................... 28

3.2.5 Temperature measurement ............................................................ 29

3.2.6 PIP – precise pipetting/diluting ....................................................... 30

3.2.7 SMPL – fully automatic sampling ................................................... 33

3.2.8 CONT – the automatic volumetric flask .......................................... 40

3.2.9 XDOS – the electronic dropping funnel .......................................... 43

3.2.10 XDOS – temperature-controlled addition ..................................... 46

3.2.11 SEQ – complex procedures under control ................................... 51

3.2.12 GLP – automatic validation ........................................................... 57

4 Detailed description 61

4.1 The keyboard ____________________________________________61

4.1.1 Menu keys ...................................................................................... 62

4.1.2 Action keys ..................................................................................... 62

4.1.3 Editing and navigating keys ........................................................... 62

4.1.4 Manual functions and other keys ................................................... 63

4.2 Editing __________________________________________________65

4.2.1 Navigating in menus ....................................................................... 65

4.2.2 Data input ....................................................................................... 65

4.2.3 Text input ........................................................................................ 66

4.3 Configuration ____________________________________________68

4.3.1 Defining the dosing units ................................................................ 68

4.3.2 The configuration menu .................................................................. 69

4.3.3 Keyboard and graphics options ..................................................... 71

711 Liquino, Instructions for use

Table of content

page

4.4 XDOS mode - controlled dosing ____________________________ 74

4.4.1 XDOS mode parameters ................................................................ 77

4.4.2 Examples of reports - XDOS mode ................................................ 81

4.5 SEQ mode - complex processes ____________________________ 83

4.5.1 Commands ..................................................................................... 84

4.5.2 SEQ mode parameters .................................................................. 89

4.5.3 Commands in a sequence ............................................................. 91

4.5.4 Example of a report - SEQ mode ................................................... 93

4.6 CONT mode - preparation of solutions ______________________ 94

4.6.1 Preparation of solutions ................................................................. 94

4.6.2 Standard solutions / Dilutions ........................................................ 95

4.6.3 CONT mode parameters ................................................................ 96

4.6.4 Example of a report - CONT mode ................................................ 99

4.7 PIP mode - precise pipetting and diluting ___________________ 100

4.7.1 PIP mode parameters .................................................................. 103

4.7.2 Example of a report - PIP mode ................................................... 105

4.8 SMPL mode - fully automatic sampling _____________________ 106

4.8.1 Sampling process in detail ........................................................... 110

4.8.2 SMPL mode parameters .............................................................. 113

4.8.3 Example of report - SMPL mode .................................................. 118

4.9 GLP mode - validation ___________________________________ 120

4.9.1 GLP mode parameters ................................................................. 123

4.9.2 Example of report - GLP mode .................................................... 125

4.10 Storing and loading methods ____________________________ 128

4.10.1 Internal method memory ............................................................ 128

4.10.2 Memory card .............................................................................. 129

5 The 711 Liquino in synthesis laboratories 133

5.1 The advantages of the 711 Liquino _________________________ 133

5.2 Please note … __________________________________________ 135

6 Appendix 139

6.1 Dosing units and Dosinos ________________________________ 139

6.1.1 Preparing and emptying the dosing units .................................... 141

6.1.2 Defining dosing units ................................................................... 143

6.2 Error messages _________________________________________ 144

6.3 Service and maintenance _________________________________ 148

6.3.1 Service .......................................................................................... 148

6.3.2 Maintenance / Care ...................................................................... 148

6.4 Validation / GLP ________________________________________ 149

6.5 Diagnosis ______________________________________________ 150

6.6 Initialize data memory ___________________________________ 160

6.7 Technical specifications _________________________________ 162

6.8 Warranty and certificates _________________________________ 164

6.8.1 Warranty ....................................................................................... 164

6.9 EC Declaration of conformity _____________________________ 165

6.9.1 Certificate of Conformity and System Validation .......................... 166

6.10 Accessories ___________________________________________ 167

7 Index 171

711 Liquino, Instructions for use

1. Overview

1 Overview

1.1 Application range

The Metrohm 711 Liquino is a very versatile laboratory instrument which can be used everywhere that liquid handling is to be simplified and automated. This is the case in both analytical laboratories and in synthesis laboratories. It is equally suitable for both the preparation of complicated formulations in filling plants and also for simple delivery and pumping tasks involving toxic or aggressive media. Owing to the freely programmable process sequences and versatile communication interfaces (RS232 or remote connection) it can be integrated into complex automated systems to undertake demanding dosing and monitoring functions, which otherwise would only be capable of realization with a considerably greater expenditure.

1.2 Application possibilities

The 711 Liquino can be used for the whole range of applications which fall under the general heading of 'Liquid Handling'.

In analytical laboratories

• manual, highly accurate liquid dosing.

• complex, process-controlled dosing tasks with freely selectable specifi-

cations, e.g. a certain volume in a given period, constant dosing speed during a preselected time interval, a certain volume with constant dosing speed. In addition this can also be temperature-controlled, i.e. if a certain temperature limit is exceeded or undercut during the dosing process then the dosing process can be interrupted and a predefined action triggered, e.g. switching on a cooling bath.

