Harvard Apparatus Pump 11 Elite OEM, Pico Plus Elite OEM User Manual

Pump 11 Elite OEM
Module Series

USER’S MANUAL

Harvard Apparatus Pump 11 Elite OEM Module Series

Publication 5420-007 Rev B

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Pump 11 Elite OEM Module USER’S MANUAL

Table of Contents

SUBJECT PAGE NO.

General Information ........................................................................................................ 4

Safety Information .................................................................................................4

Warranty and Repair Information ...........................................................................5

Manual Description .....................................................................................5

Warranty .....................................................................................................5

Repair Facilities and Parts ...........................................................................5

Serial Numbers ...........................................................................................5

Calibrations .................................................................................................5

Specifications .........................................................................................................6

Product Overview ............................................................................................................. 8

Pump Models ........................................................................................................8

Table of Contents

2

Operating Instructions ...........................................................................................9

Power Connections ...............................................................................................9

Syringe Loading ...................................................................................................10

External Pump Control .........................................................................................11

Setting up HyperTerminal .........................................................................11

Pump Chain Commands ......................................................................................12

Using the Pump 11 Elite Series Pump Chain Commands ........................12

Error Messages ........................................................................................13

Command Errors .......................................................................................13

Argument Errors .......................................................................................13

System Commands ..................................................................................13

Run Commands ........................................................................................15

Rate Commands .......................................................................................15

Volume Commands ..................................................................................16

Time Commands ......................................................................................17

Digital I/O Commands ...............................................................................18

Internal Commands ..................................................................................18

Serial Command Notes .............................................................................18

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Pump 11 Elite OEM Module Series User’s Manual • Publication 5420-007 Rev B

Pump 11 Elite OEM Module USER’S MANUAL

SUBJECT PAGE NO.

Appendices ....................................................................................................................... 19

Appendix A: Syringe Volume/Diameter Reference Table ....................................19

Appendix B: Min/Max Flow Rates .......................................................................20

Appendix C: External Connections ......................................................................22

User I/O Connector Specifications ............................................................22

Utilizing USB Interface ..............................................................................23

RS-485 ......................................................................................................25

Legacy RJ-11 Option ................................................................................26

Appendix D: Maintenance ...................................................................................27

Maintenance .............................................................................................27

Upgrading Pump 11 Elite Series Software ...............................................28

Troubleshooting ........................................................................................29

Appendix E: Ordering Information .......................................................................30

Table of Contents

3

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Pump 11 Elite OEM Module Series User’s Manual • Publication 5420-007 Rev B

Pump 11 Elite OEM Module USER’S MANUAL

General Information

SAFETY INFORMATION

Please read the following safety precautions to ensure proper use of your syringe pump. If the equipment is used in a
manner not specified, the protection provided by the equipment may be impaired.

To Prevent Hazard or Injury:

USE PROPER POWER SUPPLY

The pump is supplied with an approved power supply and line cord. To maintain the safety integrity of the device, use
only the following power supplies:

Cui Inc. Globtek Inc.
Model: 3A – 242DB24 Model: GT–41062–T3

Output: 24V – 1.0A Output: 24V – 0.75A
Input: 100–240V~50–60 Hz 0.8A Input: 100–240V~50–60 Hz 0.6A

USE PROPER LINE CORD

Use only the specified line cord for this product and make sure line cord is certified for country of use. The operating
voltage range for the Pump 11 Elite Series is 12-30 VDC. The universal power supply operating voltage range is
100-240 VAC, 50-60 Hz.

Table of Contents

4

GROUND THE PRODUCT

This product is grounded through the grounding conductor of the power cord. To avoid electric shock, the grounding
conductor must be connected to earth ground. Before making any connections to the input or output terminals of the
product, ensure that the product is properly grounded.

MAKE PROPER CONNECTIONS

Make sure all connections are made properly and securely. Any signal wire connections to the unit must be no longer than 3
meters.

OBSERVE ALL TERMINAL RATINGS

Review the operating manual to learn the ratings on all connections.

AVOID EXPOSED CIRCUITRY

Do not touch any electronic circuitry inside of the product.

AVOID PINCH HAZARD

A pinch hazard may exist between the pusher block and end blocks. Avoid placing fingers between these points while
the pump is running.

DO NOT OPERATE WITH SUSPECTED FAILURES

If damage is suspected on or to the product do not operate the product. Contact qualified service personnel to perform
inspection.

