ChEmyx
Fusion Series User Manual
Chemyx Inc.
10905 Cash Road
Stafford, TX 77477 USA
www.chemyx.com
Intellectual Property All Intellectual Properties, as defined below, owned by or
which is otherwise the property of Chemyx Inc. or its suppliers relating to the Chemyx
syringe pumps, including but not limited to, accessories, parts or software relating thereto
(Chemyx Syringe pumps), are proprietary to federal and state laws, and international treaty
provisions. Intellectual Property includes but is not limited to, inventions (patentable or
unpatentable), patents, trade secrets, copyrights, software, firmware, computer programs,
and related documentation and other works of authorship. Moreover, you agree that you
will not, and will not attempt to, modify, prepare derivative works of, reverse engineer,
disassemble the Chemyx syringe pumps, decompile or otherwise attempt to create source
code from the related software/firmware. No title to or ownership in Intellectual Property is
transferred to you. All applicable rights of the Intellectual Property shall remain with
Chemyx and its suppliers.
1
EU Declaration of Conformity (DoC)
We:
Chemyx, Inc.
10905 Cash Road
Stafford, TX 77477
(281) 277-5499
sales@chemyx.com
declare that the DoC is issued under the sole responsibility of the manufacturer and belongs to the
following product(s):
All Syringe Pump Products, including:
- Fusion 100
- Fusion 200
- Fusion 400
- Nexus 3000
- Nexus 6000
- NanoJet StereoTaxic
The object of the declaration described above is in conformity with the relevant Union
harmonization legislation:
- EMC Directive 2004/108/EC (until April 19, 2016) and Directive 2014/30/EU (from
April 20,, 2016).
- LV Directive 2006/95/EC (until April 19, 2016) and Directive 2014/35/EU (from April
20, 2016).
- Directive 2011/65/EU of the European Parliament and of the Council of 8 June 2011 on
the restriction of the use of certain hazardous substances in electrical and electronic
equipment.
The technical documentation required to demonstrate that the products meet the requirements of the
LV and EMC directives has been compiled and is available for inspection by the relevant
enforcement authorities.
Signature on behalf of manufacturer: ________________________
Authority: Jeff Wu, Senior Engineer, Chemyx, Inc.
Date: January 1, 2016
Attention!
The attention of the specifier, purchaser, installer, or user is drawn to special measures and limitations to use which must
be observed when these products are taken into service to maintain compliance with the above directives.
Details of these special measures and limitations to use are available on request,
and are also contained in the product manuals.
Table of Contents
Manual Description 5
Limited Warranty 5
Repairs 5
Dead Pixel Policy 6
Serial Number 6
Calibration 6
Operational Safety 7
Technical Specifications 8
Principle of Operation 9
Pump Features 10
Keypad 10
LCD Screen 10
Syringe Clamps 10
Safety Nut 10
Power and Fuse 11
TTL Port 11
Serial Port 11
Alarms 12
Stall Detection 12
Modes of Operation 12
Keypad Interface 13
Navigation Controls
Pump Controls
Numeric keypad controls
Operating Instructions 14
Syringe Loading
Running the Pump Interface
Pump Maintenance 16
Computer Control (RS232 Operation) 17
Cable Requirements 17
RS232 Port Settings 18
RS232 Communication Protocols 19
Testing Communication in HyperTerminal 19
USB to RS232 Dongle Converters 19
TTL, Daisy Chaining, Chemyx Software 20
Appendices 21
Fuse Replacement 21
4
Manual Description
This Manual covers the basic operational elements and usage of Chemyx syringe pumps.
This does not include all aspects of usage or OEM / custom designed systems
fabricated by Chemyx for other companies. Chemyx does not directly support OEM systems
unless otherwise specified.
that are
Limited Warranty
Chemyx warrants its products against defects in materials and workmanship for a period of
one year from the shipment date. Chemyx will repair any product that proves defective
during its stated warranty period.
The foregoing warranty will not apply to effects resulting from:
Improper or inadequate maintenance or operation
Unauthorized modification or misuse of the product
Operation outside the electrical specifications for the product
Operation outside the temperature specifications for the product
User-induced internal and external contaminations of the instrument
Failure to use proper surge protection
Improper product return, packaging, and shipping
Removing serial number from syringe pump.
You must contact either by e-mail or phone Chemyx Inc. before returning a product.
Chemyx will issue a Return Authorization (RA) number to you.
