Hamilton Microlab FAME Service Manual

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Microlab F.A.M.E.

Service MANUAL

Version 2.0

P/N 610015

Important Notice:

• Reproduction of any part of this manual in any form whatsoever without the express written consent of Hamilton Bonaduz AG is forbidden.

• The contents of this manual are subject to change without notice.

• All efforts have been made to ensure the accuracy of the contents of this manual. However, should any errors be detected, Hamilton Bonaduz AG would greatly appreciate being informed of them.

• The above notwithstanding, Hamilton Bonaduz AG can assume no responsibility for any errors in this manual or their consequences.

• Microlab is a registered trademark of Hamilton Bonaduz AG.

• IBM, OS/2 DATABASE 2 and DB2 are registered trademarks of International Business Machines Corporation.

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——— ML F.A.M.E. Service Manual V2.0————————————————————————————————————————— Table of Contents ———

Chapter 1 SYSTEM ......................................................................................................... 1-1

1.1 ML F.A.M.E. Instrument ........................................................................... 1-1

1.1.1 General Information ............................................................................................ 1-1

Location of Warning and Attention Labels .................................................. 1-2

1.1.2 Service Concept ................................................................................................... 1-4

1.1.2.1 General Information ............................................................................................ 1-4

1.1.2.2 ML F.A.M.E. Service Manual ........................................................................... 1-4

1.1.2.2.1 Description of text icons .................................................................................... 1-5

1.1.2.2.2 Updating the Service Manual .......................................................................... 1-5

1.1.2.2.3 Service Bulletins .................................................................................................. 1-5

1.1.2.2.4 Service Part Classiﬁcations ............................................................................. 1-5

1.1.2.2.5 Service Assemblies ............................................................................................ 1-6

1.1.2.2.6 ML F.A.M.E. instruments with CE conformity ............................................ 1-6

1.1.2.2.7 Pin coding for PCBs ........................................................................................... 1-7

1.1.2.2.8 Connector numbering ........................................................................................ 1-7

1.1.2.3 Feedback (Quarterly Service Call Statistics) ............................................. 1-9

1.1.2.4 Parts Return Tag .................................................................................................. 1-9

Material Return Good Authorization ............................................................. 1-9

1.1.2.5 Technical Data Sheet ......................................................................................... 1-9

1.1.2.6 Service Kit ........................................................................................................... 1-10

1.1.2.6.1 Service Kit Spare Parts List .......................................................................... 1-10

1.1.2.6.2 Service PCB (to be used with Diagnostic Master) ............................... 1-13

1.1.3 F.A.M.E. Description ........................................................................................ 1-15

1.1.3.1 Purpose of the system .................................................................................... 1-16

1.1.3.2 General Operation Procedure ...................................................................... 1-16

1.1.3.3 F.A.M.E conﬁgurations .................................................................................... 1-17

1.1.3.3.1 Overview .............................................................................................................. 1-17

1.1.3.3.2 Conﬁguration 16/20 ......................................................................................... 1-19

1.1.3.3.3 Conﬁguration 16/30 ......................................................................................... 1-27

1.1.3.3.4 Conﬁguration 24/20 ......................................................................................... 1-35

p/n 610 015

1.1.3.3.5 Conﬁguration 24/30 ......................................................................................... 1-43

1.1.3.3.6 OEM speciﬁc Part Numbers ......................................................................... 1-51

1.1.3.3.7 Exchange Modules and Exchange Module Parts Lists ...................... 1-52

1.1.3.3.8 Expansion Modules and Expansion Module Parts Lists .................... 1-55

1.1.3.3.9 Shipping Kits ...................................................................................................... 1-67

1.1.4 Microlab F.A.M.E. Installation ....................................................................... 1-69

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1.1.4.1 Workplace environment .................................................................................. 1-69

1.1.4.2 Unpacking Microlab F.A.M.E. ....................................................................... 1-71

Adjust chassis to instrument configuration .............................................. 1-72

1.1.4.3 Instrument assembly ....................................................................................... 1-74

1.1.4.3.1 Installing INCUBATOR Module ................................................................... 1-74

1.1.4.3.2 Installing WASHER/DISPENSER Module ............................................... 1-76

1.1.4.3.3 Installing ENTRY Module .............................................................................. 1-78

1.1.4.3.4 Installing END Module .................................................................................... 1-79

1.1.4.3.5 Installing Main Shuttle Rail & Panels ........................................................ 1-80

1.1.4.3.6 Installing Container Stack .............................................................................. 1-86

1.1.4.3.7 Connecting Tubing and Cables ................................................................... 1-87

1.1.4.3.8 Installing Reagent Container Carousel ..................................................... 1-90

1.1.4.3.9 Computer Installation ...................................................................................... 1-91

1.1.4.3.10 Electrical Installation ........................................................................................ 1-92

1.1.4.3.11 Software Installation ........................................................................................ 1-92

1.1.4.3.12 Login and Access ............................................................................................. 1-92

1.1.4.3.13 System Start-up and Shut-down ................................................................. 1-93

1.1.4.3.14 Downloading Firmware to Instrument ....................................................... 1-94

1.1.4.3.15 Installing Filter Case ........................................................................................ 1-96

1.1.4.3.16 Loading Check Plate into Instrument ........................................................ 1-97

1.1.4.3.17 Instrument Calibration ..................................................................................... 1-98

Rotor Calibration Pin ....................................................................................... 1-99

1.1.5 Instrument Disassembly .............................................................................. 1-101

1.1.5.1 Instrument shut down ................................................................................... 1-101

1.1.5.1.1 Removing the Photometer Filter Case .................................................. 1-101

1.1.5.1.2 Removing MTPs and Check Plates ........................................................ 1-102

1.1.5.1.3 Decontamination ............................................................................................ 1-102

1.1.5.1.4 Draining the washer system ...................................................................... 1-103

1.1.5.2 Preparing Modules for Disassembly ....................................................... 1-103

1.1.5.3 Disassembly .................................................................................................... 1-105

1.1.5.3.1 Removing Container Stack ........................................................................ 1-106

1.1.5.3.2 Removing Panels & Main Shuttle Rail ................................................... 1-108

1.1.5.3.3 Handling and Removal of Modules .......................................................... 1-111

1.1.6 Packing F.A.M.E. for Shipment .................................................................. 1-117

1.1.7 Exchange Modules ........................................................................................ 1-125

1.1.8 Expansion Modules ....................................................................................... 1-126

1.1.9 Decontamination ............................................................................................ 1-127

1.1.10 Maintenance .................................................................................................... 1-127

1.1.10.1 General maintenance ................................................................................... 1-127

1.1.10.2 Half Yearly Maintenance / Service .......................................................... 1-128

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1.1.10.2.1 Tasks .................................................................................................................. 1-128

1.1.10.2.2 Running Macros for Half Yearly Maintenance/Service .................... 1-128

1.1.10.2.3 Macros Available for Maintenance/Service .......................................... 1-129

1.1.10.3 Preventive maintenance.............................................................................. 1-130

1.2 Microlab AT / AT plus / AT plus 2 ........................................... 1-135

1.3 F.A.M.E. Software

1.3.1 Personal Computer Requirements .......................................................... 1-139

1.3.2 ML F.A.M.E. System Requirements ........................................................ 1-139

1.3.3 Software Requirements ............................................................................... 1-139

1.3.4 Microlab F.A.M.E. Software Speciﬁcations ........................................... 1-140

1.3.5 Connections to Sample Preparation Instruments .............................. 1-140

1.3.6 Overview ........................................................................................................... 1-141

