Trademark bearing the symbol in this publication are registered in the U.S. and in other countries.
Modifi cations of the design or materials may be made without prior notice.
®
ORIGINAL INSTRUCTIONS
PUMP FOR LIQUIDS
ii
A-1299-7368
Masterflex
Preface
Explanation of Symbols
Explanation of
Symbols
Please read this manual carefully before start-up of the pump and
take note of the appropriate instruction in the operating manual. See
SECTION 3 for detailed safety instruction. See drive manual for more
safety instructions.
!
CAUTION: Risk of danger. Consult operator’s manual for nature
of hazard and corrective actions.
CAUTION: Risk of injury. Keep fingers away from the coupling
while shaft is rotating. Do not operate without pump head
installed.
CAUTION: Hot surface. Do not touch.
CAUTION: Risk of electric shock. Consult operator’s manual for
nature of hazard and corrective actions.
CAUTION: Please follow the general guidelines and safety
instructions when handling with chemicals.
WARNING:
Product Use
Limitation
CAUTION: During all maintenance work it has to be ensured
that no explosive atmosphere can arise. Appropriate protection
equipment is recommended. The Quattroflow 150S must not be
operated in explosion-proof areas. Special versions for “ATEX”
applications are available. Please contact manufacturer.
This product is not designed for, nor intended for use in
!
patient connected applications; including, but not limited
to, medical and dental use, and accordingly has not been
submitted for FDA approval.
This product is not designed for, nor intended for use in
hazardous duty areas as defined by ATEX or the NEC (National
Electrical Code); including, but not limited to use with
flammable liquids. Consult the factory for products suitable
for these types of applications.
ese operating instructions are valid for the Quattrofl ow 150S pump.
No liability will be undertaken for any damages caused be non-compliance with the operating instructions and service conditions! Original
spare parts serve safety purposes. e use of other parts may cancel the
liability for the consequences and secondary failures resulting there of.
Drive Manufacturer: Cole-Parmer
650 East Bunker Ct
Vernon Hills, IL 60061 USA
Phone: 1-800-323-4340
Email: techinfo@coleparmer.com
Internet: www.coleparmer.com
Quattrofl ow quaternary diaphragm pumps are constructed according to
the state of the art and they are reliable. Imminent danger by operating
error or misuse can lead to damages of properties and/or persons. e
pumps are to be applied for the intended use in a safety-related proper
condition only.
Masterflex
Storage
In general the Quattrofl ow pump is delivered operational and packaged.
If the unit is not installed right away, proper storage conditions are important for trouble free operation later. e pump has to be protected from
wetness, coldness, dirtying, UV-radiation and mechanical infl uences. e
following storage conditions are recommended:
-Steady ventilated, dust and vibration free storage room
-Ambient temperature between 15°C (59°F) and 25°C (77°F) with a
relative humidity below 65%.
-Prevention of direct thermal infl uences (sun, heating).
1-1A-1299-7368
Section 1
General
Labeling of the Pump
e ALMATEC Machinenbau GmbH is certifi ed as a modern, qualityorientated enterprise according to DIN EN ISO 9001: 2008 and 1400: 2009.
Before release for sale, any Quattrofl ow pump has to undergo an extended
fi nal control. e performance data registered during this are archived in our
records and can be read back at any time.
As a general rule in the countries of the EU only such machines are
allowed to be placed into operation, which are determined to meet the
regulations of the EU machinery directive, the harmonized standards,
European standards and the respective national standards. Hence the
operator has to verify whether the Quattrofl ow pump manufactured and
delivered properly according to the customers order meets the mentioned
requirements.
erefore make sure, before putting the pump into operation, that the
pump and the used materials of construction are suitable for the provided
application and the installation site.
e type label of each Quattrofl ow pump can be seen on the bottom of
the pump. e serial number of the pump head is fi xed the bottom of the
pump.
Masterflex Pump Drive
For further information on the pump drive system see within this
flash drive or on the web.
1-2 A-1299-7368
Masterflex
Section 2 QF150S Pump Description
Section 2
QF150S Pump Description
Appropriate Use
e Quattrofl ow 150S is a 4 piston-diaphragm pump, which is mainly used
to pump water-like fl uids that are typically handled in research, pilot plant or
production facilities of the pharmaceutical, biotech, food or cosmetic research
centers or plants.
