3M™ Abrasive Products, 577F Flap Discs, T27, T29 03/24/14
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Germ Cell Mutagenicity
Name Route Value
Aluminum Oxide Mineral (non-fibrous) In Vitro Not mutagenic
Filler In Vitro Not mutagenic
Titanium Dioxide In Vitro Not mutagenic
Titanium Dioxide In vivo Not mutagenic
Silica In Vitro Not mutagenic
Carcinogenicity
Name Route Species Value
Aluminum Oxide Mineral (non-fibrous) Inhalation Rat Not carcinogenic
Titanium Dioxide Ingestion Multiple
animal
species
Not carcinogenic
Titanium Dioxide Inhalation Rat Carcinogenic
Silica Not
Specified
Mouse Some positive data exist, but the data are not
sufficient for classification
Reproductive Toxicity
Reproductive and/or Developmental Effects
Name Route Value Species Test Result Exposure
Duration
Filler Ingestion Not toxic to development Rat NOAEL 625
mg/kg/day
premating &
during
gestation
Silica Ingestion Not toxic to female reproduction Rat NOAEL 509
mg/kg/day
1 generation
Silica Ingestion Not toxic to male reproduction Rat NOAEL 497
mg/kg/day
1 generation
Silica Ingestion Not toxic to development Rat NOAEL
1,350
mg/kg/day
during
organogenesi
s
Target Organ(s)
Specific Target Organ Toxicity - single exposure
Name Route Target Organ(s) Value Species Test Result Exposure
Duration
Filler Inhalation respiratory system All data are negative Rat NOAEL
0.812 mg/l
90 minutes
Specific Target Organ Toxicity - repeated exposure
Name Route Target Organ(s) Value Species Test Result Exposure
Duration
Aluminum Oxide Mineral
(non-fibrous)
Inhalation pneumoconiosis |
pulmonary fibrosis
Some positive data exist, but the
data are not sufficient for
classification
Human NOAEL Not
available
occupational
exposure
Filler Inhalation respiratory system Some positive data exist, but the
data are not sufficient for
classification
Human NOAEL Not
available
occupational
exposure
Filler Inhalation pulmonary fibrosis All data are negative Human
and
animal
NOAEL Not
available
Inorganic Fluoride Inhalation bone, teeth, nails,
and/or hair
Some positive data exist, but the
data are not sufficient for
classification
HHA
Filler Inhalation respiratory system Some positive data exist, but the
data are not sufficient for
classification
Human NOAEL Not
available
occupational
exposure
Inorganic Fluoride Inhalation bone, teeth, nails,
and/or hair
Some positive data exist, but the
data are not sufficient for
classification
HHA