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Contents
1. About this edition of the operating manual ............................................................... 2
2. Safety precautions ................................................................................................... 3
3. General information .................................................................................................. 5
4. Getting started .......................................................................................................... 6
5. Operation ................................................................................................................. 8
6. Calibration .............................................................................................................. 10
7. Specifications ......................................................................................................... 11
8. Ordering information .............................................................................................. 12
9. Maintenance ........................................................................................................... 13
10. Warranty ................................................................................................................. 14
11. EU declaration of conformity .................................................................................. 15
1. About this edition of the operating manual
The manual applies to following models and versions of thermo-shakers for micro-
tubes and PCR plates:
TS-100 version V.4AW
TS-100C version V.5AW
2
2. Safety precautions
The following symbols mean:
Caution! Make sure you have fully read and understood the present Manual
before using the equipment. Please pay special attention to sections
marked by this symbol.
Caution! Hot surface! Platform surface becomes very hot during use. Always
use protective cotton gloves to install or remove samples when the
temperature is set higher than 60°C.
GENERAL SAFETY
Use only as specified in the operating manual provided.
Save the unit from shocks or falling.
Store and transport the unit in a horizontal position (see package label) at ambient
temperatures between -20°C and +60°C and maximum relative humidity of 80%.
After transportation or storage keep the unit under room temperature for 2-3 h before
connecting it to the electric circuit.
Use only original parts and accessories, provided by manufacturer for this product.
Before using any cleaning or decontamination methods except those recommended
by the manufacturer, check with the manufacturer that the proposed method will not
damage the equipment.
Do not make modifications to the design of the unit.
ELECTRICAL SAFETY
Connect only to the external power supply with voltage corresponding to that on the
serial number label.
Use only the external power supply provided with this product.
Ensure that the power switch and external power supply are easily accessible during
use.
Do not plug the unit into an ungrounded power socket, and do not use an ungrounded
extension lead.
Disconnect the unit from electric circuit before moving.
If liquid penetrates into the unit, disconnect it from the external power supply and
have it checked by a repair and maintenance technician.
Do not operate the unit in premises where condensation can form. Operating condi-
tions of the unit are defined in the Specifications section.
3
DURING OPERATION
Do not leave the operating unit unattended.
Do not impede the platform motion.
Do not operate the unit in environments with aggressive or explosive chemical mix-
tures. Please contact manufacturer for possible operation of the unit in specific atmospheres.
Do not operate the unit if it is faulty or has been installed incorrectly.
Do not use outside laboratory rooms.
Do not check the temperature by touch. Use a thermometer.
ALARM SOUND SIGNALS
Frequently repeating short notes after finishing the operation (see 5.6.3).
Infrequently repeating short notes if an error occurred (see 9.5)
BIOLOGICAL SAFETY
It is the user’s responsibility to carry out appropriate decontamination if hazardous
material is spilt on or penetrates into the equipment.
4
3. General information
TS-100 and TS-100С thermo-shakers are designed for intensive mixing of samples
in microtest tubes or PCR plates in a temperature controlled environment. The TS-100C
model of thermo-shaker differs from TS-100 in the possibility of cooling samples down to
+4°C. Features of thermo-shakers meet the highest expectations of users according to many
parameters:
Fast reaching of specified mixing speed and maintenance of equal amplitude of rota-
tion throughout the thermo-shaker block;
Stability of maintaining the set temperature in a wide range throughout the block sur-
face of thermo-shakers;
With the help of the temperature calibration function, the user can calibrate the unit
approximately ±6% of the selected temperature to compensate differences in the
thermal behaviour of tubes from different manufacturers;
LCD display indicates pre-set and current values of temperature, speed and time of
operation;
Quiet motor operation, compact size, prolonged service life;
Sensor error handling and diagnostics;
Functions of heating and mixing can be performed either simultaneously or independently, that allows using the unit as three independent devices:
1. Thermostat;
2. Shaker;
3. Thermo-shaker.
We offer five heating and cooling blocks for each model, including a block with a
plastic lid for PCR-plates. Within one model of thermo-shaker, the blocks are mutually interchangeable and can be easily installed.
The devices are applicable in:
genetic analyses – in extraction of DNA, RNA and further sample preparation;
biochemistry – for studying of enzymatic reactions and processes;
cellular biology – extraction of metabolites from cellular material.