ORIENT THE EQUIPMENT PROPERLY

Do not orient the equipment so that it is difficult to operate the disconnection device.

PLACE PRODUCT IN PROPER ENVIRONMENT

Review the operating manual for guidelines for proper operating environments.

OBSERVE ALL WARNING LABELS ON PRODUCT

Read all labels on product to ensure proper usage.

CAUTION
Refer to Manual

!

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Protective
Ground Terminal

Pump 11 Elite OEM Module Series User’s Manual • Publication 5420-007 Rev B

Pump 11 Elite OEM Module USER’S MANUAL

WARRANTY AND REPAIR INFORMATION

CAUTION: REFER TO SAFETY INFORMATION AND SETTING UP THE

HARVARD APPARATUS PUMP 11 ELITE SERIES BEFORE PLUGGING

!

IN THE PUMP.

Manual Description

This manual is designed to provide all operational and Method information required to operate and maintain the
Pump 11 Elite Syringe Pumps. The functions and features are described in the Technical Specifications section.

Warranty

Harvard Apparatus warranties this instrument for a period of two years from date of purchase. At its option,
Harvard Apparatus will repair or replace the unit if it is found to be defective as to workmanship or materials.
This warranty does not extend to damage resulting from misuse, neglect or abuse, normal wear and tear, or
accident. This warranty extends only to the original consumer purchaser.

IN NO EVENT SHALL HARVARD APPARATUS BE LIABLE FOR INCIDENTAL OR CONSEQUENTIAL
DAMAGES. Some states do not allow the exclusion or limitation of incidental or consequential damages
so the above limitation or exclusion may not apply to you. THERE ARE NO IMPLIED WARRANTIES OF
MERCHANTABILITY, OR FITNESS FOR A PARTICULAR USE, OR OF ANY OTHER NATURE. Some states

do not allow this limitation on an implied warranty, so the above limitation may not apply to you.

If a defect arises within the warranty period, promptly contact Harvard Apparatus, 84 October Hill Road,
Holliston, Massachusetts 01746 using out toll free number 1-800-272-2775 or outside the US call 1–508-893-

8999. Email address is [e-mail]. Goods will not be accepted for return unless an RMA
(returned materials authorization) number has been issued by our customer service department. The customer is
responsible for shipping charges for non-warranty repairs. Please allow a reasonable period of time for completion
of repairs or replacement. If the unit is replaced, the replacement unit is covered only for the remainder of the
original warranty period dating from the purchase of the original device.

This warranty gives you specific rights, and you may also have other rights which vary from state to state.

General Information

5

Repair Facilities and Parts

Harvard Apparatus stocks replacement and repair parts. When ordering, please describe parts as completely as
possible, preferably using a part number obtained from our Technical Support department. If practical, enclose a
sample part or sketch. We offer a complete reconditioning service.

Serial Numbers

All inquiries concerning our product should refer to the serial number of the unit, located on the rear panel.

Calibrations

All electrical apparatus are calibrated at rated voltage and frequency. While the flow and volume will stay calibrated,
the peak pressure may vary. Harvard Apparatus recommends an annual calibration of the pump.

CAUTION: FOR RESEARCH USE ONLY. NOT FOR CLINICAL USE ON
PATIENTS.

!

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Pump 11 Elite OEM Module Series User’s Manual • Publication 5420-007 Rev B

Pump 11 Elite OEM Module USER’S MANUAL

Specications Pump 11 Elite OEM Pico Plus Elite OEM

Accuracy

Reproducibility

Syringes (Min./Max.)

Flow Rate:

Minimum (0.5 µl syringe)

Maximum (10 ml syringe)

Maximum (60 ml syringe)

Display

Non-Volatile Memory

Connectors:

RS-485

USB

I/O & TTL

Footswitch

RS-232 (option)

Linear Force (Max)

Drive Motor

Motor Drive Control

Number of Microsteps
per one rev. of Lead Screw

Step Resolution

Step Rate:

Minimum

Maximum

Pusher Travel Rate:

Minimum

Maximum

Input Power

Input Power Connection

Power Supply

Dimensions 24.13 x 17.15 x 10.67 cm (9.5 x 6.75 x 4.2 in) 24.13 x 17.15 x 10.67 cm (9.5 x 6.75 x 4.2 in)

