USER GUIDE
NI USB-6221/6229/6251/6259 OEM
This document provides dimensions, pinouts, and information
about the connectors, switch, LEDs, and chassis ground of the
NI USB-6221/6229/6251/6259 OEM devices.
Caution There are no product safety, electromagnetic compatibility (EMC), or
CE marking compliance claims made for the USB-6221/6229/6251/6259 OEM devices.
Conformity to any and all compliance requirements rests with the end product supplier.
Figure 1 shows the USB-6221/6251 OEM and USB-6229/6259 OEM
devices.
USB-6221/6251 USB-6229/6259
Figure 1. USB-6221/6251 and USB-6229/6259 OEM Devices
Refer to the NI 622x Specifications document for USB-6221/6229
specifications and the NI 625x Specifications document for
USB-6251/6259 specifications. Refer to the M Series User Manual for
more information about USB-6221/6229/6251/6259 devices. You can find
all documentation at
ni.com/manuals.
Dimensions
6.950 (176.53)
4x 6.718 (170.63)
6.270 (159.26)
6.140 (155.96)
5.930 (150.62)
Figure 2 shows the dimensions of the USB-6221/6251 OEM device.
0.200 (5.08)
0.918 (23.32)
0.390 (9.91)
3.180 (80.77)
3.220 (81.79)
3.198 (81.22)
4.110 (104.39)
3.734 (94.84)
3.730 (94.74)
6.013 (152.74)
5.900 (149.86)
5.210 (132.33)
4X Ø 0.110 (2.79)
7X Ø 0.125 (3.18)
6.140 (155.96)
5.760 (146.30)
5.290 (134.37)
5.080 (129.03)
2X Ø 0.156 (3.96)
2.535 (64.39)
0.396 (10.06)
0.304 (7.72)
0.256 (6.50)
0.116 (2.95)
0.000 (0.00)
0.436 (11.07)
0.392 (9.96)
0.362 (9.19)
0.162 (4.11)
0.062 (1.57)
0.000 (0.00)
0.200 (5.08)
0.000 (0.00)
0.393 (9.98)
1.057 (26.85)
2.072 (52.63)
1.750 (44.45)
2.300 (58.42)
3.296 (83.72)
2.606 (66.19)
3.080 (78.23)
2X Ø 0.140 Cutout
in Panel for LEDs
Ø 0.330 Cutout in Panel
for Power Connector
4.780 (121.41)
6.200 (157.48)
0.304 (7.72)
0.200 (5.08)
6.400 (162.56)
0.515 (13.08)
Figure 2. USB-6221/6251 OEM Dimensions in Inches (Millimeters)
NI USB-6221/6229/6251/6259 OEM User Guide 2 ni.com
6.950 (176.53)
4x 6.718 (170.63)
6.270 (159.26)
6.140 (155.96)
5.930 (150.62)
5.839 (148.31)
5.499 (139.67)
0.396 (10.06)
0.304 (7.72)
0.256 (6.50)
0.116 (2.95)
0.000 (0.00)
Figure 3 shows the dimensions of the USB-6229/6259 OEM device.
0.200 (5.08)
0.918 (23.32)
0.390 (9.91)
3.180 (80.77)
3.220 (81.79)
3.198 (81.22)
4.110 (104.39)
3.734 (94.84)
3.730 (94.74)
6.013 (152.74)
5.900 (149.86)
5.210 (132.33)
4X Ø 0.110 (2.79)
7X Ø 0.125 (3.18)
6.140 (155.96)
5.760 (146.30)
5.290 (134.37)
5.080 (129.03)
2X Ø 0.156 (3.96)
2.535 (64.39)
0.304 (7.72)
0.200 (5.08)
0.436 (11.07)
0.392 (9.96)
0.362 (9.19)
0.162 (4.11)
0.062 (1.57)
0.000 (0.00)
0.200 (5.08)
0.000 (0.00)
0.393 (9.98)
1.057 (26.85)
2.072 (52.63)
1.750 (44.45)
2.300 (58.42)
3.296 (83.72)
2.606 (66.19)
3.080 (78.23)
2X Ø 0.140 Cutout
in Panel for LEDs
Ø 0.330 Cutout in Panel
for Power Connector
4.780 (121.41)
6.200 (157.48)
6.400 (162.56)
0.515 (13.08)
Figure 3. USB-6229/6259 OEM Dimensions in Inches (Millimeters)
© National Instruments Corporation 3 NI USB-6221/6229/6251/6259 OEM User Guide
I/O Connector Pinouts
Figures 4 through 7 show the connector pinouts for the USB-6221 OEM,
USB-6229 OEM, USB-6251 OEM, and USB-6259 OEM devices.
