Section 1. Identification
FP RNA Dilution Buffer, Part Number FP-6501-0003
CHEMTREC®: 1-800-424-9300
SAFETY DATA SHEET
Product name
In case of emergency
:
:
Supplier/Manufacturer
:
Agilent Technologies, Inc.
5301 Stevens Creek Blvd
Santa Clara, CA 95051, USA
800-227-9770
FP RNA Dilution Buffer, Part Number FP-6501-0003
Conforms to US OSHA Hazard Communication 29CFR1910.1200
FP-6501-0003
:
Part no.
Material uses
:
Analytical reagent.
FP-6501-0003 FP RNA Dilution Buffer, 3mL
Validation date
:
2/12/2021
1.2 Relevant identified uses of the substance or mixture and uses advised against
1.1 Product identifier
1.3 Details of the supplier of the safety data sheet
1.4 Emergency telephone number
Section 2. Hazards identification
Classification of the substance or mixture
Signal word
:
Danger
Hazard statements
:
H319 - Causes serious eye irritation.
H351 - Suspected of causing cancer.
H360 - May damage fertility or the unborn child.
H373 - May cause damage to organs through prolonged or repeated exposure. (blood,
Oral)
Hazard pictograms
:
Precautionary statements
Prevention
:
P201 - Obtain special instructions before use.
P280 - Wear protective gloves, protective clothing and eye or face protection.
P260 - Do not breathe vapor.
Response
:
P308 + P313 - IF exposed or concerned: Get medical advice or attention.
2.2 GHS label elements
Percentage of the mixture consisting of ingredient(s) of unknown hazards to the aquatic
environment: 60%
OSHA/HCS status
:
This material is considered hazardous by the OSHA Hazard Communication Standard
(29 CFR 1910.1200).
H319
EYE IRRITATION - Category 2A
H351
CARCINOGENICITY - Category 2
H360
TOXIC TO REPRODUCTION - Category 1B
H373
SPECIFIC TARGET ORGAN TOXICITY (REPEATED EXPOSURE) - Category 2
2.1 Classification of the substance or mixture
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FP RNA Dilution Buffer, Part Number FP-6501-0003
Section 2. Hazards identification
Storage
:
Not applicable.
Disposal
:
P501 - Dispose of contents and container in accordance with all local, regional, national
and international regulations.
Hazards not otherwise
classified
:
None known.
2.3 Other hazards
Section 3. Composition/information on ingredients
Formamide
≥50 - ≤75
75-12-7
Ingredient name
CAS number
%
Substance/mixture
:
Occupational exposure limits, if available, are listed in Section 8.
Mixture
Any concentration shown as a range is to protect confidentiality or is due to batch variation.
There are no additional ingredients present which, within the current knowledge of the supplier and in the
concentrations applicable, are classified as hazardous to health or the environment and hence require reporting
in this section.
Wash out mouth with water. Remove dentures if any. Remove victim to fresh air and
keep at rest in a position comfortable for breathing. If material has been swallowed and
the exposed person is conscious, give small quantities of water to drink. Stop if the
exposed person feels sick as vomiting may be dangerous. Do not induce vomiting
unless directed to do so by medical personnel. If vomiting occurs, the head should be
kept low so that vomit does not enter the lungs. Get medical attention. Never give
anything by mouth to an unconscious person. If unconscious, place in recovery position
and get medical attention immediately. Maintain an open airway. Loosen tight clothing
such as a collar, tie, belt or waistband.
Immediately flush eyes with plenty of water, occasionally lifting the upper and lower
eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10
minutes. Get medical attention.
Flush contaminated skin with plenty of water. Remove contaminated clothing and
shoes. Wash contaminated clothing thoroughly with water before removing it, or wear
gloves. Continue to rinse for at least 10 minutes. Get medical attention. Wash clothing
before reuse. Clean shoes thoroughly before reuse.