• automated preparation of defined solutions (e.g. standard solutions) or

mixtures of liquids (e.g. mobile phases for HPLC or IC). It is possible to connect a balance without any problems.

• highly accurate pipetting and diluting even small volumes of liquid.

• automated sampling and sample preparation for a range of analytical

methods (e.g. titrations, pH measurements, etc.) with and without a sample changer.

• preparation of complex formulations in automated filling plant.

In synthesis laboratories

• manual, highly accurate liquid dosing.

• complex, process-controlled dosing tasks with freely selectable specifi-

711 Liquino, Instructions for use

1.3 Instrument description

Slot for memory

Always insert the card so that

1.3 Instrument description

1.3.1 Front view

card

the upper edge of the card with the label faces right.

711 Liquino, Instructions for use

1. Overview

- Fire Hazard For continued pr ot ection replace only with the same type and rating of fuse

Fuse:

100/115V : 315mAT 230/240V : 160mAT

Keyboard/Display

Rem ot e

RS 232

Pt 100

Dos.4

Dos.3

Dos.2

Dos.1

Made by Metrohm Herisau Switzerland

WARNING !

Connections for

Connection for

Keyboard connection

Remote

Serial RS 232

Fuses, mains switch

Name plate

1.3.2 Rear view

4 Dosinos

Pt100 temperature sensor

interface

and mains connection

711 Liquino, Instructions for use

2.1 Instrument setup

Follow the ins supply. If the instrument is operated with the mains voltage incorrectly set and/or the wrong mains fuse there may be a fire risk!

2 Installation

2.1 Instrument setup

Packaging

The 711 Liquino is supplied in packaging which provides excellent protection. This includes a shock-absorbing plastic foam lining. Please store this packaging as it is the only way to guarantee damage-free transport of the instrument.

Checks Please check immediately on receipt whether the shipment is complete and undamaged.

Location The 711 Liquino is a robust instrument and can therefore be used even under rough conditions in laboratories and factories. However, care must be taken that it is not exposed to a corrosive atmosphere. Regular care of the instrument is essential if it is used in rough surroundings.

2.1.1 Mains connection

Setting the mains supply

Before switching on the 711 Liquino for the first time check that the mains voltage set on the instrument (see illustration on following page) corresponds to the local mains voltage. If this is not the case then the correct mains voltage must be set as follows:

• Pull out mains cable

Remove the mains cable from the mains connector of the 711 Liquino.

• Remove fuse holder

Use a screwdriver to loosen the fuse holder beside the mains connector and remove completely.

• Check and replace fuses

Remove the built-in fuses for the required mains voltage from the fuse holder and check their specifications:

100…120 V 0.315 A (slow-blow) Metrohm no. U.600.0011 220…240 V 0.16 A (slow-blow) Metrohm no. U.600.0008

tructions given below to connect the instrument to the mains

• Insert fuses

Exchange fuses if necessary and replace them in the fuse holder.

• Set mains voltage

Remove the white fuse block from the fuse holder and reinsert it so that the correct mains voltage is visible through the window in the fuse holder.

711 Liquino, Instructions for use

2. Installation

230

Mains switch

Mains connection socket

Fuse holder with window

• Insert fuse holder

Insert fuse holder and press it until it clicks into place.

2.2 Safety information

General This instrument left our factory in perfect condition from a safety point of view. The following information must be carefully observed in order to maintain this condition and to ensure hazard-free operation.

Mains connection The mains cables supplied with the instrument are three-core and are fitted with an earthing pin. If a different plug must be used then the yellow/green lead must be connected to the protective earth.

WARNING!

Any break in the earth conductor inside or outside the instrument can represent a source of danger to the operator. Making a break in the earth conductor is forbidden.

Before connecting the plug to the mains supply a check must be made that the instrument is set to the local mains voltage and that the appropriate fuses are inserted.

WARNING!

When changing a fuse and when setting a different mains voltage the mains cable must be disconnected from the mains supply.

When replacing fuses care must be taken that voltage, current and type have been selected correctly (see Technical data, fuses, page 162).

WARNING!

Short-circuiting fuses or the temporary use of incorrect fuses is forbidden.

Repair and maintenance:

If faults or malfunctions occur during the operation of the 711 Liquino it is recommended that the cable connections with the peripheral units are checked first for proper functioning (see page 9ff). It may be possible to lo-

711 Liquino, Instructions for use

2.2 Safety information

out.

cate the source of the fault with the aid of the diagnosis functions. If the cause of the malfunction cannot be found please contact the Metrohm service department.

The instrument should only be opened when switched on under exceptional circumstances. As this exposes electrically live components it should only be carried out by an expert who is familiar with the risks involved.

The instrument must be separated from all electricity sources before it is opened. Make sure that the mains plug has been pulled

Condensers in the instrument may still be charged even when the instrument is no longer connected to the mains supply.

