CombiFlash NextGen 300 User Manual
CombiFlash®
NextGen 300
Flash Chromatography System
The CombiFlash NextGen Flash Chromatography System
offers the most options in regards to system configurations.
Now there are three different models to choose from
based on your budgetary and application needs.
Setting a New Bar in Flash
Chromatography Performance
The CombiFlash NextGen 300 is configurable to your
needs. Like the 300+, active solvent and waste level
sensing is standard. The system is designed for liquid
injections, operating at up to 150 psi (10 bar). If needed,
add the solid load injection valve (increases the operating
pressure limit to 300 psi (20 bar)) and increase the
system’s versatility. Similarly, RFID rack and column read
can be added if desired. You determine what your needs
are; don’t invest in unused or unwanted features.
300
• Straightforward
Complete control on one screen
• Compact
Designed to take up minimal lab space
• Flexible
Configure to meet your specific needs
• Faster
New default methods with higher flows and
steeper gradients speed up the purification
without sacrificing performance
• Greener
Conserve solvent with optimized gradients
Standard System Features
• Flow rates from 1 to 300 mL/min
• Operating pressure up to 300 psi (20 bar)
Can be fitted with an ELSD at the time of system purchase.
NextGen 300 is compatible with PurIon Mass Spectrometer or
ELS Detection. Upgrade at the time of purchase or in the field.
• Choice of UV, UV-Vis ELSD or MS options
• Customizable to meet your application needs
Specifications: NextGen 300
Flow Rate Range: 1–300 mL/min
Sample Loading Technique: Liquid and Solid (standard)
(option at time of purchase)
Maximum Pressure: -Up to 150 psi (10 bar) Liquid Load
-Up to 300 psi (20 bar) with Solid Load option
-Lower pressure limits user defined
UV and UV-Vis Detection: Variable UV 200–400 nm
or Variable UV-Vis 200–800 nm
(PDA Technology)
Real Time UV Standard
Spectral Display:
Absorbing Solvent Standard
Baseline Substract:
ELSD Detection: Integrated option that can be combined
with either UV or UV-Vis
Number of Solvents: Binary gradient, 4 solvents
Modifier 3rd Solvent: Standard
Gradient Formation: Low pressure
Programmable Gradients: Linear, step, isocratic
User Interface: 12 or 15” capacitive touch screen
Fraction Collector: Internal
Rack Size RFID Read: Option at time of purchase
Real Time Method Editing: Standard
Active Solvent and Standard
Waste Level Monitoring:
Internal Vapor Sensor: Option at time of purchase
Vapor Enclosure for Optional
Collection Racks:
Audible Alarm: Standard
Lighted Rack Area: Standard
Dimensions (H x W x D): 26 x 14.1 x 17 in (66 x 36 x 43 cm)
Weight with ELSD: 74 lb (33.6 kg)
Weight without ELSD: 61 lb (27.7 kg
CombiFlash NextGen 300
68-5250-005 CombiFlash NextGen 300 System with 200–400 nm UV variable wavelength detector, 12” screen.
68-5250-006 CombiFlash NextGen 300 System with 200–800 nm UV-Vis variable wavelength detector, 12” screen.
68-5250-007 CombiFlash NextGen 300 System with 200–400 nm UV variable wavelength detector, 15” screen.
68-5250-008 CombiFlash NextGen 300 System with 200–800 nm UV-Vis variable wavelength detector, 15” screen.
CombiFlash NextGen 300 Factory Options
60-5257-001 Factory installed ELSD for CombiFlash NextGen 300 & 300+ (only available when ordered with initial system purchase.)
60-5257-005 Factory installed Vapor Sensor for all CombiFlash NextGen models.
60-5257-003 Factory installed Solid Load Injection Valve for NextGen 300 only; increases pressure up to 300 psi.
60-5257-004 Factory installed Active Level Sensor and RFID read for columns & collection racks for NextGen 300.
CombiFlash NextGen 300 Field Options
60-5257-008 Sample Rack Vapor Enclosure for operation outside the hood.
60-5257-007 ELSD Field Upgrade Kit for CombiFlash NextGen 300 and 300+ systems.
CombiFlash Sample Injection Options
60-5237-047 Adjustable Solid Load Cartridge Cap (SLCC), fits 2.5 and 5 gram-size sample load cartridges.
Includes one loading rod.
60-5237-048 Adjustable Solid Load Cartridge Cap (SLCC), fits 12 and 25 gram-size sample load cartridges.
Includes one loading rod.
60-5237-044 Adjustable Solid Load Cartridge Cap (SLCC), fits 32 and 65 gram-size sample load cartridges.
Includes one loading rod.
Teledyne ISCO
P.O. Box 82531, Lincoln, Nebraska, 68501 USA
Toll-free: (800) 228-4373 • Phone: (402) 464-0231 • Fax: (402) 465-3091
teledyneisco.com
Teledyne ISCO is continually improving its products and reserves the right to change product
specifications, replacement parts, schematics, and instructions without notice.
L-5216 Rev 6.0
06/20
Loading...