Panasonic MCO-19AIC User Manual

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Page 1

Cell Culture CO2 and CO2/O2 Incubators

MCO-19AIC/UV/UVH MCO-19M/UV/UVH

Sterisonic GxP Series Cell Culture Incubators

Features:

• The industry’s most complete cell culture solution for highly regulated applications or conventional incubation.

• Safe, effective and documented 3 hour in situ H decontamination for the fastest cycle turn-around.

Panasonic… the new name for SANYO

www.panasonic.com/biomedical

2O2

Page 2

MCO-19AIC

MCO-19M MCO-19AIC(UV) MCO-19AIC(UVH)

MCO-19M(UV)

MCO-19M(UVH)

Sterisonic GxP Series Cell Culture CO2 and CO2/O2 Incubators

The industry’s most complete cell culture solution for highly regulated applications or conventional incubation. Now with safe, effective and documented 3 hour in situ H fastest turn-around and maximum availability.

Sterisonic GxP Selection

Feature

H2O2 Vapor Decontamination Standard Optional Optional Standard Optional Optional

SafeCell UV Decontamination Standard Standard Optional Standard Standard Optional

Single Beam, Dual Detector IR CO

Solid Zirconia O

Control N/A N/A N/A Standard Standard Standard

Sensor Standard Standard Standard Standard Standard Standard

MCO-

19AIC(UVH)

CO2 Incubators CO2/O2 Incubators

MCO-

19AIC(UV)

MCO19AIC

decontamination for the

2O2

MCO-

19M(UVH)

MCO-

19M(UV)

MCO-

19M

Product Applications

The combination of Sterisonic GxP incubator performance functions permit use with condence in high-value cell protocols among hard-to-grow cell lines, cells highly sensitive to contamination and vibration, ultra-sensitive media and reagents, or protocols that require a strict isolation and decontamination between processes. These include but are not limited to:

• Stem cell research

• Autologous tissue regeneration

and regenerative medicine

• In vitro fertilization

• Genomic and proteomic expression

• Esoteric plant and amphibian

cell culture

• Hypersensitive and transgenic

cell culture

• Low media volume microplate work

MC O -19AIC (UV H)

Designed for use with a variety of standard cell culture vessels and protocols.

• Interior components and adjustable shelves are congured for easy access, in situ decontamination and exible arrangement for a variety of applications.

• Four adjustable shelves are included standard; maximum shelf capacity is 15 shelves.

MC O -19 M

Multi-Gas Incubator, Oxygen and CO2 Control

Ideal for in vitro fertilization (IVF), genetic research, regenerative medicine and other protocols that require CO (hypoxic) or above-ambient oxygen control.

and sub-ambient

2 Sterisonic GxP Series Cell Culture Incubators

Page 3

Sterisonic GxP Features and Benets

The Panasonic Sterisonic GxP is designed for a wide array of demanding and highly regulated applications in the biomedical, pharmaceutical, medical research and clinical laboratory. Representing years of research, development and component testing, the Sterisonic GxP incorporates a collective of mutually functional systems and design attributes to offer a holistic solution to cell culture protocols, from the most sophisticated to more familiar and conventional processes.

Decontamination System

• The unique Sterisonic GxP H2O2 decontamination system limits downtime to less than three hours when total chamber decontamination with verication is desired.

• All interior components and CO sampling loop are decontaminated in situ; no need for removal and autoclaving.

• Active Background Contamination Control ghts contamination while cell culture protocols are in process.

The patented SafeCell

system scrubs interior airow to destroy airborne and humidity pan contaminants.

Exclusive inCu-saFe

enriched stainless steel interior surfaces assure constant germicidal protection.

Shelf brackets are formed with an exaggerated angle to minimize surface contact with at shelves*.

copper-

Control and Monitoring

• The Sterisonic GxP control and information center includes an intuitive popup menu, high resolution LCD for inputs, outputs and performance at-a-glance.

• Multi-point data logging offers push-button graphical display. An optional PC interface permits remote transmission for GMP/GLP protocols as required.

• Precise PID logic controls and adjusts to all temperature, CO

set-

points and alarm parameters.

CO2 Control

Panasonic proprietary singlebeam, dual detector infrared (IR2)

sensor delivers precise CO2 control,

quick recovery following door openings, and auto sampling with no moving parts.

• Continuous zero calibration is standard.

• An optional semi-automatic, one-point calibration system is available. Catalog No. MCO-SG; see accessories.

Zirconia O2 Control System, MCO-19M Series

A zirconia oxygen sensor main-

tains sub-ambient O 1% to 18%. Additionally, enriched O levels from 22% to 80% are enabled with proper safety precautions.

• Concurrently the MCO-19M permits

a CO

range 0% to 20% via infrared

sensor.

• Nitrogen gas bubbler accelerates

recovery of chamber humidity levels following door openings.