Changing the battery The connecting wires of the old battery must be cut before desoldering so that any residual charge which may still be present cannot be shortcircuited. The polarity of the new battery must be taken into account when it is fitted. Lithium batteries cannot be recharged and should not be short-circuited or exposed to temperatures above 70 °C under any circumstances. Old batteries must be disposed of in an environmentally acceptable way and must not be burnt.

Static electricity: The circuit contains components which could be destroyed by electrostatic charges or whose functions could be affected by them. Work on an open instrument should only be carried out in ESD-protected surroundings.

Suitable measures:

1. A conductive mat on the work surface connected to the earth conductor

via a resistor of approx. 1 MΩ.

2. Earthed soldering iron.

3. Persons working with components must have their wrists connected to

the earth conductor via a resistor of approx. 1 MΩ.

4. Components and assembled PCBs should only be stored and transported in conductive packaging or foam.

5. New components should be stored in their original packaging until re- quired.

If it becomes apparent that the instrument can no longer be operated safely then it should not be used at all.

711 Liquino, Instructions for use

2. Installation

The keyboard is connected to the keyboard

Dos.1

The notch on the plug must coincide with the marking on the panel.

2.3 Setup

2.3.1 Connecting the keyboard

socket provided for it on the rear panel of the instrument.

2.3.2 Connecting the Dosinos

The Dosinos are connected to the sockets ”DOS1” to ”DOS4” on the rear panel of the 711 Liquino. Press each Dosino plug into the socket until it clicks into place!

A Dosino should only be connected when the instrument is switched off! The 711 Liquino only recognizes Dosinos which are already plugged in when it is switched on.

2.3.3 Connecting a Pt100 temperature sensor

711 Liquino, Instructions for use

The Pt100 temperature sensor 6.1111.030 with 4-wire technology can be used with the 711 Liquino. It is connected to the socket marked with ”Pt100” on the rear panel of the instrument.

2.4 Memory card

Pipet tip

Green pilot lamp

6.1562.040

Black start button

6.1562.050 Pipetting tubing

Connection to dosing port 1 of the Dosino 700

Connection cable to 711 Liquino (remote connection)

Screw nipple

2.3.4 Installing the pipetting attachment

The pipetting attachment available as an option is suitable for automatic pipetting functions with a Dosino 700.

Pipet handle

To install the pipetting attachment proceed as follows:

• Loosen the screw nipple on the pipet handle and push it over the pipet tubing.

• Guide the pipet tubing into the handle and fix the tubing with the screw nipple.

• Mount the pipet tubing on dosing port 1 of the Dosino dosing unit.

• Insert in the 25-pin connection cable plug into the remote socket of the

Liquino. The second connection cable plug is used to connect another peripheral unit to the Liquino.

• As soon as the pipet handle is connected the green pilot lamp lights up to indicate that it is ready for work.

• The angle between the tubing guide and the handle can be adjusted for strain-free work.

Important: the pipet tubing must always be clean and kink-free!

Pipetting accessories:

Pipet handle 6.1562.040

with spiral pipet tubing, 3 mL 6.1562.050

Pipet tubing, 10 mL 6.1562.100 Pipet tubing, 3 mL 6.1829.020 Pipet tubing, 0.7 mL 6.1562.010 Pipet tips for pipet tubing 0.7 mL, 10 pieces 6.1562.030 Pipet tip holder 6.2052.010

2.4 Memory card

The memory card (e.g. 6.2245.010) must be inserted in the slot on the front panel of the 711 Liquino so that the front of the memory card (with the type name) faces to the right. A little pressure is necessary to push the memory card completely into the slot. Never remove the memory card from the instrument when it is being accessed by the instrument.

711 Liquino, Instructions for use

RS 232

Remote

Dosimats

pH Meter / Conductometer

Titrino family

726 Titroprocessor

730 Sample changer

665 ..

691 692 712 713

702

751

Seiko

Citizen

Epson

IBM

other devices e. g. thermostat

730

711 Liquino

726

700 Dosinos

Pt100

Printer

Balance

pumps

heating bath

etc.

731 Relay box

other devices

Dos.1-4

772 Pump unit

683 Pump

711 Liquino

pumps

heating bath

etc.

...

776

Personal computer

2. Installation

2.5 Connections

Metrohm automated systems with the 711 Liquino

711 Liquino, Instructions for use

2.5 Connections

Input 0

START

Input 1

STOP

Input 2

HOLD / CONTINUE

Input 3

External ready

Input 4

Sample Changer ready

Input 5

not used

Input 6

PIP continue

Input 7

not used

Output 0

Ready

Output 1

Upper limit

Output 2

Lower limit

Output 3

EOD (End of Determination)

Output 4

Activate 1

Output 5

Activate 2

Output 6

External start

Output 7

Start Sample Changer

2.5.1 Remote connections

The remote control of instruments within a Metrohm automated system can (apart from data communication via RS232 interfaces) be carried out in a simple manner with the help of parallel-switched signal leads, the remote lines (or I/O lines). Signals can be set statically or transmitted as a signal pulse (usually approx. 200 ms duration); see SCAN and CONTROL commands, (page 91ff). The signal level is +5 volt (TTL-level) in each case.