1.3.7 Diagnostic Master .......................................................................................... 1-142

1.3.8 How to run macros ........................................................................................ 1-143

................................................................................. 1-139

1.4 Totally Integrated ML F.A.M.E System............................... 1-147

Chapter 2 ENTRY MODULE ............................................................................... 2-7

2.1 Entry Module Raw ..................................................................................... 2-7

2.1.1 Design ...................................................................................................................... 2-7

2.1.2 Wiring Diagram Entry Module Raw: ............................................................. 2-9

2.1.3 Functional Description Entry Module ......................................................... 2-10

2.1.4 Calibration, adjusting ........................................................................................ 2-11

2.1.5 Removing Entry Module .................................................................................. 2-11

2.1.6 Removing Assemblies .................................................................................... 2-12

2.1.6.1 Entry lift ................................................................................................................ 2-14

2.1.6.2 Inc. tower - amb. temp., contr. temp. & Inc. tower lift........................... 2-16

2.1.6.3 Mains power unit ............................................................................................... 2-20

2.1.7 Replacing spare parts ..................................................................................... 2-21

2.1.7.1 Cables E1, E2, E7, and E8............................................................................ 2-21

2.1.7.2 Cables E4, E5 and E6 ..................................................................................... 2-22

2.1.7.3 Cable E20 ............................................................................................................ 2-23

2.1.7.4 Connector board E11 & cable E22 ............................................................. 2-24

2.1.8 Reader complete .............................................................................................. 2-27

2.1.8.1 Functional Description .................................................................................... 2-27

2.1.8.2 Wiring Diagram Reader Complete ............................................................. 2-27

2.1.8.3 Replacing reader complete ........................................................................... 2-28

2.1.9 Spare Parts List ................................................................................................. 2-29

2.1.10 3D Drawings ....................................................................................................... 2-30

2.1.11 Troubleshooting ................................................................................................. 2-33

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2.2 Entry Module Frame ............................................................................ 2-39

2.2.1 Functional Description .................................................................................... 2-39

2.2.2 Connector boards ............................................................................................. 2-40

2.2.3 MTP (Micro Titer Plate)-Sensor (block diagram).................................... 2-46

2.2.4 Module Transport Assembly (wiring diagram)......................................... 2-46

2.2.5 Replacing spare parts ..................................................................................... 2-49

2.2.5.1 Connector board E1 ........................................................................................ 2-49

2.2.5.2 Connector board E5 ........................................................................................ 2-50

2.2.5.3 Connector board E2 ........................................................................................ 2-50

2.2.5.4 Temperature sensor, tower fan (front) ...................................................... 2-51

2.2.5.5 Tower fan (rear) ................................................................................................. 2-52

2.2.5.6 Connector boards E6 and E7 ....................................................................... 2-53

2.2.5.7 Connector board E13 ...................................................................................... 2-54

2.2.5.8 Step motor, and gear belt .............................................................................. 2-55

2.2.5.9 Gear belt .............................................................................................................. 2-56

2.2.5.10 Connector board E10 ...................................................................................... 2-58

2.2.5.11 Connector board E9 ........................................................................................ 2-58

2.2.5.12 Cable E9 .............................................................................................................. 2-59

2.2.6 Spare Parts List ................................................................................................. 2-60

2.2.7 3D Drawing Entry Frame ............................................................................... 2-63

2.2.8 Troubleshooting ................................................................................................. 2-65

2.3 Entry Lift ......................................................................................................... 2-73

2.3.1 Functional Description .................................................................................... 2-73

2.3.2 Connector Boards ............................................................................................. 2-74

2.3.3 Wiring Diagram .................................................................................................. 2-76

2.3.4 Replacing Spare Parts .................................................................................... 2-77

2.3.4.1 Range ﬂag ........................................................................................................... 2-77

2.3.4.2 Connector board E14 ...................................................................................... 2-78

2.3.4.3 Step motor, and belt ........................................................................................ 2-79

2.3.4.4 Thrust bearing and thrust washer ............................................................... 2-80

2.3.4.5 Lift nut ................................................................................................................... 2-80

2.3.4.6 Tension spring .................................................................................................... 2-82

2.3.5 Spare Parts List ................................................................................................. 2-83

2.3.6 3D Drawing Entry Lift ...................................................................................... 2-85

2.3.7 Troubleshooting ................................................................................................. 2-87

2.3 Incubator Towers .................................................................................... 2-93

2.3.1 Incubator Tower Ambient Temp. .................................................................. 2-93

2.3.1.1 Functional Description .................................................................................... 2-93

2.3.1.2 Block Diagram .................................................................................................... 2-93

2.3.1.3 Connector Board ............................................................................................... 2-93

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2.3.1.4 Wiring Diagram .................................................................................................. 2-93

2.3.1.5 3D Drawing ......................................................................................................... 2-93

2.3.1.6 Replacing Spare Parts .................................................................................... 2-93

2.3.1.7 Spare Parts List ................................................................................................. 2-94

2.3.2 Incubator Tower Controlled Temp. ............................................................. 2-95

2.3.2.1 Functional Description .................................................................................... 2-95

2.3.2.2 Connector Board ............................................................................................... 2-96

2.3.2.3 Wiring Diagram .................................................................................................. 2-98

2.3.2.4 Replacing Spare Parts ................................................................................. 2-101

2.3.2.4.1 How to remove an incubation slot ........................................................... 2-101

2.3.2.4.2 Over temperature switch ............................................................................. 2-102

2.3.2.4.3 Cable E22, temperature sensor ............................................................... 2-103

2.3.2.4.4 Heating element ............................................................................................. 2-104

2.3.2.5 Spare Parts List .............................................................................................. 2-105

2.3.3 3D Drawing Incubator Tower Controlled................................................ 2-106

2.3.4 Troubleshooting .............................................................................................. 2-107

2.5 Incubator Tower Lift ........................................................................... 2-117

2.5.1 Functional Description .................................................................................. 2-117

2.5.2 Connector Boards ........................................................................................... 2-118

2.5.3 Wiring Diagram ................................................................................................ 2-119

2.5.4 Replacing Spare Parts ................................................................................. 2-120

2.5.4.1 Stepper motor E SM20 and / or gear belt ............................................. 2-120

2.5.4.2 Thrust bearing, thrust washer ................................................................... 2-121

2.5.4.3 Connector board E12 ................................................................................... 2-122

2.5.4.4 Flag ..................................................................................................................... 2-123

2.5.5 Spare Parts List .............................................................................................. 2-124

2.5.6 3D Drawing Incubator Tower Lift .............................................................. 2-126

2.5.7 Troubleshooting .............................................................................................. 2-127

2.6 Mains Power Unit ................................................................................. 2-133

2.6.1 Functional Description ................................................................................. 2-133

2.6.2 Connector Board ............................................................................................ 2-134

2.6.3 Wiring Diagram ............................................................................................... 2-135

