Franklin HAD-3038 User Manual
HAD-3038
Medical Book Card
The M ed ical Letter
HANDBOOK
OF
ADVERSE
DRUG
INTERACTIONS
User’s Guide
Quick Reference Guide
To Start Using a Book Card
1. Install the book card in a slot in the
back of the Medical Book System
platform.
2. Turn the platform on.
CARD
3. If needed, press
use the
or to highlight its
and then
icon.
ENTER
4. Press
to select it.
T o Find All Other Drug Interactions
1.
2. Highlight a drug by typing its name
3. If needed, select more drugs by
4. Press
5. Highlight an interaction, if any, and
CLEAR
Press
or pressing
ENTER
.
or and then press
to select it.
highlighting them and pressing
ENTER
.
MORE
.
ENTER
press
to view it.
20
T o Find Drug Interactions
1.
2. Highlight a drug by typing its name
3. Select more drugs by highlighting
4. Press
5. Highlight an interaction, if any, and
CLEAR
Press
or pressing
ENTER
.
or and then press
to select it.
them and pressing
SEARCH
.
ENTER
press
to view it.
ENTER
.
T o Find a Glossary Entry
1.
2. Highlight a drug by typing its name
3. Press
4. Use , DN, or
5. Press
CLEAR
Press
or pressing
SPEC
BACK
.
or .
.
SPACE
to scroll.
to go back.
License Agreement
READ THIS LICENSE AGREEMENT BEFORE USING THE MEDICAL BOOK
SYSTEM.
YOUR USE OF THE MEDICAL BOOK SYSTEM DEEMS THAT YOU ACCEPT
THE TERMS OF THIS LICENSE. IF YOU DO NOT AGREE WITH THESE
TERMS, YOU MAY RETURN THIS PACKAGE WITH PURCHASE RECEIPT TO
THE DEALER FROM WHICH YOU PURCHASED THE MEDICAL BOOK SYSTEM AND YOUR PURCHASE PRICE WILL BE REFUNDED. The MEDICAL
BOOK SYSTEM means the software product, hardware, and documentation found in
this package and FRANKLIN means Franklin Electronic Publishers, Inc.
LIMITED USE LICENSE
All rights in the MEDICAL BOOK SYSTEM remain the property of FRANKLIN.
Through your purchase, FRANKLIN grants you a personal and nonexclusive license to
use the MEDICAL BOOK SYSTEM. You may not make any copies of the MEDICAL
BOOK SYSTEM or of the preprogrammed data stored therein, whether in electronic or
print format. Such copying would be in violation of applicable copyright laws. Further,
you may not modify, adapt, disassemble, decompile, translate, create derivative works
of, or in any way reverse engineer the MEDICAL BOOK SYSTEM. You may not export or re-export, directly or indirectly, the MEDICAL BOOK SYSTEM without compliance with appropriate governmental regulations. The MEDICAL BOOK SYSTEM
contains Franklin’s confidential and proprietary information which you agree to take
adequate steps to protect from unauthorized disclosure or use. This license is effective
until terminated. This license terminates immediately without notice from FRANKLIN
if you fail to comply with any provision of this license.
1
Contents
Introduction to the HADI.............. 3
Key Guide..................................... 4
Installing Book Cards .................. 5
Selecting a Book .......................... 6
Changing the Settings ................. 6
Viewing a Demonstration ............ 7
Finding Drug Interactions ........... 7
Using the Interactions Menu ..... 10
Using the Glossary .................... 11
Highlighting Search Words ....... 11
Reading Special Markers........... 12
Looking Up Words
in Other Books ........................... 13
Resetting the Medical Book
System........................................ 13
Book Card Care.......................... 14
Specifications and Patents ....... 14
Limited Warranty (U.S. only) ..... 15
Limited Warranty (outside U.S.) 16
FCC Notice ................................. 17
Index ........................................... 18
➤
About Book Card Compatibility
IMPORT ANT This book card can be
used only with the Medical Book Sys-
™
platform and will not function in any
tem
other Franklin BOOKMAN
®
platform.
The Medical Book System platform
can use Franklin BOOKMAN book
cards as well as Medical Book System
book cards. However, Franklin BOOKMAN platforms cannot use Medical
Book System book cards.
➤
For More Information
T o learn more about the Medical Book
System or other products from Franklin Electronic Publishers, call 800-6655450 or visit the Franklin Web site at
www .franklin.com.
2
Introduction to the HADI
This handbook offers a quick guide to possible
adverse effects of drug interactions, with brief
recommendations for precautionary measures.
Pairs of interacting drugs are listed alphabetically, followed by the adverse interaction, its
mechanism (in parentheses), references and
recommendations for clinical management.
These listings are usually based on clinical reports. Interactions listed for groups of drugs
(such as “cephalosporins” or “antidepressants,
tricyclic”) may not have been reported for every drug in the group; known exceptions to the
interaction are noted.
