The ADVIA® 1800 Chemistry system is for in vitro diagnostic use.
The information in this guide was correct at the time of release. However,
Siemens Healthcare Diagnostics continues to improve products and reserves the right to
change specifications, equipment, and maintenance procedures at any time without
notice.
If the system is used in a manner not specified by Siemens, the protection provided by the
equipment may be impaired. Observe all warning and hazard statements.
The ADVIA Chemistry system is manufactured in Japan for Siemens.
The Universal Rack Handling System is manufactured in Germany for Siemens.
Manufactured in Japan for:
Copyright and trademarks
ADVIA Centaur and ADVIA are trademarks of Siemens Healthcare Diagnostics.
Acrobat is a trademark of Adobe Systems Incorporated.
Clorox is a trademark of The Clorox Company.
Windows is a trademark of Microsoft Corporation.
in any form without prior consent in writing from Siemens.
2 ADVIA 1800 Operator’s Guide
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Table of Contents
Table of Contents ........................................................................................................................................ 3
1 System Overview ................................................................................................................................... 13
Display and power panel .......................................................................................................................................... 15
Analyzer back view .................................................................................................................................................. 15
Analyzer top view ..................................................................................................................................................... 16
STT rotate and SMP pause buttons ......................................................................................................................... 17
PC (front view) ......................................................................................................................................................... 18
PC (back view) ......................................................................................................................................................... 19
Opening the Top Cover............................................................................................................................................ 19
DPP probe features ............................................................................................................................................. 27
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Sample delivery to reaction tray ............................................................................................................................... 28
Reaction tank ........................................................................................................................................................... 34
Status and message boxes ................................................................................................................................. 39
Other tasks accessed from System(s) on the Operation Panel ........................................................................... 39
Menu Panel .............................................................................................................................................................. 40
Other tasks accessed from System(s) on the Menu Panel .................................................................................. 40
Description of software windows ............................................................................................................ 41
Request windows ..................................................................................................................................................... 41
Order Entry window ............................................................................................................................................. 41
Test Result Monitor window ................................................................................................................................ 42
Sample test status color codes ........................................................................................................................... 43
Test Select window* ............................................................................................................................................ 45
Setup to Use LRC ............................................................................................................................................... 46
Printing and/or Generating a PDF from the LRC ................................................................................................. 46
Data Transmit window ......................................................................................................................................... 47
Calibration windows ................................................................................................................................................. 47
Calibration/RBL History window .......................................................................................................................... 47
System Startup/Shutdown Setting window .......................................................................................................... 49
User Maintenance window .................................................................................................................................. 49
System Monitor window ...................................................................................................................................... 49
System Maintenance Monitor window ................................................................................................................. 49
Lamp Energy Monitor window ............................................................................................................................. 49
ISE Operation window ......................................................................................................................................... 50
ISE Monitor window............................................................................................................................................. 50
Controlling the number of messages listed ......................................................................................................... 52
Updating the message list ................................................................................................................................... 52
Printing the messages ......................................................................................................................................... 52
Deleting the messages ........................................................................................................................................ 52
LAS Monitor window............................................................................................................................................ 53
Test Utilization Statistics window ........................................................................................................................ 53
Reagent windows .................................................................................................................................................... 53
Executing a Barcode Scan .................................................................................................................................. 55
Deselecting a Reagent ........................................................................................................................................ 55
Printing a Reagent Summary Report................................................................................................................... 56
Viewing Total Test Summary ................................................................................................................................... 56
Viewing Cal Interval Review .................................................................................................................................... 56
Active Test List window* ...................................................................................................................................... 57
Reagent Information window* ............................................................................................................................. 57
QC windows ............................................................................................................................................................. 58
Control Data Setup window ................................................................................................................................. 60
Setup windows ......................................................................................................................................................... 61
System Specification Settings window* ............................................................................................................... 61
System Test List window ..................................................................................................................................... 62
Analysis Order Set window ................................................................................................................................. 62
