Confident.
Comprehensive.
Concise.
Tox Explorer Collection: Resolute sensitivity
enabled by Orbitrap technology
The Thermo Scientific™ Tox Explorer™ Collection features a robust LC-MS/MS platform with class-leading Thermo
Scientific™ Orbitrap™ technology and proven methods for toxicology analysis. This workstream provides forensic toxicology,
clinical research toxicology, sports anti-doping, and reference laboratories with confident, comprehensive, and concise
toxicology screening, identification and confirmation—all with one instrument.
• Confident, robust, and reliable analytical methods featuring
the Thermo Scientific™ Q Exactive™ Plus mass spectrometer
and the Thermo Scientific™ Vanquish™ Flex UHPLC system
• Streamline your methods using sample preparation
guidelines, high performance HPLC columns, intuitive
software capabilities, and comprehensive mass
spectral library
• Utilize over 1,500 compounds of interest in the spectral
library including compound details, such as exact mass,
retention time, and fragment ions encompassing a wide
range of drug classes and analytes, and gain access to
regular compound updates
• Step up productivity, reduce costs, and achieve high
quality analysis of data with confidence—all backed by
application support and training
Confident, comprehensive, concise method
Reporting
HRAM mass spectrometer
Robust LC-MS/MS platform for toxicology analysis
Optimized for quick start-up and ease of use, the Tox Explorer Collection is designed to improve
eciency and reduce cost throughout the preparation, separation, detection and analysis of drug
compounds in multiple biological matrices, such as blood, plasma, and urine with unprecedented
speed, ease, and confidence, regardless of the method complexity or user experience level.
Sample Preparation Guidelines
LIBRARY AND SOF TWARE
DATA AN ALYSIS
Chromatography Mass Spectrometry
Vanquish Flex Binary
Reporting
Training
Fast
confident
results
Support
UHPLC system
Productivity and quality in chromatography
With confident retention time stability and maximum pressure up to
1,000 bar, the Vanquish Flex UHPLC systems increase productivity
without compromising quality of results. The platform shares all
Vanquish system values, such as a design focused on uptime,
robustness, and quality, enabling every toxicology laboratory to
address their critical screening and quantitation challenges.
• System designed for maximum flexibility
• Separations with better reproducibility
• High sample throughput with fast analysis
• Better connectivity of LC-MS with dedicated software
Screening
Over 1,500 compounds in the mass spectral library
Accurate compound identification
Quantitation
Low levels of
detection: 1 ng/mL
Linear calibration
curves
Confirmation
Library matching
Screen, identify, confirm, and quantitate with
Orbitrap technology
The Q Exactive Plus hybrid quadrupole-Orbitrap mass spectrometer is
equipped with the ability to routinely and confidently identify, quantify, and
confirm in a single analysis using a single mass spectrometer. Take your
screening, quantitation, and confirmation to a new level with increased
performance meeting toxicology requirements.
• Screen, identify, confirm, and quantitate—all with one instrument
• Analyze a broad spectrum of compounds in one run
• Perform retrospective analysis without requiring additional experiments
• Comprehensive MS/MS spectra without the need to average, while
allowing accessibility to positive and negative compounds in one run
• Utilize data-dependent acquisition for the identification of unknown
structures via MS/MS spectra
• Exceptional mass accuracy and stability within and between runs—even
at low mass ranges—to ensure confidence in results
Intuitive software
Simplify high-throughput screening and quantitation
Driven by a powerful and intuitive set of acquisition and data processing tools,
Thermo Scientific™ TraceFinder™ software provides rapid access to your results
and increases output across the entire laboratory. Drive your productivity
with built-in intelligence provided through TraceFinder software acquisition
and data processing.
• Simplify sample analysis at each step of the process
• Smart sample flagging, flexible data review, and custom report generation
• Streamline and standardize operating procedures, minimizing training
requirements and simplifying lab operations
mzVault mass spectral library
HPLC columns
Fast separations with excellent resolution and sensitivity
Based on Core Enhanced Technology, Thermo Scientific™ Accucore™ columns
provide fast, high-resolution separations without the elevated backpressures
required by sub-2 μm particles.
• Robust columns with wide separation chemistry for all UHPLC applications
• Highly ecient, rugged separations for LC-MS applications
Robustness
Mass accuracy
over 400 injections
3
1
-1
-3
-5
-7
The Thermo Scientific™ mzVault™ mass spectral library seamlessly integrates
with the acquisition and processing software, TraceFinder software, while
providing an extensive repository of valuable information on critical analytes
and enables confident identification of small molecules.
• Includes exact mass of compounds
• Includes fragmentation data at dierent collisional energies to help identify
unknown compounds
Confident identification of toxicology compounds
Loading...