• An electronic P.I.D. control maintains

accurate temperature and gas setpoints over the entire system range.

• The MCO-19M includes an automatic

gas switchover system that changes from the primary to a secondary gas cylinder for either oxygen or nitrogen; an optional second gas switchover system is available for CO

• Cabinet based on MCO-19 platform

with inCu-saFe

copper-enriched stainless steel chamber, continuous contamination control, patented D.H.A. multi-point, air-jacketed temperature control system, elevated relative humidity with integral water-level sensor.

levels from

MC O-19 M

MCO-19M shown with four separate inner doors with gaskets.

Page 4

Sterisonc GxP Features and Benets

Temperature and Humidity Control

• The patented Direct Heat and Air Jacket heating system manages setpoint temperature through multiple, variable warming points under microprocessor control.

• The humidity pan is easy to ll, easy to clean; the automatic optical sensor advises of low water level.

H2O2 Decontamination

The use of H2O2 decontamination in biological safety cabinets and barrier isolators is a popular alternative to ethylene oxide (EtO) as a safer, more efcient decontamination method.

has long been widely used in the

2O2

pharmaceutical industry. In aerospace research, H satellites and cleanrooms.

is used to decontaminate

2O2

Unlike conventional incubators, unique features of the Panasonic Sterisonic GxP incubator permit use of the H process in situ with complete safety, zero impact on adjacent equipment or the environment, and speed to return the incubator to service.

• The H

decontamination process

2O2

functions with the patented Panasonic SafeCell UV system. Following a seven-minute H circulation and dwell cycle, vaporization is stopped and the SafeCell UV lamp turned ON for up to ninety minutes.

• When exposed to UV light, the H vapor breaks down into water and oxygen, leaving only traces of water droplets. These droplets automatically condense onto a cooler section of the interior oor for easy wipe-up.

• Throughout the entire cycle the Sterisonic GxP airow system continues to gently circulate interior air assuring 100% vapor contact with all interior surfaces, ultimately creating a serial dilution of H over the UV lamp.

vaporization,

2O2

as it passes

2O2

• Orientation of interior sample ports of the single beam, dual detector IR CO

sensor creates a slight Venturi

ow through the sample chamber, permitting total decontamination of the CO

system at the same time.

• Shape and location of interior components such as shelves, shelf brackets, plenum covers and the humidity pan permit the components to remain in the chamber during the decontamination process, conveniently bypassing the need for a separate autoclave cycle.

• Once the cycle is complete, the door locking system is released; the inner door can be opened, interior components repositioned and the incubator is returned to service.

Ergonomic Cabinet Design

With reversible inner and outer doors, a single Panasonic incubator offers the industry's most exible installation options available.

• Low prole cabinet with door-mounted control panel permits easy access and viewing.

• The outer door latch and door heater cable is easily switched if a reverse opening is required.

Sterisonic GxP Series H2O2 Decontamination Performance Value

3 Hours

Panasonic Sterisonic

H2O

decontamination vs. high heat decontamination

= Uptime (Hours)

The documented a 3 hour in situ H2O2 sequence puts the fully decontaminated Sterisonic GxP available and ready for use quicker than any other incubator worldwide.

4 Sterisonic GxP Series Cell Culture Incubators www.panasonic.com/biomedical

Brand X

Downtime (Hours)

14 Hours

Page 5

Sterisonc GxP Features and Benets

• Cabinet knock-outs are pre-drilled and tapped to eliminate drilling and to simplify re-mounting of door hardware.

• The heated outer door closes against a soft, easily cleaned magnetic gasket designed to eliminate ambient air shear across the glass inner door, minimizing condensation.

• A door ajar alarm provides an audible and visual warning if the outer door is left open.

• A center-mounted key lock is located beneath the door for added security. (Model MCO-19AIC(UVH) only)

Shelves and Inventory Management

Convenient space efcient inventory management is simplied through a system of adjustable, extendable shelves.

• Inventory shelves and brackets are formed from polished copperenriched stainless steel, removable without tools, and can remain inside the incubator during the H decontamination cycle or autoclaved separately if desired.

2O2

• Shelves are perforated to permit natural vertical air convection through and around labware.

• Shelf brackets are formed with an exaggerated angle to minimize surface contact with at shelves. Brackets slip easily into vertical supports that attach to interior chamber walls with clearance sufcient to permit proper air circulation.

Inner Door and Gasket

The inner design is critical to successful contamination control technique.

• The inner gasket body forms an effective thermal transition between the ambient air and warm, humidied incubator atmosphere, minimizing condensation and eliminating moisture traps which can harbor contaminants.

• The inner door gasket is a dual durometer extrusion (two levels of softness) from closed-cell silicone to inhibit contamination.

• The gasket feather-edge allows the inner glass door to close gently against the chamber opening for a tight peripheral seal.

MCO-19AIC(UVH) Double Stack Option

Stacking Doubles Capacity in Same Footprint.

