3M™ Abrasive Products, 501C Grades 24-50 Roloc™ 03/25/14
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Quartz Silica In vivo Some positive data exist, but the data are not 
sufficient for classification
Carcinogenicity
Name Route Species Value
Aluminum Oxide Mineral (non-fibrous) Inhalation Rat Not carcinogenic 
Titanium Dioxide Ingestion Multiple 
animal 
species
Not carcinogenic
Titanium Dioxide Inhalation Rat Carcinogenic 
Quartz Silica Inhalation Human 
and 
animal
Carcinogenic
Reproductive Toxicity
Reproductive and/or Developmental Effects
Name Route Value Species Test Result  Exposure 
Duration
Filler Ingestion Not toxic to development Rat NOAEL 625 
mg/kg/day
premating & 
during 
gestation
Target Organ(s)
Specific Target Organ Toxicity - single exposure
Name Route Target Organ(s) Value Species Test Result  Exposure 
Duration
Filler Inhalation respiratory system All data are negative Rat NOAEL 
0.812 mg/l
90 minutes
Specific Target Organ Toxicity - repeated exposure
Name Route Target Organ(s) Value Species Test Result  Exposure 
Duration
Aluminum Oxide Mineral 
(non-fibrous)
Inhalation pneumoconiosis | 
pulmonary fibrosis
Some positive data exist, but the 
data are not sufficient for 
classification
Human NOAEL Not 
available 
occupational 
exposure
Inorganic Fluoride Inhalation bone, teeth, nails, 
and/or hair
Some positive data exist, but the 
data are not sufficient for 
classification
HHA 
Filler Inhalation respiratory system Some positive data exist, but the 
data are not sufficient for 
classification
Human NOAEL Not 
available 
occupational 
exposure
Titanium Dioxide Inhalation respiratory system Some positive data exist, but the 
data are not sufficient for 
classification
Rat LOAEL 
0.010 mg/l
2 years
Titanium Dioxide Inhalation pulmonary fibrosis All data are negative Human NOAEL Not 
available 
occupational 
exposure
Quartz Silica Inhalation silicosis Causes damage to organs 
through prolonged or repeated 
exposure
Human NOAEL Not 
available 
occupational 
exposure
Aspiration Hazard
Name Value
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on this material and/or its components.
SECTION 12: Ecological information
Ecotoxicological information