PRIMETECH 310R Users Manual

IMS

-

310R

iPRECIO® IMS-310R Quick guide ver.1.0.0.E

Read me

Thank you for choosing iPRECIO®, programmable infusion pump for Lab animal for
your research/experiments.

This quick guide show you how to use iPRECIO® pump and operate iPRECIO
management software.

The iPRECIO® is for use in Laboratory Animal Research ONLY. Not for human

use.

®

Please obey the Guide for the Care and use of laboratory animal by your

organization and or institute when use iPRECIO®.

NOTICE TO THE USER
One or more of the following statements may be applicable for this equipment.

Notice (For Model UCD-X10R only)

The provided LAN Cable with a ferrite core shall be used when connect UCD-X10R to a PC
and do not replace the LAN cable with other LAN cable.

FCC WARNING

FCC ID: 2ACHIUCDX10R, FCC ID:2ACHI310R

This device complies with Part 15 of the FCC Rules. Operation is subject to the following
two conditions: (1) this device may not cause harmful interference, and (2) this device must
accept any interference received, including interference that may cause undesired operation.

IC:XXXXX-2ACHI310R, IC:XXXXX-2ACHIUCDX10

Changes or modifications not expressly approved by the manufacturer could void the
user’s authority to operate the equipment.

For more information:
PRIMETCH CORPORATION
TEL：[phone] E-mail : [e-mail]
URL ：www.iprecio.co m

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iPRECIO® IMS-310R Quick guide ver.1.0.0 E

INFORMATION TO THE DIGITAL DEVICE USER REQUIREMENT by FCC
(For Model UCD-X10R only)

This equipment has been tested and found to comply with the limits for a Class B
digital device, pursuant to part 15 of the FCC Rules. These limits are designed to provide
reasonable protection against harmful interference in a residential installation. This
equipment generates, uses and can radiate radio frequency energy and, if not installed
and used in accordance with the instructions, may cause harmful interference to radio
communications. However, there is no guarantee that interference will not occur in a
particular installation. If this equipment does cause harmful interference to radio or
television reception, which can be determined by turning the equipment off and on, the
user is encouraged to try to correct the interference by one or more of the following
measures:
—Reorient or relocate the receiving antenna.

—Increase the separation between the equipment and receiver.
—Connect the equipment into an outlet on a circuit different from that to which
the receiver is connected.
—Consult the dealer or an experienced radio/TV technician for help.

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iPRECIO® IMS-310R Quick guide ver.1.0.0.E

Contents

READ ME .................................................................................................................................. 2

CONTENTS ............................................................................................................................... 4

ABOUT IPRECIO® ................................................................................................................... 5

THE WORLD FIRST WIRELESS PROGRAMMABLE INFUSION PUMP ......................................................... 5

ACCESSORIES WHICH INCLUDED IN IPRECIO

IPRECIO® SYSTEM CONSTRUCTION ............................................................................................... 6

PRODUCT WARRANTY .......................................................................................................... 7

BATTERY LIFE ......................................................................................................................... 8

INSTALL MANAGEMENT APPLICATION ............................................................................. 9

PREPARATION BEFORE START ........................................................................................................... 9

INSTALL IPRECIO

CABLE CONNECTION OF DATA COMMUNICATION UNIT UCD-X10R .................................................. 11

TCP/IP CONNECTION BETWEEN DATA COM UNIT AND CONTROL PC ................................................ 11

PREPARATION BEFORE SOFTWARE USE ........................................................................ 13

FOR THE FIRST TIME EXECUTE MANAGEMENT SOFTWARE ................................................................ 13

USER REGISTRATION .................................................................................................................... 13

ACCESS CONTROL OF SOFTWARE ................................................................................................... 14

CHANGE LANGUAGE ...................................................................................................................... 15

NETWORK SETTING ...................................................................................................................... 15

CREATE INFUSION PROFILE ........................................................................................................... 15

CUSTOMIZE INFORMATION............................................................................................................. 19

START STUDY ........................................................................................................................ 19

START NEW STUDY ....................................................................................................................... 19