Setting System Parameters window** ................................................................................................................. 64
New Test Definition window* ............................................................................................................................... 64
Process Sequence window* ................................................................................................................................ 66
Ratio Parameters window* .................................................................................................................................. 66
User Code Settings window* ............................................................................................................................... 67
Other Tasks ............................................................................................................................................................. 67
Version Information window .................................................................................................................... 68
Etc. ...................................................................................................................................................................... 69
Using online help ...................................................................................................................................... 69
Viewing the content ............................................................................................................................................. 70
2 Operating the System ............................................................................................................................ 71
Start the System ........................................................................................................................................ 71
Logging on ............................................................................................................................................................... 71
Starting the system .................................................................................................................................................. 71
Performing a system-assisted startup (Start set) ..................................................................................................... 72
Checking the analyzer ............................................................................................................................................. 73
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Set up of daily washes ............................................................................................................................................. 77
Times required to perform prime, washes, and cell blank ................................................................................... 78
Using workorders ..................................................................................................................................................... 78
Using host computer workorders ......................................................................................................................... 78
Creating workorders at the analyzer .................................................................................................................... 79
Deleting or changing test selectivity for multiple workorders ............................................................................... 80
Creating a profile ..................................................................................................................................................... 81
Creating a load list ................................................................................................................................................... 81
Loading patient samples on the STT ....................................................................................................................... 82
Sample Collection and Preparation ......................................................................................................................... 83
Loading patient samples on the optional univer sa l rack hand l er .............................................................................. 85
Urgent samples and manual reruns are run from the onboard sampler (STT) .................................................... 87
Starting the run ......................................................................................................................................... 87
Running calibrators and reagent baselines (RBL) ............................................................................................... 87
Running control samples ..................................................................................................................................... 88
Monitoring samples loaded on the optional universal rack handler .......................................................................... 89
Running an interrupt (STAT) sample ................................................................................................................... 89
Monitoring an analysis while it is running ................................................................................................................. 90
Processing status ................................................................................................................................................ 90
Sample information and system status ................................................................................................................ 90
Result data information ....................................................................................................................................... 91
Using the Sample Log .............................................................................................................................. 91
Viewing the sample log entries ............................................................................................................................ 91
Searching the sample log .................................................................................................................................... 92
Deleting a specific sample log entry .................................................................................................................... 92
Deleting all sample log entries ............................................................................................................................ 92
Printing a list of the sample log entries ................................................................................................................ 92
Exporting the sample log entries ......................................................................................................................... 93
Reviewing the calibration results ............................................................................................................................. 93
Reviewing the sample results .................................................................................................................................. 93
Batch transmission to a host computer ............................................................................................................... 94
Printing sample data ................................................................................................................................................ 94
Shutting down the ADVIA Chemistry system ........................................................................................ 95
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Examples of shutdown settings ............................................................................................................................... 96
System available during the night ....................................................................................................................... 96
Automatic startup from the Sleep state ............................................................................................................... 96
Automatic startup with analyzer power kept ON .................................................................................................. 96
Performing a system-assisted shutdown (Shutdown set) ........................................................................................ 97
Emergency stop, shutdown, and recovery procedures ........................................................................ 98
Stopping operation after the analyz er is start ed .................................................................................................. 98
Managing an expected power outage ................................................................................................................. 98
Responding during a power failure while electric power is still off ....................................................................... 98
To resume operations after power is restored ..................................................................................................... 98
Using multiple reagent containers for the same test ......................................................................................... 100
Auto-calibration and auto-QC Situations that need corrective steps ...................................................................... 101
Auto calibration with system-related errors ....................................................................................................... 101
Auto-calibration with lot change ........................................................................................................................ 101