The functions which can be used for remote control or monitoring tasks each occupy a particular remote lead. The remote socket of a Metrohm instrument has input leads (Input0…7, for the control of certain functions, e.g. START or STOP) and output leads (Output0…8, to display instrument conditions, e.g. 'ready' or 'End of Determination').

The remote connection is normally a 25-pin socket. Different connection cables are available for different types of instrument. The suitable remote cable is listed in the ‘Instructions for use’ of the corresponding instrument. Special connection cables can also be made according to the customers’ particular requirements.

Remote lead occupancy for 711 Liquino:

Remote lead Pin Function

Output leads 8…13 cannot be used. In the SEQ mode remote leads Input3…7 and Output4…7 can be freely used with the commands SCAN and CONTROL (see page 91ff).

711 Liquino, Instructions for use

2. Installation

Note:

Titrino

230

cable 6.2141.090

Connection cables

Only Metrohm cables should be used to connect the 711 Liquino to other instruments as these are the only ones with which interference-free data transmission can be guaranteed.

Remote cables for the 711 Liquino always have a name on the end of the cable to indicate the instrument with which the particular plug is intended to be used and which connection it should be plugged in to. Example:

Titrino B

692 / 712 / 71 3

Liquino — Titrino

Cable 6.2141.090 is used in the SMPL mode. Details can be found on page 106ff. Control commands can also be used in an SEQ method, for example:

>SEQ sequence st ep 4 ( CONTROL command) pat t er n * 1* * ----

starts Titrino (start pulse)

>SEQ sequence st ep 5 ( Pause command) pause 00: 00: 01

>SEQ sequence st ep 6 ( CONTROL command) pat t ern *0**----

wait 1 s

reset remote interface

(end pulse)

>SEQ sequence st ep 7 ( SCAN command) pattern ****1---

wait for ready message from Titrino

711 Liquino, Instructions for use

2.5 Connections

711

Titrino

230

683 Pump Unit

I 0

683 Pump Unit

I 0

730

cable 6.2141.100

Liquino — Titrino — 683 Pump — 730 Sample Changer

Cable 6.2141.100 is used for the SMPL mode if aspiration and rinsing the titration vessel are to be carried out as quickly as possible (with 2 x Pump

683). The sample changer connection can be left open if no sample chang-

er is required. The Titrino, the pumps and the sample changer can also be addressed with the control commands of a SEQ method, for example:

Start Titrino

>SEQ sequence st ep 4 ( CONTROL command) pat t er n * 1* * ---- starts Titrino (starts pulse)

>SEQ sequence st ep 5 ( Pause command) pause 00: 00: 01

>SEQ sequence st ep 6 ( CONTROL command) pat t er n * 0* * ----

wait 1 s

starts Titrino (ends pulse)

>SEQ sequence st ep 7 ( SCAN command) pattern ****1---

wait for ready message from Titrino

Run pump 1 for 10 s

>SEQ sequence st ep 8 ( CONTROL command) pattern ***1---- switches on 1st 683 pump

>SEQ sequence st ep 9 ( Pause command) pause 00: 00: 10

wait 10 s

>SEQ sequence st ep 10 ( CONTROL command) pattern ***0----

switches off 1st pump 683 again

Run pump 2 for 1 min 5 s

>SEQ sequence st ep 11 ( CONTROL command) pat t er n * * 1* ---- switches on 2nd pump 683

>SEQ sequence st ep 12 ( Pause command) pause 00: 01: 05

wait 1 min 5 s

>SEQ sequence st ep 13 ( CONTROL command) pat t er n * * 0* ----

switches off 2nd pump 683 again

711 Liquino, Instructions for use

2. Installation

711

Titr

ino

cable 6.9921.165

Command to

730 Sample Changer

SCN:Rm: ready1 ←

CTL:Rm: START device1→

Switch sample changer to next sample

>SEQ sequence st ep 14 ( CONTROL command) pat t er n 1* * * ---- switches sample changer 1 sample further

(start pulse)

>SEQ sequence st ep 15 ( Pause command) pause 00: 00: 01

>SEQ sequence st ep 16 ( CONTROL command) pat t er n 0* * * ----

wait 1 s

resets remote interface

(end pulse)

>SEQ sequence st ep 17 ( SCAN command) pattern ***1*---

wait for ready message from sample changer

711 Liquino – 730 Sample Changer – Titrino

730 Sample Changer with Titrino and 711 Liquino for automated pipetting of different samples on the sample changer into a special beaker on the sample rack.

The 711 Liquino can be used in any automated system for pipetting tasks (PIP mode). In this case the 730 Sample Changer controls the working process. The 711 Liquino is used in the PIP mode. The determination of the samples is carried out by the Titrino which, like the Liquino, is started from the sample changer. This arrangement of instruments requires a special remote cable (6.9921.165). Other special cables for similar instrument combinations are available on request.

For this function the sample changer must be appropriately programmed with Scan and Control com-

mands!

