Leica EM RAPID User Manual
Leica EM RAPID
Pharmaceutical Milling System for Pills
2
Leica EM RAPID for Pharmaceutic
The Leica EM RAPID milling system has been designed for preparation of pills and tablets prior to investigation with NIR spectrophotometry for Research on Active Pharmaceutical Ingredient
Dispersal. With a tungsten carbide or diamond milling tool, pills
can be decapsulated and milled without any smearing effect
caused by the pills’ coating.
The operating concept of the Leica EM RAPID offers versatile features which are directly converted into user benefits to achieve
maximum ease of use and optimal results.
Perpendicular view showing
graticule for distance definition –
optional
Processing observation
Front face observation
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Leica Design by W. Hölbl
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al Surface Preparation
■ Decapsulation of pills without smearing effect
■ Adjustable cutting speed between 300–20.000 rpm
■ Defined layer removal in steps of 0.5, 1, 10 or 100 μm
■ Brilliant ring LED top light and optimised back light
illumination
■ Low noise extraction and filtration unit with Hepa-filter
Image b
Image c
Image a
Visible (a), derived single component IR image (b)
from tablet surface and (c) composite image from
3 major components
Courtesy of Perkin Elmer
170.0
150
100
50
0
-50
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-170.0
Micrometers
Micrometers
-200.0 -100 0 100 200.0
170.0
150
100
50
0
-50
-100
-150
-170.0
Micrometers
Micrometers
-200.0 -100 0 100 200.0
200.0
150
100
50
0
-50
-100
-150
-200.0
Micrometers
Micrometers
-200.0 -100 0 100 200.0
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