2.6.4 Replacing Spare Parts ................................................................................. 2-136

2.6.5 Spare Parts List .............................................................................................. 2-136

2.6.6 3D Drawing Mains Power Unit .................................................................. 2-138

2.7 Entry Module Electronic Rack .................................................. 2-143

2.7.1 Motherboard E PCB ..................................................................................... 2-144

2.7.2 Power Supply 1 PCB .................................................................................... 2-145

2.7.3 Processors PCB 1, PCB 2, PCB 3 .......................................................... 2-151

2.7.4 Stepper Motor PCB ....................................................................................... 2-159

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2.7.5 Entry PCB ......................................................................................................... 2-165

2.7.6 Incubator PCB ................................................................................................ 2-171

Chapter 3 INCUBATOR MODULE .............................................................. 3-7

3.1 Incubator Module Raw .......................................................................... 3-7

3.1.1 Design ...................................................................................................................... 3-7

3.1.2 Wiring Diagram Inc. Module Raw .................................................................. 3-9

3.1.3 Functional Description Incubator Module ................................................ 3-10

3.1.4 Calibration, Adjusting ...................................................................................... 3-10

3.1.5 Removing Incubator Module .......................................................................... 3-11

3.1.6 Removing Assemblies ..................................................................................... 3-11

3.1.7 Replacing Spare Parts ..................................................................................... 3-11

3.1.8 Spare Parts List .................................................................................................. 3-11

3.1.9 3D Drawings ....................................................................................................... 3-12

3.1.10 Troubleshooting ................................................................................................. 3-15

3.2 Incubator Module Frame .................................................................. 3-21

3.2.1 Functional Description .................................................................................... 3-21

3.2.2 Connector Boards ............................................................................................. 3-22

3.2.3 Replacing Spare Parts .................................................................................... 3-23

3.2.4 Spare Parts List ................................................................................................. 3-23

3.2.5 3D Drawings ....................................................................................................... 3-26

3.2.6 Troubleshooting ................................................................................................. 3-29

Chapter 4 WASHER / DISPENSER ........................................................... 4-7

4.1 Washer / Dispenser Module Raw ................................................ 4-7

4.1.1 Design ...................................................................................................................... 4-7

4.1.2 Functional Description W / D Module ........................................................ 4-10

4.1.3 Removing Washer / Dispenser Module ..................................................... 4-11

4.1.4 Removing Assemblies .................................................................................... 4-12

4.1.4.1 Dispenser ........................................................................................................... 4-13

4.1.4.2 Reagent Drawer ................................................................................................ 4-14

4.1.4.3 Washer Lift .......................................................................................................... 4-16

4.1.4.4 External pump station .................................................................................... 4-18

4.1.5 Replacing Spare Parts .................................................................................... 4-19

4.1.5.1 Motherboard W/D PCB ................................................................................... 4-19

4.1.5.2 DC motor W PM 70 ......................................................................................... 4-19

4.1.5.3 AC motor W PM 80 .......................................................................................... 4-21

4.1.5.4 Cable W32 .......................................................................................................... 4-21

4.1.5.5 Water separator ................................................................................................. 4-22

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4.1.8 Fluid-Flow Diagram ......................................................................................... 4-27

4.1.9 Troubleshooting ................................................................................................. 4-28

4.2 Washer / Dispenser Module Frame ........................................ 4-35

4.2.1 Functional Description .................................................................................... 4-35

4.2.2 Connector Boards ............................................................................................. 4-36

4.2.3 Wiring Diagram Washer Pumps .................................................................. 4-42

4.2.4 Replacing spare parts ..................................................................................... 4-43

4.2.4.1 Connector board I1 PCB ................................................................................ 4-43

4.2.4.2 Connector board W8 PCB ............................................................................. 4-44

4.2.4.3 Connector board W11 PCB .......................................................................... 4-45

4.2.4.4 Connector board W13 PCB and seal ........................................................ 4-46

4.2.4.5 Cable W50 .......................................................................................................... 4-47

4.2.4.6 Cable W43 .......................................................................................................... 4-48

4.2.4.7 Step motor W SE10 ......................................................................................... 4-49

4.2.4.8 Gear belt open ................................................................................................... 4-50

4.2.4.9 Gear belt MXL .................................................................................................... 4-51

4.2.5 Spare Parts List ................................................................................................. 4-53

4.2.6 3D Drawing Washer / Dispenser Frame .................................................. 4-55

4.2.7 Troubleshooting ................................................................................................. 4-56

4.3 Dispenser ...................................................................................................... 4-61

4.3.1 Functional Description .................................................................................... 4-61

4.3.2 Connector Boards ............................................................................................. 4-63

4.3.3 Wiring Diagram .................................................................................................. 4-67

4.3.4 Replacing spare parts ..................................................................................... 4-71

4.3.4.1 Connector board W9 PCB and cable W8 ................................................ 4-71

4.3.4.2 Step motor W SE30 and Gear belt MXL .................................................. 4-74

4.3.4.3 Regulating screw 2 compl. ............................................................................ 4-75

4.3.4.4 Guide bush (on guide shaft 3) ...................................................................... 4-75

4.3.4.5 Guide bush (on guide shaft 5) ...................................................................... 4-77

4.3.4.6 Step motor W SM25 and step motor W SE20 ....................................... 4-78

4.3.4.7 Gear belt MXL and Gear belt ....................................................................... 4-79

4.3.4.8 Gear belt .............................................................................................................. 4-81

4.3.4.9 Connector board W6 PCB ............................................................................. 4-84

4.3.4.10 Regulating screw 1 compl. ............................................................................ 4-86

4.3.4.11 Connector board W5 PCB ............................................................................. 4-86

4.3.4.12 Cable W7 ............................................................................................................. 4-87

4.3.5 Spare Parts List ................................................................................................. 4-89

4.3.6 3D Drawings ....................................................................................................... 4-92

4.3.7 Troubleshooting ................................................................................................. 4-94

vii

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4.4 Reagent Drawer .................................................................................... 4-103

4.4.1 Functional Description ................................................................................. 4-103

4.4.2 Connector Boards .......................................................................................... 4-104

4.4.3 Wiring Diagram ................................................................................................ 4-110

4.4.4 Replacing spare parts ................................................................................... 4-113

4.4.4.1 Connector board W1 PCB ........................................................................... 4-113

4.4.4.2 Reagent carousel support ........................................................................... 4-114

4.4.4.3 Contact spring .................................................................................................. 4-115

4.4.4.4 Step motor W SE40, Gear belts ................................................................ 4-116

4.4.4.5 Connector board W4 PCB ........................................................................... 4-117

4.4.4.6 Barcode reader BR45 ................................................................................... 4-118

4.4.4.7 Connector board W2 PCB ........................................................................... 4-119

4.4.4.8 Hall effect micro switch drawer access Cable W14 .......................... 4-120

4.4.4.9 Hall effect micro switch drawer end position

Cable W15 ........................................................................................................ 4-120

4.4.4.10 Cable W12 ....................................................................................................... 4-121

4.4.4.11 Drawer compartment .................................................................................... 4-121

4.4.5 Spare Parts List .............................................................................................. 4-122

4.4.6 3D Drawing Reagent Drawer .................................................................... 4-124

4.4.7 Troubleshooting .............................................................................................. 4-125