711 Liquino, Instructions for use

2.5 Connections

>st ar t sequence

3 Lift: 1: shift mm

1 Lift: 1: shift mm

711

731

772

cable

6.2125.100

Dosinos

heating bath

mains cable

Example of a sample changer method:

1 CTL: Rm: INIT

>sampl e sequence 1 CTL: Rm: START devi ce1 2 SCN: Rm: r eady1

4 CTL: Rm: *********1**** 5 Wai t 1 s 6 CTL: Rm: *********0**** 7 Mov e: 1: sampl e 8 Li f t : 1: wor k mm 9 CTL: Rm: *********1**** 10 Wai t 1 s 11 CTL: Rm: *********0**** 12 SCN: Rm: r eady1 13 Mov e: 1: spec. 1 14 Li f t : 1: wor k mm 15 CTL: Rm: *********1**** 16 Wai t 1 s 17 CTL: Rm: *********0**** 18 SCN: Rm: end1 19 St i r : 1: ON s 20 CTL: Rm: START devi ce2 2 1 SCN: Rm: e nd2 22 St i r : 1: OFF s 23 Pump: 1. 1: 12 s 24 Pump: 1. * : 10 s 25 Pump: 1. 1: 12 s 28 NOP

>f i nal sequence

2 NOP

← Initialize remote interface

← Start Liquino (PIP mode) ← Wait for pipetting step ← Lift out of sample vessel ← Switch pipetting further (corresponds to

<ENTER>)

— separating bubble is aspirated —

← Reset remote interface ← Position sample beaker ← Immerse pipet tubing in sample ← Switch pipetting further (corresponds to

<ENTER>)

← Reset remote interface ← Wait for next pipetting step ← Move to titrating beaker ← Pipet tubing in titrating beaker ← Switch pipetting further (corresponds to

<ENTER>)

← Reset remote interface ← Wait for end of PIP mode ← Stirrer on ← Start Titrino ← Wait for end of determination ← Switch off stirrer ← Aspirate titration beaker ← Rinse titration beaker ← Aspirate titration beaker

— sample is aspirated —

— sample is ejected —

711 Liquino – 731 Relay Box – 772 Pump Unit – Heating Bath

Liquino with 772 Pump Unit as delivery or aspiration pump and a heating bath.

With the aid of a Metrohm 731 Relay Box the output leads of the 711 Liquino can be monitored and, according to their line conditions, two low-voltage d.c. voltage outputs and two mains voltage outputs can be switched.

In this way the heating bath can be switched automatically via the temperature monitoring function. If the measured temperature falls below a certain value the bath is heated up.

A connected pump (e.g. the Metrohm 772 Pump Unit) can be selectively switched on or off during the method procedure.

711 Liquino, Instructions for use

2. Installation

731 Relay Box settings:

Connect 772 Pump Unit to DC1 (or DC2) Output voltage: 18 or 24 volt Remote address selection disk DC1: 7 (=Output 7)

Connect heating bath to AC1 (or AC2, mains voltage) Remote address selection disk AC1: 2 (=Output 2)

711 Liquino settings

Temperature monitoring

XDOS mode (contained in SEQ mode):

Par amet er s >XDOS moni t or i ng t emperat ur e: on low limit xx°C upper limit ... action: ... al ar m pi ns: under

Control commands for the pump

SEQ mode

Switch on pump:

command: CONTROL i nt er f ace: Remot e

pat t er n 1* * * ---- (Output 7)

(switch off with

0***----)

711 Liquino, Instructions for use

2.5 Connections

cable 6.2134.040 (9-pin/9-pin) or 6.2134.050 (9

printer cables: see page 17f

711

2.5.2 Serial connections

A wide range of possible connections can be made at the RS232 interface. As well as all Metrohm instruments which are equipped with the Metrohm remote control language, a printer (requirement: serial interface or parallel/serial converter) or a personal computer (PC) can also be connected. Any instrument from another manufacturer which is equipped with a serial RS232 interface can also be connected.

-pin/25-pin)

A requirement for correct data transmission is that the transmission parameters are correctly set; these must coincide with the interface settings of the connected instrument (see following page).

Control commands (examples):

>SEQ sequence st ep 4 (Control command) st r i ng &M; $G

starts Metrohm instrument

>SEQ sequence st ep 6 (Control command) st r i ng &M; $S

stops Metrohm instrument

Input data query (example):

>SEQ sequence st ep 5 (Scan command) st r i ng * R"

wait for ready message from Metrohm instrument

The following section provides information about the settings and cables necessary to connect a printer.

711 Liquino, Instructions for use

2. Installation

The Liquino must be switched off before a printer is connected to the RS232 interface!

Printer

Cable

RS232 settings

Settings on printer

IBM Proprinter

6.2125.050 +

6.2125.010

baud rate: 9600 data bit: 8 stop bit: 1 Parity: none handshake: Hardware send to: IBM

see printer manual

Seiko DPU-411

6.2125.020

6.2125.010

baud rate: 9600 data bit: 8 stop bit: 1 parity: none handshake: Hardware send to: Seiko

DIP switch settings:

DIP01 DIP02

off

1 2 3 4 5 6 7 8 1 2 3 4 5 6

Depending on the set dialog language, the adjustable 7-bit ASCII character set of the printer will be set automatically to the national character set.