Refer to the M Series User Manual at
information about USB-6221/6229/6251/6259 signals and how to
connect them.
ni.com/manuals for more
NI USB-6221/6229/6251/6259 OEM User Guide 4 ni.com
Bank 0
50-Pin Digital Connector
+5 V
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
49
50
47
48
45
46
43
44
41
42
39
40
37
38
35
36
33
34
31
32
29
30
27
28
25
26
23
24
21
22
19
20
17
18
15
16
13
14
11
12
10
8
6
4
2
Bank 0
+5 V
PFI 15
PFI 14
PFI 13
PFI 12
PFI 11
PFI 10
PFI 9
PFI 8
PFI 7
PFI 6
PFI 5
PFI 4
PFI 3
PFI 2
PFI 1
PFI 0
P0.7
P0.6
P0.5
9
P0.4
7
P0.3
5
P0.2
3
P0.1
1
P0.0
34-Pin Analog Connector
AI GND
AI 7
AI 14
AI GND
AI 5
AI 12
AI GND
AI 3
AI 10
AI GND
AI 1
AI 8
AI GND
AI GND
AI GND
AO 1
AO 0
34
33
AI 15
32
31
AI GND
30
29
AI 6
28
27
AI 13
26
25
AI GND
24
22
20
18
16
14
12
10
AI 4
23
21
AI 11
19
AI GND
17
AI 2
AI 9
15
AI GND
13
11
AI 0
9
AI SENSE
8
7
NC
6
AO GND
5
4
3
AO GND
2
1
AO GND
NC = No Connect
Figure 4. USB-6221 OEM Connector Pinout
© National Instruments Corporation 5 NI USB-6221/6229/6251/6259 OEM User Guide
Bank 1
Bank 0
50-Pin Digital Connectors
+5 V
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
50
49
48
47
46
45
44
43
42
41
40
39
38
37
36
35
34
33
32
31
30
29
28
27
26
25
24
23
22
21
20
19
18
17
16
15
14
13
12
11
10
9
8
7
6
5
4
3
2
1
Bank 1
+5 V
P0.31
P0.30
P0.29
P0.28
P0.27
P0.26
P0.25
P0.24
P0.23
P0.22
P0.21
P0.20
P0.19
P0.18
P0.17
P0.16
P0.15
P0.14
P0.13
P0.12
P0.11
P0.10
P0.9
P0.8
+5 V
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
49
50
47
48
45
46
43
44
41
42
39
40
37
38
35
36
33
34
31
32
29
30
27
28
25
26
23
24
21
22
19
20
17
18
15
16
13
14
11
12
10
8
5
6
3
4
1
2
Bank 0
+5 V
PFI 15
PFI 14
PFI 13
PFI 12
PFI 11
PFI 10
PFI 9
PFI 8
PFI 7
PFI 6
PFI 5
PFI 4
PFI 3
PFI 2
PFI 1
PFI 0
P0.7
P0.6
P0.5
9
P0.4
7
P0.3
P0.2
P0.1
P0.0
34-Pin Analog Connectors
AI GND
AI 23
AI 30
AI GND
AI 21
AI 28
AI GND
AI 19
AI 26
AI GND
AI 17
AI 24
AI GND
AI GND
AI GND
AO 3
AO 2
34
33
AI 31
32
31
AI GND
30
29
AI 22
27
8
6
4
2
25
23
21
19
17
15
13
11
9
7
5
3
1
AI 29
AI GND
AI 20
AI 27
AI GND
AI 18
AI 25
AI GND
AI 16
AI SENSE 2
NC
AO GND
AO GND
AO GND
28
26
24
22
20
18
16
14
12
10
AI GND
AI 7
AI 14
AI GND
AI 5
AI 12
AI GND
AI 3
AI 10
AI GND
AI 1
AI 8
AI GND
AI GND
AI GND
AO 1
AO 0
34
32
30
28
26
24
22
20
18
16
14
12
10
AI 15
33
AI GND
31
AI 6
29
AI 13
27
AI GND
25
AI 4
23
AI 11
21
AI GND
19
AI 2
17
AI 9
15
AI GND
13
AI 0
11
AI SENSE
9
8
NC
7
6
AO GND
5
4
AO GND
3
2
AO GND
1
NC = No Connect NC = No Connect
Figure 5. USB-6229 OEM Connector Pinout
NI USB-6221/6229/6251/6259 OEM User Guide 6 ni.com
Bank 0