4.5 Washer Lift ................................................................................................ 4-133

4.5.1 Functional Description ................................................................................. 4-133

4.5.2 Connector Boards .......................................................................................... 4-134

4.5.3 Wiring Diagram ............................................................................................... 4-141

4.5.4 Replacing spare parts .................................................................................. 4-145

4.5.4.1 Step motor W SM50, Gear belts .............................................................. 4-145

Gear belts: ........................................................................................................ 4-146

4.5.4.2 Manifold coupling compl. ............................................................................ 4-148

4.5.4.3 Shell spring ...................................................................................................... 4-150

4.5.4.4 Wash shell ........................................................................................................ 4-152

4.5.4.5 Connector board W12 PCB ....................................................................... 4-152

4.5.4.6 Connector board W14 PCB ....................................................................... 4-153

4.5.4.7 Connector board W16 PCB ....................................................................... 4-154

4.5.4.8 Cable W44 ........................................................................................................ 4-154

4.5.5 Manifold Complete ........................................................................................ 4-155

4.5.6 Spare Parts List .............................................................................................. 4-156

4.5.7 3D Drawing Washer Lift .............................................................................. 4-158

4.5.8 Troubleshooting .............................................................................................. 4-159

viii

4.6 External Pump Station .................................................................... 4-167

4.6.1 Functional Description ................................................................................. 4-167

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4.6.2 External Pump Station PCB ....................................................................... 4-168

4.6.3 Wiring Diagram External Pump Station ................................................. 4-174

4.6.4 Replacing spare parts .................................................................................. 4-175

4.6.4.1 Removing and remounting of PCB cover ............................................. 4-175

4.6.4.2 Silicone Tubing ............................................................................................... 4-175

4.6.4.3 DC motor W PM61 ........................................................................................ 4-176

4.6.4.4 External pump station PCB ........................................................................ 4-176

4.6.4.5 Wash ﬂuid level sensor ............................................................................... 4-177

4.6.4.6 Cable W61 ....................................................................................................... 4-178

4.6.4.7 O-ring ................................................................................................................. 4-178

4.6.4.8 O-Rings, Float, Compression Springs ................................................... 4-179

4.6.4.9 EPROM ............................................................................................................. 4-180

4.6.5 Spare Parts List .............................................................................................. 4-181

4.6.6 3D Drawing External Pump Station ........................................................ 4-183

4.6.7 Troubleshooting .............................................................................................. 4-184

4.7 W/D Electronic Rack ......................................................................... 4-191

4.7.1 Motherboard W / D PCB ............................................................................. 4-192

4.7.2 Power Supply 2 PCB .................................................................................... 4-193

4.7.3 Processor 2 PCB ........................................................................................... 4-194

4.7.4 Processor 3 PCB ........................................................................................... 4-194

4.7.5 Stepper Motor PCB ....................................................................................... 4-194

4.7.6 Dispenser PCB ............................................................................................... 4-195

4.7.7 Washer PCB ................................................................................................... 4-201

Chapter 5 END MODULE ........................................................................................ 5-7

5.1 End Module Raw ........................................................................................ 5-7

5.1.1 Design ...................................................................................................................... 5-7

5.1.2 Functional Description End Module .............................................................. 5-9

5.1.3 Calibration, Adjusting ......................................................................................... 5-9

5.1.4 Removing End Module ................................................................................... 5-10

5.1.5 Removing Assemblies ..................................................................................... 5-11

5.1.5.1 Dispenser ............................................................................................................ 5-12

5.1.5.2 Reagent drawer ................................................................................................. 5-13

5.1.5.3 Build-in Photometer ......................................................................................... 5-13

5.1.5.4 Exit Stack ............................................................................................................. 5-13

5.1.6 Replacing Spare Parts .................................................................................... 5-14

5.1.6.1 Pause Button ...................................................................................................... 5-14

5.1.7 Spare Parts List ................................................................................................. 5-15

5.1.8 3D Drawings End Module Raw .................................................................... 5-16

——— ML F.A.M.E. Service Manual V2.0 ———————————————————————————————————————— Table of Contents ———

5.1.9 Troubleshooting End Raw/ End Dispenser/ End Drawer ................... 5-19

5.2 End Module Frame ................................................................................ 5-31

5.2.1 Functional Description .................................................................................... 5-31

5.2.2 Connector Boards ............................................................................................. 5-33

5.2.3 Wiring Diagram .................................................................................................. 5-37

5.2.4 Replacing spare parts ..................................................................................... 5-41

5.2.4.1 Connector board P1 PCB .............................................................................. 5-41

5.2.4.2 Connector board W8 PCB ............................................................................. 5-41

5.2.4.3 Connector board P7 PCB .............................................................................. 5-42

5.2.4.4 Connector board P8 PCB .............................................................................. 5-42

5.2.4.5 Step motor P SE01 .......................................................................................... 5-43

5.2.4.6 Step motor W SE10 ......................................................................................... 5-43

5.2.4.7 Gear belt .............................................................................................................. 5-44

5.2.4.8 Gear belt (module transport) ........................................................................ 5-45

5.2.4.9 Gear belt (main shuttle drive) ....................................................................... 5-46

5.2.5 Spare Parts List ................................................................................................. 5-49

5.2.6 3D Drawing End Module Frame .................................................................. 5-51

5.2.7 Troubleshooting ................................................................................................. 5-52

5.3 Built-in Photometer .............................................................................. 5-59

5.3.1 Functional Description .................................................................................... 5-59

5.3.2 Connector Boards ............................................................................................. 5-60

5.3.3 Wiring Diagram .................................................................................................. 5-60

5.3.4 Replacing Spare Parts .................................................................................... 5-63

5.3.4.1 Filter case, ﬁlter strip ....................................................................................... 5-63

5.3.4.2 Photometer processor PCB .......................................................................... 5-64

5.3.4.3 Lamp controller PCB ....................................................................................... 5-64

5.3.4.4 Lamp-assembly PCB ....................................................................................... 5-65

5.3.4.5 Photometer fan .................................................................................................. 5-66

5.3.4.6 Cables P20, P21, P23 and P24 ................................................................. 5-67

5.3.4.7 Optical device ..................................................................................................... 5-68

5.3.4.8 Connector board P20 ..................................................................................... 5-70

5.3.4.9 Photometer air ﬁlter .......................................................................................... 5-70

5.3.4.10 Step motor ........................................................................................................... 5-71

5.3.4.11 Filter case belt ................................................................................................... 5-73

5.3.4.12 A/D converter PCB ........................................................................................... 5-75

5.3.4.13 Protective glass ................................................................................................. 5-77

5.3.5 Spare Parts List ................................................................................................. 5-79

5.3.6 Photometer Filter Order List: ........................................................................ 5-79

5.3.7 Troubleshooting ................................................................................................. 5-80

——— ML F.A.M.E. Service Manual V2.0————————————————————————————————————————— Table of Contents ———

5.4 Exit Stack ...................................................................................................... 5-87

5.4.1 Functional Description .................................................................................... 5-87

5.4.3 Wiring Diagram .................................................................................................. 5-96

