Roche COBAS INTEGRA 400 plus, Cedex Bio HT Host Interface Manual
COBAS INTEGRA 400 plus analyzer Cedex Bio HT Analyzer
Host Interface Manual
Version 1.24
Software version 3.6/5.1
2
Publication information
Revision history
Version Description Mandatory Date
1.24 Approvals for Cedex Bio HT Analyzer rephrased.
Information updated for communication, block code 04, block code 07,
block code 10, line code 00, line code 11, error codes for line code 96,
and general configuration.
Line code 56 added.
Part added for extended host interface of Cedex Bio HT Analyzer.
u What is new in publication version 1.24 (10)
1.23 Migration to latest Roche documentation standard. Information limited
to COBAS INTEGRA 400 plus analyzer and Cedex Bio HT Analyzer.
Information about Cedex Bio HT Analyzer added.
1.22 Maintenance Version. Removed simulator.
Changed files: _lc12, i4_kp.htm, i_featur.htm, i_lc10.htm, i_lc53.htm,
i_toc.htm
1.21 New files: i_e_rre1.htm, ro_ind.jpg, rr_i400_2.JPG New Collated results
and Ratio behavior. For I800 Version C, no changes in HIF.
1.20 New features I400 v3.4 & I 800 9864.b1 Typo line code 54/dead links,
Changed files: i_toc, i_ver,index, i_lc53.htm, i_lc09, i_lc54.htm, i4_kp.
New files i_lc11, i_lc12, i_lc13, i_lc15, i_lc16, i_bc05, i_bc_06, i_bc_07
1.19 Order Date handling problem in line 53/ORA-01840 with version 2.3
(NT only)
Changed files: i4_kp, i_toc, i_ver, index
1.18 Flags: Change in the flag 22: added to the list of flags where no result is
produced
Changed files: i_flags, i_toc, i_ver, index
1.17 Instrument setup: Pictures for INTEGRA 400 Plus connectors on Vectra
VL400MT, VL420MT and EVO 510.
Changed files: i_setup, i4_setup, i_ver, index
1.16 Correction of incorrect links in the INTEGRA 800 Known issues to
Workflow adaptation and flowchart, correction of links in Features and
BC 10.
Changed files: i_bc10, i_toc, i8_kp, i_featur, i_ver
1.15 Version 2.2 corrections, flags 15 to 18, Checksum issues in I400, I 400
note for line code 51, Block code 62 new info for I700/800
1.14 Instrument setup I800 + Known issues index, i_ver, i8_setup, i_lc53,
i8_kp, i7_kp, i4_kp, i_setup, i_knownp, i_toc, i7_setup
1.13 i_lc50, i_bc10, i_featur Yes Sept. 5 2001
1.12 i_lc54 Yes Jan. 18 2001
1.11 i_bc90 new for I800, i_blocks, i_lines, i_toc No Dec. 22. 2000
1.1 Final changes for I800: - new: i_i7vsi8, - changed: i_welcom, i_toc,
i_flags, i_featur, i_lc00, i_lc10, i_lc41, i_lc42, i_lc53, i_lc53, i_lc54, i_lc55,
i_lc98, appendix, rs232, i_bc02, i_bc61, i_bc62
1.04 - i_bc10: Note to qc and cal order - i4_tshoo: new - i_bc19 / i_bc11:
I400 can order 200 tests
1.03 - i_flags: Additional Flag X/C function for I400 V2.0 and I800 - i_lc55:
Test ID > Test No.
y Revision history
No March 2018
No December 2016
No March 2010
Yes Dec 2008
Yes May 2006
Yes Jun. 01 2005
Yes May. 10 2005
Yes Apr. 20 2004
Yes Nov. 5 2003
Yes Aug. 11 2003
Yes Oct. 18 2002
Yes Nov. 19. 2000
Yes July 2000
Nov.1999
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
Version Description Mandatory Date
1.01 Minor corrections and additional hyper-links No Dec. 1998
1.02 - i_index: SC, Sequence Counter, BCS added - introduc: SC link added
in error handling - i_lc00: Example modified - i_flag: LC00 link added i_bc04: correction in text (patient result) - introduc: Note added; BCS
needs fixed field length - i_lc41, i_lc43, i_lc54, i_lc55, i_lc57: Examples;
leading 0 replaced by leading • - i_lc96, i_lc99: I2 changed to S2 i_flags: leading 0 removed - i_lc53: Ratio Order note inserted - i_bc03:
Collated Order note inserted - appendix: Additional instrument codes
(AmpliLink, AmpliPrep and TaqMan) - i_lc10: More detailed
explanation
1.00 First HTML version, based on Revision 2.1 of the paper manual. Valid
for Integra SW versions 9561 and 9562.