• The Sterisonic GxP cabinet is designed for stacking, allowing one unit to be positioned on top of another, doubling interior volume without additional oor space.

• The combination of stacking and reversible doors offers the most installation options possible.

• An optional roller base is recommended for stacked installations to permit mobility if required; see accessories.

• The entire inner door gasket is removable for cleaning and/or replacement if required.

• Radiant heat from the outer door, apportioned by the microprocessor control as a function of the patented Direct Heat and Air Jacket heating cycle, automatically warms the inner door glass in proportion to total heat demand and condensation control.

Field Reversible Door

The eld-reversible door allows universal installation using the left-hand hinge (standard) or a right-hand hinge modication

• The outer door includes a universal nger grip at each side.

• Mounting holes for hinge hardware are pre-drilled and capped with easily removable trim plugs.

Elevated Humidity, Low Water Level Warning

To avoid cell culture desiccation, the Panasonic Sterisonic GxP CO maintains ~95% RH at 37°C.

• Humidication is achieved by a combined forced-air and natural evaporation method enhanced by the Direct Heat and Air Jacket heating system base heater, and protected by an optical water level indicator to warn of low water in the removable humidity pan.

• The humidity pan removes easily for regular cleaning and rell.

• When lled, the pan slides into place. The optical sensor returns to position and the SafeCell UV lamp destroys contaminants introduced during the process.

• For the H

in situ decontamination

2O2

cycle the humidity pan is repositioned against the chamber wall to eliminate the need for separate autoclaving.

incubator

Page 6

Sterisonic GxP Control System

Intelligent interface through integrated LCD control with graphical display — The Sterisonic GxP incubator is managed by an integrated microprocessor controller with LCD graphical display to simplify all incubator functions. Stable temperature and humidity conditions are achieved through a combination of performance systems supervised by the controller complete with alarm, programming, calibration and diagnostic protocols.

Control Features

• The Sterisonic GxP control and information center includes an intuitive pop-up menu, high resolution LCD for inputs, outputs and performance at-a-glance.

• Multi-point data logging offers pushbutton graphical display. An optional PC interface permits remote transmission for GMP/GLP protocols as required.

• Selected performance histories can be acquired in graphical format for easy interpretation.

• Precise PID logic controls and adjusts to all temperature and CO

setpoints

and alarm parameters.

• A range of setpoint, alarm and programmable inputs are established through pop-up menus and function keys.

• Standard parameters are factory-set for quick start-up, and all parameters can be changed as required.

• Logged parameters can be exported to remote databases, off-site alarm or data capture systems through optional communications board for compliance monitoring; see accessories.

• A remote alarm terminal mounted at the rear of the cabinet can be connected to an external alarm system.

• Tactile feedback, touch pad data shift and entry keys simplify operation.

• The control panel is center mounted in the outer door for easy access and viewing.

Decontamination Cycle

The H2O2 decontamination cycle is monitored for safety and cycle status. A physical interlock and neutralization sequence assures total decontamination and operator safety.

Start Cycle: When the H2O2 button is pressed a conrming message prompts the user to proceed with the decontamination cycle or cancel.

H2O2 Vapor Cycle: Once the door locks automatically, the cycle starts. The ashing H2O2 display conrms the process and counts down remaining H2O2 vaporization time.

UV Resolution: The H2O2 atomizer automatically completes after a 10 minute cycle. UV lamp comes ON. The ashing UV Resolve display counts down remaining time in the UV cycle as H2O2 is reduced to water and trace oxygen.

Cycle Complete: When the cycle is complete the door lock releases automatically. The H2O2 atomizer and cable can be disconnected and removed and all interior components restored to their normal position.

Sterisonic GxP H202

Decontamination Cycle

(3 Hours, total)

Elapsed Time:

Conventional High Heat

Decontamination

(24 Hours, total)

Decontaminate: 10 min.

Panasonic H2O2 atomizer creates vapor which is

circulated throughout chamber by interior blower.

PREP: 15 min.

Reposition shelves, humidity pan and plenum inside Panasonic chamber. Interior surfaces are exposed.

Start Cycle: 30 min.

Press H2O2 start button. Chamber warms to 45˚C.

15 min. 30 min. 45 min. 1 2

Resolve: 90 min.

UV lamp glows for 90 minutes, reducing H2O2 to harmless water droplets.

Finish.

Shelves, humidity pan and plenum are returned to operating position.

4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24

PREP: 15 min.

Remove interior components sensitive to high heat.

Start Cycle: 90 min.

Interior chamber elevates to high heat.

Decontaminate: 14 hours

Interior chamber remains at high heat.

6 Sterisonic GxP Series Cell Culture Incubators www.panasonic.com/biomedical

Page 7

Sterisonic GxP Control System

• Digital alphanumeric LCD display.