Weight

General Information

± 0.5% ± 0.35%

± 0.05% ± 0.05%

0.5 µl / 60 ml (10 ml dual) 0.5 µl / 10 ml

1.26 pl/min 0.54 pl/min

26.02 ml/min 11.70 ml/min

88.40 ml/min N/A

None None

Stores all settings Stores all settings

IEEE-1394, 6 pos IEEE-1394, 6 pos

Type B Type B

15 pin D-Sub Connector 15 pin D-Sub Connector

Mini phono jack Mini phono jack

RJ-11 RJ-11

16 kg (35 lbs) @ 100% Force Selection 16 kg (35 lbs) @ 100% Force Selection

0.9° Stepper Motor 0.9° Stepper Motor

Microprocessor with 1/16 microstepping Microprocessor with 1/16 microstepping

15,360 20,480

0.069 µm/µstep 0.031 µm/µstep

27.5 sec/µstep 27.5 sec/µstep

26 µsec/µstep 26 µsec/µstep

0.15 µm/min 0.068 µm/min

159.00 mm/min 71.55 mm/min

12-30 VDC (24V recommended) 12-30 VDC (24V recommended)

2.5mm ID x 5.5mm OD male plug 2.5mm ID x 5.5mm OD male plug

100-240 VAC, 50-60 Hz, 8 Watts Universal Power
Supply, Use Only a Harvard Apparatus Approved
Power Supply and Line Cord

2.3 kg (5.08 lbs) 2.3 kg (5.08 lbs)

100-240 VAC, 50-60 Hz, 8 Watts Universal Power
Supply, Use Only a Harvard Apparatus Approved
Power Supply and Line Cord

6

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Pump 11 Elite OEM Module Series User’s Manual • Publication 5420-007 Rev B

Pump 11 Elite OEM Module USER’S MANUAL

Specifications Pump 11 Elite OEM Pico Plus Elite OEM

Atmospheric Specifications:

Operating Temperature

Storage Temperature

Operating Humidity

Storage Humidity

Method of Operation

Classification

Pollution Degree

Installation Category

Supplier Name

Supplier Address

Supplier Phone Number

Regulatory Certifications

Safety Declarations

General Information

4°C to 40°C (40°F to 104°F) 4°C to 40°C (40°F to 104°F)

-10°C to 70°C (14°F to 158°F) -10°C to 70°C (14°F to 158°F)

See Chart Below See Chart Below

20% to 80% RH, non condensing 20% to 80% RH, non condensing

Continuous Continuous

Class I Class I

1 1

II II

Harvard Apparatus Harvard Apparatus

84 October Hill Rd., Holliston, MA 01746 84 October Hill Rd., Holliston, MA 01746

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CE, ETL (UL, CSA), WEEE, EU RoHS & CB Scheme CE, ETL (UL, CSA), WEEE, EU RoHS & CB Scheme

ANSI/UL 61010-1 ED. 3 ; CAN/CSA C22.2 No.
61010-1Ed 3 ; IEC 61010-1 Ed 3 ; CENELEC EN
61010-1 ; CB Scheme

ANSI/UL 61010-1 ED. 3 ; CAN/CSA C22.2 No.
61010-1Ed 3 ; IEC 61010-1 Ed 3 ; CENELEC EN
61010-1 ; CB Scheme

7

EMC Declaration

FCC 47CFR 15B Class A; EN61326-1 FCC 47CFR 15B Class A; EN61326-1

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Pump 11 Elite OEM Module Series User’s Manual • Publication 5420-007 Rev B

Pump 11 Elite OEM Module USER’S MANUAL

Product Overview

Product Overview

8

The Harvard Apparatus Pump 11 Elite Series is
the next generation of syringe pumps.

A green led light on the front panel makes it easy to see
if the pump is running.

The pumps are versatile and can be interconnected
through the RS-485 interface. Pump 11 Elite Series
models can be mixed and matched in the daisy chain
offering maximum flexibility. Up to 99 pumps can be
linked together through the RS-485 interface provided
each pump is assigned its own unique pump address.

Flow performance is optimized with a small step angle
stepping motor that drives a precision lead screw
and pusher block. The syringe mechanism is easy to
use and securely holds the syringes for smooth flow
performance.

Advanced microstepping techniques are employed
to further reduce the step angle to eliminate flow
pulsation. The accuracy is 0.5% (0.35% for Pico Plus
Elite). A wide dynamic flow range from 1.26 pl/min to

88.40 ml/min (0.54 pl/min to 11.70 ml/min for the Pico
Plus Elite) can be programmed into the pump. Flow
rates are selectable with user selected engineering
units from ml, µl, nl, pl, and hours, minutes and
seconds.