Repairs
Chemyx can repair any syringe pump without major damage. You must contact either by email or phone Chemyx Inc. before returning a product. Chemyx will issue a Return
Authorization (RA) number to you.
Return products to:
Chemyx Returns
10905 Cash Road
Stafford, TX
77477 USA
5
Dead Pixel Policy
During the LCD Monitor manufacturing process, it is not uncommon for one or more pixels
to become fixed in an unchanging state. The visible result is a fixed pixel that appears as an
extremely tiny dark or bright dot. In almost every case, these fixed pixels are hard to see
and do not detract from display quality or usability. A display with 3 to 7 bright or dark dots
is considered normal and within industry standards. If your screen has more than 7 dead
pixels during the warranty period
see the Limited warranty section for details on how to activate a warranty claim.
your system will qualify for warranty replacement. Please
Serial Number
The serial number is located on the back top left corner or center of the pump under a small
barcode. Removal of the serial number label voids your warranty.
Calibration
Chemyx Pumps are pre-calibrated upon arrival to your site. All calibrated parameters are
within stated accuracy and precision specifications of the pump. Although the pump might
be highly accurate different syringes have much greater error from Glass at 1% to Plastic at
5% error. Chemyx is not responsible for errors generated from syringes.
6
Operational Safety
Please read the following safety precautions to ensure personal safety and operational
longevity of the Chemyx syringe pump. Chemyx, Inc. is not responsible for the equipment if
used in a manner not specified by the manufacturer; warranty coverage provided by the
equipment may be dropped as a result.
CHEMYX PRODUCTS ARE NOT FOR USE ON HUMANS
USE PROPER POWER SUPPLY
Chemyx Inc is not responsible for the use of power supplies outside the stated
electrical specifications or failure to switch the power converter from 240V to 120V
while in the 240V environment or vice versa.
GROUND PRODUCT
Proper grounding is required.
DO NOT OPEN THE PUMP
Warranty coverage will be dropped if the pump is opened without authorization from
Chemyx. Do not touch any electric connectors on the product.
DO NOT OPERATE WITH SUSPECTED FAILURES
Even though the pump can operate at extremely fast speeds, the user must
determine the proper flow rate for any given application. For instance, pumping at
90ml/min using a 20 gauge needle will cause stalls and/or potential bursting of the
syringe. Chemyx is not responsible for any damage that might result from examples
similar to above.
PINCH HAZARD
Do not place fingers between the pusher block and end block while the pump is
running.
OBSERVE ALL WARNING LABELS ON PRODUCT
Read all labels on product to ensure proper usage.
CHEMYX IS NOT RESPONSIBLE FOR SYRINGE DAMAGE
It is the user’s responsibility to wet ground glass syringes and set / tighten the
safety nut appropriately for microsyringes.
7
Technical Specifications
Note: The step resolution stated is the minimum step resolution achieved by a pump.
F
usion 100
Syringe size
Voltage operating range
Drive mechanism
Step resolution (advance per microstep)
Flow rate range
Nominal linear force
Dimensions
Weight
Temperature range
Humidity
RS232 Connector
TTL Connector
usion 200
F
Syringe size
Voltage operating range
Drive mechanism
Step resolution (advance per microstep)
Flow rate range
Nominal linear force
Dimensions
Weight
Temperature range
Humidity
RS232 Connector
TTL Connector
0.5 microliter to 60 milliliter
115V~240V, 0.25 A, 55-60 Hz
Stepper motor
0.198 microns
0.001 µl/hr (10µl) to 90 ml/min
29 lbs
9.5x 6.5 x 4 inch
7.0 lbs
10°C ~ 50°C
20% - 80% RH
D9 Sub-connector
USB-B Receptacle
0.5 microliter to 60 milliliter
115V~240V, 0.25 A, 55-60 Hz
Stepper motor
0.098 microns
0.001 µl/hr (10µl) to 45 ml/min
50 lbs
9.5x 6.5 x 4.5 inch
7.0 lbs
10°C ~ 50°C
20% - 80% RH
D9 Sub-connector
USB-B Receptacle
F
usion 400
Syringe size
Voltage operating range
Drive mechanism
Step resolution (advance per microstep)
Flow rate range
Nominal linear force
Dimensions
Weight
Temperature range
Humidity
RS232 Connector
TTL Connector
0.5 microliter to 10 milliliter
115V~240V, 0.25 A, 55-60 Hz
Stepper motor
0.020 microns
2 picol/min (0.5µl) to 10 ml/min
50 lbs
9.5x 6.5 x 5.5 inch
7.5 lbs
10°C ~ 50°C
20% - 80% RH
D9 Sub-connector
USB-B Receptacle
8
Principle of Operation
All Chemyx Fusion series syringe pumps are driven via a stepping motor that drives a lead
screw and Pusher Block. The resulting action ejects fluid from the barrel of a syringe.