• Message display

• Pop-up menu

• Visual alarm indicator

decontamination sequence

• H

2O2

start key

• Menu call button

• Display contrast adjustment

• Positive feedback tactile

input buttons

• Positive feedback tactile

entry and function keys

Finish.

Incubator must cool from high heat temperatures to near ambient.

Page 8

Sterisonic GxP Design and Technology

All Panasonic CO2 incubators feature patented Direct Heat and Air Jacket heating system temperature control for accurate, uniform temperature control and inCu-saFe® for continuous contamination control. Panasonic laboratory CO2 incubators feature selected SafeCell UV with exclusive, patented Active Background Contamination Control.

Direct Heat and Air Jacket Heating System

Zone Location Function Energy Microprocessor Controller

Main (Red)

Base (Yel low )

Side, top and rear walls Dominant heat source Variable

Floor

Base heater elevates the humidity reservoir to achieve 95% RH at 37 °C

Variable

Energizes any, all or

in combination of heating

elements as required.

Front (Green)

Air Jacket (White)

Insulation (Gray)

Outer door

Side, top and rear walls

Side, top and rear walls, door

Direct Heat and Air Jacket Heating System

The patented Direct Heat and Air Jacket heating system surrounds the inner walls with a natural convection airow that converts to radiant wall heat through thermal conduction to achieve accurate, uniform and highly responsive temperature control within the chamber.

• The microprocessor controller directs proportional distribution of power to independent heating sources surrounding the chamber.

• Arranged in three zones, these sources include the side, top and rear walls, the chamber base and the outer door.

• Each zone is controlled by the microprocessor which manages continuous feedback from the incubator chamber sensors.

Warms the inner glass in response to ambient conditions; eliminates condensation on glass and around the opening and promotes temperature uniformity

Sealed. Surrounds interior chamber with natural air convection and promotes chamber wall uniformity

Promotes energy efciency, mitigates effect of ambient temperature uctuations on air jacket

The patented Direct Heat and Air Jacket heating system distributes proportional energy to the interior chamber through a natural convection air jacket surrounded by a high density insulation to protect against ambient temperature uctuations

Variable

– –

H2O2 Decontamination

The unique Sterisonic GxP H2O2

decontamination system limits downtime to less than three hours when total chamber decontamination is desired.

• All interior components and CO

sam-

pling loop are decontaminated in situ; no need for removal and autoclaving and no component stress associated with high heat cycles.

• Available as standard on the

MCO-19AIC(UVH) and MCO-19M(UVH); optional on the MCO-19AIC(UV) and MCO-19M(UV).

• Following decontamination, Panasonic

Active Background Contamination Control ghts contamination while cell culture protocols are in process.

SafeCell UV System

Sterisonic GxP Models –UVH and

–UV include SafeCell UV contamination control technology based on an integrated combination of narrow bandwidth, ozone-free ultraviolet light, reliable ceramic infrared CO enriched stainless steel alloy interiors and Direct Heat and Air Jacket heating managed by a microprocessor controller.

control, inCu-saFe® copper-

8 Sterisonic GxP Series Cell Culture Incubators www.panasonic.com/biomedical

Page 9

Sterisonic GxP Design and Technology

These incubators offer the industry's most stable cell culture environment and are useful for the most critical applications where continuous contamination control is essential to cell viability. Panasonic SafeCell UV Series CO

incubators offer signicant economic benets by minimizing interruptions for decontamination, by improving cell culture growth and expression under stable, repeatable conditions, and by minimizing the potential for product loss.

• SafeCell UV includes a programmable ultraviolet lamp, isolated from cell cultures, that decontaminates conditioned air and humidity reservoir water to prevent contamination without affecting cell cultures in vitro.

• SafeCell UV inhibits the growth of mycoplasma, bacteria, molds, spores, yeasts and fungi without costly HEPA lter air scrubbers which accumulate contaminants in the lter media HEPA lters are also ineffective on particles less than 0.3 microns.

• High temperature decontamination systems, which can actually encourage in vitro growth of heat resistant thermophilic and hyperthermophilic microorganisms, are avoided, thus eliminating key component stress.

• inCu-saFe

interior surfaces provide

natural resistance to contamination.

• The SafeCell UV lamp reduces H

2O2

to trace sterile water condensate following the ten-minute vapor decontamination process.

Dual Wavelength Infrared CO2 Control System

The Panasonic single beam, dual detector infrared CO unprecedented control accuracy and stability by simultaneously measuring two wavelengths.

The chamber sample and a reference is congured around a ceramic-based sensor linked to the microprocessor controller with a sophisticated P.I.D. (proportional, integral and derivative) algorithm. Benets include ultra-fast recovery

system offers

without overshoot and accurate CO

aver-

ages during periods of frequent incubator access with multiple door openings.

• The light frequency based technique is impervious to changes in temperature and relative humidity, highly stable during door openings, and sensitive to restoration of setpoint equilibrium when the door is closed.

• The sensor maintains a continuous auto-zero function for accuracy.

