Millipore Milliflex Plus User Manual

User Guide

Milliex® Plus

VHP Resistant Pump

The life science business of
Merck KGaA, Darmstadt, Germany
operates as MilliporeSigma in
the U.S. and Canada.

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1. Notice

The information in this document is subject to change without notice and should not be construed as a
commitment by Millipore SAS. Millipore SAS assumes no responsibility for any errors that may appear in this
document. This manual is believed to be complete and accurate at the time of publication.

2. Application

The VHP Resistant Milliex® PLUS Pump is designed to perform ltrations of samples inside an isolator.
The pump is compatible with the isolator environment. The housing and the external parts are VHP resistant.

3. Operator and Equipment safety

All employees who will operate and/or be near the Milliex® Plus Pump VHP must comply with the following:

• Read and understand the user guide of the pump before
using this pump. Failure to follow operating instructions
could result in user injury or damage to the instrument.

• Read and understand all maintenance instructions
in this user guide before performing maintenance on
the pump. Failure to follow instructions could result
in user injury or damage to the instrument.

• Any alteration of the pump from factory specication
may cause unsafe conditions, and will void the
product warranty.

• Any attempt to use the pump in a manner not specied
in this user guide may result in damage to the instrument,
operator injury, and will void the product warranty.

• Do not attempt to open and repair the pump. Service
should be performed by trained and authorized
personnel only.

• Place the pump on a clean, at, stable, horizontal
surface, away from any source of excessive heat
and close to an easily accessible, properly grounded
power supply outlet.

• The Milliex® Plus Pump VHP must be installed and
used in a clean and dry area.

• The product is not intended to be used in explosive
atmosphere.

• Do not expose the power supply to liquid. If this
happens, immediately switch o and disconnect the
pump from the power outlet, wipe up the liquid.

• Use only accessories and replacement parts designed for
the pump. Using accessories not designed for the pump
could result in user injury or damage to the instrument.

• When ltrating hazardous liquids, wear and use proper
protective clothing and equipment for the handling and
the disposal of the liquid to be ltrated.

• The system power cord is the main system disconnecting
device, and must be easily accessible at all times.

• To avoid damaging the power cord or the outlet, it is
recommended that you pull on the plug and not on
the cord to unplug the system from a wall outlet or
an electrical connector.

• Make sure the power cord is not a tripping hazard. Make
sure that it is not gripped too tightly at the plug, the
outlet or the point where it is connected to the system.

• Before use, check that the hoses are not unplugged,
folded, or damaged.

• In case of skin contact with the ltrated liquid, refer
to the safety datasheet of the ltrated liquid for rst
aid measures.

• Dispose the ltrated liquids according to local regulations.

• Do not use the Milliex® Plus Pump VHP to ltrate

ammable products.

• Before cleaning, shut down the Milliex® Plus Pump
VHP and switch o and disconnect the power supply
from power source.

• Use only the power supply (model FRA072-S24-4)
designed for the pump.

• The power supply must be connected to the earthing
system.

• The electrical installation must comply with local
standards, power supply voltage: 100–240 Volt AC,
50–60 Hz.

• Use an electrical surge protector to prevent damage
to the system.

• Milliex® Plus Pump VHP System is designed for
indoor use only.

• Use and storage temperatures

– The Milliex® Plus Pump VHP and/or its accessories
must be kept away from any heat source. Do not
expose the system to direct sunlight or to temper­ atures outside the ranges of values are given below.
– Use and storage temperatures are given below:

System operation System storage Altitude

10 to 40 °C 0 to 40 °C < 2000 m

– Maximum relative humidity (storage and operation)
80% at temperatures up to 31 °C, then linear
decrease to 50% RH at 40 °C.

• System dismantling—WEEE directive:

In accordance with to the European Union
Directive 2012/19/EC on Waste Electric and
Electronic Equipment (WEEE), the presence
of this logo on the product indicates that it
should not be disposed of in the normal waste
stream but collected separately.

Go to millipore.com/weee for details on how to ensure
proper treatment of the product in dierent countries.

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4. System description

A. VHP Pump (MXPPLUVHP)

The Milliex® Plus VHP pump is composed of the following elements:

• The pump body

• The pump head with its protective cover (MXPHEAVHP)

• A lead to protect the pump when the pump head is not in place (to be used for assembling the pumps

with the manifold tray)

VHP Resistant
Pump Head

Pump Head
Mounting Post

Control Panel
and Display

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Pump Body

The pump comes with the following documents:

• User Guide PF12640

• Certicate of conformity for the pump (MXPPLUVHPCOQ) and the pump head (MXPHEAVHPCOQ)

Note: The VHP resistant pump (MXPPLUVHP) is compatible with the VHP resistant pump head
(MXPHEAVHP) only. These items are designed for use with Milliex® ltration devices only.

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B. Manifold tray for VHP pumps (MXPTRAY03V2)

The manifold tray is used to assemble the pumps together.

C. Milliex® Plus pump VHP Hub kit (MXPHUBKIT)

The VHP Hub kit is composed of:

• Some components for the electrical parts: electrical hub, cables set and power supply

• Some components for the uidic parts: uidic hub and tubes set

MXPFHUVHP

Milliflex

®

fluidic hub

VHP compatible

MXTUBVHP—VHP
tubes set for Milliflex
fluidic hub

MXPELEHUB

Milliflex
hub VHP compatible

®

electrical

®

MXPELCVHP—VHP
cables set for Milliflex
electrical hub

MXPP0WVHP Electrical hub
power supply (with 1 power cord Eur
—1 power cord US)

®

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D. Supply set for one VHP Pump (MXPSPL001)

The supply set is composed of:

• A power supply

• A uidic tube

5. System installation

A. Single pump system

Connect the supply set (uidic tube and power cable) to the VHP pump as follows:

Then place the system in the isolator.

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B. Three pump system

When using a three pump system, it is strongly recommended to assemble the pumps on the Manifold tray,
and to use the Hub kit for the electrical and uidic connections.

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It is recommended to assemble the pumps together before placing the system in the isolator. The use of
the tray facilitates the transfer of the assembled system to the isolator.

Caution: when assembled, the system is heavy (14.3 kg without the heads). Make sure you can handle the
system to transfer to the isolator.

1. Assembly of the 3 pumps on the tray

Do not place the pump head at this stage.

• Put the pump lead on each pump to protect them through the assembly step.

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