Franklin HAD-3018 User Manual
The M ed ical Letter
HAD-3018
Medical Book Card
HANDBOOK
ADVERSE
DRUG
INTERACTIONS
User’s Guide
OF
Quick Reference Guide
T o Start Using a Book Card
1. Install the book card in a slot in the
back of the Medical Book System
platform.
2. Turn the platform on.
3. If needed, press
use the
CARD
and then
or to highlight its
icon.
4. Press
ENTER
to select it.
T o Find All Other Drug Interactions
1.
2. Highlight a drug by typing its name
3. If needed, select more drugs by
4. Press
5. Highlight an interaction, if any, and
CLEAR
Press
or pressing
ENTER
.
or and then press
to select it.
highlighting them and pressing
ENTER
.
MORE
.
ENTER
press
to view it.
18
T o Find Drug Interactions
1.
2. Highlight a drug by typing its name
3. Select more drugs by highlighting
4. Press
5. Highlight an interaction, if any, and
CLEAR
Press
or pressing
ENTER
.
or and then press
to select it.
them and pressing
SEARCH
.
ENTER
press
to view it.
ENTER
.
To Find a Glossary Entry
1.
2. Highlight a drug by typing its name
3. Press
4. Use , DN, or
5. Press
CLEAR
Press
or pressing
SPEC
BACK
.
or .
.
SPACE
to scroll.
to go back.
License Agreement
READ THIS LICENSE AGREEMENT BEFORE USING THE MEDICAL BOOK
SYSTEM.
YOUR USE OF THE MEDICAL BOOK SYSTEM DEEMS THAT YOU ACCEPT
THE TERMS OF THIS LICENSE. IF YOU DO NOT AGREE WITH THESE
TERMS, YOU MAY RETURN THIS PACKAGE WITH PURCHASE RECEIPT TO
THE DEALER FROM WHICH YOU PURCHASED THE MEDICAL BOOK SYSTEM AND YOUR PURCHASE PRICE WILL BE REFUNDED. The MEDICAL
BOOK SYSTEM means the software product, hardware, and documentation found in
this package and FRANKLIN means Franklin Electronic Publishers, Inc.
LIMITED USE LICENSE
All rights in the MEDICAL BOOK SYSTEM remain the property of FRANKLIN.
Through your purchase, FRANKLIN grants you a personal and nonexclusive license to
use the MEDICAL BOOK SYSTEM. You may not make any copies of the MEDICAL
BOOK SYSTEM or of the preprogrammed data stored therein, whether in electronic or
print format. Such copying would be in violation of applicable copyright laws. Further,
you may not modify, adapt, disassemble, decompile, translate, create derivative works
of, or in any way reverse engineer the MEDICAL BOOK SYSTEM. You may not export or re-export, directly or indirectly, the MEDICAL BOOK SYSTEM without compliance with appropriate governmental regulations. The MEDICAL BOOK SYSTEM
contains Franklin’s confidential and proprietary information which you agree to take
adequate steps to protect from unauthorized disclosure or use. This license is effective
until terminated. This license terminates immediately without notice from FRANKLIN
if you fail to comply with any provision of this license.
1
Contents
Contents ....................................... 2
Introduction to the HADI.............. 3
Key Guide.....................................4
Installing Book Cards .................. 5
Selecting a Book .......................... 6
Changing the Settings ................. 6
Viewing a Demonstration ............ 7
Finding Drug Interactions ........... 7
Using the Interactions Menu ..... 10
Using the Glossary .................... 11
Highlighting Search Words ....... 11
Reading Special Markers........... 12
Looking Up Words
in Other Books ........................... 13
Resetting the Medical Book
System........................................ 13
Book Card Care.......................... 14
Specifications and Patents ....... 14
Limited Warranty (U.S. only) ..... 15
Index ........................................... 16
➤
About Book Card Compatibility
IMPORT ANT This book card can be
used only with the Medical Book Sys-
™
platform and will not function in any
tem
other Franklin BOOKMAN
®
platform.
The Medical Book System platform
can use Franklin BOOKMAN book
cards as well as Medical Book System
book cards. However, Franklin BOOKMAN platforms cannot use Medical
Book System book cards.