5.4.4 Replacing Spare Parts .................................................................................... 5-99

5.4.4.1 Connector board P2 ........................................................................................ 5-99

5.4.4.2 Connector board P3 ..................................................................................... 5-100

5.4.4.3 Connector board P4 ..................................................................................... 5-101

5.4.4.4 Connector board P5 ..................................................................................... 5-102

5.4.4.5 Connector board P6 ..................................................................................... 5-103

5.4.4.6 Transparent cover sensor .......................................................................... 5-103

5.4.4.7 Step motor, gear belt .................................................................................... 5-105

5.4.4.8 Connector board P9 ..................................................................................... 5-106

5.4.4.9 Gear belt ........................................................................................................... 5-107

5.4.5 Spare Parts List .............................................................................................. 5-108

5.4.6 3D Drawing Exit Stack .................................................................................. 5-110

5.4.7 Troubleshooting ............................................................................................... 5-111

5.5 Electronic Rack ...................................................................................... 5-118

5.5.1 Motherboard P PCB ...................................................................................... 5-119

5.5.2 Power Supply 2 PCB .................................................................................... 5-120

5.5.3 Processor 1 PCB ........................................................................................... 5-120

5.5.4 Processor 2 PCB ........................................................................................... 5-120

5.5.5 Processor 3 PCB ........................................................................................... 5-120

5.5.6 Stepper Motor PCB ....................................................................................... 5-120

5.5.7 Dispenser PCB ............................................................................................... 5-120

5.5.8 Exit PCB ............................................................................................................ 5-121

Chapter 6 INSTRUMENT FRAMEWORK .......................................... 6-7

6.1 Instrument Error Codes ....................................................................... 6-7

6.1.1 Entry System ......................................................................................................... 6-7

6.1.2 Incubator System ................................................................................................. 6-9

6.1.3 Dispenser System ............................................................................................. 6-11

6.1.4 Washer System ................................................................................................. 6-13

6.1.5 Exit System ......................................................................................................... 6-15

6.1.6 Communication System ................................................................................. 6-16

6.1.7 Photometer System ......................................................................................... 6-17

6.2 Container Stack ........................................................................................ 6-23

6.3 Chassis

6.4 Main Shuttle Rail

6.5 Transparent Cover

6.6 Waste Cap

............................................................................................................ 6-31

................................................................................... 6-45

................................................................................. 6-55

..................................................................................................... 6-63

——— ML F.A.M.E. Service Manual V2.0————————————————————————————————————————————— SYSTEM ———

CHAPTER

1 SYSTEM

1.1 ML F.A.M.E. Instrument

1.1.1 General Information

Refer to User Manual Chapter 1.

ATTENTION

Read Chapter 1, General Instructions, of the User Manual before repairing / servicing the system.

For speciﬁc Service Information read section 1.1.2 Service Concept.

ATTENTION

Never lift a fully installed (assembled) instrument from one work bench to another. It must ﬁrst be dismantled and then reinstalled on the new work bench.

1-1

——— ML F.A.M.E. Service Manual V2.0 ———————————————————————————————————————————— SYSTEM ———

Serial No.

Attention:

Turn carousel until

Attention:

Close the reagent

Attention:

Shut down OS/2

Attention:

Do not swap

Before removing the module

Location of Warning and Attention Labels

plates after loading

Power

CE Label

Warning:

Laser Beam

Do Not Stare Into Beam! Class 2 Laser

Warning:

PAUSE

(Pause Button)

BIOHAZARD

before switching off PC. Do not change the OS/2 system time during a run.

Warning: Moving Parts

it drops into locked position.

Ensure all plungers are pushed

down and caps are properly closed.

1-2

decontaminate the instrument, unplug all the connectors and seal the ﬂuid system as described in the manual.

drawer gently to prevent spillage. Do not ﬁll containers above the

“max. 100 ml” mark.

——— ML F.A.M.E. Service Manual V2.0————————————————————————————————————————————— SYSTEM ———

Power Connection: Connect only to earth grounded outlet 115V~/...A 60Hz 230V~/...A 50Hz

The pause button should generally not be pressed unless instructed by the user software as plate processing may be interrupted leading to aborted plate. Carefully follow the software instructions.

Warning Symbols

General Warning

BIOHAZARD

HANDLE WITH CARE

Command Symbols

General Command

Danger High Voltage

Danger Laser

Wear Gloves

1-3

——— ML F.A.M.E. Service Manual V2.0 ———————————————————————————————————————————— SYSTEM ———

1.1.2 Service Concept

1.1.2.1 General Information

This Service Manual is a ﬁeld service guide and is to be used only by Service Technicians trained and/or authorized by Hamilton Bonaduz AG.

Repaired units must meet the quality standards set by Hamilton Bonaduz AG.

No part of this manual may be copied or handed on to a third party. Owners of Service Manuals are registered and only they will be issued with update information such as Service Manual Updates and Service Bulletins.

ATTENTION

In order to prevent infections caused by an unclean instrument in clinical environments (blood banks etc.), contaminated parts to be touched while repairing should be cleaned and sterilised - a precautionary measure of greatest importance.

Only after cleaning and disinfecting should repairs be carried out. In order to protect the Service Personnel from contagion, protective

vaccination is advised.

1.1.2.2 ML F.A.M.E. Service Manual

The ML F.A.M.E. Service Manual is designed to visually guide the service technician to the appropriate section as quickly as possible. It consists of 6 chapters:

1 SYSTEM 2 ENTRY MODULE 3 INCUBATOR MODULE 4 WASHER / DISPENSER 5 END MODULE 6 INSTRUMENT FRAMEWORK

❐ Chapter 1 serves as an introduction to the ML F.A.M.E. instrument

and the ML F.A.M.E. manual. Service technicians must read chapter 1 in order to provide the best service.

1-4

❐ Chapters 2-6 contain the servicing instructions.

——— ML F.A.M.E. Service Manual V2.0————————————————————————————————————————————— SYSTEM ———

1.1.2.2.1 Description of text icons

Attentions and useful notes are included in this manual to emphasize important and critical instructions. They are accompanied by a special symbol in the margin of the page and are printed in italics.

ATTENTION

All special problems, warnings or important text will be accompanied by this symbol at the appropriate position.

NOTE

Text associated with this symbol provides the user with useful notes. Carefully read the text as it is important for understanding the speciﬁc topic/command.

1.1.2.2.2 Updating the Service Manual

As the instrument or parts of the instrument are constantly being improved, this Service Manual will regularly be updated. Each Service Technician will be sent update-sets and is responsible that his Service Manual is kept up to date. Necessary instructions of how to do this will be included in the update-set.

It is most important that your Service Manual is kept up to date. On receipt of an Update, carefully follow the instructions on the cover page and then ﬁle the cover page after this section.

1.1.2.2.3 Service Bulletins

Service Bulletins are sent to File the Bulletins in this section to keep the Manual up to date.

1.1.2.2.4 Service Part Classiﬁcations

Spare Part

Class (SPC)

I Instrument A Service Technician always has these parts with him B Dealer has part in stock C Hamilton has part in stock P Promotion Material T Service Tools

immediately

Description

inform the Service Technician.