• Actual CO

is displayed on the main

control panel.

• A CO

sample port mounted on the

incubator front permits convenient conrmation of chamber CO

• An optional automatic CO

density.

switchover

system is available (see Accessories). A two-stage regulator from the supply cylinder to the incubator is required (see Accessories).

MCO-19M Series Multi-Gas Performance O2 Control System

In addition to precise CO control, the MCO-19M Series incubator delivers exceptional O

control in support

of cell culture processes which require below-ambient or above-ambient oxygen levels. These include in vitro fertilization (IVF), gene research, regenerative medicine, hypoxia research and emerging applications that are sensitive to oxygen levels other than ambient.

• A solid zirconia oxygen sensor main-

tains sub-ambient O

levels from 1%

to 18%. Additionally, enriched O from 22% to 80% are enabled with proper safety precautions.

• Concurrently the MCO-19M permits

a CO

range 0% to 20% via infrared

sensor.

• Nitrogen gas bubbler accelerates

recovery of chamber humidity levels following door openings.

• An electronic P.I.D. control maintains

accurate temperature and gas setpoints over the entire system range.

levels

• The MCO-19M includes an automatic gas switchover system that changes from the primary to a secondary gas cylinder for either oxygen or nitrogen; an optional second gas switchover system is available for CO

• Cabinet based on MCO-19 platform with inCu-saFe

InCu-saFe® Construction for Germicidal Protection

Panasonic offers exclusive use of inCu-saFe less steel alloy interior surfaces within a technical design created to eliminate contamination sources and to mitigate the effect of airborne contaminates introduced through normal use.

• Selected to provide natural germicidal

protection without rust or corrosion, inCu-saFe micidal attribute to inhibit the growth of molds, fungi, mycoplasma and bacteria.

• All interior components, including

the air management plenum, shelf supports, humidity pan and blower wheel assembly are easily removable without tools if required.

• During the H

cycle interior components can be repositioned within the chamber for in situ decontamination.

• When components are removed, all

interior surfaces are exposed for conventional wipe down.

• Large curve corners and electropol-

ished surfaces are easy to clean.

• Pass thru ports accommodate probes

or instrumentation leads as required for specialized cell culture protocols. Each chamber includes a port positioned in the interior, rear wall, upper left, with dual, non-VOC silicone stoppers inside and outside the cabinet for added protection.

copper-enriched stain-

expresses a natural ger-

decontamination

2O2

Page 10

Sterisonic GxP Design and Technology

Ozone ReleasePanasonic Lamp Germicidal Effect Eye Sensitivity Sunlight

Active Background Contamination Control

A continuous Active Background Contamination Control process eliminates contamination without downtime.

At the base of the plenum an isolated beam of high intensity, ozone-free ultraviolet light destroys contaminants in the air and in the humidity water reservoir, away from active cell cultures.

SafeCell UV Lamp Program Cycles

Mode Function

After H2O Vaporization

After Door Opening

OFF If UV protection is not desired.

24 Hour Continuous ON

The UV lamp automatic ally cycles ON for up to 90 minutes following the ten- minute H

vapor cycle, reducing the H onto a naturally cooler section of the interior oor for easy wipe -up.

UV lamp automatically ON for ve minutes after door is closed decontaminates incoming room air.

Useful for overnight decontamination prior to rst use, clinical decontamination protocols between patients, or following total chamber wipe-out af ter maintenance or ser vice.

to water droplets. These droplets automatically condense

2O2

• Contaminants trapped within the distilled water pan are destroyed by ultraviolet light.

• Decontaminated, humidied air is released from the lower plenum for vertical convection through and around the perforated shelves. Interior air motion is suspended when the door is opened, minimizing movement of room air contaminants into the chamber.

• UV light is isolated by the plenum cover to protect cell cultures

• Airborne contaminants are eliminated by an automatic UV cycle that automatically turns ON for a specied period after each door opening.

• Trace contaminants that attach to interior surfaces are destroyed by the passive germicidal properties of the inCu-saFe

surfaces.

The SafeCell UV lamp cycle is factory set for normal use, and can be re-programmed as desired by entering parameters through the central microprocessor control panel. Program parameters for the H2O2 decontamination cycle are nonadjustable for operator safety.

Mycoplasma Survival Results

Mycoplasma Strain

Mycoplasma fermentans PG18

Mycoplasma orale CH19299

Mycoplasma arginini G230

Mycoplasma hominis PG21

Chart summarizes test results with four strains of mycoplasma. Results demonstrate how Panasonic inCu-saFe® copper enriched stainless steel alloy offers germicidal properties of conventional C1100 copper while maintaining both corrosion-proof and discoloration-resistant properties of conventional Type 304 stainless steel. Detailed test results are available from Panasonic.