2.5.3 Connecting a printer

Printers with the following printer drivers can be connected:

IBM IBM Proprinter and printers with IBM emulation Epson Epson printers and printers with Epson emulation Seiko Seiko printer DPU-411 or DPU-414 Citizen Citizen printer IDP560 RS HP HP printers and printers with HP PCL3 emulation

If you wish to connect a different printer then ensure that this can emulate one of the printer modes supported by the 711 Liquino. Most printers with a serial interface are connected with cable 6.2134.050. Printers with a parallel interface require a serial/parallel converter (e.g.

2.145.0300) and cable 6.2125.020 + adapter cable 6.2125.010.

The interface parameters are entered in the configuration menu under

‘>RS232 settings’. The printer type must also be entered in the configura- tion menu under ‘>Peripheral units’ and ‘send to:’

If you use an A4 printer and the graphics do not cover the whole width of the page then you can proceed as follows: When the instrument is switched on keep the <CONFIG> key pressed down. In this way you access the setup menu. Press the <> key and <ENTER>. You can now alter the relative width and height of the graphics. In each case press <ENTER> after the entry.

The following table provides information about the connection of several selected printers.

711 Liquino, Instructions for use

2.5 Connections

Printer

Cable

RS232 settings

Settings on printer

Seiko DPU-414

6.2125.130

baud rate: 9600 data bit: 8 stop bit: 1 parity: none handshake: Hardware send to: Seiko

Recommended DIP switch settings:

Dip SW-1 Dip SW-2 Dip SW-3 1 OFF ON ON 2 ON OFF ON 3 ON ON ON 4 OFF ON ON 5 ON ON OFF 6 OFF ON ON 7 ON OFF ON 8 ON OFF ON

Depending on the set dialog language, the adjustable 7-bit ASCII character set of the printer will be set automatically to the national character set.

Citizen IDP562-RS

6.2125.050

baud rate: 9600 data bit: 8 stop bit: 1 parity: none handshake: Hardware send to: Citizen

DIP switch settings:

1 2 3 4 5 6 7 8 9

SSW1

The adjustable 7-bit ASCII character set of the printer can only be set to the national character set by switching DIP switches 4 and 5 in the printer:

4 5 Character set

OFF OFF USA ON ON United Kingdom ON OFF France OFF ON Germany

No special Spanish character set is available (it is best to select French).

Epson with 6-pin round plug

6.2125.040

6.2125.010

baud rate: 9600 data bit: 8 stop bit: 1 parity: none handshake: Hardware send to: Epson

DIP switch settings:

SW1 SW2

off

1 2 3 4 5 6 7 8 1 2 3 4 5 6 7 8

Epson with additional serial interface #8148

6.2134.050

baud rate: 9600 data bit: 8 stop bit: 1 parity: none handshake: Hardware send to: Epson

DIP switch settings at interface:

SW1 SW2

off

1 2 3 4 5 6 7 81 2 3 4 5 6

Epson LX-300

6.2134.050

baud rate: 9600 data bit: 8 stop bit: 1 parity: none handshake: Hardware send to: Epson

see printer manual

HP Deskjet with serial interface

6.2134.050

baud rate: 9600 data bit: 8 stop bit: 1 parity: none handshake: Hardware send to: HP

DIP switch settings:

A B

off

1 2 3 4 5 6 7 8 1 2 3 4 5 6 7 8

HP Laserjet with serial interface

6.2134.050

baud rate: 9600 data bit: 8 stop bit: 1 parity: none handshake: Hardware send to: HP

see printer manual *

HP Deskjet/ Laserjet with parallel interface

6.2125.020 +6.2125.01 0 + serial/ parallel converter

2.145.0300

baud rate: 9600 data bit: 8 stop bit: 1 parity: none handshake: Hardware send to: HP

see printer manual *

* The printer must be set to the PC-8 character set. PCL3 command:

esc(10U

711 Liquino, Instructions for use

2. Installation

Balance

Cable

Sartorius MP8, MC1

6.2134.060

Mettler AB, AG (LC-RS25)

supplied with balance

Mettler AM, PM

from Mettler: ME 33995: green wire to Pin 2, brown wire to Pin 3, white wire to Pin 7, yellow wire to Pin 20 of the 25-pin plug + 6.2125.010 25-pin/9-pin adapter

Mettler interface 016

cable supplied with interface 016: red wire to Pin 3, white wire to Pin 7 of the 25-pin plug + 6.2125.010 25-pin/9-pin adapter

Mettler interface 011 or 012

6.2125.020 + 6.2125.010

Mettler AT

from Mettler: ME 33995: green wire to Pin 2, brown wire to Pin 3, white wire to Pin 7, yellow wire to Pin 20 of the 25-pin plug + 6.2125.010 25-pin/9-pin adapter

AND models ER-60, 120, 180, 182 models FR-200, 300 models FX-200, 300, 320 with RS232 interface (OP-03)

6.2125.020 + 6.2125.010

Precisa, balances with RS232C interface

6.2125.080 + 6.2125.010

711

6.2125.010

printer cable

balance cable

6.2125.030

2.5.4 Connecting a balance

The following balances can be connected to the RS232 output of the 711 Liquino:

The balance type must be preselected on the 711 Liquino with the <CONFIG> key under ‘>Peripheral units’. The weight will be transmitted as a number with up to 6 places, together with sign and decimal point. Units and control characters sent by the balance will not be transmitted.

