Metrohm tiamo 2.3 User Manual

0 (0)

tiamo 2.3 (for Process Analysis)

Manual

8.101.8046EN

Metrohm AG CH-9100 Herisau Switzerland

Phone +41 71 353 85 85 Fax +41 71 353 89 01 info@metrohm.com www.metrohm.com

tiamo 2.3 (for Process Analysis)

Manual

8.101.8046EN

06.2011 ek/doe

Teachware Metrohm AG CH-9100 Herisau

teachware@metrohm.com

Although all the information given in this documentation has been checked with great care, errors cannot be entirely excluded. Should you notice any mistakes please send us your comments using the address given above.

Documentation in additional languages can be found on http://products.metrohm.com under Literature/Technical documentation.

Table of contents

1 Introduction		1
1.1	Welcome to tiamo ................................................................	1
1.2	Operation ..............................................................................	2
1.3	Connecting devices ...............................................................	3
1.4	Method editor .......................................................................	4
1.5	Database ................................................................................	5
1.6	Communication .....................................................................	6
1.7	Conformity .............................................................................	7
1.8	Versions .................................................................................	8
1.9	Online help ............................................................................	9
1.10	What is new in tiamo 2.3? .................................................	10
1.10.1	New features .........................................................................	10
1.10.2	Improvements .......................................................................	11
1.10.3 Fixed bugs and problems .......................................................		13

2 General program functions		17
2.1	Program parts .....................................................................	17
2.1.1	Program parts ........................................................................	17
2.1.2	Workplace - Desktop .............................................................	18
2.1.3	Database - Desktop ...............................................................	18
2.1.4	Method - Desktop .................................................................	19
2.1.5	Configuration - Desktop ........................................................	19
2.1.6	Manual control - Desktop ......................................................	20
2.2	Login/password protection ................................................	20
2.2.1	General information on Login/password protection ..............	20
2.2.2	Login .....................................................................................	21
2.2.3	Manual logout ......................................................................	22
2.2.4	Automatic logout ..................................................................	22
2.2.5	Change password ..................................................................	22
2.3	Electronic signatures ..........................................................	23
2.3.1	Rules for electronic signatures ...............................................	23
2.3.2	Procedure for electronic signatures ........................................	24
2.3.3	Signature Level 1 ...................................................................	25
2.3.4	Signature Level 2 ...................................................................	26
2.3.5	Delete signatures level 2 ........................................................	28
2.4	Formula editor ....................................................................	29
2.4.1	Input field ..............................................................................	29
2.4.2	Calculation algorithms ...........................................................	30
2.4.3	Variables ...............................................................................	32

tiamo 2.3 (for Process Analysis)

III

Table of contents
2.4.4	Operators/Functions ..............................................................	55
2.4.5	Molar mass calculator ............................................................	89
2.5	Editing .................................................................................	89
2.5.1	Select date ...........................................................................	89
2.5.2	Text editor .............................................................................	90
2.5.3	Hyperlink ...............................................................................	91
2.6	E-mail ...................................................................................	92
2.6.1	Send E-mail ...........................................................................	92
3 Workplace		93
3.1	Workplace - General ...........................................................	93
3.1.1	Workplace - Definition ...........................................................	93
3.1.2	Workplace - Desktop .............................................................	93
3.1.3	Workplace - Menu bar ...........................................................	93
3.1.4	Workplace - Toolbar ..............................................................	96
3.1.5	Workplace - Subwindows ......................................................	96
3.1.6	Workplace - Functions ...........................................................	97
3.1.7	Views ....................................................................................	98
3.2	Workplaces .......................................................................	101
3.2.1	Create new workplace .........................................................	101
3.2.2	Edit workplace .....................................................................	102
3.2.3	Displaying workplaces .........................................................	102
3.2.4	Close workplace ..................................................................	103
3.3	Sample tables ...................................................................	103
3.3.1	Editing the sample table ......................................................	103
3.3.2	Sample table - Properties .....................................................	113
3.3.3	Sample table manager .........................................................	122
3.4	Sample assignment table .................................................	124
3.4.1	Sample assignment table ....................................................	124
3.4.2	Sample assignment .............................................................	125
3.4.3	Enter assignment ID .............................................................	126
3.5	Text templates ..................................................................	127
3.5.1	List of text templates ...........................................................	127
3.5.2	Edit text template ................................................................	127
3.6	Subwindow Run ..............................................................	128
3.6.1	Run - General ......................................................................	128
3.6.2	Run test ...............................................................................	128
3.6.3	Single determination ............................................................	129
3.6.4	Determination series ............................................................	145
3.7	Subwindow Method .........................................................	176
3.7.1	Method window - General ..................................................	176
3.7.2	Method window - Zoom .....................................................	176
3.7.3	Method window - Live modifications ...................................	177
3.7.4	Method window - Cancel command ....................................	178
3.8	Subwindow Live display ..................................................	178
3.8.1	Live display - General ...........................................................	178

IV	tiamo 2.3 (for Process Analysis)