CATHETER CONNECTION, PLOMB ADMIN LIQUID AND ACTIVATION. .................................................. 22

PUMP DETECTION .......................................................................................................................... 23

KVO SETTING, START AND COMPLETE ........................................................................................... 24

INFUSION PROTOCOL SETTING ...................................................................................................... 26

START INFUSION PROTOCOL ......................................................................................................... 26

MONITOR THE RUNNING PUMP STATUS ........................................................................................... 27

REPLACE AND/OR REFILL THE MEDICAL SOLUTION ......................................................................... 28

END OF STUDY ............................................................................................................................. 29

SAVE STUDY FILE ......................................................................................................................... 29

EXPORT STUDY FILE ...................................................................................................................... 29

®

MANAGEMENT SOFTWARE ................................................................................. 9

®

STD SYSTEM .......................................................... 5

PRODUCT SPECIFICATION ................................................................................................. 30

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iPRECIO® IMS-310R Quick guide ver.1.0.0 E

About iPRECIO®

A subsequent of the first radio programmable infusion pump

iPRECIO® SMP-310R model is the world first programmable pump which is complete
implantable into a laboratory mouse.
Utilize high precision mechanical pump technology that was unique developed and
controlled by built in microprocessor. An administration protocol can be programmed
with dedicated management application software and pump will be work by the
programmed protocol with accurate low flow rate ( L/H order) medical solution
infusion. In addition the medical solution in the reservoir can be complimented and or
replace through septum by transcutaneous even after implanted in an animal.

Accessories which included in iPRECIO® STD System

iPRECIO® system configured with the following accessories.

Small Lab animal micro infusion pump iPRECIO® SMP-310R
iPRECIO® management system IMS-310R
Data communication unit UCD-X10R (USB Power Adapter*, LAN cable*

included)

Management Software IMS-310R
iPRECIO Quick guide (this guide)

(L) Pump in pre-sterilized pack and 5pcs box. (R) Included parts with UCD-X10R

*The attached LAN cable and USB power Adapter cable with a ferrite core shall be

used.

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①

②

③

④

⑤

⑥

⑦

⑧

UCD

-

X10R

⑤

⑦

⑥

⑧

iPRECIO® System construction

iPRECIO® IMS-310R Quick guide ver.1.0.0.E

Number name

Refill septum
Outlet tube
Reservoir
Micro cam
Pump ID print mark
LAN cable connect port
USB power adopter connect port
Reset switch

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Product Warranty

PRIMETECH CORPORATION (hereinafter PRIMETECH) guarantee the product and it’s
material are free from defect within the below period which was distributed through
the official sales channel.
PRIMETECH do not responsible with any problem that caused by using with other
company product. Also the product performance is not guaranteed when a customer
uses it beyond the original specification.

The defect part will be replaced and or repair by free of charge except, in-transit
accident, customer’s fault, breakage caused by abnormal/improper use and
damnification cause by PRIMETECH recommendation of use.
Any defect parts back to PRIMETCH for replace, always need the RMA format and
ship back through original sales channel.

Duration of guarantee

iPRECIO® Micro Infusion Pump SMP-310R: 18 months after manufacturer

iPRECIO® Management System IMS-300: 12 months after shipping date

This warrantee represent any other warrantee and include an implied consent of
merchantability and dedicated fitness for purpose, but not limited to.

Liability Limitation
Except the warrantee describe in above, PRIMTECH do not responsible any direct,
indirect and special loss caused by violence of use condition within the maximum LAW
protection. This includes any return loss and or opportunity loss (includes profit loss
by contract) with direct, indirect, and damage.
This warrantee will be no longer valid when customer (include stuff, member and any
other bystander) use iPRECIO® for any other purpose against PRIMETECH sales
conditions.