Examples:
• Solutions containing protein (albumin, IgG, Clotting factors, monoclonal,
enzymes, vaccines.)
• Solutions of polymers or suspensions (silicon, latex, chromatography media)
• Feed Pump for fi lter cartridges or plate and frame depth fi lters
General Description of
the Machine
- Chromatography:
• Packing of chromatography columns
• Feed pump to mix gradients
- Feed pump for centrifuges or separators
- Feed pump for fi lling machines
e Quattrofl ow 150S pump is a 4 piston-diaphragm pump. e four segments
of the pump diaphragm oscillate back and forth. is alternate movement is
created by a connector plate that is arranged on a ball bearing. e ball bearing
sits on an eccentric shaft. e connector plate does not turn!
e stroke of the piston is determined by the angle of the eccentric. ere are
eccentric shafts with 5° available.
Range of fl ow rate: 5° eccentric shaft: approx. 1-180 L/hr at max. 3000 rpm
Masterflex
2-1A-1299-7368
Section 2
QF150S Pump Description
General Description of
the Machine
(continued)
Start-Up
Please note:
e direction of fl ow can be adjusted by turning the pump chamber in
90° steps.
e Quattrofl ow 150S is self-priming and can run dry. Inside the pump
chamber there are no rotating parts that might cause heating up of the
product or shed particles.
e pump-motor unit is mounted on a stainless steel base plate. In case
that the pump will not be operated on the base plate but for example in a
frame, a perpendicular mounting position is possible.
Before start-up of the pump one should acquaint oneself with the explanations of the troubleshooting. Only by doing this can defects be quickly
realized and eliminated in case of trouble. Problems which cannot be solved
or with an unknown reason should be passed on to the manufacturer.
Prior to each use we recommend to fl ush the pump with a proper fl uid (e.g.
water or buff er).
Prior to the very fi rst use it might make sense to clean and sanitize the
pump chamber. A commercial caustic clear and/or 0.1 to 0.5N NaOH can
be applied. e chosen cleaning agent can be recirculated and also stored
inside the pump chamber. For Flushing out of any cleaning agent do not
recirculate! Check with appropriate analytical methods the success of the
fl ushing procedure.
Recommendation: Test run prior first use!
!
!
A-1299-73682-2
Before using your pump in your process perform a test run to
get used to the specific properties of the pump.
Pay attention to have sufficiently dimensioned piping. Too
small of for the suction line can cause cavitation as well as a
loss of performance.
If hoses are used in the suction line, make sure that they do not
collapse due to the negative pressure.
When installing the pump please insure that around the pump
enough space is available for the operation and maintenance.
Pay attention to the required space needed for assembly and
disassembly of the pump chamber.
During start-up pay attention to the warning and safety instructions of this manual.
Masterflex
Section 2
QF150S Pump Description
Cleaning (CIP)
Autoclave
Depending on the products in contact with the pump and given requirements the cleaning procedure needs to be adapted accordingly. It is the
responsibility of the user to verify the cleaning effi ciency. Safety rules and
safety measures like protective glasses, gloves, and protective clothing
have to be followed and used when working with chemicals like sodium
hydroxide (NaOH).
As a general rule we recommend to clean the pump according to the
following procedure.
1. Pre rinse the pump with pure water, until residual amounts of
product have been removed.
2. Cleaning step with 0.5 M NaOH (ca 50°C) at 80% of the maximum
RPM for approximately 30 min. Check before, if surrounding
conditions (e.g. pipe diameter, system pressure rating) allow to operate
the pump at this speed.
3. Final rinse with pure water, until neutrality has been achieved (e.g. by
measuring conductivity or pH of the rinse water).
For sterilization of the pump chamber we recommend the following steps.
1. CIP of the pump chamber according to 2.5 or any other suitable
process.
2. Empty the pump
3. Remove the pump chamber from the pump drive.
4. Close the in and outlet of the pump (e.g. by connecting hoses). Make
sure that there is free interchange available of gas and steam over a
sterile barrier (e.g. sterile fi lter) at the in and outlet.