		Table of contents
3.8.2	Live display - Tracks .............................................................	179
3.8.3	Live display - Application note .............................................	180
3.8.4	Live display - Messages ........................................................	180
3.8.5	Live display - Properties ........................................................	180
3.9	Subwindow Report .........................................................	188
3.9.1	Report - General .................................................................	188
3.9.2	Latest report .......................................................................	188
3.9.3	Selected report ...................................................................	188
3.9.4	Report overview .................................................................	188
3.9.5	Properties report overview ...................................................	189
4 Database		190
4.1	Database - General ...........................................................	190
4.1.1	Database - Definition ...........................................................	190
4.1.2	Database - Desktop .............................................................	190
4.1.3	Database - Menu bar ...........................................................	191
4.1.4	Database - Toolbar ..............................................................	195
4.1.5	Database - Subwindows ......................................................	197
4.1.6	Database - Functions ...........................................................	197
4.1.7	Views ..................................................................................	198
4.2	Database display ..............................................................	201
4.2.1	Open database ...................................................................	201
4.2.2	Select database ...................................................................	202
4.2.3	Display single database .......................................................	203
4.2.4	Display databases next to one another .................................	203
4.2.5	Display databases one below the other ................................	203
4.2.6	Close database ...................................................................	204
4.3	Manage databases ...........................................................	204
4.3.1	Manage databases .............................................................	204
4.3.2	Create new database ...........................................................	205
4.3.3	Rename database ................................................................	206
4.3.4	Delete database ...................................................................	206
4.3.5	Database properties .............................................................	206
4.3.6	Backup database manually ...................................................	210
4.3.7	Restore database ................................................................	211
4.4	Templates ..........................................................................	212
4.4.1	Report templates .................................................................	212
4.4.2	Templates for control chart ..................................................	248
4.4.3	Curve overlay templates .......................................................	252
4.4.4	Export templates .................................................................	257
4.5	Determination overview ..................................................	295
4.5.1	Determination overview - General ........................................	295
4.5.2	Determination overview - Functions .....................................	301
4.6	Subwindow Information ..................................................	347
4.6.1	Information - Overview ........................................................	347
4.6.2	Information - Determination ................................................	347
4.6.3	Information - Method ..........................................................	351

tiamo 2.3 (for Process Analysis)

Table of contents
4.6.4	Information - Sample ...........................................................	352
4.6.5	Information - Configuration .................................................	354
4.6.6	Information - Messages .......................................................	362
4.6.7	Information - Determination comment ................................	362
4.7	Subwindow Results ..........................................................	363
4.7.1	Results - General ..................................................................	363
4.7.2	Results - Results overview ....................................................	363
4.7.3	Results - Raw data ...............................................................	365
4.7.4	Results - Calculation # .........................................................	376
4.7.5	Results - Properties ..............................................................	377
4.8	Subwindow Curves ...........................................................	378
4.8.1	Curves - General ..................................................................	378
4.8.2	Curves - Measuring point list ................................................	380
4.8.3	Curves - Monitoring report ..................................................	380
4.8.4	Properties ............................................................................	381
5 Method		397
5.1	Method - General .............................................................	397
5.1.1	Method - Definition .............................................................	397
5.1.2	Method - Desktop ...............................................................	398
5.1.3	Method - Menu bar .............................................................	398
5.1.4	Method - Toolbar ................................................................	400
5.1.5	Method - Functions .............................................................	402
5.2	Method editor ...................................................................	403
5.2.1	Creating new method ..........................................................	403
5.2.2	Opening a method ..............................................................	403
5.2.3	Select method ....................................................................	405
5.2.4	Editing a method .................................................................	407
5.2.5	Checking a method .............................................................	412
5.2.6	Saving a method .................................................................	412
5.2.7	Modification comment on method ......................................	414
5.2.8	Print method report .............................................................	415
5.2.9	Closing a method ................................................................	415
5.3	Managing methods ..........................................................	416
5.3.1	Managing methods .............................................................	416
5.3.2	Renaming a method ............................................................	418
5.3.3	Copying a method ...............................................................	418
5.3.4	Moving a method ................................................................	418
5.3.5	Deleting a method ...............................................................	419
5.3.6	Sending a method to ...........................................................	419
5.3.7	Exporting a method .............................................................	420
5.3.8	Importing a method ............................................................	420
5.3.9	Renaming an imported method ...........................................	420
5.3.10	Signing methods .................................................................	421
5.3.11	Showing the method history ................................................	426
5.4	Method groups .................................................................	427
5.4.1	Manage method groups .....................................................	427

VI	tiamo 2.3 (for Process Analysis)

		Table of contents
5.4.2	Edit method groups .............................................................	428
5.5	Tracks ................................................................................	429
5.5.1	Tracks - General ...................................................................	429
5.5.2	Track types ..........................................................................	430
5.5.3	Edit tracks ...........................................................................	435
5.6	Commands ........................................................................	436
5.6.1	Commands - General ...........................................................	436
5.6.2	Track commands .................................................................	440
5.6.3	Titration commands .............................................................	455
5.6.4	Measuring commands .........................................................	930
5.6.5	Calibration commands .......................................................	1087
5.6.6	Dosing commands .............................................................	1150
5.6.7	Automation commands .....................................................	1206
5.6.8	Result commands ..............................................................	1232
5.6.9	Communications commands ..............................................	1250
5.6.10	Miscellaneous commands ..................................................	1271
5.6.11	Process analysis commands ...............................................	1286
6 Configuration		1310
6.1	Configuration - General .................................................	1310
6.1.1	Configuration - Definition ..................................................	1310
6.1.2	Configuration - Desktop ....................................................	1310
6.1.3	Configuration - Menu bar ..................................................	1311
6.1.4	Configuration - Toolbar .....................................................	1313
6.1.5	Configuration - Subwindows .............................................	1313
6.1.6	Configuration - Functions ..................................................	1314
6.1.7	Views ................................................................................	1315
6.2	Administration ................................................................	1318
6.2.1	User administration ...........................................................	1318
6.2.2	Security settings ................................................................	1327
6.2.3	Program administration .....................................................	1337
6.3	Configuration data .........................................................	1342
6.3.1	Exporting/Importing ...........................................................	1342
6.3.2	Backup/Restore ..................................................................	1348
6.3.3	Templates ..........................................................................	1350
6.3.4	Options .............................................................................	1364
6.4	Audit Trail .......................................................................	1366
6.4.1	Audit Trail - General ...........................................................	1366
6.4.2	Audit Trail table .................................................................	1370
6.5	Subwindow Devices .......................................................	1382
6.5.1	Configuration - Devices .....................................................	1382
6.5.2	Device table .......................................................................	1383
6.5.3	Device properties ...............................................................	1387
6.6	Subwindow Titrants/Solutions ......................................	1388
6.6.1	Titrants/Solutions - General ................................................	1388
6.6.2	Solution table ....................................................................	1388

tiamo 2.3 (for Process Analysis)