V Consumables Z Accessories

Not a Spare Part

1-5

——— ML F.A.M.E. Service Manual V2.0 ———————————————————————————————————————————— SYSTEM ———

1.1.2.2.5 Service Assemblies

Parts labelled with drawings are the Service Technician. If a part of the assembly is defective, the whole assembly must be replaced.

part

numbers rather than

Service Assemblies

item

numbers on the 3D

and should not be disassembled by

1.1.2.2.6 ML F.A.M.E. instruments with CE conformity

Instruments with serial numbers greater than 2000 are CE conform. Below is a table listing which board revisions may be installed into CE conform instruments.

Description Part Number

Motherboard E PCB 146 164 01 Motherboard W/D PCB 146 168 01 Motherboard P PCB 146 170 01 Incubator PCB 146 178 03 Entry PCB 146 176 03 Exit PCB 146 186 03 Power Supply 2 PCB 146 172 04 Power Supply 1 PCB 146 284 04 External Pump Station PCB 146 240 02

ATTENTION

New Revisions

CE Conform

The following boards (including those with a lower revision) must not be used in CE-conform instruments: Incubator PCB 146178/02, Exit PCB 146186/02, Power Supply 2 PCB 146172/03, and External Pump Station PCB 146240/01.

1-6

——— ML F.A.M.E. Service Manual V2.0————————————————————————————————————————————— SYSTEM ———

1.1.2.2.7 Pin coding for PCBs

= Pin fitted

•

Type:

UP 1 UP 2 UP 3 UP 4

Power Supply 1 PCB Power Supply 2 PCB

Entry

Incubator

Step Motor

Dispenser

Washer

Exit

Codes for Processor Boards:

A B C D E F G H I K L M

• •••• •

• ••• • •

Codes for Peripheral Boards:

A B C D E F G H I K L M

••• •••

•• • •••

••• • ••

•••• • •

•••• ••

••• • ••

Codes for Motherboards:

A B C D E F G H I K L M

• ••••

• • ••••

• •• •••

•••••

A B C D E F G H I K L M

• ••• •

• • ••• •

•••••

• • ••• •

••••••

• •••••

• •••• •

••••••

1.1.2.2.8 Connector numbering

The drawing on the following page 614 149 illustrates the connector numbering system used for ML F.A.M.E.

1-7

1-8

——— ML F.A.M.E. Service Manual V2.0 ———————————————————————————————————————————— SYSTEM ———

Wiring Principle

Block Diagram 614 149

revision 00

——— ML F.A.M.E. Service Manual V2.0————————————————————————————————————————————— SYSTEM ———

1.1.2.3 Feedback (Quarterly Service Call Statistics)

Information from the ﬁeld is a determining factor for improving Hamilton products. Please send/fax a copy of all of your Service Reports to Hamilton Bonaduz AG every three months so that we may continue to provide quality products and services.

1.1.2.4 Parts Return Tag

The part Return Tag has two functions:

❐ Page 1: Part identiﬁcation, reason for return and description of

problem

❐ Page 2: Decontamination Declaration

Material Return Good Authorization

Parts or instruments may only be returned to Hamilton Bonaduz AG with a Return Good Authorization (RGA).

Ask the Hamilton Order Processing Department (OPD) for an RGA number prior to sending any material. This number must be entered in the appropriate blank on the Parts Return Tag.

A completed Part Return Tag must be attached to all parts or instruments which are returned to HAMILTON BONADUZ AG. Tags may be ordered from Hamilton Bonaduz AG (p/n 612 554).

Hamilton Bonaduz AG reserves the right to return any parts or instruments which may pose a health hazard due to contamination and to charge the customer for any expenses incurred.

1.1.2.5 Technical Data Sheet

The technical data sheet is supplied with each instrument and contains all technical data of a speciﬁc instrument. It must be updated by the service technician when signiﬁcant modiﬁcations are made.

1-9

——— ML F.A.M.E. Service Manual V2.0 ———————————————————————————————————————————— SYSTEM ———

1.1.2.6 Service Kit

1.1.2.6.1 Service Kit Spare Parts List 148 236

SPARE CASE ML F.A.M.E. REV: 00

P/N DESCRIPTION REVISION

141239 KLEMMRING 01 1 1.000 A 146154 CONNECTORBOARD E1 PCB 00 2 1.000 A 146156 CONNECTORBOARD I1 PCB 00 3 1.000 A 146158 CONNECTORBOARD P1 PCB 00 4 1.000 A 146172 POWER SUPPLY 2 PCB 04 7 1.000 A 146174 STEP MOTOR PCB 00 8 1.000 A 146178 INKUBATOR PCB 02 9 1.000 A 146180 DISPENSER PCB 01 10 1.000 A 146182 WASHER PCB 02 11 1.000 A 146186 EXIT PCB 03 12 1.000 A 146188 IC27C256 PRO VEDLS10.ACH 00 13 1.000 A 146195 CONNECTORBOARD W1 PCB 02 14 1.000 A 146197 CONNECTORBOARD W2 PCB 02 15 1.000 A 146201 CONNECTORBOARD W4 PCB 00 16 1.000 A 146407 CONNECTORBOARD W5 PCB 00 17 1.000 A 146209 CONNECTORBOARD W8 PCB 00 19 1.000 A 146411 CABLE W7 00 20 1.000 A 146218 CABLE W8 00 21 1.000 A 146222 CABLE W12 00 22 1.000 A 146230 CONNECTORBOARD W11 PCB 00 23 1.000 A 146232 CONNECTORBOARD W12 PCB 00 24 1.000 A 146234 CONNECTORBOARD W13 PCB 00 25 1.000 A 146236 CONNECTORBOARD W14 PCB 00 26 1.000 A 146240 EXTERNAL PUMP STATION PCB 02 27 1.000 A 146243 PHOTOMETER PROCESSOR PCB 00 29 1.000 A 146244 CONNECTORBOARD P20 PCB 00 30 1.000 A 146245 LAMP CONTROLLER PCB 00 31 1.000 A 146256 CONNECTORBOARD W9 PCB 01 32 1.000 A 146257 CONNECTORBOARD E8 PCB 00 33 1.000 A 146259 CONNECTORBOARD P2 PCB 00 34 1.000 A 146261 CONNECTORBOARD P3 PCB 00 35 1.000 A 146263 CONNECTORBOARD P4 PCB 00 36 1.000 A 146265 CONNECTORBOARD P5 PCB 00 37 1.000 A 146266 CONNECTORBOARD P6 PCB 00 38 1.000 A 146268 CONNECTORBOARD P9 PCB 00 39 1.000 A 146271 CONNECTORBOARD P8 PCB 00 40 1.000 A 146275 LAMP-ASSEMBLY PCB 00 41 1.000 A 146278 CONNECTORBOARD W16 PCB 01 42 1.000 A 146298 CABLE W44 00 43 1.000 A 146308 TEMPERATURE SENSOR TS70 00 44 1.000 A 146311 CONNECTORBOARD E6 PCB 00 45 1.000 A 146312 CONNECTORBOARD E7 PCB 00 46 1.000 A 146313 CONNECTORBOARD E9 PCB 00 47 1.000 A

ITEM

NUMBER

QUANTITY PER

ASSEMBLY

SPARE P ART

CLASS

1-10

——— ML F.A.M.E. Service Manual V2.0————————————————————————————————————————————— SYSTEM ———