5. Autoclave the prepared pump chamber in a vacuum at max 130°C
(266°F) for max 30 min. Follow the instructions from the autoclave
manufacturer.
Please make sure that the pump chamber is not placed on the
!
clamp ring during the autoclave process. The clamp ring should
not be loaded during autoclaving.
Masterflex2-3A-1299-7368
Section 2
QF150S Pump Description
Steaming in Place
(SIP)
For steaming in place the pump chambers need to be installed on the
pump drive. During the steaming process, the temperature in the pump
must not exceed 130°C (266°F) and should not last longer than 30 min.
e cooling of the pump chamber should be against air. Depending on the
SIP conditions it may be necessary to shorten the maintenance intervals
for the elastomers signifi cantly. Tightening torques (4 Nm, 3 lb-ft) of the
front bolts of the pump chamber must be checked after each SIP cycle.
2-4 A-1299-7368
Masterflex
Section 3
Safety
Section 3 Safety
ese operating instructions contain basic hints to be observed during installation, operation and maintenance. erefore, prior to mounting and commissioning, these operating instructions must by all means be read by the fi tter as
well as the pertinent expert personnel/customer and must always be available
at the place of installation of the pump. Not only are the general safety hints
listed under this item “Safety” to be observed, but also the special safety hints
in other sub sections.
Labels on the Pump
!
Qualified Personnel
Safety Guidelines
Failure to Follow Safety
Instructions
Marking labels at the pump e.g.
- P max 6 bar
- Fluid connections
- Direction of fl ow
Must not be removed and has to be readable.
e customer is responsible for ensuring that all maintenance, inspection
and mounting operations are performed by authorized and qualifi ed expert personnel who have suffi ciently informed themselves by thoroughly
studying the operating instructions.
Please follow strictly the safety guidelines of this manual, as well as all
national and possible regulations (e.g. the handling of chemicals, like caustic
or acid, the handling of biological materials, the handling of tubing, instrumentation, fi ttings etc.).
Any case of non-compliance with the safety instructions may cause
danger to personnel, equipment and environment.
It Can Cause for Example:
- Failure of the proper function of the pump/system
- Failure of required procedures for maintenance
- Danger to personnel by electrical, mechanical, chemical, biological impacts
- Danger to equipment and environment through leakage of dangerous substances
Masterflex
Safety Hints for the
Operator
- In case of hot parts protective measures must be taken.
- Protecting covers of moving parts (e.g. coupling, cover of motor) must not
be removed.
- Leakages of dangerous products have to be handled without any danger for
persons and environment. Statutory regulations must be observed.
- Dangers by electrical energy are to be excluded (for details please refer to the
regulations of the VDE and the local energy supply associations).
3-1A-1299-7368
Section 3
Safety
Safety Maintenance,
Inspection and Mounting
Operations
• Basically, operations at the pump must be performed during standstill
only. e motor has to disconnect from the power supply, e.g. by
pulling out the power plug or using a repair switch, and has to be
secure against unintentional switch-on. is can be realized by a
lockable emergency switch. To prevent an accidental re-starting a
danger sign should be installed.
• e operator must ensure that all maintenance, inspection and
!
installation work is performed by authorized and qualifi ed skilled
personnel acquainted themselves with this manual.
• Before starting to disassemble the pump, take care that the pump has
been emptied, rinsed, depressurized and disconnected at all phases of
the power supply. Both ports piping are to be closed and drained if
applicable. If the pump is being removed from the plant, a reference
about the delivered liquid has to be attached.
• Pumps or aggregates handling noxious fl uids (e.g. caustic, biohazards) must be
decontaminated. Immediately following completion of the work, all safety
relevant and protective devices must be re-installed and/or re-activated before
being put back into operation, take care of the mentioned instructions of the
chapter “start-up” an check the tightness of the pump.
• Please respect the relevant additional security advises, if the pump has been
used for aggressive, dangerous or toxic liquids (e.g. suitable protective
equipment according to the safety data sheet of the liquid). In case of a
diaphragm rupture, it is possible that residues of the liquid remain behind the
diaphragms and in the area of the ring drive. Hence, appropriate safety
equipment according to the safety data sheet of the liquid is indispensable.