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iPRECIO® IMS-310R Quick guide ver.1.0.0.E

F

low rate

(μ

l/hr)

Battery life

(hr)

0.1 408

0.5 384

1.0 360

5.0 216

10.0

144

Battery life

iPRECIO® SMP-310R can continuous operate time below table during product
warranty period (After 16 months from manufacturing date)

Please note that below condition makes shorter battery life. :

In case of kept certain period of time without use after power on. (After

power on, internal circuit becomes active and consume battery power by
standby power requirement)

In case of not storage under proper circumstances. (Under frequent

temperature swing or exposed in over storage temp range in spec may
cause increasing self-discharge of battery)

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iPRECIO® IMS-310R Quick guide ver.1.0.0 E

Install management application

Preparation before start

iPRECIO® Management software install CD
Windows 7/Windows8/Windows 10 installed and LAN port ready PC
Data communication unit UCD-X10R (data com unit)

UCD-X10R main body
USB to DC adapter
LAN cable (Cross over cable with Ferrite core)

Install iPRECIO® management software

PC setting should be:

Off the screen saver
Get into the control panel Power option of “Change when PC sleep” and set

“Put the computer to sleep” = “Never”

1. Run the “setup.exe” in a install CD.

2. When the startup window appeared, click “Next>”. Then setup wizard window
comes up, click “Next>” again.

3. Chose the program files store folder and click “Next>”. Subsequently confirmation
screen open, then click “Next>”. For this step the installation will be started.

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4. When install complete windows appears, click “Close”.

5. Check start menu that the following software installed.

iPRECIO® Management Software IMS-X10R
Utility Base Station Manager
Utility Pump Database Manager

6. Three of those software has been installed, then the management software install
is successful.

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Connect to LAN port of

Plug in the USB Adapter to a PC

Connect to LAN port of

Plug in the power plug to a

UCD

-

X10R power in port.

Cable connection of data communication unit UCD-X10R

1. Plug in the AC Adapter to data communication unit and connect with the PC which
the management software installed by cross-over type LAN cable.

UCD-X10R

Control PC

USB port (USB 2.0 or later)

*LAN cable Ferrite core attached end shall be connected to UCD-X10R.
*USB power Adapter cable Ferrite core attached end shall be connected to PC.

TCP/IP connection between data com unit and control PC

1. Connect data com unit and control PC with LAN cable

2. Open Network and Sharing Center from control panel.

3. Click Change adapter setting, then right click on the data com Local Area Control
and open Property.

4. Open Internet Protocol version 4(TCP/IPv4) property and input IP address below

IP Address: 192.168.1.11
Subnet mask: 255.255.255.0

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Then press OK to finalize.

iPRECIO® IMS-310R Quick guide ver.1.0.0.E

The Data communication unit factory default IP address configuration is 192.168.1.10. If IP
address doesn’t work by usage environment with default configuration, please change IP
address in accordance with “Appendix A: How to change IP address of the Data communication
unit”

5. With that the Data communication unit and control PC is connected by Internet
Protocol. Subsequently network connection should be made in the management
software.

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Preparation before software use

For the first time execute management software

For the first time run the management software, the user registration window will
open automatically. To register user information, user management and access control
function will be available.
The language default setting is in English and after user registration the language
selectable function will be active to change.

User Registration

1. Input required information in the user registration window. The asterisk (*) marked
item below are mandatory.

Institution & Department
Administrator

2. In addition, at least one operator registration required at this time. Input operator’s
User Name, Login ID and Password (Confirmation required), then click on Add tab.
The operator will be listed in right table.

3. To use Access control, check the “Enable Access Control” check box. Detail of
Access Control function, please refer the nest page “Access control of software”.

4. After all fill in required column, click OK to finalize.

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Access Control of software

To utilize Access Control function, administrator can confine and or control of user
who can reach the management software. To permit to access the software, check
the “Enable Access Control” in the user registration window.
Once use control function is active, every time Login ID and Password is required
whenever the software executed.

Please note Login ID and Password. When forgot password, then software
access will be denied.

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Change Language

1. Click Language menu

2. Select language from pull down menu, then click Change.

3. Now the language has been changed.

Network Setting

1. Click network setting menu in tab.

2. Input default IP address(192.168.1.10) in the Host IP address column for the
data com unit.

3. Click “connect”

4. After confirm “Status: connected”, then close the window.

5. If the status column shows “disconnected”, check the IP address setting. Please
refer the “TCP/IP connection between data com unit and control PC”.