5
4. Getting started
4.1. Unpacking. Remove packing materials carefully and retain for future shipment or
storage of the unit. Examine the unit carefully for any damage incurred during transit.
The warranty does not cover in-transit damage. Warranty covers only units transported in the original package.
4.2. Complete sets.
4.2.1. TS-100
- TS-100 thermo-shaker for microtubes and microplates .................................... 1 pce
- External power supply ....................................................................................... 1 pce
- Power cable ...................................................................................................... 1 pce
- Spare rubber belt .............................................................................................. 2 pcs
- Operating manual, declaration of conformity ..................................................... 1 pce
- SC-18 thermoblock for microtubes ........................................................ on request
- SC-18/02 thermoblock for microtubes ................................................... on request
- SC-24 thermoblock for microtubes ........................................................ on request
- SC-24N thermoblock for microtubes ..................................................... on request
- SC-96A thermoblock for microplate and hex-key .................................. on request
4.2.2. TS-100C
- TS-100C thermo-shaker with cooling for microtubes and microplates .............. 1 pce
- External power supply ....................................................................................... 1 pce
- Power cable ...................................................................................................... 1 pce
- Spare rubber belt .............................................................................................. 2 pcs
- Operating manual, declaration of conformity ..................................................... 1 pce
- SC-18C thermoblock for microtubes ..................................................... on request
- SC-18/02C thermoblock for microtubes ................................................ on request
- SC-24C thermoblock for microtubes ..................................................... on request
- SC-24NC thermoblock for microtubes ................................................... on request
- SC-96AC thermoblock for microplate and hex-key ............................... on request
6
4.3. Setup.
- Place the unit upon even horizontal stable non-flammable surface 30 cm away from
any flammable materials, and clear 20 cm around the device on all sides for ventilation.
- Remove protective film from the display;
- Plug the external power supply into the socket at the rear side of the unit;
- Connect the power cable to the external power supply.
4.4. Thermoblock installation (if a thermoblock is not installed).
Caution! Thermoblock installation and replacement have to be performed only
when the Power switch is turned off and external power supply is
disconnect from the device.
Caution! Thermoblocks for TS-100 and TS-100C are not interchangeable! In-
stalling a thermoblock from different model will irreversibly damage
both the unit and the thermoblock! TS-100C thermoblocks have an
additional sticker.
- Choose the thermoblock, connect the plug to the contact terminal according to the
scheme on fig. 1/1 on the underside of the thermoblock. Make sure that the connector is mounted tightly.
- Align the thermoblock so that the warning label is facing the front of the unit (fig. 2).
- Secure with the four knurled screws (fig. 2/1) or four hex screws.
4.5. Changing blocks.
- Disconnect the external power supply from the device.
- Remove the four knurled screws or four hex screws (in microplate thermoblocks).
- Lift the block without damaging the cable and disconnect the plug (fig. 1/1).
- Select the new thermoblock and install it according to 4.4.
Figure 1. Thermoblock connection Figure 2. Thermoblock setup
7
5. Operation
Recommendations during operation
Please check the tubes/microplates before using, be sure that tubes and micro plates
are heat-resistant. Do not heat the microplates over the melting point of the material
they are made of.
We recommend filling tubes and plate wells up to 75% of rated volume for efficiency.
Caution! Platform surface becomes very hot during use. Please, take neces-
sary care and use protective cotton gloves to install or remove test
samples when set temperature is higher than 60°C.
Figure 3. Control Panel
5.1. Connect external power supply to a grounded power socket and set the power switch,
located on the rear panel of the unit, to position I (ON).
5.2. The display will turn on with the upper line (Set) showing time, speed and temperature
set earlier and the lower line (Actual) showing current status: STOP indication, 000
rpm speed and platform temperature in °C.
5.2.1. Simultaniously press and hold the RPM RUN/STOP and TIME RUN/STOP keys (fig.
3/4 and 3/5) to view the programming version (PV-XX).
5.3. If a temperature is set, then the platform temperature automatically changes to that
temperature. The time of temperature stabilization depends on the room temperature.
If the heating of is turned off by setting the temperature below 25°C (TS-100) or 4°C
(TS-100C), top line shows indication OFF.
5.4. Setting the parameters. Use the readings in the upper line of the display (Set), while
setting the required parameters. Pressing the key for more than 3 s will increase the
increment rate. Speed and temperature can be changed during operation.