Unauthorized
Modifications
Invalid Modes
of Operation
• Especially when delivering critical liquids, wear parts, like diaphragms, should
be replaced within a preventive maintenance.
• Procedure for pump return: According to the requirements of our 14001
certifi cation, every unit which is sent to Masterfl ex or ALMATEC for
diagnosis or maintenance reasons has to be accompanied by a fi lled out
decontamination-sheet. Otherwise a processing is not possible. e
decontamination-sheet is enclosed in this manual.
Please pay attention to the further safety regulations.
e use of non-original Quattrofl ow spare parts or non authorized accessories and
reconstructions lead to the void of the warranty immediately. When operating
such a pump, damages of properties and/or persons cannot be excluded.
A safe operation of the pump is ensured only by an appropriate use according to
the specifi c data of the enclosed pump data sheet. e values limitations given in
the data sheet must not be exceeded.
3-2
A-1299-7368
Masterflex
Section 3
Safety
Additional Safety
Warnings
!
MAX:
P
6
bar
!
These warning hints are to prevent the user from an inadmissible mode
of operation. These warning hints are to be strictly followed to avoid
any damage to the pump and/or any danger to personnel.
e maximum allowed discharge pressure depends on the temperature of the
fl uid: P max at room temperature = 6 bar (>40°C = 4 bar) [=87 psi (>104°F =
58 psi)]. Exceeding of the maximum allowed discharge pressure must avoided
in any case (do not remove the warning sign at the pump). As a result even if
only temporarily – exceeding the allowed discharge pressure, the diaphragm can
be damaged. e resulting leakage may lead to a loss of the pumping fl uid and
damages of properties and/or persons. Pay attention to a suffi ciently
dimensioned piping on the suction and discharge line to prevent too high of
pressure in the pump. e pump chamber may not be set under pressure when
it is not mounted on the drive.
• e free cross section of the suction side as well as the length must be
measured in such a way to avoid cavitation.
• e use of a safety device (e.g. pressure switch) can be necessary.
• Please make sure that prior to the start of the pump the discharge line is
checked. Make sure that there is no fl ow restriction in the discharge line to
avoid any over pressure (e.g. closed valve).
• Flush the pump prior to use with appropriate fl uid (e.g. buff er).
• Foundation design: e foundation must be designed so that it can take the
weight of the pump aggregate on the entire surface.
• Please make sure that the pump is operated with the proper mains voltage and
frequency to avoid damages and electrical danger.
• Make sure that the slots for the cooling air are not blocked.
• Due to the versatile possibilities to use the Quattrofl ow pump it is highly
recommended to check case by case if the pump will be the right tool for
the specifi c application. e user/operator is responsible to perform a proper
method of testing if the pump should be applied for his specifi c application.
e chemical and thermal compatibility of the elastomeric parts of the pump
with the fl uid that will be pumped are to be checked by the operator before
the fi rst process run. E.g. Oily, fatty fl uids or solvents might cause a swelling
and/or destruction of the elastomeric components. If in doubt, please
contact the manufacturer!
• Operating the pump in humid or aggressive air can cause damages to the
motor and control box.
Masterflex
• e control box should not be exposed to spray/splash water or to heat
sources.
A-1299-7368
3-3
Section 3
Safety
Additional Safety
Warnings (Continued)
• Depending on the conditions of operation, the liquid conveyed might escape
from the pump in case of a diaphragm rupture. For further safety requirements
the optional equipment diaphragm monitoring is recommended.
• Pools of liquid which appear in the near outer area of the pump have to be
inspected on danger potential, if necessary safety measures are to be taken.
• Chemical and biological reactions in the product chamber of the pump (mixture
of diff erent substances) and the freezing of the liquid have to be avoided.
• To avoid corrosion the contact of aggressive solutions (e.g. NaCl, HCl) with the
outer stainless steel surfaces of the pump (e.g. hood, base plate) has to be
prevented.
• e Quattrofl ow pump is a positive displacement pump and can theoretically
generate an infi nitely high pressure even at low speed (rpm). Prior to each start
of the pump check and make sure that the discharge line is not closed or
restricted. e design of the discharge line must not build up a pressure of > 6
bar (78 psi).