Create Infusion Profile

Administration protocol that perform in vivo pump of a subject animal of experiments,
it is required create in the management software in advance and store as a
“administration protocol”. The administration profile should be determined by each
group of dosing preparation and concentrations and assign administration schedule.

1. Open Administration profile menu by clicking.

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2. Administration window comes up.

3. Add new administration profile, click “Add” button.

4. Group profile creating window will be opened.

5. Input and or select basic information. When chose the injected amount unit as

μg/kg/hr(Dose) or mg/kg/hr(Dose), amount set by dose. It is therefore the
animal weight range and concentration input are mandatory.

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6. Input dose amount and duration from Step1 to create the infusion schedule. Input
the value to the each boxes and press Enter to finalize dose. The starting time and
finish time will be shown in elapsed time that accumulate the injection period. The
battery life shown in the bottom of window indicate the expected battery life which
calculated as a new battery. It may help to create an administration schedule.

Weight range should be input by maximum to minimum.
Please do not forget to finalize the data by pressing “Enter” key.
Do not refer the battery life when the pump was re-use and or re-

programming. The indicated battery life was calculated from the battery
capacity as a new one.

7. When ditto the same schedule, the use the “Repeat Setting”. Check the
“Repeat Start” box for start of repeated schedule step then check the
“Repeat End” box for termination ditto schedule. For number of cycle,
input “Times” of “Repeat Start” column and finalize to press Enter key.

8. After all information input, press OK then new administration profile will
be registered in the Infusion Profile list.

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9. When to change the existing Infusion Profile, select intended Infusion Profile and
click “Edit”button.
If want to eliminate the existing Infusion Profile on the list, select the intended
Infusion profile to delete and click the “Delete” button.

10. Close the Infusion profile window by clicking “Close” button.

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Customize information

Pull down menu registration and elimination are possible for Study Setting. And KVO
setting of flow rate and duration also set in advance.

1. Open customize window from “Customize(Z)” menu in the tool bar.

2. Input a desire information in the Animal Species, Animal Strain and
Administration Route, then click Add button in the below of each boxes.

3. If would like to delete existing information, select information and click Del button
in the below of each boxes.

4. Input the numerical value of KVO Flow Rate and Duration.

5. To complete the input value, click OK button in the left bottom of the Window.

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iPRECIO® IMS-310R Quick guide ver.1.0.0.E

The

Data access Radi

o system of

iPRECIO

®

is not Broadband type in

Start Study

Start New Study

iPRECIO® Management software has a function to abort the study during the KVO and
Administration with pumps which implanted in under study animals. For example, to
be able to except individual animal from study that is slow-healing than others during
KVO. Also even during Administration to be able to deselect individual animal that is
difficult to continue Administration by some trouble.

use. For that reason, the management system can control only one
pump in the same time, then it may require long time to complete
the following data communication.

Pump detection
Start KVO
Abort KVO
Complete KVO
Start Administration protocol
Abort Administration protocol
Finish Administration protocol
Extract executed study log

Administration

Change medical solution

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iPRECIO® IMS-310R Quick guide ver.1.0.0 E

1. Click New from file menu bar.

2. Appear Study Header window. (*) marked items are mandatory.

3. Click Next after fill the information input boxes.

4. Pumps and Animals setting window comes up. Input intend animal number in the
Number of Animals and click Set button. Default Number of Animal is 20. The
information input column will be active in answer to input animal number.

5. Input and select by pull down for except Pump ID and Calibration Factor, such as
individual information. (Animal ID, weight[g] etc.)

6. Can copy and paste of the column which already input individual information to
another column.

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iPRECIO® IMS-310R Quick guide ver.1.0.0.E

Catheter connection, plomb admin liquid and activation.

Activate the pump by switch on to communication enable. If required connect
additional catheter as necessary.

To fill administration liquid till the end of catheter before power on, because
once a pump switched on, the internal cam will start moving to the initial
position to block the inner tube.

1. Open pump pre-sterilization pack in clean environment.

2. Cut, replace tube and/or catheter connection of pump as necessary.

Each pump dead volume can be calculated in KVO setting, so keep final tube
length and inner diameter or measured dead volume need to be recorded.