VII

Table of contents
6.6.3	Solution properties ............................................................	1392
6.7	Subwindow Sensors .......................................................	1411
6.7.1	Sensors - General ...............................................................	1411
6.7.2	Sensor table ......................................................................	1411
6.7.3	Sensor properties ...............................................................	1415
6.8	Subwindow Colorimetric sensors .................................	1436
6.8.1	Colorimetric sensors - General ...........................................	1436
6.8.2	Table - Colorimetric sensors ...............................................	1436
6.8.3	Properties - Colorimetric sensor .........................................	1440
6.9	Subwindow Common variables ...................................	1447
6.9.1	Configuration - Common variables ...................................	1447
6.9.2	Table of common variables ................................................	1448
6.9.3	Common variables properties ............................................	1451
6.10	Subwindow Global variables .........................................	1456
6.10.1	Configuration - Global variables .........................................	1456
6.10.2	Table of global variables ....................................................	1457
6.10.3	Properties Global variables .................................................	1460
6.11 Subwindow Sample solutions (TC conductivity) .........		1465
6.11.1	Sample solutions (TC conductivity) - General ......................	1465
6.11.2	Sample solutions (TC conductivity) table .............................	1466
6.11.3	Sample solutions (TC conductivity) properties .....................	1469
6.12	Subwindow Rack data ...................................................	1473
6.12.1	Configuration - Rack data .................................................	1473
6.12.2	Rack table .........................................................................	1473
6.12.3	Rack properties ..................................................................	1475
7 Instruments		1483
7.1	Titrando ..........................................................................	1483
7.1.1	Titrando - Overview ...........................................................	1483
7.1.2	Properties - General ...........................................................	1483
7.1.3	Properties - Measuring inputs ............................................	1484
7.1.4	Properties - MSB # .............................................................	1485
7.1.5	Properties - GLP ................................................................	1487
7.1.6	Load new program version ...............................................	1488
7.2	Titrino ..............................................................................	1489
7.2.1	Titrino - Overview ..............................................................	1489
7.2.2	Properties - General ...........................................................	1490
7.2.3	Properties - Int. Dosing device D0 ......................................	1491
7.2.4	Properties - Ext. Dosing device D# ......................................	1492
7.2.5	Properties - RS-232 ............................................................	1493
7.2.6	Properties - GLP ................................................................	1494
7.3	756/831 Coulometer ......................................................	1496
7.3.1	756/831 Coulometer - Overview ........................................	1496
7.3.2	Properties - General ...........................................................	1496
7.3.3	Properties - RS-232 ............................................................	1497
7.3.4	Properties - GLP ................................................................	1498

VIII	tiamo 2.3 (for Process Analysis)

		Table of contents
7.4	712 Conductometer .......................................................	1500
7.4.1	712 Conductometer - Overview .........................................	1500
7.4.2	Properties - General ...........................................................	1500
7.4.3	Properties - RS-232 ............................................................	1501
7.4.4	Properties - GLP ................................................................	1502
7.5	856 Conductivity Module ..............................................	1504
7.5.1	856 Conductivity Module - Overview .................................	1504
7.5.2	Properties - General ...........................................................	1504
7.5.3	Properties - Measuring inputs ............................................	1505
7.5.4	Properties - MSB # .............................................................	1506
7.5.5	Properties - GLP ................................................................	1507
7.6	867 pH Module ...............................................................	1509
7.6.1	867 pH Module - Overview ................................................	1509
7.6.2	Properties - General ...........................................................	1510
7.6.3	Properties - Measuring inputs ............................................	1511
7.6.4	Properties - MSB # .............................................................	1512
7.6.5	Properties - GLP ................................................................	1513
7.7	846 Dosing Interface .....................................................	1515
7.7.1	846 Dosing Interface - Overview ........................................	1515
7.7.2	Properties - General ...........................................................	1515
7.7.3	Properties - MSB # .............................................................	1516
7.7.4	Properties - GLP ................................................................	1517
7.8	730 Sample Changer ......................................................	1519
7.8.1	730 Sample Changer - Overview ........................................	1519
7.8.2	Properties - General ...........................................................	1520
7.8.3	Properties - Tower .............................................................	1521
7.8.4	Properties - Rack ................................................................	1522
7.8.5	Properties - Dosing device ..................................................	1522
7.8.6	Properties - RS-232 ............................................................	1523
7.8.7	Properties - GLP ................................................................	1523
7.9	774 Oven Sample Processor ..........................................	1525
7.9.1	774 Oven Sample Processor - Overview .............................	1525
7.9.2	Properties - General ...........................................................	1526
7.9.3	Properties - Tower .............................................................	1527
7.9.4	Properties - Rack ................................................................	1527
7.9.5	Properties - Dosing device ..................................................	1528
7.9.6	Properties - Oven ...............................................................	1529
7.9.7	Properties - Gas .................................................................	1530
7.9.8	Properties - RS-232 ............................................................	1530
7.9.9	Properties - GLP ................................................................	1531
7.10	778/789 Sample Processor ............................................	1533
7.10.1	778/789 Sample Processor - Overview ...............................	1533
7.10.2	Properties - General ...........................................................	1533
7.10.3	Properties - Tower # ..........................................................	1534
7.10.4	Properties - Rack ................................................................	1536
7.10.5	Properties - MSB # .............................................................	1537
7.10.6	Properties - RS-232 ............................................................	1538

tiamo 2.3 (for Process Analysis)

