Instructions for Use
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HUMALOG®Mix75/25™ KwikPen
®
75% insulin lispro protamine suspension and
25% insulin lispro injection (rDNA origin)
Read the Instructions for Use before you start taking HUMALOG Mix75/25 and each
time you get a refill. There may be new information. This information does not take
the place of talking to your healthcare provider about your medical condition or your
treatment.
Do not share your HUMALOG Mix75/25 KwikPen with other people, even if
the needle has been changed. You may give other people a serious infection
or get a serious infection from them.
HUMALOG®Mix75/25™ KwikPen®(“Pen”) is a disposable pen containing 3 mL
(300 units) of U-100 HUMALOG®Mix75/25™ [75% insulin lispro protamine
suspension and 25% insulin lispro injection (rDNA origin)] insulin. You can inject
from 1 to 60 units in a single injection.
This Pen is not recommended for use by the blind or visually impaired
without the assistance of a person trained in the proper use of the product.
Supplies you will need to give your HUMALOG Mix75/25 injection:
• HUMALOG Mix75/25 KwikPen
• HUMALOG Mix75/25 KwikPen compatible needle (Becton, Dickinson and
Company Pen Needles recommended)
• Alcohol swab
Preparing HUMALOG Mix75/25 KwikPen:
• Wash your hands with soap and water.
• Check the HUMALOG Mix75/25 KwikPen Label to make sure you are taking the
right type of insulin. This is especially important if you use more than 1 type of
insulin.
• Do not use HUMALOG Mix75/25 past the expiration date printed on the Label.
• Always use a new needle for each injection to help ensure sterility and
prevent blocked needles. Do not reuse or share your needles with
other people. You may give other people a serious infection or get a
serious infection from them.
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Step 1:
Pull the Pen Cap straight off.
Wipe the Rubber Seal with an alcohol
swab.
• Do not twist the cap.
• Do not remove the KwikPen Label.
Step 2:
Gently roll the Pen ten times.
Invert the Pen ten times.
HUMALOG Mix75/25 should look white
and cloudy after mixing. Do not use if it
looks clear or contains any lumps or
particles.
Step 3:
Pull off the Paper Tab from Outer Needle
Shield.
Step 4:
Push the capped Needle straight onto the
Pen and turn the Needle forward until it is
tight.
Step 5:
Pull off the Outer Needle Shield. Do not
throw it away.
Pull off the Inner Needle Shield and throw
it away.
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Priming your HUMALOG Mix75/25 KwikPen:
Prime before each injection. Priming ensures the Pen is ready to dose and
removes air that may collect in the cartridge during normal use. If you do not prime
before each injection, you may get too much or too little insulin.
Step 6:
Turn the Dose Knob to select 2 units.
Step 7:
Hold your Pen with the Needle pointing
up. Tap the Cartridge Holder gently to
collect air bubbles at the top.
Step 8:
Hold your Pen with Needle pointing up.
Push the Dose Knob in until it stops, and
“0” is seen in the Dose Window. Hold the
Dose Knob in and count to 5 slowly.
• A stream of insulin should be seen
from the needle.
- If you do not see a stream of
insulin, repeat steps 6 to 8, no
more than 4 times.
- If you still do not see a stream
of insulin, change the needle
and repeat steps 6 to 8.
Selecting your dose:
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Step 9:
Turn the Dose Knob to select the number
of units you need to inject. The Dose
Indicator should line up with your dose.
• The dose can be corrected by
turning the Dose Knob in either
direction until the correct dose
lines up with the Dose Indicator.
• The even numbers are printed on
the dial. The odd numbers, after
the number 1, are shown as full
lines.
(10 units shown)
(15 units shown)
• The HUMALOG Mix75/25 KwikPen will not let you dial more than the number of
units left in the Pen.
• If your dose is more than the number of units left in the Pen, you may either:
- inject the amount left in your Pen and then use a new Pen to give the rest
of your dose, or
- get a new Pen and inject the full dose.
• The Pen is designed to deliver a total of 300 units of insulin. The cartridge
contains an additional small amount of insulin that can’t be delivered.
Giving your HUMALOG Mix75/25 injection:
• Inject your HUMALOG Mix75/25 as your healthcare provider has shown you.
• Change (rotate) your injection site for each injection.
• Do not try to change your dose while injecting HUMALOG Mix75/25.
Step 10:
Choose your injection site.
HUMALOG Mix75/25 is injected under the
skin (subcutaneously) of your stomach
area, buttocks, upper legs or upper arms.
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Wipe the skin with an alcohol swab, and
let the injection site dry before you inject
your dose.
Step 11:
Insert the Needle into your skin.
Step 12:
Put your thumb on the Dose Knob and
push the Dose Knob in until it stops. Hold
the Dose Knob in and slowly count to
5.