For the simultaneous connection of printer and balance the adapter cable

6.2125.010 + with junction plug 6.2125.030 are required. If the balance only works with 7 bit and the printer only works with 8 bit then the balance parity must be set to "space" while the 711 Liquino and printer run with 8 bit, "no parity".

711 Liquino, Instructions for use

3.1 The Liquino concept

3 Introduction

3.1 The Liquino concept

The 711 Liquino is designed so that, together with one or more 700 Dosinos, it can automate a wide range of tasks in the laboratory. Everything which falls under the general heading of 'liquid handling', i.e. the transport of liquids in any form, belongs to its range of applications. Its functions can be divided up into three steps.

• Simple manual dosing and dispensing with up to four dosing devices.

• Automated procedures for frequently reoccurring and defined tasks. The

preset modes in the instrument are used for this. When they are appropriately set they can be stored as methods in the Liquino itself or on a memory card and can be reloaded at any time.

• Complex process sequences, which can be made up from several indi- vidual methods or modes with additional auxiliary commands as required. In this way a large number of instruments can be controlled for use in demanding analytical or synthesis units.

The practical 700 Dosinos are used as dosing instruments; they can be conveniently operated with the functions and commands of the 711 Liquino. Special functions (PREP, EMPTY) are available for preparatory work (i.e. bubble-free filling and rinsing of the tubing) and emptying dosing units when a reagent needs to be changed. In order to carry out these procedures in as comfortable and reagent-saving manner as possible you can define different types of dosing unit. As the length and diameter of the tubing used can be defined the 711 Liquino is able to calculate and then use the optimal volumes for the above-mentioned functions.

With the help of the special GLP mode the 711 Liquino can be used to validate all your dosing units, i.e. to determine their accuracy. In this way GLPconform work can be ensured and also documented. The dosing procedures in the GLP mode have been optimized and realized for the 700 Dosino in such a way that meaningful characteristic values can be determined; these allow detailed information about the accuracy of the dosing cylinder to be obtained. You can adapt the necessary limits for the assessment of the reliability of the dosing accuracy yourself to suit your requirements. The limits recommended by Metrohm are set as standard. We recommend that you use these limits.

711 Liquino, Instructions for use

3 Introduction

CONFIG

The dialog language, date and time can be set in the configuration menu.

ENTER

YES

• and then <> and <ENTER>.

DOS NR

SELECT

•

• With <ENTER> the entry ‘dialog: english’ can be accepted.

CLEAR

• The number keys are used to enter the current date in the format year-

lete the entry. (The date is “year 2000 safe“!)

•

• Enter the current time and confirm it with <ENTER>.

QUIT

•

3.2 Tutorial

This tutorial will introduce you step by step to the operation of the Metrohm 711 Liquino. It is arranged so that you can work through it from the beginning to the end and in this way become familiar with the most important functions of the instrument. You will be guided through each section step by step so that you will be able to carry out the simplest settings. You can also carry out further fine adjustments. The necessary information for this can be found in section 4.

3.2.1 Basic configuration

The most important basic settings are carried out as follows:

• Press <CONFIG>

Di s pl ay : conf i gur at i on >per i pher al uni t s

Di s pl ay : >auxi l i ar i es di al og: engl i sh

The colon in this menu entry indicates that parameters can be selected from a list here. Press the <SELECT> key several times in order to view the different selection possibilities and become familiar with this operating mode.

Di s pl ay : >auxi l i ar i es di al og: deut sch

Di s pl ay : >auxi l i ar i es dat e: 90- 01- 01

month-date. If a mistake is made then <CLEAR> can be used to de-

The entry is accepted with <ENTER>.

Di s pl ay : >auxi l i ar i es t i me: 01: 00: 00

Di s pl ay : >auxi l i ar i es device l abel ********

Press <QUIT> 2x in order to exit the configuration menu.

711 Liquino, Instructions for use

3.2 Tutorial

Except for the "Sampling dosing unit" in the SMPL mode the standard port occupancy for all modes is as follows:

Port 1: dosing unit output Port 2 (bottle): refilling opening

CONFIG

• Press <CONFIG> and then 3x <>.

ENTER

YES

•

DOS NR

SELECT

• One of the ten configurable dosing units can be selected with the

Di s pl ay : >dosi ng uni t s 1

3.2.2 Defining dosing units

In order for the complete tubing system of a Dosino to be fully filled with the reagent solution without any air bubbles the 711 Liquino must know the dimensions of the connected tubing. For this reason a dosing unit can be de-

fined in the configuration menu and then selected for the method.