Remove victim to fresh air and keep at rest in a position comfortable for breathing. If
not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial
respiration or oxygen by trained personnel. It may be dangerous to the person providing
aid to give mouth-to-mouth resuscitation. Get medical attention. If unconscious, place
in recovery position and get medical attention immediately. Maintain an open airway.
Loosen tight clothing such as a collar, tie, belt or waistband. In case of inhalation of
decomposition products in a fire, symptoms may be delayed. The exposed person may
need to be kept under medical surveillance for 48 hours.
Section 4. First aid measures
Eye contact
Skin contact
Inhalation
Ingestion
:
:
:
:
4.1 Description of necessary first aid measures
4.2 Most important symptoms/effects, acute and delayed
Inhalation
:
No known significant effects or critical hazards.
No known significant effects or critical hazards.
:
Ingestion
Skin contact
:
No known significant effects or critical hazards.
Causes serious eye irritation.
:
Eye contact
Potential acute health effects
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Date of issue :
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FP RNA Dilution Buffer, Part Number FP-6501-0003
Section 4. First aid measures
Protection of first-aiders
:
No action shall be taken involving any personal risk or without suitable training. If it is
suspected that fumes are still present, the rescuer should wear an appropriate mask or
self-contained breathing apparatus. It may be dangerous to the person providing aid to
give mouth-to-mouth resuscitation. Wash contaminated clothing thoroughly with water
before removing it, or wear gloves.
Notes to physician
:
In case of inhalation of decomposition products in a fire, symptoms may be delayed.
The exposed person may need to be kept under medical surveillance for 48 hours.
Specific treatments
:
No specific treatment.
Over-exposure signs/symptoms
Skin contact
Ingestion
Inhalation
Adverse symptoms may include the following:
reduced fetal weight
increase in fetal deaths
skeletal malformations
Adverse symptoms may include the following:
reduced fetal weight
increase in fetal deaths
skeletal malformations
Adverse symptoms may include the following:
reduced fetal weight
increase in fetal deaths
skeletal malformations
:::
Eye contact
:
Adverse symptoms may include the following:
pain or irritation
watering
redness
See toxicological information (Section 11)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Section 5. Fire-fighting measures
Promptly isolate the scene by removing all persons from the vicinity of the incident if
there is a fire. No action shall be taken involving any personal risk or without suitable
training.
Hazardous thermal
decomposition products
Specific hazards arising
from the chemical
Decomposition products may include the following materials:
carbon dioxide
carbon monoxide
nitrogen oxides
In a fire or if heated, a pressure increase will occur and the container may burst.
Fire-fighters should wear appropriate protective equipment and self-contained breathing
apparatus (SCBA) with a full face-piece operated in positive pressure mode.
Special protective
equipment for fire-fighters
Use an extinguishing agent suitable for the surrounding fire.
5.1 Extinguishing media
:
:
:
None known.
Suitable extinguishing
media
:
Unsuitable extinguishing
media
:
Special protective actions
for fire-fighters
:
5.2 Special hazards arising from the substance or mixture
5.3 Advice for firefighters
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FP RNA Dilution Buffer, Part Number FP-6501-0003
Section 6. Accidental release measures
6.2 Environmental
precautions
6.1 Personal precautions, protective equipment and emergency procedures
:
:
No action shall be taken involving any personal risk or without suitable training.
Evacuate surrounding areas. Keep unnecessary and unprotected personnel from
entering. Do not touch or walk through spilled material. Avoid breathing vapor or mist.
Provide adequate ventilation. Wear appropriate respirator when ventilation is
inadequate. Put on appropriate personal protective equipment.
Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains
and sewers. Inform the relevant authorities if the product has caused environmental
pollution (sewers, waterways, soil or air).
Stop leak if without risk. Move containers from spill area. Dilute with water and mop up
if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and
place in an appropriate waste disposal container. Dispose of via a licensed waste
disposal contractor.