Reagent pack switch in mid-calibration ............................................................................................................. 101
When to calibrate ................................................................................................................................................... 103
Setting up the calibration ....................................................................................................................................... 103
Entering absolute or single-point (STD) calibration methods ............................................................................ 103
Entering multi-standar d calibr a tion meth od s ..................................................................................................... 104
How to calibrate a multi-standard method ......................................................................................................... 105
Reviewing the calibration ....................................................................................................................................... 106
Using the Calibration/RBL History window ............................................................................................................. 106
4 Quality Control ..................................................................................................................................... 109
Quality control overview ........................................................................................................................ 109
When to run control samples ................................................................................................................................. 109
Setting up quality control ................................................................................................................................... 109
Running the control samples ............................................................................................................................. 109
Reviewing the control results at different windows ................................................................................................ 110
Inspecting and cleaning the probes ....................................................................................................................... 115
The probe cleaning tool kit ..................................................................................................................................... 117
Inspecting and cleaning the mixing rods and mixer wash cups ............................................................................. 119
Checking reagents and system solutions ............................................................................................................... 120
Monitoring Reagent Tray Temperature ............................................................................................................. 120
Inspecting and cleaning the reaction (WUD) and dilution (DWUD) cuvette washers ............................................. 121
Inspecting and cleaning the cuvette splash covers ................................................................................................ 123
Inspecting and cleaning the probe wash cups ....................................................................................................... 124
Inspecting the pumps ............................................................................................................................................. 125
Performing the startup wash (WASH3) .................................................................................................................. 127
Performing the shutdown wash .............................................................................................................................. 128
Performing additional ISE electrode washes ......................................................................................................... 129
Recording ISE slopes ............................................................................................................................................ 130
Performing the weekly wash .................................................................................................................................. 131
Checking and replenishing the lamp coolant ......................................................................................................... 132
Checking lamp energy ........................................................................................................................................... 133
Reading lamp energy data ................................................................................................................................ 135
Cleaning the turntable interiors (STT/CTT and RTT) ............................................................................................. 138
Cleaning the inside of the STT/CTT housing ..................................................................................................... 138
Cleaning the inside of the reagent tray refrigerated housing ............................................................................. 139
Cleaning or replacing the wash solution reagent containers (53 – 56) .................................................................. 140
Cuvette wash and cuvette conditioner usage .................................................................................................... 140
Cleaning and replenishing the dilution bottle ......................................................................................................... 141
Cleaning and replenishing the cuvette wash bottle ................................................................................................ 142
Cleaning the chiller filter ......................................................................................................................................... 143
Cleaning the large water pump (LWP) filter ........................................................................................................... 144
Every 2 months maintenance ................................................................................................................ 146
Cleaning the dilution tray cuvettes ......................................................................................................................... 146
Cleaning and replenishing the cuvette conditioner bottle ....................................................................................... 147
Every 3 months maintenance ................................................................................................................ 149
Replacing the lamp ................................................................................................................................................ 149
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Washing the electrodes lines ................................................................................................................................. 151
Every 4 months maintenance ................................................................................................................ 153
Cleaning the ancillary reagent bottle filters ............................................................................................................ 153
Cleaning the pure-water bottle filter ....................................................................................................................... 154
Replacing the reaction and dilution cuvettes .......................................................................................................... 155
As required maintenance ....................................................................................................................... 158
Backing up system files ......................................................................................................................................... 158
Restoring system files ............................................................................................................................................ 159
Replacing the SPP, RPP1, and RPP2 probes ....................................................................................................... 160
Removing a probe ............................................................................................................................................. 160
Install a new probe ............................................................................................................................................ 162
Replacing DPP probes equipped with crash detection .......................................................................................... 163
Removing the DPP probe cover ........................................................................................................................ 163
Removing the probe from the probe arm ............................................................................................................... 164
Install the new DPP probe ................................................................................................................................. 165
Aligning the DPP probe ..................................................................................................................................... 166
Replenishing the RRV (reaction) bath oil bottle ..................................................................................................... 166
