M10, Plastic Polish (original formulation): M1008
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Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3one
In vivo Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3one
In Vitro Some positive data exist, but the data are not
sufficient for classification
Carcinogenicity
Name Route Species Value
White mineral oil (petroleum) Dermal Mouse Not carcinogenic
White mineral oil (petroleum) Inhalation Multiple
animal
species
Not carcinogenic
Distillates (petroleum), hydrotreated light Dermal Mouse Some positive data exist, but the data are not
sufficient for classification
Glycerin Ingestion Mouse Some positive data exist, but the data are not
sufficient for classification
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl2H-isothiazol-3-one
Dermal Mouse Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl2H-isothiazol-3-one
Ingestion Rat Not carcinogenic
Reproductive Toxicity
Reproductive and/or Developmental Effects
Name Route Value Species Test result Exposure
Duration
White mineral oil (petroleum) Ingestion Not toxic to female reproduction Rat NOAEL
4,350
mg/kg/day
13 weeks
White mineral oil (petroleum) Ingestion Not toxic to male reproduction Rat NOAEL
4,350
mg/kg/day
13 weeks
White mineral oil (petroleum) Ingestion Not toxic to development Rat NOAEL
4,350
mg/kg/day
during
gestation
Glycerin Ingestion Not toxic to female reproduction Rat NOAEL
2,000
mg/kg/day
2 generation
Glycerin Ingestion Not toxic to male reproduction Rat NOAEL
2,000
mg/kg/day
2 generation
Glycerin Ingestion Not toxic to development Rat NOAEL
2,000
mg/kg/day
2 generation
Mixture of 5-chloro-2-methyl-2Hisothiazol-3-one and 2-methyl-2Hisothiazol-3-one
Ingestion Not toxic to female reproduction Rat NOAEL 10
mg/kg/day
2 generation
Mixture of 5-chloro-2-methyl-2Hisothiazol-3-one and 2-methyl-2Hisothiazol-3-one
Ingestion Not toxic to male reproduction Rat NOAEL 10
mg/kg/day
2 generation
Mixture of 5-chloro-2-methyl-2Hisothiazol-3-one and 2-methyl-2Hisothiazol-3-one
Ingestion Not toxic to development Rat NOAEL 15
mg/kg/day
during
organogenesis
Target Organ(s)
Specific Target Organ Toxicity - single exposure
Name Route Target Organ(s) Value Species Test result Exposure
Duration
Distillates (petroleum),
hydrotreated light
Inhalation central nervous
system depression
May cause drowsiness or
dizziness
NOAEL Not
available
Distillates (petroleum),
hydrotreated light
Inhalation respiratory irritation Some positive data exist, but the
data are not sufficient for
classification
NOAEL Not
available
Mixture of 5-chloro-2methyl-2H-isothiazol-3one and 2-methyl-2H-
Inhalation respiratory irritation Some positive data exist, but the
data are not sufficient for
classification
similar
health
hazards
NOAEL Not
available