Methods for cleaning up
:
6.3 Methods and materials for containment and cleaning up
For non-emergency
personnel
For emergency responders
:
If specialized clothing is required to deal with the spillage, take note of any information in
Section 8 on suitable and unsuitable materials. See also the information in "For nonemergency personnel".
Section 7. Handling and storage
Advice on general
occupational hygiene
7.2 Conditions for safe
storage, including any
incompatibilities
Eating, drinking and smoking should be prohibited in areas where this material is
handled, stored and processed. Workers should wash hands and face before eating,
drinking and smoking. Remove contaminated clothing and protective equipment before
entering eating areas. See also Section 8 for additional information on hygiene
measures.
Store in accordance with local regulations. Store in original container protected from
direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials
(see Section 10) and food and drink. Store locked up. Keep container tightly closed
and sealed until ready for use. Containers that have been opened must be carefully
resealed and kept upright to prevent leakage. Do not store in unlabeled containers.
Use appropriate containment to avoid environmental contamination. See Section 10 for
incompatible materials before handling or use.
:
:
Protective measures
Put on appropriate personal protective equipment (see Section 8). Avoid exposure obtain special instructions before use. Avoid exposure during pregnancy. Do not
handle until all safety precautions have been read and understood. Do not get in eyes
or on skin or clothing. Do not breathe vapor or mist. Do not ingest. If during normal
use the material presents a respiratory hazard, use only with adequate ventilation or
wear appropriate respirator. Keep in the original container or an approved alternative
made from a compatible material, kept tightly closed when not in use. Empty containers
retain product residue and can be hazardous. Do not reuse container.
:
7.1 Precautions for safe handling
Recommendations
:
:
Industrial sector specific
solutions
Not available.
Industrial applications, Professional applications.
7.3 Specific end use(s)
4/11
Date of issue :
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FP RNA Dilution Buffer, Part Number FP-6501-0003
Formamide
ACGIH TLV (United States, 3/2020).
Absorbed through skin.
TWA: 1 ppm 8 hours.
OSHA PEL 1989 (United States, 3/1989).
TWA: 20 ppm 8 hours.
TWA: 30 mg/m³ 8 hours.
STEL: 30 ppm 15 minutes.
STEL: 45 mg/m³ 15 minutes.
NIOSH REL (United States, 10/2016).
Absorbed through skin.
TWA: 10 ppm 10 hours.
TWA: 15 mg/m³ 10 hours.
Section 8. Exposure controls/personal protection
Ingredient name
Exposure limits
Hand protection
Based on the hazard and potential for exposure, select a respirator that meets the
appropriate standard or certification. Respirators must be used according to a
respiratory protection program to ensure proper fitting, training, and other important
aspects of use.
Chemical-resistant, impervious gloves complying with an approved standard should be
worn at all times when handling chemical products if a risk assessment indicates this is
necessary. Considering the parameters specified by the glove manufacturer, check
during use that the gloves are still retaining their protective properties. It should be
noted that the time to breakthrough for any glove material may be different for different
glove manufacturers. In the case of mixtures, consisting of several substances, the
protection time of the gloves cannot be accurately estimated.
Safety eyewear complying with an approved standard should be used when a risk
assessment indicates this is necessary to avoid exposure to liquid splashes, mists,
gases or dusts. If contact is possible, the following protection should be worn, unless
the assessment indicates a higher degree of protection: chemical splash goggles.
Eye/face protection
Respiratory protection
:
:
:
Body protection
Personal protective equipment for the body should be selected based on the task being
performed and the risks involved and should be approved by a specialist before
handling this product.
:
Environmental exposure
controls
:
Emissions from ventilation or work process equipment should be checked to ensure
they comply with the requirements of environmental protection legislation. In some
cases, fume scrubbers, filters or engineering modifications to the process equipment
will be necessary to reduce emissions to acceptable levels.
Appropriate engineering
controls
:
If user operations generate dust, fumes, gas, vapor or mist, use process enclosures,
local exhaust ventilation or other engineering controls to keep worker exposure to
airborne contaminants below any recommended or statutory limits.