y Revision history
No Feb. 1999
Oct. 1998
Edition notice This publication is for Host Interface programmers and
Roche field engineers of the
COBAS INTEGRA 400 plus analyzer and the
Cedex Bio HT Analyzer. It explains the details of
communication between a host computer and an
instrument.Every effort has been made to ensure that all
the information contained in this publication is correct at
the time of publishing. However, the manufacturer of this
product may need to update the publication information
as output of product surveillance activities, leading to a
new version of this publication.
3
Where to find information The User Manual / Operator’s Manual for the
respective analyzer focuses on operation, maintenance,
troubleshooting, and basic configuration of the analyzers.
They also contain important safety information. You must
read the Safety chapter before operating the analyzer.
The Online Help includes all information of the User
Manual / Operator’s Manual. In addition it contains all
error messages and a complete software reference.
!
General attention
To avoid incorrect results, ensure that you are familiar
with the instructions and safety information.
r Pay particular attention to all safety notices.
r Always follow the instructions in this publication.
r Do not use the software in a way that is not described
in this publication.
r Store all publications in a safe and easily retrievable
place.
Training Do not carry out operation tasks or maintenance actions
unless you have received training from Roche
Diagnostics. Leave tasks that are not described in the
user documentation to trained Roche Service
representatives.
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
4
Images The screenshots and hardware images in this publication
have been added exclusively for illustration purposes.
Configurable and variable data in screenshots, such as
tests, results, or path names visible therein must not be
used for laboratory purposes.
Warranty Any customer modification to the system renders the
warranty or service agreement null and void.
For conditions of warranty, contact your local sales
representative or refer to your warranty contract partner.
Always leave software updates to a Roche Service
representative, or perform such updates with their
assistance.
Copyright © 1998-2018, F. Hoffmann-La Roche Ltd. All rights
reserved.
License information The COBAS INTEGRA 400 plus analyzer and the
Cedex Bio HT Analyzer software are protected by
contract law, copyright law, and international treaties. The
COBAS INTEGRA 400 plus analyzer and the
Cedex Bio HT Analyzer contain a user license between
F. Hoffmann-La Roche Ltd. and a license holder, and only
authorized users may access the software and use it.
Unauthorized use and distribution may result in civil and
criminal penalties.
Open Source and Commercial Software The COBAS INTEGRA 400 plus analyzer and the
Cedex Bio HT Analyzer may include components or
modules of commercial or open-source software. For
further information on the intellectual property and other
warnings, as well as licenses pertaining to the software
programs included in the
COBAS INTEGRA 400 plus analyzer and the
Cedex Bio HT Analyzer, refer to the electronic distribution
included with this product.
This open source and commercial software and the
COBAS INTEGRA 400 plus analyzer or
Cedex Bio HT Analyzer as a whole can constitute a device
regulated in accordance with applicable law. For more
detailed information, refer to the respective User
Manual / Operator’s Manual and labeling.
Please note that the respective authorization is no longer
valid according to the corresponding legislation should
any unauthorized changes be made to the
COBAS INTEGRA 400 plus analyzer or
Cedex Bio HT Analyzer.
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
Trademarks The following trademarks are acknowledged:
Feedback Every effort has been made to ensure that this publication
Contact addresses
5
COBAS, COBAS INTEGRA, CEDEX, and LIFE NEEDS
ANSWERS are trademarks of Roche.
All other trademarks are the property of their respective
owners.
fulfills the intended use. All feedback on any aspect of
this publication is welcome and is considered during
updates. Contact your Roche representative, should you
have any such feedback.
Roche Diagnostics GmbH
Sandhofer Strasse 116
68305 Mannheim
Germany
Made in Switzerland
Approvals for
COBAS INTEGRA 400 plus analyzer
The COBAS INTEGRA 400 plus analyzer meets the
requirements laid down in:
Directive 98/79/EC of the European Parliament and of the
Council of 27 October 1998 on in vitro diagnostic medical
devices.