When withdrawing the operation is the same with only the motor reversing direction.
9
Pump Features
A: Pusher block – locking mechanism varies
B: Spring loaded syringe holder
C: Withdraw holder (Fusion 200 only)
D: Locking nut
E: Safety nut
F: Numeric keypad
G: LCD screen
H: Directional keypad
I: Start button
J: Pause button
K: Stop button
Note: Fusion 400 systems have 4 channel screw clamp holders.
10
Features continued
A: Power switch
B: Power plug
C: 2 Amp fuse
D: Voltage Converter
E: TTL port USB – B Receptacle
F: D9 RS232 serial port
11
Features continued
Alarms
Audible Alarms will sound in case of a stall and on power on.
Stall Detection
Stall detection occurs when an optical detector used in verifying expected movement
of the motor detects jamming or excessive pressure.
In the case of severe stalls from corroded guide rods, the mechanical locking nut will
decouple and unlock the pusher block
Modes of Operation
Infuse:
Pump runs continuously ejecting fluids from a syringe until stopped.
Withdraw (Fusion 200 only):
Pump runs in the reverse direction until stopped.
Multi-Step (Optional Multi-step Firmware Upgrade):
Pump operates a specific sequence of infusion steps inputted by the user.
Looping (Optional Multi-step Firmware Upgrade):
Pump operates a specific sequence of steps and repeats the steps a certain
number of times determined by the user.
Ramping Rate (Optional Multi-step Firmware Upgrade):
Pump linearly increases or decreases the rate over a period of time
determined by the user.
12
Keypad Interface
The green circles represent depressible buttons on the membrane surface.
A) Navigation controls
The navigation key pad is for tabbing between inputs on the interface. Once you
select an input the enter button is used to confirm the input to memory.
B) Pump controls
The pump controls are used for starting pausing and stopping the pump. If any
input is out of the pump’s range, the pump will not start.
C) Numeric Keypad Controls
The numeric keypad is for entering inputs into the available data entry boxes. The C
in the bottom right corner clears an input box if an error has been made in entry.
13
Operating Instructions
Syringe Loading
Place the syringe into one of the V shaped slots by lifting the spring clamp (part A).
Depress the locking nut (Part C) to release the pusher block (Part B). The pusher
block should be pressed firm against the plunger of the syringe before initiating
pumping.
Running the Pump Interface
1) When you power on the system you will see a startup screen.
14
2) After the startup screen a unit selection screen will appear. Ml/Min is the default
setting for the Fusion 100 and 200 series. ul/min is the default setting for Fusion
400 series pump. Use the arrow keys to tab your selection up and down and press
enter to accept your selection. You can come back to this screen later if you are not
sure what units to use initially.
3) In the data input screen users can enter any parameter by using the navigation
keys to tab to any input. The selected input box will highlight in black and a small
cursor will appear and blink. You can type in any number on the numeric keypad to
enter in your parameter. If the parameter is out of bounds, the pump will blink the
max and min inputs at the top of the page. When you are ready to start the pump,
press “start” on the keypad.
15
Pump Maintenance
Chemyx pumps require limited maintenance that can be performed with minimal
downtime and effort. Proper maintenance of your pump will ensure the system’s
operating life to over 5 years. On a routine basis, the following procedures should be
followed:
Oil your system:
1. Apply motor oil or machine oil to the lead screw and guide rod. This should be
performed once every 4 months to maintain optimal lubrication.
2. Clean contact surfaces and debris. Take care to remove any debris on the lead
screw and guide rods.
Consistent oiling of your pump will protect the pump from oxidizing fumes in fume
hoods and extend the pumps performance and operating life many years.
Approved Lubricants:
Engine oil or Motor oil – any type
Silicone oil
Machine oil
Tooling oil or “WD-40”
Contact Chemyx if you wish to use other lubricants.
Signs that your system is not adequately lubricated:
1) Grinding sounds coming from the lead screw.
2) Locking nut is decoupling under load before stall
3) Slow decrease of max pushing force.
16
Computer Control (RS232 Operation)
Cable Req
In order to interface to a PC you need the following hardware cable pictured below:
DB9 Serial Cable Male to Female – Straight through configuration. Do not purchase a
“Null Modem,” “crossover,” or “crossed over” cables.