3. Fill the admin into the end of tube with 27G syringe needle through upper port.

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iPRECIO® IMS-310R Quick guide ver.1.0.0 E

Under red marked area,

magnet SW was built in.

4. Slide the south pole of a magnet (100mT or stronger) on the surface of the
protracted area of a pump to power on the pump.

Pump detection

1. Place pumps by recommended position with a data com unit UCD-X10R.

2. Click Detect button. During Communication progress bar is shown, the powered
on and communication enable pump will be detected. If a pimp is not detect wait
a minute or over, please try the power on action (power on by magnet).

If there is no response from pump, please check the followings:

It may take long term to detect pump due to radio wave back ground

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environment.

Verify PC and UCD-X10R connect properly. For detail, please refer “TCP/IP

connection between data com unit and control PC” and “Network Setting”.

Verify pump activation. For detail, please refer “Catheter connection,

plomb admin liquid and activation”.

3. After all pumps detected, then click Next button.

KVO setting, start and complete

KVO is abbreviate of Keep Vein Open, semantics to prevent the catheter edge clog by
continuous liquid dosing by low flow rate. Be normally administrate biocompatible
liquid such as saline as KVO by low flow rate after implant surgery and prevent clog
of catheter end during animal healing period. After animal comeback form the surgery,
the KVO liquid in reservoir can be replaced by medicine liquid from the septum. And
acknowledge user the timing that when the medicine liquid will reach the catheter end
by pump and appurtenant catheter dead volume calculation.

1. Open desire Group profile and check the KVO check BOX and click the dead volume
setting button. Then KVO setting window pops up. If KVO is not required, then
remove check the KVO check box to skip KVO.

2. Click individual column dead volume setting.

3. Input the required information for dead volume calculation and click OK button.

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Even if there is no need to change dead volume setting, it need to open every
animal dead volume setting and determine the dead volume choice. If this
determine was lost, the dead volume and flash rate will not apply to the
administration start schedule.

4. Check KVO flow rate and KVO duration and if it’s ok then click to KVO start. The
pump status will be KVO after start KVO. Pump status color will change in
accordance with communication stats, red Yellow Green. When the color will
be Green, then injection is started.

During KVO is running, please DO NOT STOP the management software.

5. When the pre-set KVO period will end, pumps will stop and Pump status changes
into Finished. Click Next>, the injection schedule setting. All of animal looks fully
recovered before pre-setting KVO period, you can abort all KVO by clicking abort
as a pack and start administration schedule. When some animal cannot heal
enough during KVO period and need to terminate the experiment of that animal,
then click the remove button from individual animal column.

After KVO stopped, please check the Pump status as “Finish”. Demepnd on the
communication condition, “Finish” status appears very slow after prompt to
end KVO from management software due to communication condition.

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Infusion Protocol setting

1. Group information window appears.

2. Chose infusion group name (Profile) from Group ID pull down menu and set
Administration Start Time, then click Set button.

3. When click Stagger, the administration will be staggered from set time in that value.

4. If the proper infusion group name does not found, then create new one. Please
refer “Create Infusion Profile”.

5. After all animal are assigned to profile group, click Next>> button.

Start Infusion Protocol

1. Infusion Protocol window comes up.

2. Click Start all or click start for individual animal to start Infusion Protocol.

During Infusion Protocol is running, please DO NOT STOP the management
software.

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Monitor the running pump status

1. Open Monitor window by clicking Monitor (M) from menu bar.

2. Upper part of window shows Study Name, Group and Animal. Select Group ID
from pull down menu in Group column and Animal ID from Animal column.

3. There is Refill Log table in the Right side. At first input the medical solution refill
time and volume, then click Enter button. For detail, please refer “Replace and/or
refill drag solution”. (Nest chapter)

4. The estimated remain solution volume is shown by calculated from infusion
schedule and duration in the bottom of window. Also software alarm will be appear
when the calculated volume reaches the Alarm Setting volume.