It is not possible to determine the frequency of
most interactions. When an interaction is documented by one or two case reports rather than
clinical studies or reports in many patients, the
year of each report is given as some indication of
frequency.
Reports of interactions between more than two
drugs have begun to appear in the medical literature. Where these have been documented, they
are noted in the comments under interacting pairs
of drugs.
CRITERIA FOR LISTING INTERACTIONS –– New adverse interactions are continu-
ally being reported; the absence of a listing in this
book does not necessarily mean that drugs will
not interact when given concurrently. Interactions
extrapolated from animal studies or from interac-
tions reported with related drugs, may not be included here.
Interactions between general anesthetics and
drugs likely to be administered during surgery ,
such as autonomic drugs and local anesthetics, are
not included. Interactions useful in therapy, such
as the increased plasma concentration of penicillin with concurrent use of probenecid, are also not
listed. Drug combinations should be looked up
under their components.
Common additive effects, such as occur with use
of two antihypertensive agents or two central-nervous-system depressants or two drugs that affect
blood clotting, are generally not listed. Effects expected from the mechanism of a drug’s action,
such as that of potassium on digitalis glycosides or
calcium on calcium-entry blockers, and useful antagonist effects, such as that between a poison and
an antidote, are also not included. Most interactions of drugs with foods, beverages or other nutrients are not listed, but foods interacting with
monoamine oxidase inhibitors are included.
MECHANISMS OF INTERACTIONS —
Genetic differences can affect drug metabolism
and interactions. Some drugs can interact by
changing the metabolism of other drugs, either
through inhibition or induction of any of several
hepatic enzyme activities or through alterations in
hepatic blood flow. Many drugs are metabolized
by cytochrome P450 isozymes. A reference table
3
Introduction to the HADI
Key Guide
of drugs and their CYP450 isoforms is available
on the internet at www.drug-interactions.com.
These isozymes are named according to a standard system, e.g. CYP3A4 or P4503A4. Drugs
that are substrates or inhibitors for the same
isozyme in vitro are likely to interact, but no inter-
action may be detectable, or it may not be clinically significant. Other drugs alter the binding of
another drug to plasma proteins or tissue receptors, alter the distribution of drugs to active receptor sites, delay or enhance excretion, or cause
additive or synergistic effects.
Elimination of a drug can also be affected by the
P-glycoprotein membrane-bound transport system. Digoxin, for example, moves across cell
membranes by a P-glycoprotein controlled process. Drugs such as quinidine that inhibit P-glycoprotein activity, can increase the serum
concentration and toxicity of digoxin.
RECOMMENDATIONS — Monitoring is
most important when one of the interacting drugs
is stopped or started. Some experienced clinicians
may prefer to monitor the patient’s clinical status
rather than follow serum concentrations of drugs.
Concurrent use of drugs from the same group,
e.g., aspirin and other NSAIDs, should be
avoided.
Color Keys
MORE
(red) Displays interactions between
selected drug(s) and all other drugs
in this book.
SPEC
(green) Displays a glossary entry.
(yellow) Searches for interactions
SEARCH
among the selected drugs.
LIST
(blue) Lists the items currently selected from the main drug list.
Function Keys
BACK
Erases typed letters, or backs up to
the previous screen.
CAP
Shifts keys to type capitals or punctuation.
CARD
Exits the currently selected book.
CLEAR
Clears your search and returns to
the main drug list.
ENTER
Enters a word, selects a menu item,
or starts the highlight in text.
HELP
Displays help messages.
MENU
Displays the main menus.
ON/OFF
Turns the platform on or off.
SPACE
At menus and text, pages down. At
entry screens, types a space.
✻
At menus, displays the title of a high-
?
lighted item. At text, displays the current
entry title. With
4
(✽) to stand for letters in a word.
CAP
, types an asterisk
Key Guide
Installing Book Cards
Direction Keys
DN
UP
Pages up or down.
Moves the cursor, text, or highlight.
Key Combinations*
CARD
✩
+
Transfers a highlighted word
between installed book cards.
ENTER
+
✩
At text, highlights special markers (e.g., bibliographic
references, MAO inhibitor information , etc.).
+Q-P Types numbers.
✩
DN
+
✩
UP
or
CAP
or
* Hold the first key while pressing the second.
➤
Understanding the Keys
At text, displays the next or
previous interaction or search
match.
+
Goes to the top or bottom of
a menu or text.
The functions of the keys may vary according to which book card is installed
and selected in the platform. To learn
how to use a particular book card, read
its User’s Guide.
CAUTION Never install or remove a
book card when the platform is turned on.
If you do, information entered in any
installed book cards may be erased.
1. T urn the platform off.
2. T urn the platform over.
3. Align the book card tabs with the
notches in a card slot.
4. Press the book card until it snaps
into the slot.
➤
Removing Book Cards
CAUTION When you remove a book
card from a platform, information entered in that book card may be erased.
5
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