Directive 2011/65/EU of the European Parliament and of
the Council of 8 June 2011 on the restriction of the use of
certain hazardous substances in electrical and electronic
equipment.
RoHS compliant from Serial No. 410001 (with ISE module)
and 510001 (without ISE module).
Compliance with the applicable directive(s) is provided by
means of the Declaration of Conformity.
The following marks demonstrate compliance:
For in vitro diagnostic use.
Complies with the provisions of the applicable EU
directives.
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
6
Issued by Underwriters Laboratories, Inc. (UL) for
CUS
®
Approvals for Cedex Bio HT Analyzer The Cedex Bio HT Analyzer meets the requirements laid
Canada and the US.
down in:
• Directive 2014/30/EU of the European Parliament and
Council of 26 February 2014 relating to
electromagnetic compatibility (EMC).
• Directive 2014/35/EU of the European Parliament and
Council of 26 February 2014 relating to electrical
equipment designed for use within certain voltage
limits.
• Directive 2011/65/EU of the European Parliament and
of the Council of 8 June 2011 on the restriction of the
use of certain hazardous substances in electrical and
electronic equipment.
CUS
®
Compliance with the applicable directive(s) is provided by
means of the Declaration of Conformity.
The following marks demonstrate compliance:
Complies with the provisions of the applicable EU
directives.
RoHS compliant from Serial No. 610001.
Issued by Underwriters Laboratories, Inc. (UL) for
Canada and the US.
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
Table of contents
Table of contents 7
Publication information 2
Table of contents 7
Intended use for
COBAS INTEGRA 400 plus analyzer 9
Intended use for Cedex Bio HT Analyzer 9
Symbols and abbreviations 9
What is new in publication version 1.24 10
What is new in publication version 1.23 11
Communication
1 About communication
Communication concept 17
Message structure 18
Communication control 21
Error handling 24
Host communication handling 25
Synchronization and sequence counter use 26
2 About host interface features
About host interface modes and features 29
Patient mode 30
Orders 33
Host query mode 40
Result requests 44
Protocol version 50
Reference
Messages
6 Flags and error codes
About flags 105
Flag X 106
Flag CALC (result error) 108
Flag QC 110
About error codes 111
List of line code 96 error codes 112
List of line code 99 error codes 114
Extended host interface of
Cedex Bio HT Analyzer
7 Block codes for extended host interface
About block codes for extended HIF 119
Result blocks 120
Operation settings blocks 126
Service Action Blocks 127
Test status blocks 129
Calibration status blocks 130
Cassette status blocks 131
Multi-configuration service block 132
Message Log blocks 133
Sample order status blocks 134
System status blocks 136
Date and time blocks 137
Serial number blocks 138
3 General codes
ASCII code 55
Control characters 56
Instrument codes 57
4 Block codes
About block codes 61
Idle and synchronization blocks 62
Result blocks 63
Order blocks 69
Patient blocks 74
Multi-configuration service blocks 76
Protocol version blocks 79
Control messages blocks 80
5 Line codes
About line codes 83
List of line codes 84
8 Line codes for extended host interface
About line codes 141
List of line codes for extended HIF 142
Troubleshooting
9 Troubleshooting
About troubleshooting 175
Enabling host interface tracing 176
Viewing the trace file 177
Known host interface issues 178
Appendices
10 Instrument setup
Setting up the instrument for host
communication 185
About the RS-232 serial interface 195
Index
Index 201
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
8 Table of contents
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
Intended use for COBAS INTEGRA 400 plus analyzer
The COBAS INTEGRA 400 plus analyzer is a fully
automated, computerized chemistry analyzer. It is
intended for in vitro quantitative or qualitative
determination of a wide range of analytes in various body
fluids.
Intended use for Cedex Bio HT Analyzer
The Cedex Bio HT Analyzer is a fully automated,
computerized analyzer for professional use. It is intended
for determination of a wide range of analytes in various
aqueous solutions like cell culture and fermentation
media.