Table of contents
7.10.7	Properties - GLP ................................................................	1539
7.11	814/815 USB Sample Processor ....................................	1541
7.11.1	814/815 USB Sample Processor - Overview ........................	1541
7.11.2	Properties - General ...........................................................	1541
7.11.3	Properties - Tower # ..........................................................	1542
7.11.4	Properties - Rack ................................................................	1544
7.11.5	Properties - MSB # .............................................................	1545
7.11.6	Properties - GLP ................................................................	1546
7.11.7	Configuration Robotic arm ................................................	1548
7.11.8	External position ...............................................................	1549
7.12	855 Robotic Titrosampler ..............................................	1550
7.12.1	855 Robotic Titrosampler - Overview .................................	1550
7.12.2	Properties - General ...........................................................	1550
7.12.3	Properties - Measuring inputs ............................................	1551
7.12.4	Properties - Tower # ..........................................................	1552
7.12.5	Properties - Rack ................................................................	1554
7.12.6	Properties - MSB # .............................................................	1555
7.12.7	Properties - GLP ................................................................	1556
7.13	864 Balance Sample Processor .....................................	1558
7.13.1	864 Balance Sample Processor - Overview .........................	1558
7.13.2	Properties - General ...........................................................	1559
7.13.3	Properties - Tower # ..........................................................	1560
7.13.4	Properties - Rack ................................................................	1562
7.13.5	Properties - MSB # .............................................................	1563
7.13.6	Properties - GLP ................................................................	1564
7.14	874 Oven Sample Processor ..........................................	1566
7.14.1	874 Oven Sample Processor - Overview .............................	1566
7.14.2	Properties - General ...........................................................	1566
7.14.3	Properties - Tower .............................................................	1567
7.14.4	Properties - Rack ................................................................	1568
7.14.5	Properties - MSB # .............................................................	1568
7.14.6	Properties - Oven ...............................................................	1570
7.14.7	Properties - GLP ................................................................	1571
7.15	Avantes Spectrometer ...................................................	1573
7.15.1	Avantes Spectrometer - Overview ......................................	1573
7.15.2	Properties - General ...........................................................	1573
7.15.3	Properties - Settings ...........................................................	1574
7.15.4	Properties - Detector ..........................................................	1575
7.15.5	Properties - Calibration ......................................................	1575
7.15.6	Properties - Dark spectrum ................................................	1576
7.15.7	Properties - Reference spectrum ........................................	1577
7.15.8	Properties - GLP ................................................................	1578
7.16	089 Photometer ............................................................	1580
7.16.1	089 Photometer - Overview ...............................................	1580
7.16.2	Properties - General ...........................................................	1580
7.16.3	Properties - Settings ...........................................................	1581
7.16.4	Properties - Adjustment .....................................................	1582

X	tiamo 2.3 (for Process Analysis)

		Table of contents
7.16.5	Properties - MSB # .............................................................	1583
7.16.6	Properties - GLP ................................................................	1584
7.17	RS-232 device .................................................................	1586
7.17.1	RS-232 device - Overview ..................................................	1586
7.17.2	Properties - General ...........................................................	1586
7.17.3	Properties - RS-232 ............................................................	1587
7.17.4	Properties - GLP ................................................................	1589
7.17.5	Establish a connection to the RS-232 device ......................	1591
7.18	Balances ..........................................................................	1591
7.18.1	Balance - Overview ............................................................	1591
7.18.2	Properties - General ...........................................................	1592
7.18.3	Properties - RS-232 ............................................................	1593
7.18.4	Properties - GLP ................................................................	1594
7.18.5	Establish a connection to the balance ................................	1596
7.19	Barcode reader ...............................................................	1597
7.19.1	Barcode reader - General ...................................................	1597
7.19.2	Barcode reader - Overview .................................................	1598
7.19.3	Properties - General ...........................................................	1598
7.19.4	Properties - Settings ...........................................................	1599
7.19.5	Properties - GLP ................................................................	1599
7.19.6	Establish a connection to the barcode reader .....................	1601
7.20	IO controller ....................................................................	1602
7.20.1	IO controller - Overview .....................................................	1602
7.20.2	Properties - General ...........................................................	1602
7.20.3	Properties - Settings ...........................................................	1603
7.20.4	Properties - Digital inputs ...................................................	1604
7.20.5	Properties - Digital outputs ................................................	1608
7.20.6	Properties - Analog inputs ..................................................	1611
7.20.7	Properties - Analog outputs ...............................................	1613
7.20.8	Properties - Controller ........................................................	1616
7.20.9	Properties - GLP ................................................................	1635
7.21	Stepping motor controller .............................................	1637
7.21.1	Stepping motor controller - Overview ................................	1637
7.21.2	Properties - General ...........................................................	1637
7.21.3	Properties - Settings ...........................................................	1638
7.21.4	Properties - Digital inputs ...................................................	1639
7.21.5	Properties - Digital outputs ................................................	1643
7.21.6	Properties - Stepping motors .............................................	1646
7.21.7	Properties - GLP ................................................................	1648
8 Manual control		1651
8.1	Manual control - General ...............................................	1651
8.2	Manual control - Desktop ..............................................	1651
8.3	Manual control - Device selection ................................	1652
8.4	Manual control - Functions ...........................................	1652
8.4.1	Dosing ...............................................................................	1652

tiamo 2.3 (for Process Analysis)