5.4.1. Setting time (TIME). Using the and TIME keys (fig. 3/1) set the required working time interval in hours and minutes (increment 1 min).
5.4.2. Setting speed (RPM). Using the and RPM keys (fig. 3/2) set the required speed
(increment 10 rpm).
8
5.4.3. Setting temperature (Т, ºС). Using the and Т, ºС keys (Fig. 3/3) set the necessary temperature (increment 0.1°C).
Caution! Heating/temperature maintenance process does not stop when the
timer is finished. Platform thermal regulation can be turned off only
by setting the required temperature below 25°C (TS-100) or 4°C (TS-
100C), top line shows indication OFF. In this mode, thermo-shaker
can be used in the cold rooms as a mixing device without thermoregulation.
5.5. Program execution. After the thermal stabilization of the thermo-shaker, i.e. when
the set and current temperature readings become the same:
5.5.1. Place samples on the platform.
Caution! Do not fill microtubes or microplates directly inside the unit.
5.5.2. Press the RPM RUN/STOP key (fig. 3/4). The platform will start rotating and the timer
indicator will start counting up the time interval (with 1 min precision).
Note! If the rotation speed is set to zero, pressing RPM RUN/STOP key will
start the timer but the platform will not move.
5.5.3. After finishing the program (after the set time elapses) the platform motion will stop
and the timer will show the flashing reading STOP accompanied by the repetitive
sound signal until the RPM RUN/STOP key is pressed.
5.6. If the working time is not set (or is reset) and the timer indicator in the upper line
shows 00:00, pressing the RPM RUN/STOP key will start continuous operation of the
device with countdown timer in the lower line (Actual) until the RPM RUN/STOP key
is pressed again.
5.7. If required, there is possibility to restart the timer when it is running. Press the TIME
RUN/STOP key once (fig. 3/5) to stop the timer. Press the TIME RUN/STOP key
again to restart the timer.
5.8. The platform motion can be stopped at any time by pressing the RPM RUN/STOP
key. In this case the program realization and the platform motion will stop and the
timer will switch into the STOP mode saving previously set time. Press the RPM
RUN/STOP key to repeat the operation with the same time and speed.
Caution! At the end of the set time period the platform movement is stopped
automatically, but the heating can be stopped only manually by reducing the temperature using the T, °C key (Fig. 3/3 - lower key)
till the OFF sign appears in the upper line (Set) of the display
Caution! The platform remains hot after use. Please, take necessary care and
use protective cotton gloves to install or remove test samples when
set temperature is higher than 60°C.
5.9. After finishing the operation, set the Power switch, located on the rear panel of the
unit, in position O (Off) and disconnect the external power supply from electric circuit.
9
6. Calibration
Figure 5. Changing the coefficient:
1. Calibration coefficient; 2. Temperature
with current coefficient
Figure 6. Display after calibration:
1. Set temperature; 2. Current calibrated
temperature
6.1. The device is precalibrated at the factory (calibrating coefficient is 1.000) for operation
with temperatures measured by a sensor in the heating block.
6.2. To change the calibration coefficient, hold the TIME RUN/STOP key pressed for more
than 8 s to activate calibration mode. The calibration coefficient appears on the display (figure 4).
Figure 4. Display in calibration mode: 1. Calibration mode indicator;
2. Calibration coefficient; 3. Temperature with current coefficient
Note. Values marked in grey on figures 4 and 5 are not used in calibration
and are meant for service engineers.
6.3. Restoring factory settings. Set 1.000 value using the ▲ and ▼ T, °C keys as shown
on fig. 4/1 to restore the factory settings. Press the RPM RUN/STOP key once to
save the changes and exit the calibration mode.
Note. Coefficient value changes are recommended after the unit has
reached 30°C temperature.
6.4. Calibration procedure. To calibrate the unit, use an independent sensor with 0.5°C
accuracy, which can fit in the cell of a microplate on the platform.
6.4.1. Install the sensor into a celll of the microplate.
6.4.2. Set the required temperature in operation mode (e.g. 40°C).
6.4.3. After the unit reaches the set temperature (when the set and current temperature
readings equal), leave the unit for 30 min for thermal stabilization.
6.4.4. Let us assume that the readings of independent sensor is 39°C, but the display’s
actual temperature is 40°C. Then, it is necessary to add 1°C correction.