• If suction and/or discharge line are fl exible tubing, then make sure that these
tubing do have the proper pressure rating for the full range of temperatures that
are applied.
• Please follow the general safety guidelines when handling chemical fl uids (wear
gloves and/or glasses) before the pump chamber will be opened.
• Never operate the pump without coupling protection and motor housing.
• Quattrofl ow pumps can lead to bruises when lifting, sinking or assembling them.
Appropriate accessories and safety equipment are to be used. Big and heavy
modules have to fi xed and secured to lifting gears when transporting/replacing
them.
• Disconnect mains before doing any maintenance! e housing of the control
box or the motor is to be opened only by skilled personnel. Check the electrical
cables before connecting to mains supply.
• During all maintenance work it has to be ensured that no explosive atmosphere
can arise. Appropriate protection equipment is recommended. e Quattrofl ow
150S must not be operated in explosion-proof areas. Special versions for
“ATEX” applications are available. Please contact the manufacturer.
Attention! Inadmissible modes of operation, arbitrary reconstruction, spare
parts production and/or any changes of the design (without permission of the
manufacturer) may cancel the liability resulting there from.
3-4 A-1299-7368
Masterflex
Section 4
Maintenance/Servicing
Section 4 Maintenance/Servicing
Due to the robust construction the Quattrofl ow pump are widely maintenance free.
e ball bearings do not need any extra lubrication.
e diaphragms, valves, and O-rings should be checked in regular intervals and if
needed they have to be replaced. We recommend the following maintenance intervals
for the diff erent pump parts:
ComponentMaintenance IntervalAction
Elastomer parts
(diaphragm, valves, and
O-rings)
Shaft-bearing-cap unit1000 h operating hours,
1000 h operating hours,
at least once a year
at least once a year
Replacement of the elastomer parts
(Contact Masterflex for order number).
Replacement of the complete unit (Contact Masterflex for order number).
MotorRefer to the maintenance information of the manual of the Drive
CouplingRefer to the maintenance information of the manual of the Drive
GearRefer to the maintenance information of the manual of the Drive
Depending on the operation conditions (pressure, temperature, fl ow rate, SIP, etc.) it
may be necessary to shorten the maintenance intervals for the elastomers signifi cantly.
In case that the diaphragm is broken the pump chamber should be replaced. At that
time is also recommended to check the ball bearings. For corrosion reasons or a clearly
audible operating noise the parts of the bearing service kit should be also replaced.
Please follow the general guidelines and safety advise
when handling with chemicals.
Disconnect mains supply before opening the pump housing!
Basically, operations at the pump must be performed during standstill only. The motor has to be disconnected from the power supply,
e.g. by pulling out the power plug or using a repair switch, and has
to be secure against unintentional switch-on. This can be realized by
a lockable emergency switch. To prevent an accidental re-starting a
danger sign should be installed.
Masterflex
A-1299-7368
4-1
Section 4
Maintenance/Servicing
Maintenance/Servicing
(Continued)
Replacing Diaphragm,
After purging the pump with air there might be a small residual
amount of fluid inside the pump chamber. Flush the pump
!
chamber thoroughly and check the rinse fluid.
The dismounting and mounting of the pump should be done on a
rigid table or work bench. Please note: the pump is heavy.
All further warning and safety instructions of Section 3 must be
respected.
e replacement of the diaphragm and the valves can be conducted by
the operator. e following drawings describe it step-by-step. In case
Valves, and O-rings
of bursting diaphragms by overpressure we advise also to change the
bearing unit.
Disassembling the Pump Chamber
1. Unlock Clamping Ring and Pump Chamber2. Removing Pump Chamber
3. Loosen the four
hex bolts and remove
pressure plate
together with pump
chamber.
2. Loosen screw of clamping
ring inside the drive.
(NOTE: Pressure plate only used in Single Use pumps)
1. Loosen and
remove hexagon
screw plug.
1. Pull off pump chamber.
4-2 A-1299-7368Masterflex
Exchange of Elastomer Parts
Section 4
Maintenance/Servicing
1. Opening the Pump Chamber
1. Loosen and remove bolts.
2. Take off pressure plate
including diaphragms and
clamping ring.