Wash hands, forearms and face thoroughly after handling chemical products, before
eating, smoking and using the lavatory and at the end of the working period.
Appropriate techniques should be used to remove potentially contaminated clothing.
Wash contaminated clothing before reusing. Ensure that eyewash stations and safety
showers are close to the workstation location.
Hygiene measures
:
8.1 Control parameters
Individual protection measures
Occupational exposure limits
Skin protection
Other skin protection
:
Appropriate footwear and any additional skin protection measures should be selected
based on the task being performed and the risks involved and should be approved by a
specialist before handling this product.
8.2 Exposure controls
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Date of issue :
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FP RNA Dilution Buffer, Part Number FP-6501-0003
Section 9. Physical and chemical properties
Physical state
Melting point
Vapor pressure
Relative density
Vapor density
Solubility
Liquid.
Not available.
Not available.
Not available.
Not available.
Easily soluble in the following materials: cold water and hot water.
Not available.
Odor
pH
Not available.
Color
Evaporation rate
Not available.
Auto-ignition temperature
Flash point
Not available.
Not available.
Not available.
8
Viscosity
Not available.
Not available.
Odor threshold
Partition coefficient: noctanol/water
:::::
:::
:
:
:
:::
:
Appearance
Boiling point
:
Not available.
Flammability (solid, gas)
:
Not applicable.
Lower and upper explosive
(flammable) limits
:
Not available.
Decomposition temperature
:
Not available.
9.1 Information on basic physical and chemical properties
Section 10. Stability and reactivity
10.6 Hazardous
decomposition products
10.4 Conditions to avoid
No specific data.
Under normal conditions of storage and use, hazardous decomposition products should
not be produced.
The product is stable.
10.2 Chemical stability
May react or be incompatible with oxidizing materials.
:
::10.5 Incompatible materials
:
10.3 Possibility of
hazardous reactions
:
Under normal conditions of storage and use, hazardous reactions will not occur.
10.1 Reactivity
:
No specific test data related to reactivity available for this product or its ingredients.
Section 11. Toxicological information
Acute toxicity
Formamide
LC50 Inhalation Dusts and mists
Rat - Male
>21 mg/l
4 hours
LD50 Dermal
Rabbit
17 g/kg
-
LD50 Oral
Rat
4000 mg/kg
-
Product/ingredient name
Result
Species
Dose
Exposure
11.1 Information on toxicological effects
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FP RNA Dilution Buffer, Part Number FP-6501-0003
Section 11. Toxicological information
Carcinogenicity
Conclusion/Summary
:
Not available.
Mutagenicity
Conclusion/Summary
:
Not available.
Teratogenicity
Conclusion/Summary
:
Not available.
Reproductive toxicity
Conclusion/Summary
:
Not available.
Irritation/Corrosion
Formamide
Eyes - Severe irritant
Rabbit
-
100 mg
-
Product/ingredient name
Result
Score
Exposure
Observation
Sensitization
Not available.
Species
Information on the likely
routes of exposure
Inhalation
:
No known significant effects or critical hazards.
No known significant effects or critical hazards.
:
Ingestion
Skin contact
:
No known significant effects or critical hazards.
Causes serious eye irritation.
:
Eye contact
Symptoms related to the physical, chemical and toxicological characteristics
Skin contact
Ingestion
Inhalation
Adverse symptoms may include the following:
reduced fetal weight
increase in fetal deaths
skeletal malformations
Adverse symptoms may include the following:
reduced fetal weight
increase in fetal deaths
skeletal malformations
Adverse symptoms may include the following:
reduced fetal weight
increase in fetal deaths
skeletal malformations
:
:
:
Eye contact
:
Adverse symptoms may include the following:
pain or irritation
watering
redness
Specific target organ toxicity (single exposure)
Specific target organ toxicity (repeated exposure)
Not available.
Name
Category
Formamide
Category 2
-
blood, Oral
Aspiration hazard
Not available.
