M18, Mirror Glaze Clear Plastic Detailer (24-27A): M1808
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Respiratory Sensitisation
Name Species Value
Germ Cell Mutagenicity
Name Route Value
Propane-1,2-diol In Vitro Not mutagenic
Propane-1,2-diol In vivo Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3one
In vivo Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3one
In Vitro Some positive data exist, but the data are not
sufficient for classification
Carcinogenicity
Name Route Species Value
Propane-1,2-diol Dermal Mouse Not carcinogenic
Propane-1,2-diol Ingestion Multiple
animal
species
Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl2H-isothiazol-3-one
Dermal Mouse Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl2H-isothiazol-3-one
Ingestion Rat Not carcinogenic
Reproductive Toxicity
Reproductive and/or Developmental Effects
Name Route Value Species Test result Exposure
Duration
Propane-1,2-diol Ingestion Not toxic to female reproduction Mouse NOAEL
10,100
mg/kg/day
2 generation
Propane-1,2-diol Ingestion Not toxic to male reproduction Mouse NOAEL
10,100
mg/kg/day
2 generation
Propane-1,2-diol Ingestion Not toxic to development Multiple
animal
species
NOAEL
1,230
mg/kg/day
during
organogenesis
Mixture of 5-chloro-2-methyl-2Hisothiazol-3-one and 2-methyl-2Hisothiazol-3-one
Ingestion Not toxic to female reproduction Rat NOAEL 10
mg/kg/day
2 generation
Mixture of 5-chloro-2-methyl-2Hisothiazol-3-one and 2-methyl-2Hisothiazol-3-one
Ingestion Not toxic to male reproduction Rat NOAEL 10
mg/kg/day
2 generation
Mixture of 5-chloro-2-methyl-2Hisothiazol-3-one and 2-methyl-2Hisothiazol-3-one
Ingestion Not toxic to development Rat NOAEL 15
mg/kg/day
during
organogenesis
Target Organ(s)
Specific Target Organ Toxicity - single exposure
Name Route Target Organ(s) Value Species Test result Exposure
Duration
Propane-1,2-diol Ingestion central nervous
system depression
May cause drowsiness or
dizziness
Human NOAEL Not
available
poisoning
and/or abuse
Mixture of 5-chloro-2methyl-2H-isothiazol-3one and 2-methyl-2Hisothiazol-3-one
Inhalation respiratory irritation Some positive data exist, but the
data are not sufficient for
classification
similar
health
hazards
NOAEL Not
available
Specific Target Organ Toxicity - repeated exposure
Name Route Target Organ(s) Value Species Test result Exposure
Duration