Positive Control

survival no survival no survival survival

Conventional Type

304 Stainless Steel

Panasonic

InCu-saFe

Conventional

Copper C1100

10 Sterisonic GxP Series Cell Culture Incubators www.panasonic.com/biomedical

Page 11

Sterisonic GxP Specications

Sterisonic GxP Series Energy, Electrical and Utilties

MCO-19AIC-PA

Description

Maximum Power Consumption 310W 310W

Maximum Heat Discharge 1062 BTU/HR 1062 BTU/HR

Electrical Connection 115V,60Hz, 1 phase, NEMA 5 -15P plug provided; 115V,60Hz, 1 phase, NEMA 5 -15P plug provided;

Gas Connection ¼" Barb Fitting ¼" Barb Fitting

CO2 Gas Input Pressure Nominal 5 psi from two -stage CO2 regulator Nominal 5 psi from two-stage CO2 regulator

CO2 Gas Cylinder Switchover System Optional Optional

O2 Control System N/A Microprocessor PID, Zirconia Sensor

O2 Range and Variation N/A 1-18%, 22-8 0%

N2/O2 Inlet Connect/ Pressure N/A Nominal 7 psi from two-stage regulator

N2/O2 Switchover System N/A Standard

MCO-19AICUV-PA

MCO-19AICUVH-PA

MCO-19M-PA

MCO-19MUV-PA

MCO-19MUVH-PA

Sterisonic GxP Series Dimensions, Weights and Capacities

Model Number

MC O-19AI C -PA MCO-19AIC(UV)-PA MCO-19AIC(UVH)-PA

MC O-19 M-PA MC O-19 M(UV ) - PA MC O-19 M(UV H)- PA

Volume

(cu.ft.)

6.0

170 L

6.0

170 L

Exterior Dimensions

(w x f-b x h)

24.4" x 27.9" x 35.4"

620 x 710 x 900 mm

24.4" x 27.9" x 35.4"

620 x 710 x 900 mm

Interior Dimensions

(w x f-b x h)

19.3" x 20.6" x 26 .2"

490 x 523 x 665 mm

19.3" x 20.6" x 26 .2"

490 x 523 x 665 mm

Shelves Net Weight

15 max / 4 supplied std.

17.7" x 17.7" (15.4 lbs capacity)

450 x 450 mm (7 kg capacity)

15 max / 3 supplied std.

17.7" x 17.7" (15.4 lbs capacity)

450 x 450 mm (7 kg capacity)

(nominal)

205 lbs

93 kg

207 lbs

94 kg

4.5"

(115 mm)

4.9" (125 mm)

FRONT SIDE

24.4" (620 mm)

19.3" (490 mm)

22.8" (580 mm)

26.2" (665 mm)

34.6" (880 mm)

0.8" (20 mm)

24.8" (630 mm)

20.6" (523 mm)

18.4" (469 mm)

3.1"

(80 mm)

1.9" (49 mm)

1.3" (34 mm)

1.7" (44 mm)

Page 12

Sterisonic GxP CO2 Series Specications

Sterisonic GxP CO2 Incubators

Description

Model Number MCO-19AICUVH-PA MCO-19AICUV-PA MCO-19AIC-PA

Major Operating Systems

Decontamination System Standard Optional Optional

2O2

SafeCell UV System Standard Standard Optional

Single Beam, Dual Detector IR CO

inCu-saFe

Copper Enriched Stainless Steel Interior Standard Standard Standard

LCD Graphical Controller/ Display, Door Mounted Standard Standard Standard

Direct Heat, Air (DHA) Air Jacket Standard Standard Standard

Decontamination

Decontamination System Vaporization in situ Optional Optional

2O2

Interior UV Lamp, Programmable, Ozone Free Standard Standard Optional

Copper Enriched Stainless Steel Interior with Germicidal Protection

Environmental Performance

Temperature Control Range +5ºC above ambient to 50°C

Temperature Control Uniformity Deviation ±0.25ºC (in 25ºC ambient, setting 37 ºC, 5% CO

Control Range and Deviation 0% to 20%, ±0.15% in 25ºC ambient, setting 37º C, 5% CO2, no load

Sensor Platform

Calibration Single point zero automatic; semi- automatic one point span @ reference optional.

Airow Gentle vertical air ow, continuous with inner door closed.

Interior Humidity 95%RH @ 37°C through evaporation via DHA heating system; reective optical low water sensor.

Sensor Standard Standard Standard

Standard Standard Standard

, no load)

Ceramic based, single beam, dual wavelength measurement

of actual vs. contrast, with continuous auto-zero calibration.

Control, Monitoring, Alarm

Temperature and CO

Control P.I.D., setpoint resolution 0.1% and 0.1°C

Display Alphanumeric LCD digital display messaging.

Data Acquisition Data Acquisition Automatic log function of temperature and CO

Communications

Optional PC interface, Catalog No. MTR- 4 80 with RS232/RS4 85 data ports available

Remote alarm contacts standard. Optional 4-20mA connection.