9
Important note The Cedex Bio HT Analyzer is only intended for the
Symbols and abbreviations
Product names Except where the context clearly indicated otherwise, the
For use in quality control/manufacturing process only.
determination of analytes in aqueous solutions such as
cell culture and fermentation media and is not intended
for any kind of in vitro diagnostics applications. Therefore,
the term "patient" does not apply to the
Cedex Bio HT Analyzer and does not appear anywhere
within the software. Instead, all references to "Patient" in
the COBAS INTEGRA 400 plus analyzer software appear
as "Sample" in the Cedex Bio HT Analyzer software. The
Cedex Bio HT Analyzer software does not contain any
references to "patient", "patient mode", or "patient ID" and
does not request patient information.
following product names and descriptors are used.
Product name Descriptor
COBAS INTEGRA 400 plus analyzer instrument
Cedex Bio HT Analyzer instrument
Host computer, laboratory information
system or other computer system
connected to the instrument
y Product names
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
host
10
Symbols used in this publication
Abbreviations The following abbreviations are used.
Symbol Used for
<LF> All characters between the two angle
brackets indicate an ASCII control
character.
_ Space character (ASCII 20H) that is used as
a separator between single data fields
within a data line.
• Space character (ASCII 20H) that is used as
a place holder inside a single data fields
and is part of this data field.
y Symbols used in this publication
Abbreviation Meaning
ASCII American standard code for information
interchange
BC Block code
BCS Block check sum
CR Carriage return
EOT End of transmission
ETX End of text
LC Line code
LF Line feed (line terminator)
LIS Laboratory information system
MCS Multi-configuration service
SC Sequence counter
SOH Start if header
STX Start of text
y Abbreviations
What is new in publication version 1.24
Approvals for the Cedex Bio HT Analyzer The approvals for the Cedex Bio HT Analyzer were
rephrased.
u Approvals for Cedex Bio HT Analyzer (6)
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
Updated information The information in the following sections was updated:
u Communication concept (17)
u Example for Message structure (18)
u Block check (20)
u Host communication handling (25)
u Block 04: Patient Results (64)
u Block 07: Patient Results with Lot Information (67)
u Block 10: Order Entry (69)
u Line code 00: Result Data (84)
u Example for Line code 11: Reagent Lot
Information (89)
u List of line code 96 error codes (112)
11
u Configuration General > Interface (190)
Added information The following information was added:
u Line Code 56: Sample name (98)
Extended host interface of
Cedex Bio HT Analyzer
The block codes and line codes were added that are
available if the extended host interface on the
Cedex Bio HT Analyzer is enabled.
u Extended host interface of
Cedex Bio HT Analyzer (115)
What is new in publication version 1.23
• The COBAS INTEGRA 400 plus analyzer and
Cedex Bio HT Analyzer host interface information that
was available online, was migrated to the latest Roche
documentation standards.
• Information was limited to COBAS INTEGRA 400 plus
analyzer and Cedex Bio HT Analyzer.
• Information about the Cedex Bio HT Analyzer has
been added to this publication.
• No other content changes have been made.
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
12
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
Communication
1 About communication.......................................................................................... 15
2 About host interface features............................................................................ 27
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
Table of contents
About communication 1
Before proceeding to set up the instrument, it is useful to
understand the basics and concepts of the various
communication elements.
15
In this chapter
Communication concept . . . . . . . . . . . . . . . . . . . . . . . . 17
Message structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18
Block header . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
Block data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
Block check. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20
Communication control . . . . . . . . . . . . . . . . . . . . . . . . . 21
Parity check. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
Flow control (hardware/software handshake) . . . 22
Sequence counter and block check sum . . . . . . . 22
Check of block and line composition . . . . . . . . . . 23
Receive timeout . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
Error handling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24
Host communication handling . . . . . . . . . . . . . . . . . . . 25
Synchronization and sequence counter use. . . . . . . . 26
1
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
1 About communication
16
Table of contents
1 About communication
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
Communication concept
The communication is a data communication based on a
request/response dialog, whereby the host delivers the
requests and the instrument provides responses.
Following a request from the host, the instrument will
transmit a specific response message.
Assuming there are no transmission errors and the
message can be handled correctly, the instrument will
respond with a positive acknowledgment message.
If an error occurs for any reason, the instrument will
respond with a negative acknowledgment message.
If the host does not receive a response upon a request
within a certain time, a timeout should be activated.
About communication 17
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
1 About communication
18 Message structure
Message structure
All messages are based on the same block structure. The
number of lines within a block can vary.