➤
For More Information
To learn more about the Medical Book
System or other products from Franklin Electronic Publishers, call 800-6655450 or visit the Franklin Web site at
www.franklin.com.
2
Introduction to the HADI
This handbook offers a quick guide to possible adverse effects of drug interactions,
with brief recommendations for precautionary measures. Pairs of interacting drugs are
listed alphabetically, followed by the adverse interaction, its mechanism (in parentheses), references and recommendations
for clinical management. These listings are
usually based on clinical reports. Interactions listed for groups of drugs (such as
“cephalosporins” or “antidepressants, tricyclic”) may not have been reported for every
drug in the group; known exceptions to the
interaction are noted.
It is not possible to determine the frequency of
most interactions. When an interaction is documented by one or two case reports rather than
clinical studies or reports in many patients, the
year of each report is given as some indication
of frequency.
Reports of interactions between more than two
drugs have begun to appear in the medical literature. Where these have been documented,
they are noted as comments under interacting
pairs of drugs.
UNDOCUMENTED INTERACTIONS ––
New adverse interactions are continually being
reported; the absence of a listing in this book
does not necessarily mean that drugs will not
interact when given concurrently. Interactions
extrapolated from animal studies or interactions reported with related drugs, frequently
mentioned in other sources, such as the
manufacturer’s package insert may not be included here.
Interactions between general anesthetics and
drugs likely to be administered during surgery ,
such as autonomic drugs and local anesthetics,
are not included. Interactions useful in therapy,
such as increased plasma concentration of
penicillin with concurrent use of probenecid,
are also not listed. Drug combinations should
be looked up under their components.
Common additive effects, such as occur with
use of two antihypertensive agents or two central nervous system depressants, are generally
not listed. Effects expected from the mechanism
of a drug’s action, such as that of potassium on
digitalis glycosides or calcium on calcium-entry
blockers, and useful antagonist effects, such as
that between a poison and an antidote, are also
not included. Most interactions of drugs with
foods, beverages, or other nutrients are not
listed, but foods interacting with monoamine
oxidase inhibitors are included.
3
Introduction to the HADI
Key Guide
MECHANISMS OF INTERACTIONS —
Genetic differences can affect drug metabolism
and interactions. Some drugs can interact by
changing the metabolism of other drugs, either
through inhibition or induction of any of several hepatic enzyme activities or through alterations in hepatic blood flow. Many drugs are
metabolized by cytochrome P450 isozymes.
These isozymes are named according to a standard system, e.g., CYP3A4 or P4503A4.
Drugs that are substrates or inhibitors for the
same isozyme in vitro are likely to interact, but
no interaction may be detectable, or it may not
be clinically significant. Other drugs alter the
binding of another drug to plasma proteins or
tissue receptors, alter the distribution of drugs
to active receptor sites, delay or enhance excretion, or cause additive or synergistic effects.
RECOMMENDATIONS — Monitoring is
most important when one of the interacting
drugs is stopped or started. Some experienced
clinicians may prefer to monitor the patient’s
clinical status rather than follow serum concentrations of drugs. Concurrent use of drugs from
the same group, e.g., aspirin and other
NSAIDs, should be avoided.
Color Keys
MORE
(red) Displays interactions between
selected drug(s) and all other drugs
in this book.
SPEC
(green) Displays a glossary entry.
(yellow) Searches for interactions
SEARCH
among the selected drugs.
LIST
(blue) Lists the items currently selected from the main drug list.
Function Keys
BACK
Erases typed letters, or backs up to
the previous screen.
CAP
Shifts keys to type capitals or punctuation.
CARD
Exits the currently selected book.
CLEAR
Clears your search and returns to
the main drug list.
ENTER
Enters a word, selects a menu item,
or starts the highlight in text.
HELP
Displays help messages.
MENU
Displays the main menus.
ON/OFF
Turns the platform on or off.
SPACE
At menus and text, pages down. At
entry screens, types a space.
✻
At menus, displays the title of a high-
?
lighted item. At text, displays the current
entry title. With
4
(✽) to stand for letters in a word.
CAP
, types an asterisk
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