50-Pin Digital Connector
+5 V
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
49
50
47
48
45
46
43
44
41
42
39
40
37
38
35
36
33
34
31
32
29
30
27
28
25
26
23
24
21
22
19
20
17
18
15
16
13
14
11
12
10
8
6
4
2
Bank 0
+5 V
PFI 15
PFI 14
PFI 13
PFI 12
PFI 11
PFI 10
PFI 9
PFI 8
PFI 7
PFI 6
PFI 5
PFI 4
PFI 3
PFI 2
PFI 1
PFI 0
P0.7
P0.6
P0.5
9
P0.4
7
P0.3
5
P0.2
3
P0.1
1
P0.0
34-Pin Analog Connector
AI GND
AI 7
AI 14
AI GND
AI 5
AI 12
AI GND
AI 3
AI 10
AI GND
AI 1
AI 8
AI GND
AI GND
AI GND
AO 1
AO 0
34
33
AI 15
32
31
AI GND
30
29
AI 6
28
27
AI 13
26
25
AI GND
24
22
20
18
16
14
12
10
AI 4
23
21
AI 11
19
AI GND
17
AI 2
AI 9
15
AI GND
13
11
AI 0
9
AI SENSE
8
7
APFI 0
6
AO GND
5
4
3
AO GND
2
1
AO GND
Figure 6. USB-6251 OEM Connector Pinout
© National Instruments Corporation 7 NI USB-6221/6229/6251/6259 OEM User Guide
50-Pin Digital Connectors
+5 V
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
Bank 1
50
49
48
47
46
45
44
43
42
41
40
39
38
37
36
35
34
33
32
31
30
29
28
27
26
25
24
23
22
21
20
19
18
17
16
15
14
13
12
11
10
9
8
7
6
5
4
3
2
1
+5 V
P0.31
P0.30
P0.29
P0.28
P0.27
P0.26
P0.25
P0.24
P0.23
P0.22
P0.21
P0.20
P0.19
P0.18
P0.17
P0.16
P0.15
P0.14
P0.13
P0.12
P0.11
P0.10
P0.9
P0.8
+5 V
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
D GND
Bank 0
49
50
47
48
45
46
43
44
41
42
39
40
37
38
35
36
33
34
31
32
29
30
27
28
25
26
23
24
21
22
19
20
17
18
15
16
13
14
11
12
10
8
5
6
3
4
1
2
+5 V
PFI 15
PFI 14
PFI 13
PFI 12
PFI 11
PFI 10
PFI 9
PFI 8
PFI 7
PFI 6
PFI 5
PFI 4
PFI 3
PFI 2
PFI 1
PFI 0
P0.7
P0.6
P0.5
9
P0.4
7
P0.3
P0.2
P0.1
P0.0
Bank 0
34
33
32
31
30
29
28
27
26
25
24
23
22
21
20
19
18
17
16
15
14
13
12
11
10
8
6
4
2
9
7
5
3
1
AI 15
AI GND
AI 6
AI 13
AI GND
AI 4
AI 11
AI GND
AI 2
AI 9
AI GND
AI 0
AI SENSE
APFI 0
AO GND
AO GND
AO GND
34-Pin Analog Connectors
AI GND
AI 23
AI 30
AI GND
AI 21
AI 28
AI GND
AI 19
AI 26
AI GND
AI 17
AI 24
AI GND
AI GND
AI GND
AO 3
AO 2
Bank 1
34
33
32
31
30
29
28
27
26
25
24
23
22
21
20
19
18
17
16
15
14
13
12
11
10
9
8
7
6
5
4
3
2
1
AI 31
AI GND
AI 22
AI 29
AI GND
AI 20
AI 27
AI GND
AI 18
AI 25
AI GND
AI 16
AI SENSE 2
APFI 1
AO GND
AO GND
AO GND
AI GND
AI 7
AI 14
AI GND
AI 5
AI 12
AI GND
AI 3
AI 10
AI GND
AI 1
AI 8
AI GND
AI GND
AI GND
AO 1
AO 0
Figure 7. USB-6259 OEM Connector Pinout
NI USB-6221/6229/6251/6259 OEM User Guide 8 ni.com
LEDs
USB-6221/6229/6251/6259 OEM devices have two LEDs that reflect
the device state. The green READY LED indicates whether the device is
powered on and configured as a USB device. The yellow ACTIVE LED
indicates whether there is USB bus activity.