Route of
exposure
Target organs
:
Routes of entry anticipated: Oral, Dermal, Inhalation.
Potential acute health effects
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Date of issue :
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FP RNA Dilution Buffer, Part Number FP-6501-0003
Section 11. Toxicological information
May cause damage to organs through prolonged or repeated exposure.
General
:
Suspected of causing cancer. Risk of cancer depends on duration and level of
exposure.
Carcinogenicity
:
No known significant effects or critical hazards.
Mutagenicity
:
Potential chronic health effects
Delayed and immediate effects and also chronic effects from short and long term exposure
Numerical measures of toxicity
Acute toxicity estimates
Potential immediate
effects
:
Not available.
Short term exposure
Potential delayed effects
:
Not available.
Potential immediate
effects
:
Not available.
Long term exposure
Potential delayed effects
:
Not available.
Product/ingredient name
FP RNA Dilution Buffer, Part Number FP-6501-0003
8003.1
N/A
N/A
N/A
N/A
Formamide
4000
17000
N/A
N/A
N/A
Oral (mg/
kg)
Dermal
(mg/kg)
Inhalation
(gases)
(ppm)
Inhalation
(vapors)
(mg/l)
Inhalation
(dusts and
mists) (mg/
l)
May damage fertility or the unborn child.
Reproductive toxicity
:
Section 12. Ecological information
LogP
ow
BCF
Potential
12.3 Bioaccumulative potential
Product/ingredient name
Formamide
-0.82
-
low
Product/ingredient name
Aquatic half-life
Photolysis
Biodegradability
Formamide
--Readily
12.1 Toxicity
Not available.
12.2 Persistence and degradability
Formamide
OECD 301A
Ready
Biodegradability DOC Die-Away
Test
99 % - Readily - 28 days
-
-
Product/ingredient name
Test
Dose
Result
Inoculum
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FP RNA Dilution Buffer, Part Number FP-6501-0003
Section 12. Ecological information
12.5 Other adverse effects
:
No known significant effects or critical hazards.
Soil/water partition
coefficient (KOC)
:
Not available.
12.4 Mobility in soil
Section 13. Disposal considerations
The generation of waste should be avoided or minimized wherever possible. Disposal
of this product, solutions and any by-products should at all times comply with the
requirements of environmental protection and waste disposal legislation and any
regional local authority requirements. Dispose of surplus and non-recyclable products
via a licensed waste disposal contractor. Waste should not be disposed of untreated to
the sewer unless fully compliant with the requirements of all authorities with jurisdiction.
Waste packaging should be recycled. Incineration or landfill should only be considered
when recycling is not feasible. This material and its container must be disposed of in a
safe way. Care should be taken when handling emptied containers that have not been
cleaned or rinsed out. Empty containers or liners may retain some product residues.
Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains
and sewers.
:
Disposal methods
Disposal should be in accordance with applicable regional, national and local laws and regulations. Local
regulations may be more stringent than regional or national requirements.
The information presented below only applies to the material as supplied. The identification based on
characteristic(s) or listing may not apply if the material has been used or otherwise contaminated. It is the
responsibility of the waste generator to determine the toxicity and physical properties of the material generated to
determine the proper waste identification and disposal methods in compliance with applicable regulations.
Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
for additional handling information and protection of employees.
13.1 Waste treatment methods
Section 14. Transport information
DOT / TDG / Mexico / IMDG /
IATA
:
Not regulated.
Special precautions for user
Transport in bulk according
to IMO instruments
Transport within user’s premises:
always transport in closed containers that are
upright and secure. Ensure that persons transporting the product know what to do in the
event of an accident or spillage.
:
Not available.