Di s pl ay : conf i gur at i on >dosi ng uni t s

Access the submenu ‘dosing units’ with <ENTER>.

Di s pl ay : > dosi ng uni t s dos. uni t : D1

<SELECT> key. Press <ENTER> to access the settings for the corresponding dosing unit. The index for the dosing unit is located in the top right-hand corner of the display.

Di s pl ay : >dosi ng uni t s 1 I D D1

• Enter an identification text for the dosing unit or leave the preset entry as it is. Text input is explained on page 63.

• Accept the entry with <ENTER>.

Di s pl ay : >dosi ng uni t s 1 l engt h t ube1 400 mm

• Now enter the length of tubing at Dosino port 1 (for tandem dosing including the tubing length up to the T-piece) and accept the entry with <ENTER>.

Di s pl ay : >dosi ng uni t s 1 di am. t ube1 2. 0 mm

• The inner diameter of the tubing at Dosino port 1 can be entered here and confirmed with <ENTER>.

Di s pl ay : >dosi ng uni t s 1 l engt h t ube2 250 mm

• Now enter the length of the tubing at Dosino port 2 (bottle) and accept the entry with <ENTER>.

In a single method ‘standard’ can also be selected for the dosing unit used. For the modes XDOS, CONT and GLP ‘standard’ means: Port1 (dosing port): L = 40cm, D = 2mm Port2 (bottle): L = 25cm, D = 2mm.

For PIP ‘standard’ means: Port1 (pipetting tubing): L = 150cm, D = 2mm Port2 (bottle): L = 25cm, D = 2mm. For SMPL ‘standard’ means: Port1 (sample tubing): L = 40cm, D = 2mm Port2 (measuring cell): L = 16cm, D = 2mm Port3 (rinsing agent): L = 50cm, D = 2mm.

711 Liquino, Instructions for use

3 Introduction

di am. t ube2 2. 0 mm

QUIT

• The dosing unit has now been defined. Press <QUIT> 2x to exit the

• The inner diameter of the tubing at Dosino port 2 can be entered here

and confirmed with <ENTER>.

Di s pl ay : >dosi ng uni t s 1 l engt h t ube3 0 mm

• As no tubing is connected to Dosino ports 3 and 4 the tubing lengths

must be set to 0 mm. Check this for port 3, press <ENTER> and check the value for port 4 (the diameter is not requested if the length has been set to 0 mm). Press <ENTER> again.

Di s pl ay : >dosi ng uni t s 2 I D D2

configuration menu.

711 Liquino, Instructions for use

3.2 Tutorial

MANUAL

MAN OFF

DOS NR

SELECT

• Now use the <DOS NR / SELECT> key to select the connected dosing

PREP

•

DOSING

START

• If you now press the <START> key and hold it down then dosing will take

3.2.3 Dosing and dispensing

This is where you learn the simplest functions of the Liquino: manual dosing and dispensing.

Fit a reagent bottle with a dosing unit and a Dosino and connect the Dosino to the Liquino. Select, e.g. connection socket 'Dos. 1' or 'Dos. 2' for this. Now switch the 711 Liquino briefly off and then on again. In this way the instrument recognizes the connected Dosino. Details about setting up dosing units can be found in section 6.1.2, page

143.

Now immerse the dosing tip, which must be connected to Dosino Port 1 by tubing, in a rinsing beaker.

• Switch the Liquino to the manual operating mode. Press the <MANUAL>

key.

Di spl ay: manual r eady 0. 000 mL

device. On the 711 Liquino keyboard there are four LEDs. If you have connected the Dosino to socket ' SELECT> key once so that the LED '

Dos. 2' then press the <DOS NR /

DOS 1' lights up.

<1>

• Prepare the dosing unit by pressing the <PREP> key.

The PREP function is used to rinse the tubing and fill the dosing cylinder free from bubbles.

Di s p l ay: wast e por t : tip(1) or flask(2)?

• Now select whether the rinsing volume of the reagent solution should be

discharged via the dosing tip (connected to Dosino Port 1) or returned to the storage bottle (via filling Port 2 of the Dosino). Press <

1>.

Di spl ay: manual PREP r unni ng. . .

• The tubing is now automatically rinsed with the required volume of

reagent. Excess reagent solution is discharged into the rinsing beaker. Wait until the Liquino reports 'ready'.

Now exchange the rinsing beaker for the vessel into which you wish to carry out dosing.

• Press the <DOSING> key.

Di spl ay: man u a l DOSI NG

r eady 0. 000 mL

place when the Dosino has switched the stopcock. You will notice that the dosing speed increases slowly. If you release the <START> key and then press it down again it will again start dosing at a slow speed which is gradually increased. This behavior can be very useful when you need to dose accurately, e.g. to fill a volumetric flask up to the mark.

711 Liquino, Instructions for use

+ 150 hidden pages

Metrohm 711 User Manual

Specifications and Main Features

Frequently Asked Questions

User Manual