RS232 Por
uirements
t Settings
Before interfacing with a PC, make sure a RS232 port exists on your PC. RS232
ports will be in parentheses and named “COM1-100” like the one above named COM1
17
RS232 Port Settings (continued)
Baud Rate - 9600, Data Bits - 8, Parity - none, Stop bits - 1, Flow control – none.
Most programming packages like LabView, LabWindows and Visual Studio will allow
you to program comport settings dynamically in program.
RS232 Communication Protocols
Protocols:
help - Show help information
stop - Pump Stop
pause - Pump Pause
start - Pump Run
status - Pump Return Status
set units [xxx] - Pump Set units
set diameter [x.x] - Pump Set diameter
set rate [x.x] - Pump Set rate
set time [xxx] - Pump Set time@volume
set volume [x.x] - Pump Set volume
set delay [xxx] - Pump Set delay@start
save setting - Pump parameter saved
read limit parameter - Pump Returns Limit Parameter
view parameter - Pump parameter settings
restart - Pump restart
Example: “set volume 1.35” send the command to set the volume to 1.35.
Resulting Action by Pump
18
Testing Communication in HyperTerminal
HyperTerminal is a Microsoft utility where users can manually enter in protocols one
by one to get the pump to communicate. All Windows based PCs have the
HyperTerminal utility. Located in START > Programs > Accessories >
Communications > HyperTerminal
Click HyperTerminal to start the program. Configure the COM port with the following
settings.
After you press OK you will come to a blank window with a blinking cursor. You can
type in protocols here to test communication or to run the pump from a remote
computer. Connect the pump to the PC. Type in “help” and then press enter to get
a complete list of protocols available to the pump.
USB to RS232 Dongle Converters
Due to the large numbers of computers made without RS232 ports, USB to RS232
dongles have been popular to “emulate” a RS232 port. Most but not all USB to
RS232 dongles work with chemyx pumps due to driver conflict issues.
19
TTL
TTL is a holdover from classical syringe pumps built in the 1970s before RS232 ports
existed. However Chemyx does have a TTL port grandfathered in for triggering starts
and stops. The TTL port has a USB-B receiver configuration.
TTL works with Chemyx’s foot switch, hand switch or parallel switches.
Other
Multi pu
Pumps
contact chemyx for more details on daisy chaining pumps.
mp control “Daisy Chaining”
can be daisy chained via a RS232 Y connector or parallel switches. Please
Chemyx Pump Controller Program (Freeware not supported)
hemyx does not provide technical support
C
attached to the manual CD.
This
program is freeware to control Chemyx syringe pumps.
for the free pump controller program
20
Appendices -A
Replacing The Fuse.
In the event of a power surge resulting from a lightning strike, plugging the pump
into an incorrect voltage or other surge event, the fuse in the syringe pump will
break. If the fuse breaks, no power will be supplied to the pump.
Chemyx syringe pumps come with a complimentary backup fuse inside the pump.
Please follow the instructions below on how to access the fuse holder and replace a
broken fuse.
Step 1: Locate the power plug on the back of the pump. The Fuse holder is located
underneath the 3 prongs of the power plug.
21
Step 2: Remove the fuse holder from the power plug. There is a small indentation
on the bottom edge of the power plug. A small coin or screwdriver may be needed
to remove the fuse holder from the pump.
There
are 2 fuses in the fuse holder. The exposed fuse in the back is the fuse that is
being currently used. In the event of a power surge this fuse will be the broken
fuse.
22
Step 4: Remove the broken fuse from the active slot in the holder. Most of the time
and broken fuse will be visible to the naked eye.
Remove the back-up fuse from the plastic casing represented below by the check
mark. Place the back-up fuse in the active slot. Insert the fuse holder back into the
pump’s power plug to reactivate the pump.
23
Chemyx
Inc. Parts List
Part
Number
Pump systems
10010 Fusion 100
10020 Fusion 200
10040 Fusion 400
10050 NanoJet
10002
10003
10051
10005
10006
50000 Hex-allen wrench for safety nut
50001 Safety nut screw
50002 Black insulated foot pad
Item Description
Options and accessories
▲10 channel infuse/withdraw holder
▲In-pump multi-step automation program
▲Pump head module
▲RS232 Cable
▲ Foot Switch
Universal replacement parts
www.chemyx.com
Compatible
Options
▲▲▲
▲▲▲▲▲
▲▲▲
▲
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