Table of contents
8.4.2	Stirring ..............................................................................	1658
8.4.3	Remote functions ..............................................................	1660
8.4.4	Sample changer functions ..................................................	1662
8.4.5	Measure ............................................................................	1672
8.4.6	Process analysis functions ..................................................	1676
8.5	Manual control - Graphical display ...............................	1695
9 How to proceed?		1696
9.1	Audit Trail .......................................................................	1696
9.1.1	Opening Audit Trail ..........................................................	1696
9.1.2	Filtering Audit Trail ...........................................................	1696
9.1.3	Exporting Audit Trail .........................................................	1697
9.1.4	Archiving Audit Trail .........................................................	1698
9.1.5	Deleting Audit Trail ...........................................................	1699
9.2	Backup ............................................................................	1700
9.2.1	Backing up database .........................................................	1700
9.2.2	Restoring database ............................................................	1702
9.2.3	Backing up configuration data ...........................................	1703
9.2.4	Restoring configuration data .............................................	1705
9.2.5	Backing up methods ..........................................................	1706
9.2.6	Archive Audit Trail ............................................................	1708
9.3	Determinations ...............................................................	1709
9.3.1	Starting single determination .............................................	1709
9.3.2	Starting determination series .............................................	1710
9.3.3	Search for determinations ..................................................	1712
9.3.4	Filter determinations ..........................................................	1713
9.3.5	Signing determination .......................................................	1714
9.3.6	Export determinations .......................................................	1716
9.3.7	Importing determinations ..................................................	1717
9.3.8	Deleting determinations ...................................................	1718
9.3.9	Make the determination version current	............................ 1719
9.3.10	Reprocessing determinations ............................................	1720
9.3.11	Printing determination report ............................................	1724
9.3.12	Printing determination overview .......................................	1725
9.4	Databases .......................................................................	1726
9.4.1	Database in general ...........................................................	1726
9.4.2	Open database .................................................................	1727
9.4.3	Close database .................................................................	1727
9.4.4	Create database ................................................................	1728
9.4.5	Backing up database .........................................................	1729
9.4.6	Restoring database ............................................................	1730
9.4.7	Delete database .................................................................	1731
9.5	Configuration data .........................................................	1732
9.5.1	Configuration data in general ............................................	1732
9.5.2	Export configuration data ..................................................	1732
9.5.3	Importing configuration data .............................................	1733
9.5.4	Backing up configuration data ...........................................	1733

XII	tiamo 2.3 (for Process Analysis)

		Table of contents
9.5.5	Restoring configuration data .............................................	1735
9.6	Methods ..........................................................................	1736
9.6.1	Open method ....................................................................	1736
9.6.2	Closing method ................................................................	1736
9.6.3	Create method .................................................................	1737
9.6.4	Save method .....................................................................	1737
9.6.5	Deleting method ..............................................................	1738
9.6.6	Exporting method .............................................................	1739
9.6.7	Import methods ...............................................................	1739
9.6.8	Sign methods ...................................................................	1740
9.6.9	Making previous method version current ..........................	1742
9.6.10	Print method report ..........................................................	1742
9.6.11	Backup methods ...............................................................	1743
9.7	Method groups ...............................................................	1745
9.7.1	Creating method group ....................................................	1745
9.7.2	Deleting method group ....................................................	1746
9.8	Sample tables .................................................................	1746
9.8.1	Create sample table ..........................................................	1746
9.8.2	Edit sample table ..............................................................	1747
9.8.3	Loading working sample table ..........................................	1749
9.8.4	Edit working sample table .................................................	1749
9.9	Reports ............................................................................	1750
9.9.1	Creating report template ..................................................	1750
9.9.2	Edit report template .........................................................	1752
9.9.3	Printing determination report ............................................	1753
9.9.4	Printing determination overview .......................................	1754
Index		1756

tiamo 2.3 (for Process Analysis)

XIII

1 Introduction

1.1Welcome to tiamo

Introduction

tiamo = titration and more

tiamo is a control and database software for titrators, dosing devices and sample changers and makes complete laboratory automation possible. It is for that reason that the name tiamo stands for "titration and more" - tiamo can do more than just titrate.

tiamo is the successor software to TiNet and Workcell. Metrohm thus provides a uniform software product for laboratory automation. Companies with international operations can use the same software platform at all sites around the globe for the processing of its samples and exchange data and methods without loss.

Overview of the main program features

Program interface: easy to operate and configure

Simple integration of devices and accessories

Convenient method editor

Database-based program with Client/Server functionality

A wide range of import and export functions

FDA-compatibility in accordance with 21 CFR Part 11

Comprehensive online help

tiamo 2.3 (for Process Analysis)

1.2 Operation

Program versions

What is new in tiamo 2.3?

Overview of the most important information concerning process analysis instruments under tiamo

Process analysis instruments

–IO controller

–Stepping motor controller

Process analysis - Commands

Process analysis - Manual control

1.2Operation

Introduction

The modern user interface makes it simple for the user to find his/her way around tiamo. All the commands and control elements are where you would expect to find them. The bar on the left edge of the screen gives you access to the five basic elements of tiamo:

Workplace	Database	Method	Configura-	Manual
			tion

Depending on the access permissions, these buttons are either visible or invisible. The menu bar is in the upper part of the screen. It is also possible for the individual commands to be masked out, depending on the access permissions.

In the centre of the screen are the information windows with the settings, sample entry masks, live curves or results. This view can be set individually for each user with the aid of the new Layout Manager. This means that the users only see the windows or buttons needed for their work. This reduces the introductory period for routine users to a minimum; incorrect operation as a result of overcrowded screens are also a thing of the past.

The method and calculation templates successfully introduced with the Titrando system are also available in tiamo. A wide range of tried and tested methods allow any user to create new methods fast and simply and to use them immediately.

2	tiamo 2.3 (for Process Analysis)

1 Introduction

1.3Connecting devices

Introduction

tiamo brings together the world of Titrino devices and the new generation of the Titrando System under the same roof. Compatibility with existing Metrohm devices is not a matter of course in the software sector. The entire product range of the Titrino family, which was already integrated in TiNet, can be used with tiamo, and this after more than 10 years on the market! In addition, sample changers which to some extent are no longer included in the sales program, are integrated in tiamo. That is how Metrohm secures your investments!