P/N DESCRIPTION REVISION

146314 CONNECTORBOARD E10 PCB 00 48 1.000 A 146322 CONNECTORBOARD E11 PCB 00 49 1.000 A 146352 CABLE E20 00 50 1.000 A 146384 A/D CONVERTER PCB 00 53 1.000 A 146386 CONNECTORBOARD E14 PCB 00 54 1.000 A 146388 CONNECTORBOARD E12 PCB 00 55 1.000 A 146390 CONNECTORBOARD E13 PCB 00 56 1.000 A 147417 ISOLIERSCHEIBE 00 58 1.000 A 147489 SCHWIMMER 01 59 1.000 A 147638 KABELKLEMME 00 61 1.000 A 147683 FILTERMATTE 00 62 1.000 A 147693 VERBINDUNGSSTUECK NW 8/45? 00 63 1.000 A 147720 SHELL-FEDER 00 64 1.000 A 147777 ABDECKFOLIE 00 65 1.000 A 147935 MTP-TRANSPORTER 00 66 1.000 Z 148157 KONTAKTFEDER 00 67 1.000 A 148228 MODULE TRANSPORT FORK COMPL. 01 68 1.000 A 148230 REGULATING SCREW 1 COMPL. 00 69 1.000 A 148231 REGULATING SCREW 2 COMPL. 00 70 1.000 A 249944 SCHLAUCHVERBINDER 6/10/6 00 71 1.000 A 254101 O-RING 85.32x3.53 VITON 75 00 72 1.000 A 254106 O-RING 12.00X2.00 VITON 00 73 1.000 A 254110 O-RING 76.00X2.00 VITON 00 74 1.000 A

254111 O-RING 5.00X1.50 VITON 00 75 1.000 A 254121 O-RING 79X2 NBR 70.5/P5 00 76 1.000 A 256115 ZUGFED. D 0,32 DA 3,52 LO 12,9 00 77 1.000 A 256116 ZUGFEDER D 0.50 DM 3.0 LO 24.5 00 78 1.000 A 257036 DISTANZHALTER M3 X 8 I/I GEW. 00 79 1.000 A 257040 DIST.HALTER M4X20 I/A GEW. 00 80 1.000 A 257041 DIST.HALTER M4X 25 I/A GEW. 00 81 1.000 A 279448 SCHWINGUNGSDAEMPFER D=15 H=20 83 1.000 A 279648 WINKELSTUECK 90? PP ID 4-5 00 84 1.000 A 279649 WINKELSTUECK 90? PP ID 8-9 00 85 1.000 A 361019 KABELBEF. SES-CT 00 86 3.000 422002 SPREIZNIETE KST D=5 KB=3.5-4.5 00 90 1.000 A 420214 PT-SENKKOPFSCHRAUBE KA 30 X 8 00 91 2.000 A

7279355 KLEBBAND 1-SEITIG D= 2 B= 6 00 92 0.200

147963 PHOTOMETER AIR FILTER 00 93 1.000 A 511006 LOCTITE 222 50mL 00 94 1.000 T 511010 LOCTITE 638 50mL 00 96 1.000 T

7249057 SILIKONSCHL 4 X 7 TRANSP 00 97 1.000 B 7260010 SILIKONSCHL 8 X12 TRANSP 00 98 1.000 B

148248 KLETTVERSCHLUSS 00 99 4.000 A

7281149 PTFE-KLEBEBAND EXTR.B=9MM 00 100 0.200 7281122 KLEBBAND 2-SEITIG D=0,8 B=9 00 101 0.200

146328 TRANSPARENT COVER SENSOR HS03 00 102 1.000 A 146416 REAGENT DRAWER SWITCH SET 00 103 1.000 A 254105 O-RING 8.00X2.00 VITON 00 104 1.000 A 254126 O-RING Di 5x2.5 VITON 75 00 105 1.000 A

281110 STOPFEN D5.8 D7 L5 SILIKON 00 106 1.000 A

ITEM

NUMBER

QUANTITY PER

ASSEMBLY

SPARE P ART

CLASS

1-11

——— ML F.A.M.E. Service Manual V2.0 ———————————————————————————————————————————— SYSTEM ———

P/N DESCRIPTION REVISION

146405 IC27C256 PRO VEEPS11.ACH 00 107 1.000 A 235416 FARBFL. 7,5ML HELLBLAU HAM 00 108 1.000 T 235425 FARBFL. 7,5ML GRAUBLAU HAM 00 109 1.000 T 235418 HAERTERFLASCHE 7,5 ML 00 110 1.000 T 235417 FARBFL. 7,5ML DUNKELBLAU HAM 00 111 1.000 T 147581 JUSTIERSCHEIBE 00 112 2.000 A 369051 VERPACK CHIP CONTAINER TYP 2 00 114 1.000 511057 OEL MICROGLISS D-5 20ML 00 115 1.000 T 146394 CABLE MODULE CONNECTION 00 116 2.000 T 146395 SERVICE PCB 00 117 1.000 T 239038 ELEKTRONIKKOFFER 00 118 2.000 239039 EINLEGEPLATTE 00 119 8.000 148245 SETSCREW 00 120 1.000 A 147516 WASH FLUID LEVEL SENSOR 00 121 1.000 A 361036 KABELHALTER 00 122 3.000 361002 KABELBEF. 375 S 00 123 3.000 361004 KABELBEF. CFCC-4 1/2” 00 124 3.000 369038 VERRIEGELUNGSMUTTER 00 125 1.000 B 255038 KENNZEICHNUNG LABEL 21X9 WEISS 00 126 2.000 148339 SUPPORT ENTRY MODULE 00 128 1.000 T 148355 TRANSP COVER MAGNET 00 129 1.000 T 146409 CONNECTORBOARD W6 PCB 00 130 1.000 A 622054 PACKING LIST ML FAME 05 131 1.000 511069 MOLYKOTE FETTPASTE DX 00 132 1.000 T 146317 PROCESSOR 4 PCB 01 135 1.000 A 235426 FARBFL.7,5ML SIGNALSCHW. 00 136 1.000 T 235427 FARBFL.7,5ML ACHATGRAU 00 137 1.000 T

ITEM

NUMBER

QUANTITY PER

ASSEMBLY

SPARE P ART

CLASS

1-12

——— ML F.A.M.E. Service Manual V2.0————————————————————————————————————————————— SYSTEM ———

1.1.2.6.2 Service PCB (to be used with Diagnostic Master)

Component Layout

146.395

revision 00

1-13

——— ML F.A.M.E. Service Manual V2.0 ———————————————————————————————————————————— SYSTEM ———