Cabinet Design and Construction

Interior, Shelves 4, Copper-enriched stainless steel.

Inner Door Tempered glass.

Insulation Rigid foam polyurethane.

Outer Door Reversible, heated.

Access Port Single opening with interior and exterior 1.18" (30 mm) silicone stoppers.

Leveling Feet 4, adjustable.

12 Sterisonic GxP Series Cell Culture Incubators www.panasonic.com/biomedical

Page 13

Sterisonic GxP CO2/O2 Series Specications

Sterisonic GxP CO2/O2 Incubators

Description

Model Number MCO-19MUVH-PA MCO-19MUV-PA MCO-19 M - PA

Major Operating Systems

Decontamination System Standard Optional Optional

2O2

SafeCell UV System Standard Standard Optional

Single Beam, Dual Detector IR CO

inCu-saFe

Copper Enriched Stainless Steel Interior Standard Standard Standard

LCD Graphical Controller/ Display, Door Mounted Standard Standard Standard

Direct Heat, Air (DHA) Air Jacket Standard Standard Standard

Decontamination

Decontamination System Vaporization in situ Optional Optional

2O2

Interior UV Lamp, Programmable, Ozone Free Standard Standard Optional

Copper Enriched Stainless Steel Interior with Germicidal Protection

Environmental Performance

Temperature Control Range +5ºC above ambient to 50°C

Temperature Control Uniformity Deviation ±0.25ºC (in 25ºC ambient, setting 37 ºC, 5% CO

Control Range and Deviation 0% to 20%, ±0.15% in 25ºC ambient, setting 37º C, 5% CO2, no load

Sensor Platform

Calibration Single point zero automatic; semi-automatic one point span at reference (optional).

Control Range and Deviation 1-18%, 22-80%, ±0.2% in 25º C ambient, setting 37º C, no load

Sensor Platform Zirconia sensor, microprocessor P.I.D. control

Airow Gentle vertical air ow, continuous with inner door closed.

Interior Humidity 95%RH @ 37°C through evaporation via DHA heating system; reective optical low water sensor.

Sensor Standard Standard Standard

Standard Standard Standard

, no load)

Ceramic based, single beam, dual wavelength measurement

of actual vs. contrast, with continuous auto-zero calibration.

Control, Monitoring, Alarm

Temperature and CO

Control P.I.D., setpoint resolution 0.1% and 0.1°C

Display Alphanumeric LCD digital display messaging.

Data Acquisition Data Acquisition Automatic log function of temperature and CO

Communications

Optional PC interface, Catalog No. MTR- 4 80 with RS232/RS4 85 data ports available

Remote alarm contacts standard. Optional 4-20mA connection.

Cabinet Design and Construction

Interior, Shelves 3, Copper-enriched stainless steel.

Inner Door 4 separate, gasketed inner doors, tempered glass

Insulation Rigid foam polyurethane.

Outer Door Reversible, heated.

Access Port Single opening with interior and exterior 1.18" (30 mm) silicone stoppers.

Leveling Feet 4, adjustable.

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Sterisonic GxP CO2 Series Accessories

Panasonic Biomedical products include a broad range of accessories to meet specic application requirements. For accessories or options not listed herein, contact Panasonic or your authorized Panasonic sales representative.

Sterisonic GxP CO2 Series Incubators

Model Number MCO-19AICUVH-PA MCO-19AICUV-PA MCO-19AIC-PA

Catalo g No. Catalog No. C atalog No.

Decontamination K it Built-in MCO-HL N / A

2O2

Vapor Atomizer MCO-HP- PW N/A N / A

2O2

Reagent (Formulated for Panasonic Sterisonic GxP) MCO- H2O2-PV N/A N / A

2O2

Automatic CO

Gas Calibration System, semi-automatic one point calibration function. MCO-SG-PW MCO-SG-PW MCO-SG-PW

Cylinder Regulator, CGA tting 320 M CO -100L MCO-10 0 L MCO-10 0 L

Roller Base. For use in single or stacked installations. MCO-18 RB- P W MCO -18RB- P W MCO-18 RB- P W

inCu-saFe

Integrated Cooling Option MCO-CL MCO-CL MCO-CL

Communications Port. Located at rear of chamber. Connector, cable and software not supplied.

Communications Port. Located at rear of chamber, analog 4 -20 mA . MCO- 420MA-PW MCO-420MA-PW MCO-420MA-PW

SafeCell UV System Kit Narrow -bandwidth 253.7nm lamp and assembly. Built-In Built-In MC O -19U VS

Cylinder Switchover System M CO-21G C-P W MCO-21G C-PW MCO-21G C-PW

Shelf and Brackets. Includes two shelf brackets. Full shelf M CO -47ST- PW M CO - 47ST- P W M CO - 47ST-P W

Half Tray System MCO -25ST- PW MCO-25S T-P W MCO -25ST- PW

MTR-480-PW MTR-480-PW MTR- 480-PW

H2O2 Reagent (MCO-H2O2-PV)

Panasonic H2O2 solution is specially formulated for optimal use with the MCO-HP atomizer. Each premeasured bottle is sufcient for a complete H2O2 decontamination sequence. Unit of issue: six per carton.