3. Removing Old Valves
1. Cut off collars of the valves.
2. Pull out the valves.
3. Loosen and remove the bolt from
the outlet valve.
4. Remove the outlet valve.
2. Dismounting Diaphragms and O-rings
1. Loosen old diaphragms
2. Lift up valve plate
3. Remove old o-rings.
4. Mounting the New Valves
1. Use the rubber stem to guide
the valves in straight.
5. Insert and lock the bolt for the
outlet valve.
3. Cut off the rubber stem
2. Pull rubber stem and collar through the
valve plate.
4. Insert new outlet valve
5. Mounting Pump Chamber
Masterflex
4. Lock plastic bolt.
3. Lock new diaphragms through
pressure plate into clamping ring.
2. Insert the valve plate.
1. Insert the new o-rings.
A-1299-7368
4-3
Section 4
Maintenance/Servicing
Reassembling Pump Chamber
Pay attention to the following torque values:
Image 2 item 1: Pump chamber bolts 4 Nm (3 lb-ft)
Image 2 item 2: Clamping ring bolt 2 Nm (1.5 lb-ft)
1. Mounting Pump Chamber
1. Straighten pump chamber
to the ring drive! Clamping
ring bolt must be horizontal
on top!
2. Lock Clamping Ring
2. Lock clamping ring
bolt inside the housing with an Allen key,
wrench size 2 mm.
1. Tighten bolts
3. Lock hexagon
socket screw
plug
(NOTE: Pressure plate only used in Single Use pumps)
4-4 A-1299-7368Masterflex
Maintenance/ Servicing
Replacing Bearing Unit
e replacement of the bearing unit (contact Masterfl ex for shaft-bearing-cap unit kit) can be conducted by the
operator. e following drawings describe it step-by-step.
Section 4
1. Removing Bearing Housing
1. Loosen and
remove bolts.
2. Pull off bearing housing.
3. Remove WLC- unit
(including eccentric shaft)
1. Lift WLC- unit
5. Locking the WLC into the
Bearing Housing
2. Lock bolt into bearing retainer.
2. Unlock Coupling
1. Loosen bolt of coupling
2. Pull off the coupling
3. Loosen and remove
hexagon socket screw
4. Mount new WLC- unit
(including eccentric shaft)
1. Use the threaded rod to
straighten the WLC- unit into
the bearing housing
6. Lock Coupling and WLC
2. Fit coupling and locking
blot of coupling.
Masterflex
1. Fix WLC with threaded rod
7. Insert Bearing Housing
2. Insert and Lock bolts
1. Mount bearing housing to the pump.
1. Remove threaded rod, and
insert the locking bolt.
Between both coupling
halves there has to be
a gap of 1 mm (0.039 in)
For further questions and ordering of spare parts please
contact the manufacturer.
A-1299-7368 4-5
Item #
1
2
Pump
Does Not
Start
Section 5 Troubleshooting
Troubleshooting Operations
Pump
Does Not
Prime
Delivery is
Not
Obtained
or Reduced
XX
X
Pressure
Head
is Not
Obtained
Irregular
Pump
Delivery
Pump
Operates
Noisily
Pump is
Leaky
Motor
Gets too
Warm
Display
Shows
Error Code
Causes and Remedial Action
The screws of the pump-chamber maybe not tightened
enough. Fix it!
Check the direction of flow showed by the arrow on
the pump, in case of wrong way, turn the pump head.
Section 5
Troubleshooting
3
4
5
6
7
8
9
10
11
12
13
14
XX
XXX
XXX
XXXX
XXX
XXX
XX
X
X
X
X
XXX
Check suction pipeline and TC-Seals for tightness.
Check suction head-increase suction line cross section.
Check viscosity of liquid pumped.
See Drive Manual
Avoid air inclusions in the liquid to be pumped.
Check pressure head-open valve in discharge line
completely, remove obstruction in discharge line.
Pressure line completely or partly clogged, diaphragm
maybe broken, change diaphragm!
The diameter of the pipes in suction or pressure line
are too small.
Check the coupling halves. They must be fixed with
2-3 mm space.
Check longitudinal play of coupling rod pins. The spider
might be worn.