NOT MOUNTED

HEATING ELEMENT on IN STEP MOTOR on SM, ET, EX

HEATING ELEMENT on IN STEP MOTOR on SM, ET, DS, EX

HEATING ELEMENT on IN

STEP MOTOR on SM, ET, DS, EX

HEATING ELEMENT on IN STEP MOTOR on SM, DS, EX

HEATING ELEMENT on IN STEP MOTOR on SM, DS, WA, EX

HEATING ELEMENT on IN STEP MOTOR on SM, DS, WA

HEATING ELEMENT on IN STEP MOTOR on SM, WA

+35VDC on IN

STEP MOTOR on SM, WA

VACUUM PUMP on WA STEP MOTOR on SM

VACUUM PUMP on WA

+35VDC on WA

+5VDC

GND_5V

Service PCB

GND_5V

+5VDC

GND_5V

+5VDC

1a1b2a1c3b3a2c

TP16

TP15

TP14

TP13

TP12

TP11

TP10

TP9

TP8

TP7

TP6

TP5

TP4

TP3

TP2

TP1

+35VDC on WA

6a5c5b5a4c4b4a

Wiring Diagram

11b

11a

10c

10b

10a9c9b9a8c8b8a7c7b7a6c

13c

13b

13a

12c

12b

12a

11c

604.852

VACUUM PUMP on WA

19a

18c

18b

18a

17c

17b

17a

16c

16b

16a

15c

15b

15a

14c

14b

14a

revision 00

STEP MOTOR on SM, WA /HEATING ELEMENT on IN

STEP MOTOR on SM, WA / +35VDC on IN

STEP MOTOR on SM / VACUUM PUMP on WA

22a

21c

21b

21a

20c

20b

20a

19c

19b

22b

STEP MOTOR on SM, DS, EX / HEATING ELEMENT on IN

STEP MOTOR on SM, DS, WA, EX / HEATING ELEMENT on IN

STEP MOTOR on SM, DS, WA / HEATING ELEMENT on IN

25a

24c

24b

24a

23c

23b

23a

22c

GND_5V

+5VDC

STEP MOTOR on SM, ET, EX / HEATING ELEMENT on IN

STEP MOTOR on SM, ET, DS, EX / HEATING ELEMENT on IN

STEP MOTOR on SM, DS, EX / HEATING ELEMENT on IN

32c

32b

32a

31c

31b

31a

30c

30b

30a

29c

29b

29a

28c

28b

28a

27c

27b

27a

26c

26b

26a

25c

25b

1-14

2a1c1b

+5VDC

GND_5V

SM => STEP MOTOR PCB

IN => INCUBATOR PCB

LEGEND:

5a4c4b

4a3c3b

3a2c2b

WA => WASHER PCB

DS => DISPENSER PCB

EX => EXIT PCB

ET => ENTRY PCB

6a5c5b

11c

10c

12a

11b

11a

10b

10a

14c

13c

12c

15a

14b

14a

13b

13a

12b

17c

16c

15c

18a

17b

17a

16b

16a

15b

20c

19c

18c

21a

20b

20a

19b

19a

18b

23c

22c

21c

24a

23b

23a

22b

22a

21b

26c

25c

24c

27a

26b

26a

25b

25a

24b

29c

28c

27c

30a

29b

29a

28b

28a

27b

32c

31c

30c

32b

32a

31b

31a

30b

+5VDC

GND_5V

9a8c8b

8a7c7b

7a6c6b

EL-RACK MOTHERBOARD E PCB/- W PCB/- P PCB

——— ML F.A.M.E. Service Manual V2.0————————————————————————————————————————————— SYSTEM ———

1.1.3 F.A.M.E. Description

Microlab F.A.M.E., aFullyAutomatedMicroplateELISA processor, carries out all necessary steps of a microplate ELISA after sample distribution with minimum user interference: plate incubation, plate washing, reagent dispensing and photometric evaluation.

With modular design of the different functions, the instrument can be adjusted to individual laboratory requirements. The standard conﬁguration contains enough plate incubation and reagent capacity to ensure a throughput of approximately 10 microplates/hour with continuous loading capability. Bar codes on plates and reagents ensure positive identiﬁcation throughout the process. Zero carry-over is achieved using disposable reagent containers and syringes.

The instrument is driven by a user-friendly software for deﬁnition, processing and interpretation of the vast majority of available ELISA tests.

❐ Modular, extendable design, can be adapted to the various

laboratory needs.

❐ Modular design allows parallel processing of ELISA steps. ❐ Automation

The standard conﬁguration comprises enough plate incubation (20 slots) and reagent capacity (16 containers), to ensure high throughput.

❐ Walk-away

Continuous processing: ML F.A.M.E. may be continuously loaded with micro titer plates (up to 4) which are processed as long as there is capacity available. A separate exit stack, where up to ten micro titer plates can be stacked, keeps the entry stack free for loading plates.

❐ Complete instrumentation

Microlab F.A.M.E. ensures positive identiﬁcation via barcodes on plates and reagents.

No carry-over, using disposable syringes (for each reagent container a syringe).

No carry-over with the intelligent cleaning procedure and the autorinse of wash system.

❐ Open System

Microlab F.A.M.E. is able to process tests of various manufacturers simultaneously.

Test kits can easily be adapted. Method library , kit lot library, reagents library, wash solutions library. Complete test evaluation (qualitative, quantitative, semi

quantitative) and test reports.

❐ Communication and LAN Integration

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Communication with sample preparation instruments, e.g. ML AT / ATplus 2. Barcode data of pipetted samples and pipetting information are linked to the patient results. Results and protocols can be sent via external communication systems to a HOST computer.

1.1.3.1 Purpose of the system

ML F.A.M.E. is an automated bench-top analyzer for immunological tests based on the ELISA (Enzyme Linked Immuno Sorbent Assay) test principle in a deﬁned format, so-called micro titration plates (MTP). ML F.A.M.E. will carry out all necessary processing steps for an ELISA test, including data evaluation and interpretation; however, the primary sample preparation step (i.e. transferring the samples into the MTP wells) is not included in ML F.A.M.E. This step will be carried out with pipetting robots like the Hamilton Microlab AT, ATplus or the Microlab

2200. An ELISA test usually includes several steps, thus the following features

are included into ML F.A.M.E.:

❒ incubation of the MTP at a deﬁned temperature for a deﬁned time ❒ washing of the MTP, i.e. aspirating the liquid in the wells, ﬁlling it

with wash ﬂuid and emptying the wells

❒ dispensing of reagents into the MTP wells ❒ photometric measurement of the MTP wells ❒ validation and interpretation of the photometric data and creation of

result documentation.

The analyzer is designed as a walk-away device i.e. minimum user interaction during processing is required. Walk-away means that the operator is occupied with other tasks, but is able to respond fast if necessary.

ML F.A.M.E. is controlled by a computer system running the OS/2 operating system. DB/2 is used for the storage of data. The computer is not a built-in device and the customer is expected to provide it at his/her cost. A list of compatible computer types will be provided by Hamilton.

1.1.3.2 General Operation Procedure

Test plates with serum, controls and standards pipetted into the wells either manually or by using a sample pipetting instrument, are loaded onto the entry position of ML F.A.M.E. Plates can be introduced either individually or in stacks of up to four MTPs. The barcoded plate is identiﬁed by the ML F.A.M.E. bar code reader (with manual identiﬁcation also possible) and then processed according to the method to which the plate barcode has been assigned. After the last processing step, the MTP is automatically placed on the exit stack, which can hold up to 10 MTPs. Also, photometric data evaluation and test interpretation is started once the O.D. values have been read. If ML F.A.M.E. communicates with a sample pipetting device, the barcode ﬁles (i.e. the barcodes of the samples being pipetted into the wells of the MTP) are combined with the results of the patients and result protocols are either printed out or sent to external communication systems (HOST, LAN).

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Hamilton Microlab FAME Service Manual

Specifications and Main Features

Frequently Asked Questions

User Manual

Table of Contents

1 SYSTEM