5. The Infusion Profile Graph locates in the left side of window. Clicking “Time Unit”
button upper right, the Graph axis unit can be switched. Also clicking “Schedule”
button bottom right, the Infusion schedule table will be shown. TO return, just
click “Graph” button.

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Replace and/or Refill the medical solution

1. Open Monitor (M) window.

2. Verify the estimated remain volume in the bottom area.

3. Make pump implanted animal immobilization by weak anesthesia or retention.

4. When replace the solution, aspirate remain fluid in reservoir by 27G syringe needle
through the skin to port. Subsequently fill the replacing solution into syringe and
refill it to reservoir. To restock the drag solution, just fill the solution in a loaded
syringe through the skin to port.

5. Input Refill Time and Volume, click Enter button. When executed by dose mode,
input new weight and click Calculate button, recast New Concentration result will
be displayed to keep dose condition.

6. After fix the Refill Log, the table record automatically the Refill time, volume and
comments (weight and density). To remove the refill log, select target refill log and
click “Delete” button.

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End of Study

After all infusion protocol finished, click “Study End” makes automatically record
study date and finish study. If study should be abort during infusion schedule, click
“AbortAll” then click “Study End”

Save Study file

1. Click Save Study from the File (F) in menu bar. The data file stored in
C:\Users\XXX\AppData\Local\iPRECIO\study

2. The save data can be loaded from “Open” in the File (F) in the menu bar.

Export Study file

1. Chose “Export” from the File (F) in menu bar.

2. Select folder to export, save with file name.

3. The exported data format is “csv”. To view the data, simply import it by regular
spreadsheet program.

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iPRECIO® IMS-310R Quick guide ver.1.0.0.E

A

dministration method

Rotary

finger type

(Patented:

Peristaltic mechanism)

guaranteed.

Inner Tube:

(Material) Medical grade

SEBS

(Size)

ID=0.5mm, L=140mm

(Recommend below 27Ga

size needle

)

ISM band

radio

(

Frequency:

916.2,

923.1, 926.1

MHz

) C

om unit

：

Within 3m from

UCD

-

X10R

Material: Polyamide FPC

(FR）

Discharge flow by 360 degree roll of cam:

3.2μL I

nfusion accuracy

±5 (

Under pressure

0~80cmH

2

O）

FR 10

.0μL/hr.

: 7 days

Power on

By

applying the magnet force to power on.

(Except accompanying catheter)

Weight

3.4

g (

Include accompanying catheter

) S

olid content

2.4cc Type of usage

Disposable

Package

EOG

Pre-Sterilization pack (5 package/box)

Sterilization TTL

2yrs (

Built in batter cause

s self-discharge during storage)

Data com unit.

Data com unit and individual pump.

pump number

P

ower source

[Weight]

35

g [Cable length

] 1.2m S

ize and Weight

140 60(H) mm

347g

Product Specification

Micro infusion pump for small laboratory animal iPRECIO®（Model:SMP-310R）

Reservoir 130μL Built-in reservoir: (Material) Medical grade SEBS

The Maximum capacity is 130μL, but out of accuracy

guarantee range. To keep accuracy, only within 100μL is

Tube

Outer Tube: (Material) Medical grade SEBS (3Fr)

Replace/Refill port 2mm size refill port stick out in the pump.

Data communication

Antenna Built in pattern antenna.

Programmable Flow Rate

Battery Life Continuous motion FR 0.1μL/hr.: 19days,

Size 25.6(L) 15.8(W) 8.2 (H) mm

0.1~10.0μL/hr. (setting resolution:0.1μL/hr.）

Data com unit (Model UCD-X10R)

Interface with control PC

LAN ( Cross type cable with ferrite core)

Control through Ethernet by setting fixed IP address to the

Communication way with
pump

One unit controllable

ISM band radio (Frequency: 916.2, 923.1, 926.1MHz)

Not broadband type. One–on one communication between

20~25 pumps (Theoretical value without time expense )

USB DC adapter cable included.

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(3m)

1 cable

S

upported

OS Windows 7

/

Windows 8/Windows 10

Japanese

English

STD accessory Anchorage to cage(Velcro) LAN cable with ferrite core

Management software

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