H2O2 Vapor Atomizer (MCO-HP-PW)

Shown with connecting cable, standard.

Integrated Cooling Coil (MCO-CL)

Factory installed; specify when ordering. Water bath/ circulator not included. Permits stable operation at ambient or below ambient temperatures. Extends performance specications as follows:

• Temperature Range: +18°C to +50°C, distribution

±0.25°C, variation ±0.1°C.

• Relative Humidity: +5ºC above ambient to +50ºC, 95%

± 5%RH; 20ºC to 25ºC > 80%RH; 18ºC > 70%RH Includes temperature mapping results for individual unit per serial number.

Relative Temperature Performance

+50ºC +50ºC

With

Cooling Coil

+18 ºC

Without

Cooling Coil

+5ºC over

Ambient

Ambient Temperature +24ºC

14 Sterisonic GxP Series Cell Culture Incubators www.panasonic.com/biomedical

Page 15

Sterisonic GxP CO2/O2 Series Accessories

Sterisonic GxP CO2/O2 Series Incubators

Model Number MCO-19MUVH-PA MCO-19MUV-PA MCO-19M-PA

Catalo g No. Catalog No. C atalog No.

Decontamination K it Built-in N/A N / A

2O2

Vapor Atomizer MCO-HP- PW N/A N / A

2O2

Reagent (Formulated for Panasonic Sterisonic GxP) MCO- H2O2-PV MCO-H2O2-PV N / A

2O2

Automatic CO

Gas Calibration System, semi-automatic one point calibration function. MCO-SG-PW MCO-SG-PW MCO-SG-PW

Cylinder Regulator, CGA tting 320 M CO -100L MCO-10 0 L MCO-10 0 L

Cylinder Regulator, CGA tting 5 80 (for low oxygen applications) MCO -10 0N MC O -100N MCO -10 0N

Cylinder Regulator, CGA tting 5 40 (for high oxygen applications) MCO-10 0 M MCO-10 0 M MCO-100M

Roller Base. For use in single or stacked installations. MCO-18 RB- P W MCO -18RB- P W MCO-18 RB- P W

inCu-saFe

Integrated Cooling Option (separate recirculating refrigerated water bat required)

Communications Port. Located at rear of chamber. Connector, cable and software not supplied.

Communications Port. Located at rear of chamber, analog 4 -20 mA . MCO- 420MA-PW MCO-420MA-PW MCO-420MA-PW

SafeCell UV System Kit Narrow -bandwidth 253.7nm lamp and assembly. Built-In Built-In MC O -19U VS

Cylinder Switchover System M CO-21G C-P W MCO-21G C-PW MCO-21G C-PW

Shelf and Brackets. Includes two shelf brackets. Full shelf M CO -47ST- PW M CO - 47ST- P W M CO - 47ST-P W

Half Tray System MCO -25ST- PW MCO-25S T-P W MCO -25ST- PW

MCO-CL MCO-CL MCO-CL

MTR-480-PW MTR-480-PW MTR- 480-PW

Integrated Cooling Option

Feature

Temperature Range +18ºC to + 50 ºC, distribution ± 0.25ºC, variation ± 0.1ºC

Relative Humidity

Components Stainless Steel Cooling Coil, Interconnection Lines, 6 L, Refrigerated Water Bath & Circulator ( Optional /Not Provided)

+5º C above ambient to +50ºC, 95% ± 5%R H; 20 ºC to 25ºC > 80% RH; 18ºC > 70%RH

Includes temperature mapping results for individual unit per serial number

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Service and Technical Support

Unique Panasonic Services

• On-site consultation

• Specialized documentation for each individual unit

• Customized testing procedures based on personalized customer requirements

Panasonic Connect

Panasonic’s customer-driven biomedical service program guarantees local attention from qualied Panasonic service representatives, whenever and wherever you need it.

• New Unit Installation and Training

• Preventative Maintenance

• Warranty and Non-Warranty Repairs

• Calibration/Validation Services

• Refurbishment and Reconditioning

• Customized Service and Warranty Programs

• In-Stock Parts for Immediate Delivery

Predelivery and On-Site Services

Predelivery services include factory acceptance testing, calibration, and temperature mapping. On-site services include installation qualication, operational qualication, performance qualication, calibration and temperature mapping.

Product conforms to RoHS (European Restriction of Hazardous Substance directives)

Panasonic Healthcare Company of North America

1300 Michael Drive, Suite A, Wood Dale, IL 60191 Toll Free USA (800) 858-8442, Fax (630) 238-0074 www.panasonic.com/biomedical