G123, PlastX (22-121A): G12306, G12310
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one
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3one
In Vitro Some positive data exist, but the data are not
sufficient for classification
Carcinogenicity
Name Route Species Value
Solvent naphtha (petroleum), medium aliphatic Dermal Mouse Some positive data exist, but the data are not
sufficient for classification
Solvent naphtha (petroleum), medium aliphatic Inhalation Human
and
animal
Some positive data exist, but the data are not
sufficient for classification
Aluminium oxide Inhalation Rat Not carcinogenic
White mineral oil (petroleum) Dermal Mouse Not carcinogenic
White mineral oil (petroleum) Inhalation Multiple
animal
species
Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl2H-isothiazol-3-one
Dermal Mouse Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl2H-isothiazol-3-one
Ingestion Rat Not carcinogenic
Reproductive Toxicity
Reproductive and/or Developmental Effects
Name Route Value Species Test result Exposure
Duration
Solvent naphtha (petroleum), medium
aliphatic
Inhalation Not toxic to development Rat NOAEL 2.4
mg/l
during
organogenesis
White mineral oil (petroleum) Ingestion Not toxic to female reproduction Rat NOAEL
4,350
mg/kg/day
13 weeks
White mineral oil (petroleum) Ingestion Not toxic to male reproduction Rat NOAEL
4,350
mg/kg/day
13 weeks
White mineral oil (petroleum) Ingestion Not toxic to development Rat NOAEL
4,350
mg/kg/day
during
gestation
Mixture of 5-chloro-2-methyl-2Hisothiazol-3-one and 2-methyl-2Hisothiazol-3-one
Ingestion Not toxic to female reproduction Rat NOAEL 10
mg/kg/day
2 generation
Mixture of 5-chloro-2-methyl-2Hisothiazol-3-one and 2-methyl-2Hisothiazol-3-one
Ingestion Not toxic to male reproduction Rat NOAEL 10
mg/kg/day
2 generation
Mixture of 5-chloro-2-methyl-2Hisothiazol-3-one and 2-methyl-2Hisothiazol-3-one
Ingestion Not toxic to development Rat NOAEL 15
mg/kg/day
during
organogenesis
Target Organ(s)
Specific Target Organ Toxicity - single exposure
Name Route Target Organ(s) Value Species Test result Exposure
Duration
Solvent naphtha
(petroleum), medium
aliphatic
Inhalation central nervous
system depression
May cause drowsiness or
dizziness
Human
and
animal
NOAEL Not
available
Solvent naphtha
(petroleum), medium
aliphatic
Inhalation respiratory irritation Some positive data exist, but the
data are not sufficient for
classification
NOAEL Not
available
Solvent naphtha
(petroleum), medium
aliphatic
Inhalation nervous system Some positive data exist, but the
data are not sufficient for
classification
Dog NOAEL 6.5
mg/l
4 hours
Mixture of 5-chloro-2methyl-2H-isothiazol-3one and 2-methyl-2Hisothiazol-3-one
Inhalation respiratory irritation Some positive data exist, but the
data are not sufficient for
classification
similar
health
hazards
NOAEL Not
available