Naturally, all of the models of the new Titrando generation, as well as the new sample processors, are compatible with tiamo. Thus, for example, the advantages of USB communications, such as plug-and-play or recognition of intelligent dosing systems, can be used with tiamo to their fullest extent. Even a mixed operation made up of older RS-232-operated devices and newer USB devices is possible without any problem.

With the process analysis version of tiamo, an IO controller integrated in the company network can also be directly controlled by tiamo.

Devices that can be used with tiamo

Titrando

808, 809, 835, 836, 841, 842, 851, 852, 855, 857, 888, 890, 901, 902, 904, 905, 906, 907

Titrino

702, 716, 718, 719, 720, 721, 736, 751, 758, 784, 785, 794, 795, 798, 799

Conductometer

712, 856

KF coulometer

756, 831

Sample changer

730, 774, 778, 789, 814, 815, 855, 864, 874

Miscellaneous

846 Dosing Interface, 859 Titrotherm, 867 pH Module, Avantes spectrometer, 089 Photometer, balances, barcode readers, IO controllers,

…

tiamo 2.3 (for Process Analysis)

1.4 Method editor

1.4Method editor

Introduction

The new graphic method editor gets more out of your titration system. With the aid of the numerous templates, methods can be created fast and easily. For most routine and automated tasks, there are tried and tested methods available. Just a few clicks and they are adapted and ready to use.

One new feature is that actions running parallel in terms of time can now be programmed and linked. Together with the new Titrando System and the Robotic Sample Processors, a sample can be prepared while the previous one is being titrated. This saves time and increases the sample throughput. The crowning feature is the simultaneous processing of several samples at once. This means that one Titrando can carry out two titrations at the same time. As a result, sample throughput is doubled!

tiamo is flexible and accommodates itself to analysis procedures, and not the other way around.

Overview of functions

Graphical method editor (see Chapter 5.6.1.2, page 437)

Method manager (see Chapter 5.3.1, page 416)

Separate management of access permissions for each method group

(see Chapter 5.4.2.3, page 428)

Templates for method development and calculation (see Chapter 5.2.1, page 403)

Plausibility check for methods (see Chapter 5.2.5, page 412)

Comments can be added to the methods (see Chapter 5.2.4.2.9, page 411)

Parallel runs (see Chapter 5.6.10.3.1, page 1276)

Loop functions (see Chapter 5.6.10.4.1, page 1278)

4	tiamo 2.3 (for Process Analysis)

1 Introduction

1.5Database

Introduction

tiamo is based on an object-oriented database, that has proven itself in practice. All program settings, the user administration, methods and templates are stored in the configuration database and the determination data is stored in the determination databases defined by the user. These databases can be installed locally on the computer reserved for measurements and make up a simple measurement system. tiamo is however scalable and grows with operational requirements. As soon as data security and central data management make it necessary, tiamo is installed as a Client/Server configuration. The tiamo database is then installed on a server. All measurement and office computers work as clients. All results are stored centrally in this network and can be accessed and processed by all Client PCs. All clients also access the same pool of methods.

The new database has all the major tools necessary for management of, searching for and grouping of results. Quick filters allow the user to search through thousands of determinations within seconds and to display the result clearly. Chart plots give a fast overview of the sequence of results based on time.

All options for reprocessing are available to the user.

Overview of functions

Object-oriented Client/Server database (see Chapter 6.2.3.1, page 1337).

Layout manager for the database view (see Chapter 3.1.7, page 98).

Quick filter (see Chapter 4.5.2.4.3, page 305).

Efficient search functions (see Chapter 4.5.2.3, page 302).

Access permissions control for every database (see Chapter 4.3.5.3, page 207).

Automatic database backup (see Chapter 4.3.5.4, page 208).

Control charts (see Chapter 4.5.2.17, page 344).

Reprocess determinations (see Chapter 4.5.2.6, page 315).

tiamo 2.3 (for Process Analysis)

1.6 Communication

1.6Communication

Introduction

The decisive factor for the acceptance of PC-controlled analysis systems is being able to integrate it easily and economically in existing laboratory information systems, central databases and long-term archiving systems.

tiamo is communicative. LIMS systems can easily import work lists into the tiamo sample table and control them remotely, without extra modules. Data generated in tiamo can be exported in XML format. Connection to LIMS systems on the market is thus not difficult. Export to longterm archiving systems such as NuGenesis SDMS or Scientific Software Cyberlab is also supported.

The Report generator provides a simple and flexible solution for creating analysis reports. The report generator allows you to freely define the report templates. It is therefore possible at any time to display one or more determinations in a choice of PDF layouts or as a printout.

A special feature is that tiamo messages, error messages or results from the method run can be sent to the user by e-mail.

Overview of functions

Import of sample data (see Chapter 3.3.1.6, page 110).

Various export formats , e.g. XML, CSV, SLK (see Chapter 4.4.4.2.1, page 258).

Automatic data export, e.g. to NuGenesis SDMS, Scientific Software CyberLAB, etc. (see Chapter 5.6.8.5.1, page 1249).

Report designer (see Chapter 4.4.1.4.1.1, page 215).

E-mail functions for status messages, error messages or results (see Chapter 2.6, page 92).

Import of external measured values (see Chapter 5.6.3.11.2, page 929).

6	tiamo 2.3 (for Process Analysis)

1 Introduction

1.7Conformity

Introduction

tiamo also sets new standards with respect to the fulfilling of GMP, GLP and FDA requirements. The latest quality standards and validation procedures were implemented in developing and programming the software. tiamo has been designed to fulfill the FDA directive 21 CFR Part 11 and the customer-specific interpretations. This is evidenced by a Certificate of Conformity. A centralized user administration defines the access permissions for program functions, methods and results, whereby any number of users with freely definable access profiles are possible. The system administrator can conveniently access the user administration from any tiamo client. Access to the software is password-protected and there is a choice of tiamo or Windows login.