6.4.5. Hold the TIME RUN/STOP key pressed for more than 8 s to activate calibration mode
(figure 4).
6.4.6. Using the ▲ and ▼ T, °C keys, change the calibration coefficient (fig. 5/1) so that the
new temperature value (fig. 5/2) corresponds to the independent sensor temperature.
In our example, the calibration coefficient will be 0.974.
Note. Calibration coefficient can be changed in range from 0.936 to 1.063
(±0.063), with increment of 0.001. This calibrating coefficient will correct temperature through all the operation range.
Note. Coefficient value changes are recommended after the unit has
reached 30°C temperature.
6.4.7. Press the RPM RUN/STOP key once to save the changes and exit the calibration.
6.5. The display will show calibrated temperature as shown on fig. 6/1 and the unit will
continue thermal stabilization according to the previously set temperature.
10
7. Specifications
Temperature parameters
TS-100
TS-100C
Setting range
+25°С to +100°C
+4°С to +100°C
Control range
5°С above RT
1
to +100°C
15°С below RT1
to +100°C
Setting resolution
0.1°С
Stability2, at +37°C
±0.1°C
Maintaining accuracy2, at +37°C
±0.5°C
Uniformity over the plat-
form2,
at +4°C
-
±0.6°C
at +37°C
±0.2°C
±0.1°C
at +100°C
±0.2°C
±0.3°C
Average heating speed from +25°С to +100°С
4°С/min
5°С/min
Average cooling
speed
from +100°С to +25°C
-
5°С/min
from +25°C to +4°С
-
1.8°С/min
Calibration option
yes
Calibration coefficient range
0.936...1.063 (± 0.063)
General parameters
TS-100
TS-100C
Speed range
250-1400 rpm
Speed setting resolution
10 rpm
Maximal speed
deviation
for 250 rpm
2%
for 1400 rpm
0.7%
Orbit
2 mm
Digital time setting
1 min - 96 h
Time setting and countdown resolution
1 min
Maximal continuous operation time3
168 h
Display
16x2 symbols, LCD
Dimensions
Without thermoblock, LxWxH
220x240x90 mm
With thermoblock, LxWxH
max
220x240x130 mm
Input voltage and current / power consumption
12 V, 3.5 A / 42 W
12 V, 4.9 A / 60 W
External power supply
in AC 100-240 V, 50/60 Hz, out DC 12 V
Weight4
3.7 kg
1
2
3
4
The unit is designed for operation in cold rooms, incubators (excluding CO2 incuba-
tors) and closed laboratory rooms at ambient temperature from +4°C to +40°C in a non-
condensing atmosphere and maximum relative humidity 80% for temperatures up to 31°C
decreasing linearly to 50% relative humidity at 40°C.
Biosan is committed to a continuous programme of improvement and reserves the
right to alter design and specifications of the equipment without additional notice.
Room temperature
Data for 75% filled tubes or microplates
Recommended interval between prolonged operation sessions not less than 1 hour
Accurate within ± 10%.
11
8. Ordering information
Model
Version
Description
Catalogue number
TS-100
V.4AW
100-240 V, 50/60 Hz
BS-010120-AAI
TS-100C
V.5AW
100-240 V, 50/60 Hz
BS-010143-AAI
Model
Description
Weight1, kg
Catalogue number
SC-18
For 20x0.5 ml + 12x1.5ml tubes
0.5
BS-010120-AK
SC-18/02
For 20x0.2 ml + 12x1.5ml tubes
0.5
BS-010120-CK
SC-24
For 24x2.0 ml microtubes
0.4
BS-010120-EK
SC-24N
For 24x1.5 ml microtubes
0.5
BS-010120-GK
SC-96A
For 96-well microplate for PCR, w/o skirt,
with half skirt, low and high profile
0.5
BS-010120-FK
Model
Description
Weight1, kg
Catalogue number
SC-18C
For 20x0.5 ml + 12x1.5ml tubes
0.7
BS-010143-AK
SC-18/02C
For 20x0.2 ml + 12x1.5ml tubes
0.7
BS-010143-CK
SC-24C
For 24x2.0 ml microtubes
0.6
BS-010143-EK
SC-24NC
For 24x1.5 ml microtubes
0.7
BS-010143-GK
SC-96AC
For 96-well microplate for PCR, w/o skirt,
with half skirt, low and high profile
0.7
BS-010143-FK
Replacement part
Description
Catalogue number
Rubber belt
122x6x0.6 mm
BS-000000-S18
1
8.1. Models and versions available:
8.2. To inquire about or order the optional accessories or the replacement parts, contact
Biosan or your local Biosan representative.