Three connectors on the device allow you to connect an external LED
circuit to the device. To connect an external READY LED, use E1 as the
positive connection (+3.3 V) and E2 as the negative connection. To connect
an external ACTIVE LED, use E1 as the positive connection and E3 as the
negative connection. E1 is current limited with a 100 Ω resistor to the 3.3 V
internal supply. This configuration limits the current to approximately
16 mA into a single external LED or approximately 8 mA each when both
LEDs are on. You also can limit this current further by using external
resistors as shown in Figure 8.
DS1
E3
E2 E1
Figure 8. USB-6221/6229/6251/6259 OEM LEDs
Figure 9 shows how to connect an external READY or ACTIVE LED
circuit to the device.
Internal
3.3 V
100 Ω
External
READY LED
External Resistor
E2
Figure 9. Schematics of the USB-6221/6229/6251/6259 OEM LEDs
© National Instruments Corporation 9 NI USB-6221/6229/6251/6259 OEM User Guide
E1
External
ACTIVE LED
External Resistor
E3
Power Switch
The power switch on the USB-6221/6229/6251/6259 OEM device powers
the device on and off. Figure 10 shows the pins on the power switch.
100 kΩ
Provides
Power to
Device
SW1
Switch
45
VDC Comes
123
from Fuse
XF1
Outer
Shell
J4
Figure 10. Power Switch (USB-6229/6259 OEM Shown)
Pin 1 is connected to VDC through the fuse (reference designator XF1).
The VDC is the voltage provided by the power supply through the power
connector (reference designator J4) and must be 11–30 V, 20 W.
Pin 2 provides power to the circuitry on the USB-6221/6229/6251/6259
OEM device. When the switch is in the On position, the VDC power supply
from pin 1 is routed to pin 2.
Pin 3 connects pin 2 to ground through a 100 kΩ resistor when the switch
is in the Off position. This allows the internal power supply in the
USB-6221/6229/6251/6259 OEM device to safely discharge to ground
when it is powered off. Figure 11 shows a schematic of the switch.
XF1
FUSE
Power to
Device
SW1
2
1
3
100 kΩ
Figure 11. Schematic of the USB-6221/6229/6251/6259 OEM Switch
NI USB-6221/6229/6251/6259 OEM User Guide 10 ni.com
J4
Powe r
Connector
Chassis Ground
Note The holes that are labeled B are reserved for an external shield. Do not use these
holes as mounting holes.
Chassis ground provides a connection between the enclosure and USB
ground.
D GND is connected to the chassis ground through an internal connection
to hole A, shown in Figure 12. The chassis ground directly connects to USB
shield ground.
The USB-6221/6229/6251/6259 OEM device includes several mounting
holes that are plated and designed for user-configured ground connections
between the device chassis ground and the appropriate system ground.
Figure 12 shows where the different grounds are connected.
B
B
B
A
Mounting Hole Connected
to Chassis Ground
Figure 12. Ground Connections (USB-6229/6259 OEM Shown)
© National Instruments Corporation 11 NI USB-6221/6229/6251/6259 OEM User Guide
Device Components
Table 1 contains information about the components used for interfacing
and interacting with the USB-6221/6229/6251/6259 OEM device.
Table 1. USB-6221/6229/6251/6259 OEM Components
Reference
Designator(s)
Component
on PCB
Manufacturer
LEDs DS1 Dialight 553-0332
34-pin connectors J1, J2
50-pin connectors P1, P2
*
*
3M N2534-6002RB
3M N2550-6002UB
USB connector J3 AMP 787780-1
Power connector J4 Switchcraft 722RA
Power switch SW1 ITT Industries, Cannon E101J1A3QE2
F 2A L 250V fuse XF1 Littelfuse 217.002
68-pin connectors
*
J2, P2, and J6 are available on USB-6229/6259 OEM devices only.
†
Optional mass termination connectors. These are not populated by default.
†
J6*, J7 Honda PCS-E68RLMD1+
Manufacturer
Part Number
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371910B-01 Oct06
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