Preventive cleaning of the wash station lines ........................................................................................................ 168
Washing all the ISE lines ....................................................................................................................................... 172
Washing the lines .............................................................................................................................................. 173
Rinsing the lines ................................................................................................................................................ 173
Priming and initializing the ISE module ............................................................................................................. 174
Replacing ISE electrodes ....................................................................................................................................... 174
Priming the ISEs ............................................................................................................................................... 175
Calibrating the ISEs........................................................................................................................................... 176
Storing the reference electrode ......................................................................................................................... 176
Conditioning the Na and K electrodes ................................................................................................................... 177
Cleaning the dilution bowl and waste-drain nozzle ................................................................................................ 178
Cleaning the dilution bowl ................................................................................................................................. 178
Cleaning the waste drain nozzle ....................................................................................................................... 179
Maintaining the ISE unit after the dilution bowl and waste-drain nozzle are clean ............................................ 180
Saving the error log to a test file ........................................................................................................... 183
Capturing the error report: ................................................................................................................................. 183
Saving the test data from the User Maintenance window ...................................................................................... 184
Saving test data ................................................................................................................................................ 184
Saving reaction data in CSV format ....................................................................................................................... 185
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Saving a data archive from User Maintenance window ......................................................................................... 186
Viewing data that was previously archived ........................................................................................................ 187
8 System Setup ....................................................................................................................................... 189
Connecting the ADVIA Chemistry System and your host computer ................................................. 189
Setting the System Monitor.................................................................................................................... 189
During operation system settings area .............................................................................................................. 190
Setting up the ISE ................................................................................................................................... 190
Activating the ISE .............................................................................................................................................. 190
Setting up ISE parameters ..................................................................................................................................... 191
ISE calibration ................................................................................................................................................... 191
Checking ISE calibration ........................................................................................................................................ 191
Laser information .............................................................................................................................................. 197
Appendix B – Warranty and Support Information ............................................................................... 199
Limited Instrument Warranty and Service Delivery Policy ................................................................. 199
Warranty period ..................................................................................................................................................... 199
Additional service period ........................................................................................................................................ 199
Service calls ........................................................................................................................................................... 200
Service during normal hours ............................................................................................................................. 200
Extent of a service call ...................................................................................................................................... 200
Service outside normal hours ............................................................................................................................ 200
Replacement of parts ............................................................................................................................................. 200
Warranty and service exclusions ........................................................................................................................... 200
Design changes and retrofitting of instruments ................................................................................................. 202
ADVIA Contact information .................................................................................................................................... 203
Appendix C – Customer replaceable parts ........................................................................................... 205
Appendix D – Specifications .................................................................................................................. 207
Specifications – all ................................................................................................................................................. 207
Appendix E – Symbols ........................................................................................................................... 213
Explanations of symbols associated with the ADVIA 1800 system .................................................. 213
Warning and caution symbols ................................................................................................................................ 213
System operation symbols ..................................................................................................................................... 214
System rating label symbols .................................................................................................................................. 215
The ADVIA 1800 Chemistry System is an automated, clinical chemistry analyzer that
can run tests on human serum, plasma, or urine in random access, batch, and STAT
(interrupt) modes at a throughput rate of 1200 photometric tests per hour and 600
electrolyte tests per hour.
The ADVIA 1800 Chemistry System is for in vitro diagnostic use.
Operating principle
This sequence summarizes a photometric analysis on the Chemistry System:
1. The system performs cell blank measurements before reagents are added .
2. The first reagent (R1) for a test is aspirated from reagent tray 1 and dispensed by the
reagent probe into the cuvette in the reaction tray.
3. Samples on the sample tray or rack handler are aspirated and diluted by the dilution
probe, then dispensed into cuvettes in the dilution tray.
4. The dilution mixer stirs the diluted sample.
5. The sample probe dispenses the required amount of diluted sample into the RRV
cuvettes (the reagent is already in the cuvettes).
The system can use the remaining diluted sample in the DTT cuvettes for additional tests
on a workorder, a rerun, dilution, or reflex testing.
6. The reaction mixer 1 mixes the first reagent and the sample.
7. The second reagent (R2) for a test is aspirated from reagent tray 2 and dispensed by
the reagent probe into the cuvette in the reaction tray .
8. The reaction mixer 2 mixes sample and reagent 1 and reagent 2.
9. The reaction takes place for the amount of time designated in the assay.
10. The spectrophotometer obtains the concentration data every six seconds.
The spectrophotometer takes measurement readings as the RRV turns.
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11. You can view and print the results of the analysis.
12. When measurement is complete, the RRV cuvettes are washed.
13. When the analysis is complete, the lamp energy is checked at each wavelength.