The use of digital signatures makes it possible to sign methods and results. There are two signatures available with differing properties. With the first signature (Level 1, Review) the user confirms that he has programmed the method correctly or carried out the analysis correctly. With the second signature (Level 2, Release) the method or result is released and protected against further modifications. It is thus possible to mirror customized workflows in tiamo.

All data is organized according to the version and protected against unauthorized access, modification or deletion in the database. The database itself controls access to the data in network operation and provides archiving and restore functions.

The "Audit Trail" protocols all actions by the user and all major system processes.

Conformity relevant properties of tiamo

Conformity is priority in development and validation.

Centralized user administration (see Chapter 6.2.1.1, page 1318).

Detailed access permissions (see Chapter 6.2.1.2.2, page 1321).

Password protection under tiamo or Windows (see Chapter 6.2.2.2, page 1328).

Digital signature on two levels (see Chapter 2.3, page 23).

One signature each for methods and results.

Documentation of all method and result modifications (see Chapter 4.5.2.14, page 342).

Traceability thanks to detailed Audit Trail (see Chapter 6.4.1.1, page 1366).

tiamo 2.3 (for Process Analysis)

1.8 Versions

1.8Versions

Introduction

tiamo is available in three sales versions, which differ with regard to the scope of functions. An upgrade is possible at any time.

	tiamo 2.3	tiamo 2.3	tiamo 2.3
	light	full	multi

Product	6.6056.231	6.6056.232	6.6056.233
Maximum number	2	unlimited	unlimited
of devices per PC
Compatible with		•	•
FDA 21 CFR Part
11
User administra-	•	•	•
tion
Security settings		•	•
Traceability		•	•
("Audit Trail")
Client/Server sup-			•
port
Number of licen-	1	1	3
ses
Additional licenses			•
as an option
XML data export		•	•
to LIMS
Parallel titrations		•	•
Upgrade possible	•	•

8	tiamo 2.3 (for Process Analysis)

1 Introduction

1.9Online help

Introduction

Calling up the help

tiamo has an extensive and detailed online help that can be accessed in two ways:

General call With the menu item Help tiamo help, or the symbol

the online help with the topic Welcome to tiamo is opened. From there you can jump via Contents, Index, Search or personal Favorites to the desired topic.

Context-sensitive call With the function key [F1] on the keyboard you can jump directly to the topic which will show information on the active element in tiamo (dialog window, tab).

Symbols and conventions

The following symbols and styles are used in this documentation:

Device table		Link to another help topic in which information is
		shown for the marked term.

	Method	Dialog text
		Designation for names of parameters, menu items,
		tabs and dialog windows in the software.

100		Designation for parameter values in input fields.

File New		Menu or menu item; Path needed to reach a certain
		point in the program.

	[Next]	Button

		Formula editor
		Formulae can be entered in fields with this symbol,
		and the formula editor opens when you click on the
		symbol (see Chapter 2.4, page 29).

		Instruction step
		Carry out these steps in the sequence shown.

		Caution
		This symbol draws attention to a possible damage of
		instruments or instrument parts.

		Note
		Note
		This symbol marks additional information and tips.
		This symbol marks additional information and tips.

tiamo 2.3 (for Process Analysis)

1.10 What is new in tiamo 2.3?

1.10What is new in tiamo 2.3?

In this chapter the changes since tiamo 2.2 are described.

1.10.1New features

General

tiamo now also supports the device activation with 64-bit operating systems and is thus completely 64-bit-capable.

New instruments

089 Photometer

New instrument firmware

5.089.0010

5.814.0024

5.815.0025

5.846.0021

5.855.0013

5.856.0021

5.857.0021

5.867.0021

5.874.0011

5.888.0021

5.890.0021

5.901.0021

5.902.0021

5.904.0021

5.905.0021

5.906.0021

5.907.0021

New or updated commands

MET Cond: Command for monotonic equivalence point titrations with conductometric measurement.

MEAS TMF: Command for the determination of the transmission factor of a measurement configuration.

MEAS Opt: Command for extinction measurements (new for the 089 Photometer).

MEAS Opt Conc: Command for concentration measurements (direct measurement) with spectrometer or photometer.

CAL LOOP Opt: Loop command for the calibration of colorimetric sensors, used together with the command CAL MEAS Opt.

10	tiamo 2.3 (for Process Analysis)

1 Introduction

CAL MEAS Opt: Command for measuring standard solutions for the calibration of colorimetric sensors, used together with the command

CAL LOOP Opt.

ELT LOOP: Loop command for the electrode test (test of pH electrodes), used together with the command ELT MEAS.

ELT MEAS: Command for measuring calibration buffers for the electrode test (test of pH electrodes), used together with the command

ELT LOOP.

CONTROL: Command for controlling Beckhoff instruments.

New features in the program part Database

The determination comment is available as an additional column in the determination overview; it is also possible to search for it and to generate a filter for this purpose.

New features in the program part Method

There are method templates available for MET Ipol, MET Cond,

STDADD auto, CAL Cond and ELT LOOP.

Drift-controlled measurements are now possible with the Avantes spectrometer.

In the case of commands with conditioning, it is possible to control the sample addition time manually ("infinite" sample addition time).

The command MEAS Opt has a tab Additional measured values.

New features in the program part Configuration

New subwindow Colorimetric sensors. They are used in the commands CAL MEAS Opt and MEAS Opt Conc.

In the configuration of the sample changers, a position can be defined on the tab Initializing position which is automatically moved to when initializing the sample changer.

One can define electrode type templates for the electrode test, of which three are supplied in the default settings (Gel, Non-aqueous,

Standard).