:
Section 15. Regulatory information
U.S. Federal regulations
Clean Water Act (CWA) 311
: Edetic acid
:
Clean Air Act Section 112
(b) Hazardous Air
Pollutants (HAPs)
:
Not listed
TSCA 8(a) PAIR
: Formamide
TSCA 8(a) CDR Exempt/Partial exemption
: Not determined
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
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FP RNA Dilution Buffer, Part Number FP-6501-0003
Section 15. Regulatory information
The following components are listed: FORMAMIDE
Massachusetts
:
California Prop. 65
Clean Air Act Section 602
Class I Substances
:
Not listed
Clean Air Act Section 602
Class II Substances
:
Not listed
DEA List I Chemicals
(Precursor Chemicals)
:
Not listed
DEA List II Chemicals
(Essential Chemicals)
:
Not listed
New York
:
None of the components are listed.
New Jersey
:
The following components are listed: FORMAMIDE
Pennsylvania
:
The following components are listed: FORMAMIDE
State regulations
SARA 302/304
SARA 304 RQ
:
Not applicable.
No products were found.
Composition/information on ingredients
SARA 311/312
Classification
:
EYE IRRITATION - Category 2A
CARCINOGENICITY - Category 2
TOXIC TO REPRODUCTION - Category 1B
SPECIFIC TARGET ORGAN TOXICITY (REPEATED EXPOSURE) - Category 2
International regulations
Chemical Weapon Convention List Schedules I, II & III Chemicals
Montreal Protocol
Not listed.
Stockholm Convention on Persistent Organic Pollutants
Not listed.
Rotterdam Convention on Prior Informed Consent (PIC)
Not listed.
UNECE Aarhus Protocol on POPs and Heavy Metals
Not listed.
Inventory list
Australia
:
All components are listed or exempted.
Canada
:
All components are listed or exempted.
This product does not require a Safe Harbor warning under California Prop. 65.
Formamide
≥50 - ≤75
EYE IRRITATION - Category 2A
CARCINOGENICITY - Category 2
TOXIC TO REPRODUCTION - Category 1B
SPECIFIC TARGET ORGAN TOXICITY (REPEATED EXPOSURE) - Category 2
Name
%
Classification
Composition/information on ingredients
Not listed.
10/11
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FP RNA Dilution Buffer, Part Number FP-6501-0003
Section 15. Regulatory information
China
:
All components are listed or exempted.
Europe
:
All components are listed or exempted.
Japan
:
Japan inventory (ENCS)
: All components are listed or exempted.
Japan inventory (ISHL)
: All components are listed or exempted.
Republic of Korea
:
All components are listed or exempted.
New Zealand
:
All components are listed or exempted.
Philippines
:
All components are listed or exempted.
Taiwan
:
All components are listed or exempted.
Turkey
:
Not determined.
United States
:
All components are active or exempted.
Thailand
:
Not determined.
Viet Nam
:
All components are listed or exempted.
Section 16. Other information
History
Date of issue
Version
Date of previous issue
:::
Indicates information that has changed from previously issued version.
Key to abbreviations
:
02/12/2021
10/08/2018
2
Notice to reader
Disclaimer: The information contained in this document is based on Agilent’s state of knowledge at the time of
preparation. No warranty as to its accurateness, completeness or suitability for a particular purpose is expressed
or implied.
Procedure used to derive the classification
Classification
Justification
EYE IRRITATION - Category 2A
Calculation method
CARCINOGENICITY - Category 2
Calculation method
TOXIC TO REPRODUCTION - Category 1B
Calculation method
SPECIFIC TARGET ORGAN TOXICITY (REPEATED EXPOSURE) - Category 2
Calculation method
ATE = Acute Toxicity Estimate
BCF = Bioconcentration Factor
GHS = Globally Harmonized System of Classification and Labelling of Chemicals
IATA = International Air Transport Association
IBC = Intermediate Bulk Container
IMDG = International Maritime Dangerous Goods
LogPow = logarithm of the octanol/water partition coefficient
MARPOL = International Convention for the Prevention of Pollution From Ships, 1973
as modified by the Protocol of 1978. ("Marpol" = marine pollution)
N/A = Not available
UN = United Nations
11/11
Date of issue :
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