Block header
Block data
Block check
q Information inside the message is in ASCII code.
ASCII codes from 0 to 31 and 127 to 255 are not allowed
within data fields.
Example Result response from an instrument:
<SOH><LF>
09_COBAS.INTEGRA..._04<LF>
<STX><LF>
53_Order#.211044711_20/10/93_SER<LF>
55_178<LF>
00_+3.234000E+01_mg/dl_004_023_014_000<LF>
<ETX><LF>
1<LF>
562<LF>
<EOT><LF>
In this section
(1 line)
(0 to n lines)
(0 or 2 lines)
Block header (19)
Block data (19)
Block check (20)
1 About communication
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
Block header
The block header contains the following information:
Instrument code Instrument identifier Block code
09_ COBAS•INTEGRA•••_ 04<LF>
About communication 19
Two digit code. It identifies the type of
instrument.
y Structure of block header
Sixteen digit alphanumeric. It is helpful in
case more then one instrument of the
same type is connected to the host. The
instrument's identifier can be defined in
the instrument set-up menu. The host
may use any 16 digit string. The
instrument does not refer to it.
Block data
Line code Data fields
Two digit code used to identify the type
of information which follows. Details on
the block codes can be found in the
reference of each instrument.
q The number of characters of the block header is
fixed. If the instrument identifier is not used in its full
length, digits left over have to be filled with spaces.
Block data contains the main information. The size of this
part can vary.
53_
55_
00_
Two digit code, used to identify the
contents of the line, separated by a
delimiter (space) from the rest of the line
y Structure of block data
Order#211044711_20/10/93_SER04<LF>
178<LF>
+3.234000E+01_mg/dl_004_023_014_000<LF>
Each line contains 1 to n data fields, separated by a delimiter (space). The amount
and the size of the data fields depend on the type of line.
q oDepending on the block, the block data has 0 to n data
lines.
o The length of the data fields is fixed. Therefore unused
or partially used data fields have to be filled out with
spaces.
o Some of the lines contain optional data fields. If any of
the optional data fields are not used they can be left
out.
u Related topics
• Block codes (59)
• Line codes (81)
1 About communication
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
20 Message structure
Block check
The block check contains a sequence counter (SC) and
the block check sum (BCS).
Instrument code
1<LF>
562<LF>
The length of the block check sum field is fixed. In case of one
or two digit numbers, the field has to be filled out with leading
spaces.
y Structure of block check
1 About communication
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
Communication control
To maintain safe data communication, the following
communication control mechanisms are used:
Location Controls
RS-232 specific Parity check
Instrument and host Sequence counter (SC)
Instrument specific Check of block and line
Host specific Time-out control
y Communication control mechanisms
About communication 21
Flow control
(hardware/software
handshake)
Block check sum (BCS)
composition
Parity check
In this section
Parity check (21)
Flow control (hardware/software handshake) (22)
Sequence counter and block check sum (22)
Check of block and line composition (23)
Receive timeout (23)
This is the most common method used for detecting
errors on asynchronous interfaces. The number of active
data bits in each character is counted prior to
transmission. A parity bit is then added on so that the
total number of binary 1’s in the complete character
frame is either odd or even according to the preselection
in the interface configuration. The receiving device will
then perform the same inspection.
Any mismatch will generate a parity error: Instruments
will transmit an error message (block 99). Host systems
will use the error handling.
u Related topics
• Error handling (24)
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
1 About communication
22 Communication control
Flow control (hardware/software handshake)
If the instrument or the host is currently not able to
receive data, it must be able to stop the communication.
This is done by the flow control.
There are two possibilities, either hardware handshake or
software handshake.
Suggestion: Software handshake simplifies RS-232 cable
wiring and host SW handling.
u Related topics
• About the handshake (197)
• About the RS-232 cable (186)
Sequence counter and block check sum
Sequence counter The sequence counter (SC) is a one digit number, which
alternates between 0 and 1. The SC is used by the host to
initiate retransmit of data. The host's SC must be
synchronized to the instrument's SC. Both SCs (host and
instrument) must be updated simultaneously, otherwise a
sequence error will occur f instrument will retransmit its
previous message.
The mathematical presentation appears as follows:
z 1
SC (inc SC) mod 2=
Block check sum The block check sum (BCS) is a 3-digit, ASCII-coded
number.
