Leica FL400 User Manual
Leica FL400
Invisible Becomes Visible
Living up to Life
Pioneering Fluorescence Innovation
The development of fluorescence microscopy has a long tradition
at Leica Microsystems, dating back to the beginning of the 20th
century. An important contribution to biological research, fluores-
cence science now integrates with the technology of the surgical
microscope to provide state-of-the-art oncological fluorescence.
The Leica FL400 enables fluorescence guided tumor resection. In
addition to the visible white light image, the Leica FL400 provides
the surgeon with information from fluorescence imaging and
the infrared spectrum, previously not visible to the human eye.
The ability to view fluorescence images intraoperatively through
the microscope’s eyepieces during surgery can benefit surgical
* The Leica FL400 is not approved
for sale in the USA, Japan,
and some other countries.
Please check the status of approval
with your local Leica representative.
2
outcomes.
Oncological Fluorescence
*
Photo Dynamic Imaging (PDI) during surgery combines a tumor-
selective photosensitizer, excitation light of an appropriate wave-
length, and a well-adjusted observation spectrum. Leica Micro-
systems provides the ideal combination of filters and crisp, clear
optics to provide good orientation in the resection area. The vital
tumor shines with red sensitizer fluorescence in good contrast to
normal tissue under blue light illumination.
Observation modes
Changing observation modes is easy. To switch from white light
mode to fluorescence mode and back requires only the click of
a button on the handle or the foot pedal. The Leica CAN bus con-
trols the type of illumination, the observation filters for different
fluorescence applications, and an optional mode-controlled video
camera specifically aligned for fluorescence.
View: White light mode
5-ALA Spectras
0.1
8.0
6.0
4.0
2.0
excitation spectrum
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noissime
murtceps
007006005004
λ/ mn
3
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