Step 13:
Pull the Needle out of your skin.
You should see “0” in the Dose Window.
If you do not see “0” in the Dose
Window, you did not receive your full
dose.
If you see blood after you take the
Needle out of your skin, press the
injection site lightly with a piece of gauze
or an alcohol swab. Do not rub the area.
A drop of insulin at the needle tip is
normal. It will not affect your dose.
If you do not think you received your
full dose, do not take another dose.
Call Lilly or your healthcare provider for
assistance.
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Step 14:
Carefully replace the Outer Needle
Shield.
Step 15:
Unscrew the capped Needle and throw it
away.
Do not store the Pen with the Needle
attached to prevent leaking, blocking of
the Needle, and air from entering the
Pen.
Step 16:
Replace the Pen Cap by lining up the Cap
Clip with the Dose Indicator and pushing
straight on.
After your injection:
• Put your used needles in a FDA-cleared sharps disposal container right away
after use. Do not throw away (dispose of) loose needles in your household
trash.
• If you do not have a FDA-cleared sharps disposal container, you may use a
household container that is:
- made of a heavy-duty plastic,
- can be closed with a tight-fitting, puncture-resistant lid, without sharps
being able to come out,
- upright and stable during use,
- leak-resistant, and
- properly labeled to warn of hazardous waste inside the container.
• When your sharps disposal container is almost full, you will need to follow your
community guidelines for the right way to dispose of your sharps disposal
container. There may be state or local laws about how you should throw away
used needles and syringes. For more information about safe sharps disposal,
and for specific information about sharps disposal in the state that you live in,
go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal
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• Do not dispose of your used sharps disposal container in your household trash
unless your community guidelines permit this. Do not recycle your used sharps
disposal container.
• The used Pen may be discarded in your household trash after you have
removed the needle.
How should I store my HUMALOG Mix75/25 KwikPen?
• Store unused HUMALOG Mix75/25 Pens in the refrigerator at 36°F to 46°F
(2°C to 8°C). The Pen you are currently using can be stored out of the
refrigerator below 86°F (30°C).
• Do not freeze HUMALOG Mix75/25. Do not use HUMALOG Mix75/25 if it has
been frozen.
• Unused HUMALOG Mix75/25 Pens may be used until the expiration date
printed on the Label, if kept in the refrigerator.
• The HUMALOG Mix75/25 Pen you are using should be thrown away after 10
days, even if it still has insulin left in it.
• Keep HUMALOG Mix75/25 away from heat and out of the light.
General information about the safe and effective use of HUMALOG Mix75/25
KwikPen
• Keep HUMALOG Mix75/25 KwikPen and needles out of the reach of
children.
• Always use a new needle for each injection.
• Do not share your Pen or needles with other people. You may give
other people a serious infection or get a serious infection from them.
• Do not use your Pen if any part looks broken or damaged.
• Always carry an extra Pen in case yours is lost or damaged.
• If you can not remove the Pen Cap, gently twist the Pen Cap back and forth,
and then pull the Pen Cap straight off.
• If it is hard to push the Dose Knob or the Pen is not working the right way:
- Your Needle may be blocked. Put on a new Needle and prime the Pen.
- You may have dust, food, or liquid inside the Pen. Throw the Pen away and
get a new one.
- It may help to push the Dose Knob more slowly during your injection.
• Use the space below to keep track of how long you should use each HUMALOG
Mix75/25 KwikPen.
- Write down the date you start using your HUMALOG Mix75/25 KwikPen.
Count forward 10 days.
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- Write down the date you should throw it away.
Example:
Pen 1 - First used on _______ + 10 days = Throw out on ______
Date Date
Pen 1 - First used on _______ Throw out on _______
Date Date
Pen 2 - First used on _______ Throw out on _______
Date Date
Pen 3 - First used on _______ Throw out on _______
Date Date
Pen 4 - First used on _______ Throw out on _______
Date Date
Pen 5 - First used on _______ Throw out on _______
Date Date
If you have any questions or problems with your HUMALOG Mix75/25 KwikPen,
contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) or call your healthcare provider for
help. For more information on HUMALOG Mix75/25 KwikPen and insulin, go to
www.humalog.com.
These Instructions for Use have been approved by the U.S. Food and Drug
Administration.
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Humalog®Mix75/25™ and Humalog®Mix75/25™ KwikPen®are trademarks of Eli Lilly
and Company.
Revised: February 25, 2015
Marketed by: Lilly USA, LLC
Indianapolis, IN 46285, USA
Copyright © 2007, 2015, Eli Lilly and Company. All rights reserved.
Humalog Mix75/25 KwikPen meets the current dose accuracy and functional
requirements of ISO 11608-1:2000.
LOG7525KP-0001-IFU-20150225
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