The BCS contains the sum of all values of the message
starting with <SOH> ... to <SC> (<CR>) <LF> modulo
1000.
z 2
BCS sum (ord(<SOH>) .. ord(<LF>)) mod 1000=
If any mismatch occurs, the receiving station has to react
accordingly.
Enable / disable of the SC and BCS can be done in the
Host Interface Configuration menu (either both BCS
and SC exist or neither).
1 About communication
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
q We strongly recommend that you enable the block
check. Otherwise you cannot be sure that all data are
correctly transmitted.
Check of block and line composition
Upon any mismatch in block and line composition,
instruments will transmit an error message (block 99)
containing the appropriate error code.
Whenever a block or line composition error occurs, this
indicates that the host software is not completely
configured as described in this manual and has to be
modified accordingly.
Instruments never change the block and line composition
unless the relevant configuration settings have been
changed.
u Related topics
About communication 23
Receive timeout
• Instrument setup (183)
An exactly defined response time cannot be guaranteed.
However, a returned response can be expected within
60 seconds. As a result, we recommend setting the host’s
time-out to 180 seconds.
q Time-out control is only foreseen on the host side.
Use the error handling as described.
Incompletely received messages (without an <EOT>
termination) will not be acknowledged by the instruments
(host time-out).
u Related topics
• Error handling (24)
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
1 About communication
24 Error handling
Error handling
Whenever the host detects any transmission error, it has
to re-transmit the previous message keeping the same
sequence counter as before.
Whenever the instrument detects any transmission error,
it expects the host to re-transmit the previous message,
keeping the same sequence counter as before. If you
want to skip this retransmission, send a synchronization
request to the instrument, then resume the normal
communication.
Possible transmission errors:
• Incorrect block check sum, i.e. a corrupted message
was received
• Parity error was detected
• General error message (block 99) was received
• Time-out occurred
u Related topics
• Synchronization and sequence counter use (26)
1 About communication
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
Host communication handling
About communication 25
w Suggestion for host communication handling
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
1 About communication
26 Synchronization and sequence counter use
Synchronization and sequence counter use
The protocol only works properly when the sequence
counters (SC) of both host and instrument have the same
value. Therefore, whenever the host’s communication
software is started up, the first step will be to synchronize
the SCs.
The following procedure is recommended:
w Recommended procedure for sequence counter synchronization
1 About communication
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
Table of contents
About host interface features 2
Communication for the various information items follow
certain patterns and workflows.
27
In this chapter
About host interface modes and features. . . . . . . . . . 29
Patient mode . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30
Patient entry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31
Patient modification . . . . . . . . . . . . . . . . . . . . . . . . . 32
Patient deletion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32
Orders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33
Order entry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33
Order modification (add tests) . . . . . . . . . . . . . . . . 39
Order deletion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
Host query mode . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40
Result requests . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44
About result requests. . . . . . . . . . . . . . . . . . . . . . . . 44
Example of result query . . . . . . . . . . . . . . . . . . . . . . 46
Example of unspecific result request. . . . . . . . . . . 48
Example of result request with ratio (collated
result request). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
Protocol version . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50
2
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
2 About host interface features
28
Table of contents
2 About host interface features
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
About host interface features 29
About host interface modes and features
Item Action
(1)
Patient
Order Entry Modification Deletion Host
Results Single
Status Protocol
y Host interface modes and features and their actions
(1) Additional option. When using patient mode, the other 3 actions in
the table are available.
u Related topics
Entry Modification Deletion .
results
version
Collated
results
..
..
query
• Patient mode (30)
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
2 About host interface features
30 Patient mode
Patient mode
Patient information is only required when in patient mode.
q oWhen in patient mode, set up the patient on the
instrument prior to an order entry.
o When connected to a host, we recommend working in
sample mode.
!
WARNING
Incorrect result assignment due to multiple use of
same patient ID
If you work with patient mode, the patient ID must be
unique.
r Do not use the same patient ID for more than one
patient.
In this section
Patient entry (31)
Patient modification (32)
Patient deletion (32)
2 About host interface features
Roche Diagnostics
COBAS INTEGRA 400 plus analyzer/Cedex Bio HT Analyzer · Software version 3.6/5.1 · Host Interface Manual · Version 1.24
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