8.2.1. Optional thermoblocks for TS-100:
8.2.2. Optional thermoblocks for TS-100C:
Caution! Thermoblocks for TS-100 and TS-100C are not interchangeable! In-
stalling a thermoblock from different model will irreversibly damage
both the unit and the thermoblock! TS-100C thermoblocks have an
additional sticker.
8.2.3. Universal replacement parts for TS-100 and TS-100C
Accurate within ± 10%.
12
9. Maintenance
9.1. If the unit requires maintenance, disconnect the unit from the electric circuit and contact Biosan or your local Biosan representative.
9.2. All maintenance and repair operations must be performed only by qualified and specially trained personnel.
9.3. Standard ethanol (75%) or other cleaning agents recommended for cleaning of laboratory equipment can be used for cleaning and decontamination of the unit.
9.4. Rubber belt replacement. For maintenance of reliable operation of the device, the
manufacturer recommends to replace rubber belts after 1.5 years or 2000 hours of operation time.
- Disconnect the external power supply from the device.
- Remove 4 fixation screws on the device bottom and remove the bottom plate.
- Replace the rubber belt (Fig. 7).
- Reassemble the device.
Figure 7. Rubber belt replacement
9.5. Error codes in case of a defect. Some malfunctions trigger an error code to appear
on display, accompanied by a sound signal every 8 s. Press RPM RUN/STOP key to
turn off the signal. Error code format is letters ER and a single digit. Disconnect the
unit from the electric circuit and report the error code to Biosan or your local Biosan
representative.
13
10. Warranty
Technical support
Warranty registration
Product class description
biosan.lv/en/support
biosan.lv/register-en
biosan.lv/classes-en
Model
TS-100 / TS-100C
Thermo-shaker for microtubes and microplates
Serial number
Date of sale
10.1. The manufacturer guarantees the compliance of unit with the requirements of specifications, if the customer follows the operation, storage and transportation instructions.
10.2. The warranted service life of unit from date of delivery to the customer is 24 months.
For extended warranty, register the unit, see 10.5.
10.3. Warranty covers only the units transported in the original package.
10.4. If any manufacturing defects are discovered by the Customer, an unsatisfactory
equipment report shall be compiled, certified and sent to the local distributor address.
To obtain the claim form, visit section Technical support on our website at link below.
10.5. Extended warranty. For TS-100 and TS-100C, the Premium class models, one year
of extended warranty is available free of charge after registration, during 6 months
from the date of sale. Online registration form can be found in section Warranty reg-
istration on our website at the link below.
10.6. Description of the classes of our products is available in the Product class descrip-
tion section on our website at the link below.
10.7. The following information will be required in the event that warranty or post-warranty
service comes necessary. Complete the table below and retain for your records.
14
11. EU declaration of conformity
Unit type Thermo-shakers
Models TS-100, TS-100C, TS-DW, PST-60HL,
PST-60HL-4, PST-100HL
Serial number 14 digits styled XXXXXXYYMMZZZZ, where XXXXXX is
model code, YY and MM – year and month of production,
ZZZZ – unit number.
Manufacturer SIA BIOSAN
Latvia, LV-1067, Riga, Ratsupites str. 7/2
Applicable Directives EMC Directive 2014/30/EU
LVD Directive 2014/35/EU
RoHS2 2011/65/EU
WEEE 2012/19/EU
Applicable Standards LVS EN 61326-1: 2013
Electrical equipment for measurement, control and
laboratory use. EMC requirements. General requirements.
LVS EN 61010-1: 2011
Safety requirements for electrical equipment for
measurement, control, and laboratory use. General
requirements.
LVS EN 61010-2-010: 2015
Particular requirements for laboratory equipment for the
heating of materials.
LVS EN 61010-2-051: 2015
Particular requirements for laboratory equipment for mixing
and stirring.
We declare that this product conforms to the requirements of the above Directives
____________________ ____________________
Signature Signature
Svetlana Bankovska Aleksandr Shevchik
Managing director Engineer of R&D
____________________ ____________________
Date Date
Edition 4.-5.01 – December 2018
15
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