Up to 16 kg (35 lbs) of linear force is available. This force
is user adjustable to ensure the right force is applied for
the various syringe sizes.

Easy external connections to a computer or other
control devices are made through USB interface. Simple
ASCII commands make communication with the pump
easy. For direct control of the pump, the user can use
the I/O interface (15pin Dsub). One trigger output and
a trigger input in for external events such as a process
parameter are available. The footswitch input will allow
the control of the pump through an external device.
The unit also has an output for run indication allowing
connection to a remote LED.

The 11 Elite OEM Pumps are available with single and
dual syringe options. Complete flexibility is offered with
the ability to use most manufacturers syringes ranging
from 0.5 µl to 60 ml single syringe and 5 µl to 10 ml dual
syringe.

Pump Models

Single Syringe Infuse/Withdraw Programmable

Dual Syringe Infuse/Withdraw Programmable

Pico Plus (dual) Infuse/Withdraw
Programmable

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Pump 11 Elite OEM Module Series User’s Manual • Publication 5420-007 Rev B

Pump 11 Elite OEM Module USER’S MANUAL

OPERATING INSTRUCTIONS

I/O Connector

Product Overview

9

DC Power Input

Main Switch

Foot Switch

USB Serial Input

(Type B)

RS-485 Connection

(Pump to Pump)

*Power Source -

When powering
a pump in a chain
through an RS­485 cable, toggle
switch to RS-485.
Only one pump can
be powered from
master through
RS-485

POWER CONNECTIONS

1. Plug the power cord in. The Pump 11 Elite Series has a DC power input connector on the rear of the unit. The
operating range for the Pump 11 Elite Series series is 12-30 Vdc.

2. Turn on the main power switch.

CAUTION: DO NOT CONNECT TO
FIREWIRE PORTS ON A COMPUTER.

Best performance guaranteed when using
24V power supply.

!

DAMAGE MAY OCCUR TO THE
PUMP OR COMPUTER.

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Pump 11 Elite OEM Module Series User’s Manual • Publication 5420-007 Rev B

Pump 11 Elite OEM Module USER’S MANUAL

SYRINGE LOADING

12

Product Overview

10

2 4 5 3

6

7

1

9

The Pump 11 Elite Series can accommodate up to two
syringes. Depending on the mechanism, any type of
syringe, glass, plastic or stainless steel can be used.
The Pump 11 Elite OEM Module can accommodate
from 0.5 µl to 60 ml single syringe and 0.5 µl to 10 ml
dual syringe. The syringe barrel clamp should be flipped
for syringes larger than 30 ml.

1. Press the release button (1) and move the
pusher block (2) to the approximate length of
the syringe.

2. Unscrew the bracket clamping knobs (7,8)
to loosen the retaining brackets (4,5) on the
pusher block (2) and the Syringe holder block
(3).

3. Unscrew the syringe barrel clamp by
unscrewing the syringe barrel clamp knob (6).

4. Place the syringe on the syringe holder block
(3). Ensure the barrel flange is with in the
syringe holder’s block’s retaining bracket (5)
and the plunger flange is in the pusher block’s
retaining bracket.

*The Pico Plus Elite can accomodate from 0.5 µl

to 10 ml.

5. Screw down the syringe clamp knob (6)

> 30 cc syringes

11

10

8

until the syringe barrel clamp (10) is tight
against the syringe barrel. Do not overtighten,
especially when using glass syringes.

6. Secure the syringe flanges by pushing the
retaining brackets (4,5) tightly against the
syringe flanges using the bracket clamping
knobs (7,8). The syringe plunger should be
secured by the pusher block retaining bracket
and the flange of the syringe should be
secured by the syringe holder block retaining
bracket.

7. Tighten the mechanical stop collars (9) using
allen wrench (12) to prevent excess travel of
the pusher block.

The syringe barrel clamp (10) may need to be
flipped depending on your syringe size. To
do so, completely unscrew and remove the
syringe barrel clamp knob from the syringe
block. Then remove lock nut (11). Flip the
bracket and reassemble.

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< 30 cc syringes

CAUTION: BE SURE MECHANICAL
STOP COLLARS ARE POSITIONED

!

PROPERLY TO PREVENT THE
PLUNGER FROM BOTTOMING OUT
ON GLASS SYRINGES.

Pump 11 Elite OEM Module Series User’s Manual • Publication 5420-007 Rev B