New features in the program Remote Control

The remote control can extract all of the results of a method which are to be generated.

1.10.2Improvements

General

For the Avantes spectrometer, the measuring range of 200 … 1100 nm has been expanded to 100 … 2000 nm. This affects the commands

MEAS Spec, MEAS Opt, CAL Spec and the manual control.

tiamo 2.3 (for Process Analysis)

1.10 What is new in tiamo 2.3?

Program part Database

In the subwindow Results, the variables used more than once in calculations will be identified only once.

Program part Method

In the command CAL LOOP pH, the selection for the parameter Number of buffers has been raised from 5 to 9.

For an unambiguous and unmistakable recognition of the Merck buffers, the name of the previously used buffer has been changed from

Merck to Merck CertiPUR 20°C/Titrisol in the command CAL LOOP pH.

The determination ID is available as the system variable SV.DID.

The term "Electrode test" for commands with Ipol/Upol has been replaced by Electrode check. The electrode test determines the quality of the electrodes with the commands ELT LOOP and ELT MEAS, whereas the electrode check looks only for the presence of the electrode.

With the command MEAS Cond, the option Measurement without drift control is the new default setting on the tab Measuring parameters.

Program part Configuration

The number of calibration buffers of its own has been raised in the configuration from 5 to 9. In order to ensure robust recognition, however, the clearance between the individual buffers must be at least one pH unit.

A new feature is that the Settings according to 21 CFR Part 11 can now be set by means of a single check box; an audit trail entry is also generated when the check box is activated and deactivated. The elements affected by this setting become inactive.

The determination ID can be copied in the program part Configuration. It can be found at the following locations:

–in the dialog window Properties – Avantes Spectrometer on the tabs Calibration, Dark spectrum and Reference spectrum.

–in the dialog window Sample solution (TC conductivity) - %1 on the tab TC data.

–in the dialog window Colorimetric sensor - %1 on the tab

Calibration data.

Program part Manual control

A new feature is that the parameters Shift rate, Lift rate and Swing rate are now to be found on the tab Move for the manual operation of the sample changer (previously: tab General).

12	tiamo 2.3 (for Process Analysis)

1 Introduction

1.10.3Fixed bugs and problems

Program part Workplace

If the monitoring of the titer validity, the common variable, the global variable or the calibration data had expired, then it was not possible to redetermine the titer, the common variable or the global variable via the CALC command ("Save result as..." ) or to carry out a calibration (the error was rectified previously in tiamo 2.2 Patch 1).

The program crashed when running MET determinations with Titrinos (the error was rectified previously in tiamo 2.2 Patch 1).

If the beaker test was enabled and the action Cancel determination and series was selected in the MOVE command for the beaker test, then the error track was not being run through when a beaker was missing (the error was rectified previously in tiamo 2.2 Patch 1).

Communications problems sometimes occurred with the 855 Robotic Titrosampler during the run of a determination with the command STDADD auto. The problem has been solved with a new device firmware.

If the action Cancel determination and series was activated in the command MOVE under Beaker test and if a beaker or a vial was missing on the rack during the sequence, then the message 016-002 Beaker missing would correctly appear. The series was however interrupted without the error track being run through.

If work was performed with the start volume in connection with the command TET, then this start volume would be ignored in the evaluation.

A chip (IDU/IEU) with invalid data sometimes led to a crash (e.g. in connection with the titer assignment).

If a determination series was started and a new workplace was created during the determination, the currently running determination was repeated once again.

If a determination was started in which a result was to be saved both as a common variable and as a global variable (whereby only the common variable and not the global variable had been defined in the configuration), then the message 019-108 Global variable not found would appear. The common variable would however remain reserved in the configuration and would no longer be enabled.

Determinations could still be started, even if the ACTUAL statistic counter in the subwindow Run was greater than the NOMINAL statistic counter.

During a KFC determination in which a stop time was defined for the conditioning, tiamo would "freeze up" after the expiration of the stop time.

tiamo 2.3 (for Process Analysis)

1.10 What is new in tiamo 2.3?

If one wished to edit a line in the sample data table (e.g., in order to change a sample size) in situations where the method group was different from the one in the last line, then the method was replaced automatically by the first method in the last method group.

If a waiting time was specified in a KFC method as a start condition (Pause) and if a determination series was started with the method, then the time was depicted correctly in the live display only in the first run-through. This had however no effect on the sequence.

In the command START, Number or Date/Time was selected on the tab Method variables for IDx as the type, while at the same time the check box Check at start was also active. If the IDx fields were still empty at the start of the determination, then the message 014-152 Field empty would appear after the start of the conditioning.

Determinations with the command STAT pH with monitoring (action: Wait for [Continue]) did not function correctly.

The Round() function supplied incorrect results under certain conditions.

Formula	Result

Round( 1000 * 10 / 50 )/1000	0.00	wrong

(Round( 1000 * 10 / 50 )/1000)	0.20	right

If the iConnect was disconnected during a measurement, then the message Unhandled error would appear.

If a method was comprised of several tracks with WAIT commands in which one track called up the next with a command CALL, then this sometimes led to deadlocks.

Program part Database

The table was not displayed in the dialog window Reprocessing on the tab Statistics (the error was rectified previously in tiamo 2.2 Patch 1).

Problems sometimes arose in connection with titrations with conditioning in cases where more than one database was entered in the command DATABASE.

If a track (e.g. which contained a command STAT pH) was run through more than once, then all of the curves were displayed in the database, even if the function Delete old data was activated.

The break points found were not output in the database in the subwindow Results on the tab Raw data with the command MEAS Opt.

The x smoothing was not applied on the y1 axis in the database with the properties of the curve in the dialog window Curve evaluation.

14	tiamo 2.3 (for Process Analysis)

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